EP3914251A4 - N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors - Google Patents
N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors Download PDFInfo
- Publication number
- EP3914251A4 EP3914251A4 EP20895135.0A EP20895135A EP3914251A4 EP 3914251 A4 EP3914251 A4 EP 3914251A4 EP 20895135 A EP20895135 A EP 20895135A EP 3914251 A4 EP3914251 A4 EP 3914251A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- benzamides
- phenylsulfonyl
- bcl
- inhibitors
- related compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2019122608 | 2019-12-03 | ||
CN2020078364 | 2020-03-09 | ||
CN2020095844 | 2020-06-12 | ||
CN2020100903 | 2020-07-08 | ||
CN202011352984 | 2020-11-27 | ||
PCT/CN2020/133621 WO2021110097A1 (en) | 2019-12-03 | 2020-12-03 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3914251A1 EP3914251A1 (en) | 2021-12-01 |
EP3914251A4 true EP3914251A4 (en) | 2022-03-23 |
Family
ID=76111461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20895135.0A Pending EP3914251A4 (en) | 2019-12-03 | 2020-12-03 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220305034A1 (en) |
EP (1) | EP3914251A4 (en) |
CN (1) | CN112898295A (en) |
TW (1) | TWI772992B (en) |
WO (1) | WO2021110097A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA125241C2 (en) * | 2018-07-31 | 2022-02-02 | Есентейдж Фарма (Сучжоу) Ко., Лтд. | Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/orbendamustine or bcl-2 inhibitor combined with chop |
JP2023539114A (en) * | 2020-08-21 | 2023-09-13 | アセンテージ ファーマ(スーチョウ)カンパニー,リミティド | Compositions and methods for treating systemic lupus erythematosus |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017040617A1 (en) * | 2015-08-31 | 2017-03-09 | Pharmacyclics Llc | Btk inhibitor combinations for treating multiple myeloma |
WO2021110136A1 (en) * | 2019-12-04 | 2021-06-10 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical combination and use thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3179991T3 (en) * | 2014-08-11 | 2022-02-14 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor |
AU2016314082B2 (en) * | 2015-08-28 | 2019-07-25 | Novartis Ag | Mdm2 inhibitors and combinations thereof |
EP4129999A1 (en) | 2016-08-05 | 2023-02-08 | The Regents Of The University Of Michigan | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
UA125241C2 (en) * | 2018-07-31 | 2022-02-02 | Есентейдж Фарма (Сучжоу) Ко., Лтд. | Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/orbendamustine or bcl-2 inhibitor combined with chop |
AU2019314819A1 (en) * | 2018-07-31 | 2020-10-22 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
CN110772521A (en) * | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2 inhibitor or Bcl-2/Bcl-xL inhibitor and BTK inhibitor combination product and application thereof |
KR20210003731A (en) * | 2018-07-31 | 2021-01-12 | 어센테지 파마 (쑤저우) 컴퍼니 리미티드 | Combination products of Bcl-2 inhibitor and MDM2 inhibitor and their use in the prevention and/or treatment of diseases |
WO2020103921A1 (en) * | 2018-11-23 | 2020-05-28 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition and use thereof |
-
2020
- 2020-12-03 TW TW109142556A patent/TWI772992B/en active
- 2020-12-03 WO PCT/CN2020/133621 patent/WO2021110097A1/en active Application Filing
- 2020-12-03 CN CN202011411048.3A patent/CN112898295A/en active Pending
- 2020-12-03 US US17/287,661 patent/US20220305034A1/en active Pending
- 2020-12-03 EP EP20895135.0A patent/EP3914251A4/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017040617A1 (en) * | 2015-08-31 | 2017-03-09 | Pharmacyclics Llc | Btk inhibitor combinations for treating multiple myeloma |
WO2021110136A1 (en) * | 2019-12-04 | 2021-06-10 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical combination and use thereof |
Non-Patent Citations (2)
Title |
---|
MARINA KONOPLEVA ET AL: "Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia", CANCER DISCOVERY, vol. 6, no. 10, 12 August 2016 (2016-08-12), US, pages 1106 - 1117, XP055642391, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-16-0313 * |
See also references of WO2021110097A1 * |
Also Published As
Publication number | Publication date |
---|---|
TWI772992B (en) | 2022-08-01 |
TW202133848A (en) | 2021-09-16 |
CN112898295A (en) | 2021-06-04 |
WO2021110097A1 (en) | 2021-06-10 |
US20220305034A1 (en) | 2022-09-29 |
EP3914251A1 (en) | 2021-12-01 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20220221 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 471/04 20060101ALI20220215BHEP Ipc: A61P 35/02 20060101ALI20220215BHEP Ipc: A61P 35/00 20060101ALI20220215BHEP Ipc: A61K 45/06 20060101ALI20220215BHEP Ipc: A61K 31/706 20060101ALI20220215BHEP Ipc: A61K 31/55 20060101ALI20220215BHEP Ipc: A61K 31/519 20060101ALI20220215BHEP Ipc: A61K 31/497 20060101ALI20220215BHEP Ipc: A61K 31/4745 20060101ALI20220215BHEP Ipc: A61K 31/454 20060101ALI20220215BHEP Ipc: A61K 31/496 20060101AFI20220215BHEP Ipc: A61K 31/573 20060101ALI20220215BHEP |
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Effective date: 20220318 |
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