JP2012506896A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012506896A5 JP2012506896A5 JP2011533714A JP2011533714A JP2012506896A5 JP 2012506896 A5 JP2012506896 A5 JP 2012506896A5 JP 2011533714 A JP2011533714 A JP 2011533714A JP 2011533714 A JP2011533714 A JP 2011533714A JP 2012506896 A5 JP2012506896 A5 JP 2012506896A5
- Authority
- JP
- Japan
- Prior art keywords
- meta
- compound
- och
- formula
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08167982 | 2008-10-30 | ||
| EP08167982.1 | 2008-10-30 | ||
| PCT/EP2009/064243 WO2010049466A1 (en) | 2008-10-30 | 2009-10-29 | Thienotriazolodiazepine derivatives active on apo a |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012506896A JP2012506896A (ja) | 2012-03-22 |
| JP2012506896A5 true JP2012506896A5 (enExample) | 2012-12-20 |
| JP5490811B2 JP5490811B2 (ja) | 2014-05-14 |
Family
ID=40380148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533714A Expired - Fee Related JP5490811B2 (ja) | 2008-10-30 | 2009-10-29 | アポａに対して活性なチエノトリアゾロジアゼピン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8569288B2 (enExample) |
| EP (1) | EP2362876B1 (enExample) |
| JP (1) | JP5490811B2 (enExample) |
| KR (1) | KR101633742B1 (enExample) |
| CN (1) | CN102292341B (enExample) |
| AU (1) | AU2009309691B2 (enExample) |
| BR (1) | BRPI0914406A2 (enExample) |
| CA (1) | CA2741934C (enExample) |
| EA (1) | EA018620B1 (enExample) |
| ES (1) | ES2448567T3 (enExample) |
| WO (1) | WO2010049466A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009008099A (es) | 2007-02-01 | 2009-12-14 | Resverlogix Corp | Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares. |
| NZ595747A (en) | 2009-03-18 | 2015-06-26 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
| EP2421533B1 (en) | 2009-04-22 | 2018-10-17 | Resverlogix Corp. | Novel anti-inflammatory agents |
| WO2011143660A2 (en) | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| CN103180318B (zh) | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
| EP2902030B1 (en) | 2010-05-14 | 2016-09-14 | Dana-Farber Cancer Institute, Inc. | Thienotriazolodiazepine compounds for treating neoplasia |
| US20130252331A1 (en) * | 2010-05-14 | 2013-09-26 | James Elliott Bradner | Compositions and methods for modulating metabolism |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| CA2918910A1 (en) | 2013-07-25 | 2015-01-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| EP3066101B1 (en) | 2013-11-08 | 2020-07-29 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| KR20160115953A (ko) | 2014-01-31 | 2016-10-06 | 다나-파버 캔서 인스티튜트 인크. | 디아미노피리미딘 벤젠술폰 유도체 및 그의 용도 |
| JP2017504651A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体の使用 |
| CN106456653A (zh) | 2014-02-28 | 2017-02-22 | 腾沙治疗公司 | 高胰岛素血症相关病症的治疗 |
| PT3157928T (pt) | 2014-06-20 | 2019-05-30 | Constellation Pharmaceuticals Inc | Formas cristalinas de 2-((4s)-6-(4-clorofenil)-1-metil-4h-benzo[c] isoxazolo[4,5-e]azepin-4-il)acetamida |
| CN106793775B (zh) | 2014-08-08 | 2020-06-02 | 达纳-法伯癌症研究所股份有限公司 | 二氢碟啶酮衍生物及其用途 |
| JP2017526741A (ja) | 2014-08-08 | 2017-09-14 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体およびその使用 |
| SG11201703414VA (en) | 2014-10-27 | 2017-05-30 | Tensha Therapeutics Inc | Bromodomain inhibitors |
| EP3268007B1 (en) | 2015-03-13 | 2022-11-09 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| PE20181287A1 (es) | 2015-09-11 | 2018-08-07 | Dana Farber Cancer Inst Inc | Ciano tienotriazolpirazinas y usos de las mismas |
| HK1256419A1 (zh) | 2015-09-11 | 2019-09-20 | 达纳-法伯癌症研究所股份有限公司 | 乙酰胺噻吩並三唑並二氮雜環庚三烯及其用途 |
| SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
| CN112312916A (zh) | 2018-06-13 | 2021-02-02 | 戴布里股份公司 | 缩合三氮杂卓衍生物的制备及其作为bet抑制剂的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155913A (en) * | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
| DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| US4960770A (en) * | 1987-05-28 | 1990-10-02 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses thereof |
| BR9610390A (pt) | 1995-09-09 | 1999-07-06 | Hoffmann La Roche | O uso de uma tienotriazolodiazepina para aumentar os níveis da apoliproteína a-i |
| US6444664B1 (en) | 1997-04-18 | 2002-09-03 | Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) | Method for controlling the plasma level of lipoproteins to treat alzheimeris disease |
-
2009
- 2009-10-29 AU AU2009309691A patent/AU2009309691B2/en not_active Ceased
- 2009-10-29 CN CN200980150891.6A patent/CN102292341B/zh not_active Expired - Fee Related
- 2009-10-29 KR KR1020117012290A patent/KR101633742B1/ko not_active Expired - Fee Related
- 2009-10-29 ES ES09740899.1T patent/ES2448567T3/es active Active
- 2009-10-29 EA EA201100698A patent/EA018620B1/ru not_active IP Right Cessation
- 2009-10-29 US US13/126,600 patent/US8569288B2/en not_active Expired - Fee Related
- 2009-10-29 WO PCT/EP2009/064243 patent/WO2010049466A1/en not_active Ceased
- 2009-10-29 BR BRPI0914406A patent/BRPI0914406A2/pt active Search and Examination
- 2009-10-29 JP JP2011533714A patent/JP5490811B2/ja not_active Expired - Fee Related
- 2009-10-29 EP EP09740899.1A patent/EP2362876B1/en not_active Not-in-force
- 2009-10-29 CA CA2741934A patent/CA2741934C/en not_active Expired - Fee Related