AU2017305508B2 - N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors - Google Patents

N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors Download PDF

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AU2017305508B2
AU2017305508B2 AU2017305508A AU2017305508A AU2017305508B2 AU 2017305508 B2 AU2017305508 B2 AU 2017305508B2 AU 2017305508 A AU2017305508 A AU 2017305508A AU 2017305508 A AU2017305508 A AU 2017305508A AU 2017305508 B2 AU2017305508 B2 AU 2017305508B2
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methyl
compound
cancer
disclosure
bcl
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AU2017305508A1 (en
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Jianyong Chen
Shaomeng Wang
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University of Michigan System
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University of Michigan System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AU2017305508A 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors Active AU2017305508B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021202113A AU2021202113B2 (en) 2016-08-05 2021-04-06 N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 Inhibitors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662371504P 2016-08-05 2016-08-05
US62/371,504 2016-08-05
US201762454101P 2017-02-03 2017-02-03
US62/454,101 2017-02-03
PCT/US2017/045428 WO2018027097A1 (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Related Child Applications (1)

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AU2021202113A Division AU2021202113B2 (en) 2016-08-05 2021-04-06 N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 Inhibitors

Publications (2)

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AU2017305508A1 AU2017305508A1 (en) 2019-02-07
AU2017305508B2 true AU2017305508B2 (en) 2021-01-07

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US (3) US10829488B2 (enExample)
EP (3) EP4129999A1 (enExample)
JP (2) JP6651180B2 (enExample)
KR (2) KR102429704B1 (enExample)
CN (2) CN110483501B (enExample)
AU (2) AU2017305508B2 (enExample)
CA (1) CA3031419C (enExample)
CY (1) CY1123859T1 (enExample)
DK (1) DK3494115T3 (enExample)
ES (1) ES2849959T3 (enExample)
HR (1) HRP20202073T1 (enExample)
HU (1) HUE053414T2 (enExample)
IL (2) IL264059B (enExample)
LT (1) LT3494115T (enExample)
MX (2) MX381588B (enExample)
MY (1) MY199409A (enExample)
PE (1) PE20190711A1 (enExample)
PH (1) PH12019500231A1 (enExample)
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RS (1) RS61821B1 (enExample)
RU (2) RU2722560C1 (enExample)
SA (1) SA519401020B1 (enExample)
SG (2) SG11201900135YA (enExample)
SI (1) SI3494115T1 (enExample)
SM (1) SMT202100025T1 (enExample)
WO (1) WO2018027097A1 (enExample)
ZA (2) ZA201900240B (enExample)

