KR102376764B1 - Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물 - Google Patents

Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물 Download PDF

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KR102376764B1
KR102376764B1 KR1020197002744A KR20197002744A KR102376764B1 KR 102376764 B1 KR102376764 B1 KR 102376764B1 KR 1020197002744 A KR1020197002744 A KR 1020197002744A KR 20197002744 A KR20197002744 A KR 20197002744A KR 102376764 B1 KR102376764 B1 KR 102376764B1
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KR20190035710A (ko
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샤오멩 왕
지안용 첸
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더 리젠츠 오브 더 유니버시티 오브 미시건
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020197002744A 2016-08-05 2017-08-04 Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물 Active KR102376764B1 (ko)

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KR1020217026744A KR102429704B1 (ko) 2016-08-05 2017-08-04 Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물

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US201662371504P 2016-08-05 2016-08-05
US62/371,504 2016-08-05
US201762454101P 2017-02-03 2017-02-03
US62/454,101 2017-02-03
PCT/US2017/045428 WO2018027097A1 (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

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KR1020197002744A Active KR102376764B1 (ko) 2016-08-05 2017-08-04 Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물

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TWI777438B (zh) * 2020-03-06 2022-09-11 大陸商蘇州亞盛藥業有限公司 N- (苯基磺醯基) 苯甲醯胺類化合物的結晶形式
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WO2021227763A1 (en) * 2020-05-14 2021-11-18 Ascentage Pharma (Suzhou) Co., Ltd. Hplc analysis method for n- (phenylsulfonyl) benzamide compound
US20230159524A1 (en) * 2020-07-01 2023-05-25 Ascentage Pharma (Suzhou) Co., Ltd. Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof
CN111537654B (zh) * 2020-07-07 2020-11-10 上海亚盛医药科技有限公司 N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法
CN115697967B (zh) * 2020-07-10 2024-10-22 江苏恒瑞医药股份有限公司 磺酰苯甲酰胺类衍生物及其偶联物、其制备方法及其应用
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
US20230398110A1 (en) * 2020-08-21 2023-12-14 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
CN114073707A (zh) * 2020-08-21 2022-02-22 苏州亚盛药业有限公司 治疗系统性红斑狼疮的组合物和方法
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US10221174B2 (en) 2019-03-05
US10829488B2 (en) 2020-11-10
MY199409A (en) 2023-10-25
KR102429704B1 (ko) 2022-08-04
HRP20202073T1 (hr) 2021-02-19
SMT202100025T1 (it) 2021-03-15
PT3494115T (pt) 2021-01-15
PE20190711A1 (es) 2019-05-17
AU2021202113B2 (en) 2022-08-18
EP3569601B1 (en) 2022-06-22
US20190315739A1 (en) 2019-10-17
US20180354950A1 (en) 2018-12-13
CN110483501B (zh) 2022-07-01
JP2020007311A (ja) 2020-01-16
US20210002277A1 (en) 2021-01-07
CN109311871B (zh) 2020-02-28
KR20210107170A (ko) 2021-08-31
WO2018027097A1 (en) 2018-02-08
RS61821B1 (sr) 2021-06-30
IL264059A (en) 2019-01-31
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IL282099B (en) 2022-03-01
ES2849959T3 (es) 2021-08-24
CN109311871A (zh) 2019-02-05
CA3031419C (en) 2021-08-24
BR112019001666A2 (pt) 2019-05-28
RU2744358C2 (ru) 2021-03-05
JP6651180B2 (ja) 2020-02-19
EP3494115B1 (en) 2020-10-21
AU2021202113A1 (en) 2021-05-06
EP4129999A1 (en) 2023-02-08
MX2020013014A (es) 2021-02-22
CA3031419A1 (en) 2018-02-08
SA519401020B1 (ar) 2022-03-16
EP3569601A2 (en) 2019-11-20
PH12019500231A1 (en) 2019-07-29
EP3494115A1 (en) 2019-06-12
NZ750100A (en) 2021-01-29
RU2020114660A (ru) 2020-06-19
SG10201913643YA (en) 2020-03-30
SI3494115T1 (sl) 2021-02-26
MX381588B (es) 2025-03-12
ZA201908466B (en) 2020-05-27
HUE053414T2 (hu) 2021-06-28
KR20190035710A (ko) 2019-04-03
CN110483501A (zh) 2019-11-22
IL282099A (en) 2021-05-31
MX2019001391A (es) 2019-06-06
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EP3569601A3 (en) 2019-11-27
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LT3494115T (lt) 2021-01-25
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US11718613B2 (en) 2023-08-08
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