AU2017305508B2 - N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors - Google Patents

N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors Download PDF

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AU2017305508B2
AU2017305508B2 AU2017305508A AU2017305508A AU2017305508B2 AU 2017305508 B2 AU2017305508 B2 AU 2017305508B2 AU 2017305508 A AU2017305508 A AU 2017305508A AU 2017305508 A AU2017305508 A AU 2017305508A AU 2017305508 B2 AU2017305508 B2 AU 2017305508B2
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methyl
compound
cancer
disclosure
bcl
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AU2017305508A1 (en
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Jianyong Chen
Shaomeng Wang
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University of Michigan System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AU2017305508A 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors Active AU2017305508B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021202113A AU2021202113B2 (en) 2016-08-05 2021-04-06 N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 Inhibitors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662371504P 2016-08-05 2016-08-05
US62/371,504 2016-08-05
US201762454101P 2017-02-03 2017-02-03
US62/454,101 2017-02-03
PCT/US2017/045428 WO2018027097A1 (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Related Child Applications (1)

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AU2021202113A Division AU2021202113B2 (en) 2016-08-05 2021-04-06 N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 Inhibitors

Publications (2)

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AU2017305508A1 AU2017305508A1 (en) 2019-02-07
AU2017305508B2 true AU2017305508B2 (en) 2021-01-07

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EP (3) EP3494115B1 (enExample)
JP (2) JP6651180B2 (enExample)
KR (2) KR102429704B1 (enExample)
CN (2) CN109311871B (enExample)
AU (2) AU2017305508B2 (enExample)
CA (1) CA3031419C (enExample)
CY (1) CY1123859T1 (enExample)
DK (1) DK3494115T3 (enExample)
ES (1) ES2849959T3 (enExample)
HR (1) HRP20202073T1 (enExample)
HU (1) HUE053414T2 (enExample)
IL (2) IL264059B (enExample)
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MY (1) MY199409A (enExample)
PE (1) PE20190711A1 (enExample)
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RS (1) RS61821B1 (enExample)
RU (2) RU2722560C1 (enExample)
SA (1) SA519401020B1 (enExample)
SG (2) SG10201913643YA (enExample)
SI (1) SI3494115T1 (enExample)
SM (1) SMT202100025T1 (enExample)
WO (1) WO2018027097A1 (enExample)
ZA (2) ZA201900240B (enExample)

