CN109311871B - 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物 - Google Patents

作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物 Download PDF

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CN109311871B
CN109311871B CN201780035965.6A CN201780035965A CN109311871B CN 109311871 B CN109311871 B CN 109311871B CN 201780035965 A CN201780035965 A CN 201780035965A CN 109311871 B CN109311871 B CN 109311871B
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bcl
methyl
compounds
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CN109311871A (zh
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S·王
J·陈
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University of Michigan Ann Arbor
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
CN201780035965.6A 2016-08-05 2017-08-04 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物 Active CN109311871B (zh)

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US201662371504P 2016-08-05 2016-08-05
US62/371,504 2016-08-05
US201762454101P 2017-02-03 2017-02-03
US62/454,101 2017-02-03
PCT/US2017/045428 WO2018027097A1 (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

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AU2017305508B2 (en) * 2016-08-05 2021-01-07 The Regents Of The University Of Michigan N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors
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SI3788042T1 (sl) 2018-04-29 2025-06-30 Beigene Switzerland Gmbh Zaviralci BCL-2
EP3672594B1 (en) * 2018-07-31 2021-09-29 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases
AU2019315466B2 (en) * 2018-07-31 2022-05-19 Ascentage Pharma (Suzhou) Co., Ltd. Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP
TWI725488B (zh) * 2018-07-31 2021-04-21 大陸商蘇州亞盛藥業有限公司 Bcl-2抑制劑與化療藥的組合產品及其在預防及/或治療疾病中的用途
CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CN111214471B (zh) * 2018-11-23 2021-04-02 苏州亚盛药业有限公司 药物组合物及其用途
TWI770503B (zh) * 2019-05-13 2022-07-11 大陸商蘇州亞盛藥業有限公司 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物
TW202114692A (zh) * 2019-07-02 2021-04-16 大陸商蘇州亞盛藥業有限公司 一種含有mTOR抑制劑的藥物組合及其應用
WO2021018240A1 (en) * 2019-07-31 2021-02-04 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of a bcl-2/bcl-xl inhibitor and a chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
TWI885019B (zh) 2019-11-27 2025-06-01 大陸商蘇州亞盛藥業有限公司 用於預測靶向細胞凋亡途徑的化合物的抗癌功效的方法和組合物
CN119097631A (zh) * 2019-12-03 2024-12-10 苏州亚盛药业有限公司 作为bcl-2抑制剂的n-(苯基磺酰基)苯甲酰胺及相关化合物
EP4069233A4 (en) * 2019-12-04 2024-03-13 Ascentage Pharma (Suzhou) Co., Ltd. PHARMACEUTICAL COMBINATION AND USE THEREOF
MX2022006631A (es) 2019-12-06 2022-09-07 Loxo Oncology Inc Dosificacion de un inhibidor de la tirosina cinasa de bruton.
US12358912B2 (en) * 2020-03-06 2025-07-15 Ascentage Pharma (Suzhou) Co., Ltd. Crystalline forms or amorphous forms of N-(phenyl sulfonyl) benzamide compounds or its salts or solvates
CN115244051B (zh) * 2020-03-12 2024-10-18 南京明德新药研发有限公司 苯并五元环类化合物
WO2021208963A1 (en) 2020-04-15 2021-10-21 Beigene, Ltd. Bcl-2 inhibitor
WO2021227763A1 (en) * 2020-05-14 2021-11-18 Ascentage Pharma (Suzhou) Co., Ltd. Hplc analysis method for n- (phenylsulfonyl) benzamide compound
