JP6651180B2 - Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物 - Google Patents

Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物 Download PDF

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JP6651180B2
JP6651180B2 JP2019506191A JP2019506191A JP6651180B2 JP 6651180 B2 JP6651180 B2 JP 6651180B2 JP 2019506191 A JP2019506191 A JP 2019506191A JP 2019506191 A JP2019506191 A JP 2019506191A JP 6651180 B2 JP6651180 B2 JP 6651180B2
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compound
bcl
methyl
pharmaceutically acceptable
cancer
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JP2019527705A (ja
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ワン シャオモン
ワン シャオモン
チエンヨン チェン
チエンヨン チェン
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University of Michigan System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
JP2019506191A 2016-08-05 2017-08-04 Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物 Active JP6651180B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662371504P 2016-08-05 2016-08-05
US62/371,504 2016-08-05
US201762454101P 2017-02-03 2017-02-03
US62/454,101 2017-02-03
PCT/US2017/045428 WO2018027097A1 (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Related Child Applications (1)

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JP2019135624A Division JP7205903B2 (ja) 2016-08-05 2019-07-23 Ｂｃｌ－２阻害剤としてのｎ－（フェニルスルホニル）ベンズアミドおよび関連化合物

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JP2019527705A JP2019527705A (ja) 2019-10-03
JP6651180B2 true JP6651180B2 (ja) 2020-02-19

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JP2019135624A Active JP7205903B2 (ja) 2016-08-05 2019-07-23 Ｂｃｌ－２阻害剤としてのｎ－（フェニルスルホニル）ベンズアミドおよび関連化合物

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US (3) US10829488B2 (enExample)
EP (3) EP3494115B1 (enExample)
JP (2) JP6651180B2 (enExample)
KR (2) KR102429704B1 (enExample)
CN (2) CN110483501B (enExample)
AU (2) AU2017305508B2 (enExample)
CA (1) CA3031419C (enExample)
CY (1) CY1123859T1 (enExample)
DK (1) DK3494115T3 (enExample)
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IL (2) IL264059B (enExample)
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PE (1) PE20190711A1 (enExample)
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PT (1) PT3494115T (enExample)
RS (1) RS61821B1 (enExample)
RU (2) RU2722560C1 (enExample)
SA (1) SA519401020B1 (enExample)
SG (2) SG11201900135YA (enExample)
SI (1) SI3494115T1 (enExample)
SM (1) SMT202100025T1 (enExample)
WO (1) WO2018027097A1 (enExample)
ZA (2) ZA201900240B (enExample)

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JP2020007311A (ja) * 2016-08-05 2020-01-16 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物

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CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
BR112020018978A2 (pt) * 2018-07-31 2021-03-02 Ascentage Pharma (Suzhou) Co., Ltd. produto de combinação que compreende um inibidor de bcl-2 e um inibidor de mdm2 e uso dos ditos inibidores na prevenção e/ou tratamento de câncer
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TWI770503B (zh) * 2019-05-13 2022-07-11 大陸商蘇州亞盛藥業有限公司 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物
TW202114692A (zh) * 2019-07-02 2021-04-16 大陸商蘇州亞盛藥業有限公司 一種含有mTOR抑制劑的藥物組合及其應用
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CN112898295A (zh) * 2019-12-03 2021-06-04 苏州亚盛药业有限公司 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物
CN112891353B (zh) * 2019-12-04 2024-01-30 苏州亚盛药业有限公司 药物组合及其用途
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BR112022019525A2 (pt) 2020-04-15 2023-11-14 Beigene Ltd Composto, composição farmacêutica e método para tratar doenças apoptóticas desreguladas
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CN111537654B (zh) * 2020-07-07 2020-11-10 上海亚盛医药科技有限公司 N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法
WO2022007940A1 (zh) * 2020-07-10 2022-01-13 江苏恒瑞医药股份有限公司 磺酰苯甲酰胺类衍生物及其偶联物、其制备方法及其应用
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
US20230301989A1 (en) * 2020-08-21 2023-09-28 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating systemic lupus erythematosus
WO2022037683A1 (en) * 2020-08-21 2022-02-24 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
JP2023551056A (ja) * 2020-11-25 2023-12-06 アセンテージ ファーマ（スーチョウ）カンパニー，リミティド 固体分散体、医薬製剤、その製造方法及び応用
WO2022143602A1 (en) * 2020-12-28 2022-07-07 Ascentage Pharma (Suzhou) Co., Ltd. Methods of treating multiple sclerosis
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Publication number Priority date Publication date Assignee Title
JP2020007311A (ja) * 2016-08-05 2020-01-16 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物
JP7205903B2 (ja) 2016-08-05 2023-01-17 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン Ｂｃｌ－２阻害剤としてのｎ－（フェニルスルホニル）ベンズアミドおよび関連化合物

