RU2722560C1 - N-(фенилсульфонил) бензамиды и родственные соединения в качестве ингибиторов bcl-2 - Google Patents

N-(фенилсульфонил) бензамиды и родственные соединения в качестве ингибиторов bcl-2 Download PDF

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RU2722560C1
RU2722560C1 RU2019105721A RU2019105721A RU2722560C1 RU 2722560 C1 RU2722560 C1 RU 2722560C1 RU 2019105721 A RU2019105721 A RU 2019105721A RU 2019105721 A RU2019105721 A RU 2019105721A RU 2722560 C1 RU2722560 C1 RU 2722560C1
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methyl
pyrrolo
oxy
chlorophenyl
pyridin
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RU2019105721A
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Russian (ru)
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Шаомэн Ван
Цзяньюн Чэнь
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Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
RU2019105721A 2016-08-05 2017-08-04 N-(фенилсульфонил) бензамиды и родственные соединения в качестве ингибиторов bcl-2 RU2722560C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662371504P 2016-08-05 2016-08-05
US62/371,504 2016-08-05
US201762454101P 2017-02-03 2017-02-03
US62/454,101 2017-02-03
PCT/US2017/045428 WO2018027097A1 (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

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RU2020114660A RU2744358C2 (ru) 2016-08-05 2017-08-04 N-(фенилсульфонил) бензамиды и родственные соединения в качестве ингибиторов bcl-2

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CN118542872A (zh) * 2019-12-04 2024-08-27 苏州亚盛药业有限公司 药物组合及其用途
KR20220100992A (ko) 2019-12-06 2022-07-18 록쏘 온콜로지, 인코포레이티드 브루톤 티로신 키나제 억제제의 투여
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CN115244051B (zh) * 2020-03-12 2024-10-18 南京明德新药研发有限公司 苯并五元环类化合物
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CN114073707A (zh) * 2020-08-21 2022-02-22 苏州亚盛药业有限公司 治疗系统性红斑狼疮的组合物和方法
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
JP2023551056A (ja) * 2020-11-25 2023-12-06 アセンテージ ファーマ（スーチョウ）カンパニー，リミティド 固体分散体、医薬製剤、その製造方法及び応用
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AU2021202113A1 (en) 2021-05-06
PH12019500231A1 (en) 2019-07-29
MX2020013014A (es) 2021-02-22
SG10201913643YA (en) 2020-03-30
SI3494115T1 (sl) 2021-02-26
US20210002277A1 (en) 2021-01-07
RU2744358C2 (ru) 2021-03-05
HUE053414T2 (hu) 2021-06-28
RU2020114660A (ru) 2020-06-19
AU2017305508A1 (en) 2019-02-07
AU2017305508B2 (en) 2021-01-07
DK3494115T3 (da) 2021-01-18
JP2020007311A (ja) 2020-01-16
SMT202100025T1 (it) 2021-03-15
IL282099B (en) 2022-03-01
NZ750100A (en) 2021-01-29
HRP20202073T1 (hr) 2021-02-19
WO2018027097A1 (en) 2018-02-08
RU2020114660A3 (enExample) 2020-09-15
KR102429704B1 (ko) 2022-08-04
US20180354950A1 (en) 2018-12-13
IL264059B (en) 2021-05-31
ZA201908466B (en) 2020-05-27
CN110483501A (zh) 2019-11-22
EP3569601B1 (en) 2022-06-22
AU2021202113B2 (en) 2022-08-18
RS61821B1 (sr) 2021-06-30
LT3494115T (lt) 2021-01-25
EP3494115B1 (en) 2020-10-21
ES2849959T3 (es) 2021-08-24
US20190315739A1 (en) 2019-10-17
KR20210107170A (ko) 2021-08-31
JP2019527705A (ja) 2019-10-03
IL282099A (en) 2021-05-31
IL264059A (en) 2019-01-31
CN110483501B (zh) 2022-07-01
CY1123859T1 (el) 2022-05-27
SG11201900135YA (en) 2019-02-27
PT3494115T (pt) 2021-01-15
US10829488B2 (en) 2020-11-10
KR20190035710A (ko) 2019-04-03
EP3569601A3 (en) 2019-11-27
CN109311871A (zh) 2019-02-05
EP3569601A2 (en) 2019-11-20
BR112019001666A2 (pt) 2019-05-28
RU2020134802A (ru) 2022-04-25
ZA201900240B (en) 2020-05-27
MX2019001391A (es) 2019-06-06
CA3031419A1 (en) 2018-02-08
KR102376764B1 (ko) 2022-03-18
CA3031419C (en) 2021-08-24
SA519401020B1 (ar) 2022-03-16
JP6651180B2 (ja) 2020-02-19
EP4129999A1 (en) 2023-02-08
PE20190711A1 (es) 2019-05-17
EP3494115A1 (en) 2019-06-12
US11718613B2 (en) 2023-08-08
JP7205903B2 (ja) 2023-01-17
MY199409A (en) 2023-10-25
MX381588B (es) 2025-03-12
US10221174B2 (en) 2019-03-05
CN109311871B (zh) 2020-02-28

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