WO2022002178A1 (en) * 2020-07-01 2022-01-06 Ascentage Pharma (Suzhou) Co., Ltd. Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof
CN111537654B (zh) * 2020-07-07 2020-11-10 上海亚盛医药科技有限公司 N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法
EP4180422A4 (en) * 2020-07-10 2024-01-24 Jiangsu Hengrui Pharmaceuticals Co., Ltd. SULFONYL BENZAMIDE DERIVATIVE AND CONJUGATE THEREOF, PROCESS THEREOF AND USE THEREOF
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
US20230301989A1 (en) * 2020-08-21 2023-09-28 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating systemic lupus erythematosus
US20230398110A1 (en) * 2020-08-21 2023-12-14 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
CN114533677A (zh) * 2020-11-25 2022-05-27 苏州亚盛药业有限公司 固体分散体、制剂、其制备方法及其应用
CN114681458B (zh) * 2020-12-28 2023-07-18 苏州亚盛药业有限公司 治疗多发性硬化症的方法
US20240166644A1 (en) * 2021-02-01 2024-05-23 Ascentage Pharma (Suzhou) Co., Ltd. Sulfonyl benzamide derivatives as bcl-2 inhibitors
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JP7765790B2 (ja) * 2021-12-06 2025-11-07 杭州和正医薬有限公司 抗アポトーシスタンパク質ｂｃｌ－２阻害剤、医薬組成物及びその使用
CN115260191B (zh) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 哌啶类化合物及其制备方法和应用
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CA3031419A1 (en) 2018-02-08
JP7205903B2 (ja) 2023-01-17
JP6651180B2 (ja) 2020-02-19
IL264059A (en) 2019-01-31
US20180354950A1 (en) 2018-12-13
SA519401020B1 (ar) 2022-03-16
EP3569601A3 (en) 2019-11-27
HRP20202073T1 (hr) 2021-02-19
IL264059B (en) 2021-05-31
US10829488B2 (en) 2020-11-10
IL282099A (en) 2021-05-31
JP2019527705A (ja) 2019-10-03
AU2017305508B2 (en) 2021-01-07
CA3031419C (en) 2021-08-24
CN110483501A (zh) 2019-11-22
CN110483501B (zh) 2022-07-01
ZA201900240B (en) 2020-05-27
KR102376764B1 (ko) 2022-03-18
KR20190035710A (ko) 2019-04-03
CY1123859T1 (el) 2022-05-27
KR102429704B1 (ko) 2022-08-04
RU2020134802A (ru) 2022-04-25
EP3569601B1 (en) 2022-06-22
ZA201908466B (en) 2020-05-27
PE20190711A1 (es) 2019-05-17
PH12019500231A1 (en) 2019-07-29
HUE053414T2 (hu) 2021-06-28
LT3494115T (lt) 2021-01-25
EP3494115A1 (en) 2019-06-12
PT3494115T (pt) 2021-01-15
EP4129999A1 (en) 2023-02-08
RU2744358C2 (ru) 2021-03-05
RU2020114660A (ru) 2020-06-19
AU2017305508A1 (en) 2019-02-07
MX381588B (es) 2025-03-12
NZ750100A (en) 2021-01-29
AU2021202113B2 (en) 2022-08-18
CN109311871A (zh) 2019-02-05
KR20210107170A (ko) 2021-08-31
US20210002277A1 (en) 2021-01-07
DK3494115T3 (da) 2021-01-18
SG11201900135YA (en) 2019-02-27
MX2020013014A (es) 2021-02-22
WO2018027097A1 (en) 2018-02-08
US10221174B2 (en) 2019-03-05
US20190315739A1 (en) 2019-10-17
EP3569601A2 (en) 2019-11-20
MY199409A (en) 2023-10-25
JP2020007311A (ja) 2020-01-16
IL282099B (en) 2022-03-01
EP3494115B1 (en) 2020-10-21
US11718613B2 (en) 2023-08-08
ES2849959T3 (es) 2021-08-24
SI3494115T1 (sl) 2021-02-26
SG10201913643YA (en) 2020-03-30
BR112019001666A2 (pt) 2019-05-28
SMT202100025T1 (it) 2021-03-15
RU2020114660A3 (enExample) 2020-09-15
RU2722560C1 (ru) 2020-06-01
AU2021202113A1 (en) 2021-05-06
RS61821B1 (sr) 2021-06-30
MX2019001391A (es) 2019-06-06

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