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SA519401020B1 (ar) 2022-03-16
KR20210107170A (ko) 2021-08-31
RU2020114660A (ru) 2020-06-19
US20210002277A1 (en) 2021-01-07
EP3569601B1 (en) 2022-06-22
MX2019001391A (es) 2019-06-06
DK3494115T3 (da) 2021-01-18
MY199409A (en) 2023-10-25
PE20190711A1 (es) 2019-05-17
SMT202100025T1 (it) 2021-03-15
RU2744358C2 (ru) 2021-03-05
US20180354950A1 (en) 2018-12-13
EP3569601A2 (en) 2019-11-20
CY1123859T1 (el) 2022-05-27
HRP20202073T1 (hr) 2021-02-19
ZA201900240B (en) 2020-05-27
SI3494115T1 (sl) 2021-02-26
LT3494115T (lt) 2021-01-25
CN110483501A (zh) 2019-11-22
JP2020007311A (ja) 2020-01-16
NZ750100A (en) 2021-01-29
CN109311871A (zh) 2019-02-05
RU2020114660A3 (enExample) 2020-09-15
EP4129999A1 (en) 2023-02-08
IL282099A (en) 2021-05-31
EP3494115B1 (en) 2020-10-21
KR20190035710A (ko) 2019-04-03
AU2021202113A1 (en) 2021-05-06
PH12019500231A1 (en) 2019-07-29
IL282099B (en) 2022-03-01
AU2017305508A1 (en) 2019-02-07
KR102429704B1 (ko) 2022-08-04
WO2018027097A1 (en) 2018-02-08
CN110483501B (zh) 2022-07-01
CN109311871B (zh) 2020-02-28
ES2849959T3 (es) 2021-08-24
IL264059A (en) 2019-01-31
RS61821B1 (sr) 2021-06-30
MX381588B (es) 2025-03-12
BR112019001666A2 (pt) 2019-05-28
AU2021202113B2 (en) 2022-08-18
US10829488B2 (en) 2020-11-10
SG11201900135YA (en) 2019-02-27
PT3494115T (pt) 2021-01-15
CA3031419A1 (en) 2018-02-08
KR102376764B1 (ko) 2022-03-18
IL264059B (en) 2021-05-31
HUE053414T2 (hu) 2021-06-28
ZA201908466B (en) 2020-05-27
EP3569601A3 (en) 2019-11-27
SG10201913643YA (en) 2020-03-30
JP7205903B2 (ja) 2023-01-17
MX2020013014A (es) 2021-02-22
AU2017305508B2 (en) 2021-01-07
US10221174B2 (en) 2019-03-05
US20190315739A1 (en) 2019-10-17
CA3031419C (en) 2021-08-24
EP3494115A1 (en) 2019-06-12
US11718613B2 (en) 2023-08-08
RU2020134802A (ru) 2022-04-25
JP2019527705A (ja) 2019-10-03
RU2722560C1 (ru) 2020-06-01

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