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CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CN110772639B (zh) * 2018-07-31 2021-04-13 苏州亚盛药业有限公司 Bcl-2抑制剂与MDM2抑制剂的组合产品及其在预防和/或治疗疾病中的用途
CA3095699A1 (en) * 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
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CN112168830B (zh) * 2019-07-02 2022-01-25 苏州亚盛药业有限公司 一种含有mTOR抑制剂的药物组合及其应用
CN112294966B (zh) * 2019-07-31 2021-12-17 苏州亚盛药业有限公司 Bcl-2/Bcl-xL抑制剂与化疗药的组合产品及其在预防和/或治疗疾病中的用途
CN112852959A (zh) 2019-11-27 2021-05-28 苏州亚盛药业有限公司 用于预测靶向细胞凋亡途径的化合物的抗癌功效的方法和组合物
CN119097631A (zh) * 2019-12-03 2024-12-10 苏州亚盛药业有限公司 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物
CN112891353B (zh) * 2019-12-04 2024-01-30 苏州亚盛药业有限公司 药物组合及其用途
IL292882A (en) 2019-12-06 2022-07-01 Loxo Oncology Inc Dosage of Bruton's tyrosine kinase inhibitor
CN113354636B (zh) * 2020-03-06 2022-08-09 苏州亚盛药业有限公司 N-(苯基磺酰基)苯甲酰胺类化合物或其盐、溶剂合物的结晶形式或无定形形式
WO2021180040A1 (zh) * 2020-03-12 2021-09-16 南京明德新药研发有限公司 苯并五元环类化合物
JP2023520843A (ja) 2020-04-15 2023-05-22 ベイジーン リミテッド Ｂｃｌ－２阻害剤
WO2021227763A1 (en) * 2020-05-14 2021-11-18 Ascentage Pharma (Suzhou) Co., Ltd. Hplc analysis method for n- (phenylsulfonyl) benzamide compound
WO2022002178A1 (en) * 2020-07-01 2022-01-06 Ascentage Pharma (Suzhou) Co., Ltd. Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof
CN111537654B (zh) * 2020-07-07 2020-11-10 上海亚盛医药科技有限公司 N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法
WO2022007940A1 (zh) * 2020-07-10 2022-01-13 江苏恒瑞医药股份有限公司 磺酰苯甲酰胺类衍生物及其偶联物、其制备方法及其应用
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
CN114073707A (zh) * 2020-08-21 2022-02-22 苏州亚盛药业有限公司 治疗系统性红斑狼疮的组合物和方法
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
CN114533677A (zh) * 2020-11-25 2022-05-27 苏州亚盛药业有限公司 固体分散体、制剂、其制备方法及其应用
US20240316069A1 (en) * 2020-12-28 2024-09-26 Ascentage Pharma (Suzhou) Co., Ltd. Methods of treating multiple sclerosis
WO2022161496A1 (en) * 2021-02-01 2022-08-04 Ascentage Pharma (Suzhou) Co., Ltd. Sulfonyl benzamide derivatives as bcl-2 inhibitors
US20250319183A1 (en) 2021-04-07 2025-10-16 David Avigan Compositions and methods for the treatment of cancer
JP2024528174A (ja) 2021-08-02 2024-07-26 アセンテージ ファーマ（スーチョウ）カンパニー，リミティド 医薬組合せおよびその使用
EP4442685A4 (en) * 2021-12-06 2025-11-19 Hangzhou Healzen Therapeutics Co Ltd BCL-2 PROTEIN ANTI-APOPTOTIC INHIBITOR: PHARMACEUTICAL COMPOSITION AND USES
CN115260191B (zh) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 哌啶类化合物及其制备方法和应用
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US20190315739A1 (en) 2019-10-17
WO2018027097A1 (en) 2018-02-08
CN110483501B (zh) 2022-07-01
HUE053414T2 (hu) 2021-06-28
EP4129999A1 (en) 2023-02-08
KR20190035710A (ko) 2019-04-03
EP3494115A1 (en) 2019-06-12
KR20210107170A (ko) 2021-08-31
MX2020013014A (es) 2021-02-22
SG10201913643YA (en) 2020-03-30
RU2020114660A (ru) 2020-06-19
EP3494115B1 (en) 2020-10-21
KR102429704B1 (ko) 2022-08-04
MX2019001391A (es) 2019-06-06
HRP20202073T1 (hr) 2021-02-19
BR112019001666A2 (pt) 2019-05-28
LT3494115T (lt) 2021-01-25
RU2020114660A3 (enExample) 2020-09-15
RS61821B1 (sr) 2021-06-30
CN110483501A (zh) 2019-11-22
IL282099A (en) 2021-05-31
ZA201908466B (en) 2020-05-27
RU2722560C1 (ru) 2020-06-01
IL282099B (en) 2022-03-01
KR102376764B1 (ko) 2022-03-18
US20180354950A1 (en) 2018-12-13
SA519401020B1 (ar) 2022-03-16
CN109311871B (zh) 2020-02-28
US11718613B2 (en) 2023-08-08
ZA201900240B (en) 2020-05-27
SI3494115T1 (sl) 2021-02-26
DK3494115T3 (da) 2021-01-18
ES2849959T3 (es) 2021-08-24
RU2744358C2 (ru) 2021-03-05
US10221174B2 (en) 2019-03-05
CY1123859T1 (el) 2022-05-27
PE20190711A1 (es) 2019-05-17
IL264059B (en) 2021-05-31
JP2020007311A (ja) 2020-01-16
RU2020134802A (ru) 2022-04-25
AU2017305508A1 (en) 2019-02-07
EP3569601A2 (en) 2019-11-20
CA3031419C (en) 2021-08-24
JP2019527705A (ja) 2019-10-03
US10829488B2 (en) 2020-11-10
NZ750100A (en) 2021-01-29
AU2021202113A1 (en) 2021-05-06
PT3494115T (pt) 2021-01-15
PH12019500231A1 (en) 2019-07-29
MX381588B (es) 2025-03-12
EP3569601A3 (en) 2019-11-27
US20210002277A1 (en) 2021-01-07
CN109311871A (zh) 2019-02-05
CA3031419A1 (en) 2018-02-08
IL264059A (en) 2019-01-31
EP3569601B1 (en) 2022-06-22
SMT202100025T1 (it) 2021-03-15
JP6651180B2 (ja) 2020-02-19
MY199409A (en) 2023-10-25
JP7205903B2 (ja) 2023-01-17
SG11201900135YA (en) 2019-02-27
AU2021202113B2 (en) 2022-08-18

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