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EP3494115B1 (en) * 2016-08-05 2020-10-21 The Regents of The University of Michigan N-(phenylsulfonyl)benzamide derivatives as bcl-2 inhibitors
WO2018127130A1 (en) 2017-01-07 2018-07-12 Shanghai Fochon Pharmaceutical Co., Ltd. Compounds as bcl-2-selective apoptosis-inducing agents
PT3612531T (pt) * 2017-04-18 2022-10-04 Shanghai Fochon Pharmaceutical Co Ltd Agentes indutores de apoptose
SG11202009933WA (en) 2018-04-29 2020-11-27 Beigene Ltd Bcl-2 INHIBITORS
TWI752335B (zh) * 2018-07-31 2022-01-11 大陸商蘇州亞盛藥業有限公司 Bcl-2抑制劑與MDM2抑制劑的組合產品及其在預防及/或治療疾病中的用途
CA3095699A1 (en) * 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
EP3672591B1 (en) * 2018-07-31 2024-02-14 Ascentage Pharma (Suzhou) Co., Ltd. Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/or bendamustine or bcl-2 inhibitor combined with chop
CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CN111214471B (zh) * 2018-11-23 2021-04-02 苏州亚盛药业有限公司 药物组合物及其用途
TWI770503B (zh) * 2019-05-13 2022-07-11 大陸商蘇州亞盛藥業有限公司 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物
TW202114692A (zh) * 2019-07-02 2021-04-16 大陸商蘇州亞盛藥業有限公司 一種含有mTOR抑制劑的藥物組合及其應用
CN112294966B (zh) * 2019-07-31 2021-12-17 苏州亚盛药业有限公司 Bcl-2/Bcl-xL抑制剂与化疗药的组合产品及其在预防和/或治疗疾病中的用途
CN112852959A (zh) * 2019-11-27 2021-05-28 苏州亚盛药业有限公司 用于预测靶向细胞凋亡途径的化合物的抗癌功效的方法和组合物
WO2021110097A1 (en) 2019-12-03 2021-06-10 Ascentage Pharma (Suzhou) Co., Ltd. N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
WO2021110136A1 (en) * 2019-12-04 2021-06-10 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical combination and use thereof
JP7142173B2 (ja) 2019-12-06 2022-09-26 ロクソ オンコロジー， インコーポレイテッド ブルトン型チロシンキナーゼ阻害剤の投薬
TWI777438B (zh) * 2020-03-06 2022-09-11 大陸商蘇州亞盛藥業有限公司 N- (苯基磺醯基) 苯甲醯胺類化合物的結晶形式
CN115244051B (zh) * 2020-03-12 2024-10-18 南京明德新药研发有限公司 苯并五元环类化合物
CN116969936A (zh) 2020-04-15 2023-10-31 百济神州有限公司 Bcl-2抑制剂
WO2021227763A1 (en) * 2020-05-14 2021-11-18 Ascentage Pharma (Suzhou) Co., Ltd. Hplc analysis method for n- (phenylsulfonyl) benzamide compound
CN113880834B (zh) * 2020-07-01 2023-01-20 苏州亚盛药业有限公司 N-(苯基磺酰基)苯甲酰胺类化合物及其中间体的合成方法
CN111537654B (zh) * 2020-07-07 2020-11-10 上海亚盛医药科技有限公司 N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法
TW202214565A (zh) * 2020-07-10 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 磺醯苯甲醯胺類衍生物及其偶聯物、其製備方法及其應用
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
WO2022037684A1 (en) * 2020-08-21 2022-02-24 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating systemic lupus erythematosus
WO2022111558A1 (en) * 2020-11-25 2022-06-02 Ascentage Pharma (Suzhou) Co., Ltd. Solid dispersion, pharmaceutical preparations, preparation method, and application thereof
US20240316069A1 (en) * 2020-12-28 2024-09-26 Ascentage Pharma (Suzhou) Co., Ltd. Methods of treating multiple sclerosis
WO2022161496A1 (en) * 2021-02-01 2022-08-04 Ascentage Pharma (Suzhou) Co., Ltd. Sulfonyl benzamide derivatives as bcl-2 inhibitors
US20250319183A1 (en) 2021-04-07 2025-10-16 David Avigan Compositions and methods for the treatment of cancer
WO2023011488A1 (zh) 2021-08-02 2023-02-09 苏州亚盛药业有限公司 一种药物组合及其用途
WO2023104043A1 (zh) * 2021-12-06 2023-06-15 杭州和正医药有限公司 一种抗凋亡蛋白bcl-2抑制剂、药物组合物及其应用
CN115260191B (zh) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 哌啶类化合物及其制备方法和应用
EP4421075A1 (en) * 2023-02-27 2024-08-28 KRKA, d.d., Novo mesto Process for the preparation of venetoclax and intermediates used therein
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US20180354950A1 (en) 2018-12-13
CA3031419C (en) 2021-08-24
IL264059A (en) 2019-01-31
SG11201900135YA (en) 2019-02-27
AU2017305508A1 (en) 2019-02-07
ZA201900240B (en) 2020-05-27
KR20190035710A (ko) 2019-04-03
MX381588B (es) 2025-03-12
EP3569601A2 (en) 2019-11-20
SG10201913643YA (en) 2020-03-30
RU2020114660A3 (enExample) 2020-09-15
MX2019001391A (es) 2019-06-06
KR102429704B1 (ko) 2022-08-04
RU2722560C1 (ru) 2020-06-01
SA519401020B1 (ar) 2022-03-16
EP4129999A1 (en) 2023-02-08
CN109311871A (zh) 2019-02-05
HRP20202073T1 (hr) 2021-02-19
RS61821B1 (sr) 2021-06-30
MY199409A (en) 2023-10-25
CN110483501A (zh) 2019-11-22
CN109311871B (zh) 2020-02-28
LT3494115T (lt) 2021-01-25
EP3494115B1 (en) 2020-10-21
BR112019001666A2 (pt) 2019-05-28
PT3494115T (pt) 2021-01-15
ES2849959T3 (es) 2021-08-24
SI3494115T1 (sl) 2021-02-26
RU2020114660A (ru) 2020-06-19
KR102376764B1 (ko) 2022-03-18
US20190315739A1 (en) 2019-10-17
US11718613B2 (en) 2023-08-08
US20210002277A1 (en) 2021-01-07
US10221174B2 (en) 2019-03-05
HUE053414T2 (hu) 2021-06-28
MX2020013014A (es) 2021-02-22
NZ750100A (en) 2021-01-29
JP2019527705A (ja) 2019-10-03
DK3494115T3 (da) 2021-01-18
PE20190711A1 (es) 2019-05-17
RU2744358C2 (ru) 2021-03-05
PH12019500231A1 (en) 2019-07-29
IL282099B (en) 2022-03-01
ZA201908466B (en) 2020-05-27
KR20210107170A (ko) 2021-08-31
RU2020134802A (ru) 2022-04-25
US10829488B2 (en) 2020-11-10
EP3569601B1 (en) 2022-06-22
JP6651180B2 (ja) 2020-02-19
CN110483501B (zh) 2022-07-01
CA3031419A1 (en) 2018-02-08
JP2020007311A (ja) 2020-01-16
WO2018027097A1 (en) 2018-02-08
CY1123859T1 (el) 2022-05-27
EP3569601A3 (en) 2019-11-27
IL282099A (en) 2021-05-31
SMT202100025T1 (it) 2021-03-15
JP7205903B2 (ja) 2023-01-17
EP3494115A1 (en) 2019-06-12
AU2021202113A1 (en) 2021-05-06
IL264059B (en) 2021-05-31
AU2021202113B2 (en) 2022-08-18

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