JP2008517020A5 - - Google Patents
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- Publication number
- JP2008517020A5 JP2008517020A5 JP2007537198A JP2007537198A JP2008517020A5 JP 2008517020 A5 JP2008517020 A5 JP 2008517020A5 JP 2007537198 A JP2007537198 A JP 2007537198A JP 2007537198 A JP2007537198 A JP 2007537198A JP 2008517020 A5 JP2008517020 A5 JP 2008517020A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- aryl
- alkyl
- oxazin
- benzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- -1 hydroxy, aminosulfonyloxy Chemical group 0.000 claims 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 *c1ccc(CN(*)C(O2)=O)c2c1 Chemical compound *c1ccc(CN(*)C(O2)=O)c2c1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0423405.0A GB0423405D0 (en) | 2004-10-21 | 2004-10-21 | Organic compounds |
| PCT/EP2005/011233 WO2006045505A1 (en) | 2004-10-21 | 2005-10-19 | Mif-inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517020A JP2008517020A (ja) | 2008-05-22 |
| JP2008517020A5 true JP2008517020A5 (enExample) | 2008-09-04 |
Family
ID=33484961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537198A Pending JP2008517020A (ja) | 2004-10-21 | 2005-10-19 | Ｍｉｆ阻害剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7378416B2 (enExample) |
| EP (1) | EP1805170B1 (enExample) |
| JP (1) | JP2008517020A (enExample) |
| KR (1) | KR100875767B1 (enExample) |
| CN (1) | CN101035782A (enExample) |
| AT (1) | ATE464307T1 (enExample) |
| AU (1) | AU2005298923B2 (enExample) |
| BR (1) | BRPI0516981A (enExample) |
| CA (1) | CA2581981A1 (enExample) |
| DE (1) | DE602005020666D1 (enExample) |
| ES (1) | ES2344655T3 (enExample) |
| GB (1) | GB0423405D0 (enExample) |
| MX (1) | MX2007004738A (enExample) |
| PL (1) | PL1805170T3 (enExample) |
| PT (1) | PT1805170E (enExample) |
| RU (1) | RU2383541C2 (enExample) |
| WO (1) | WO2006045505A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0507695D0 (en) * | 2005-04-15 | 2005-05-25 | Novartis Ag | Organic compounds |
| CA2623072A1 (en) | 2005-09-26 | 2007-04-05 | Avigen, Inc. | Use of ibudilast for treating drug and behavioral addictions |
| US20070281924A1 (en) * | 2006-05-31 | 2007-12-06 | Gaeta Federico C | MIF inhibitors for treating neuropathic pain and associated syndromes |
| CA2653345A1 (en) * | 2006-05-31 | 2007-12-13 | Avigen, Inc. | Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity |
| EA201170349A1 (ru) | 2008-08-18 | 2011-08-30 | Йейл Юниверсити | Модуляторы mif |
| US9643922B2 (en) * | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| EP2198879A1 (en) | 2008-12-11 | 2010-06-23 | Institut Curie | CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell |
| WO2014200872A1 (en) | 2013-06-09 | 2014-12-18 | Rjs Biologics Llc | Pharmaceutical compounds targeted by mif affinity-tethered moieties |
| WO2015095052A1 (en) | 2013-12-17 | 2015-06-25 | Controlled Chemicals, Inc. | Isoindolin-1-ones as macrophage migration inhibitory factor (mif) inhibitors |
| EP2944310B1 (en) | 2014-05-16 | 2018-03-21 | Mifcare | MIF inhibitors for the acute or chronic treatment of pulmonary hypertension |
| US10899739B2 (en) | 2017-11-15 | 2021-01-26 | Yale University | Macrophage migration inhibitory factor inhibitors, and methods of making and using same |
| WO2019178480A1 (en) | 2018-03-15 | 2019-09-19 | Yale University | Pyrazole-containing macrophage migration inhibitory factor inhibitors |
| US12485178B2 (en) | 2018-04-09 | 2025-12-02 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| US20230097887A1 (en) | 2018-04-09 | 2023-03-30 | Yale University | Bi-functional Molecules to Degrade Circulating Proteins |
| WO2019199634A1 (en) | 2018-04-09 | 2019-10-17 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| CA3134765A1 (en) * | 2018-04-09 | 2019-10-17 | Yale University | Bi-functional molecules to degrade circulating proteins |
| BR112021012113A2 (pt) | 2018-12-19 | 2021-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Moléculas bifuncionais para direcionamento lisossomal e composições e métodos relacionados |
| WO2022093817A1 (en) * | 2020-10-26 | 2022-05-05 | Yale University | Macrophage migration inhibitory factor inhibitors, and methods of making and using same |
| EP4237002A4 (en) * | 2020-10-28 | 2025-02-12 | University Health Network | METHODS OF TREATING SPONDYLOARTHRITIS OR SYMPTOMS THEREOF |
| CN117957020A (zh) | 2021-07-14 | 2024-04-30 | 利西亚治疗公司 | Asgpr细胞表面受体结合化合物和缀合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6081182A (ja) * | 1983-10-12 | 1985-05-09 | Kissei Pharmaceut Co Ltd | チオフエン誘導体及びその製造方法 |
| US5696117A (en) * | 1995-11-07 | 1997-12-09 | Ortho Pharmaceutical Corporation | Benzoxazine antimicrobial agents |
| JP4403305B2 (ja) * | 2001-09-03 | 2010-01-27 | 武田薬品工業株式会社 | １，３−ベンゾチアジノン誘導体および用途 |
| GB0507695D0 (en) * | 2005-04-15 | 2005-05-25 | Novartis Ag | Organic compounds |
-
2004
- 2004-10-21 GB GBGB0423405.0A patent/GB0423405D0/en not_active Ceased
-
2005
- 2005-10-19 RU RU2007118727/04A patent/RU2383541C2/ru not_active IP Right Cessation
- 2005-10-19 DE DE602005020666T patent/DE602005020666D1/de not_active Expired - Lifetime
- 2005-10-19 PT PT05798257T patent/PT1805170E/pt unknown
- 2005-10-19 KR KR1020077008985A patent/KR100875767B1/ko not_active Expired - Fee Related
- 2005-10-19 AT AT05798257T patent/ATE464307T1/de active
- 2005-10-19 EP EP05798257A patent/EP1805170B1/en not_active Expired - Lifetime
- 2005-10-19 PL PL05798257T patent/PL1805170T3/pl unknown
- 2005-10-19 MX MX2007004738A patent/MX2007004738A/es active IP Right Grant
- 2005-10-19 US US11/576,610 patent/US7378416B2/en not_active Expired - Fee Related
- 2005-10-19 CN CNA2005800342065A patent/CN101035782A/zh active Pending
- 2005-10-19 BR BRPI0516981-0A patent/BRPI0516981A/pt not_active IP Right Cessation
- 2005-10-19 AU AU2005298923A patent/AU2005298923B2/en not_active Expired - Fee Related
- 2005-10-19 CA CA002581981A patent/CA2581981A1/en not_active Abandoned
- 2005-10-19 WO PCT/EP2005/011233 patent/WO2006045505A1/en not_active Ceased
- 2005-10-19 JP JP2007537198A patent/JP2008517020A/ja active Pending
- 2005-10-19 ES ES05798257T patent/ES2344655T3/es not_active Expired - Lifetime