CN102292341B - 对apo a有活性的噻吩并三唑并二氮杂*衍生物 - Google Patents

对apo a有活性的噻吩并三唑并二氮杂*衍生物 Download PDF

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Publication number
CN102292341B
CN102292341B CN200980150891.6A CN200980150891A CN102292341B CN 102292341 B CN102292341 B CN 102292341B CN 200980150891 A CN200980150891 A CN 200980150891A CN 102292341 B CN102292341 B CN 102292341B
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compound
formula
och
hydrogen
purposes
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN102292341A (zh
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H·柯莫潘
D·比鲁斯
B·斯蒂赫林
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DYBLY AG
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DYBLY AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN200980150891.6A 2008-10-30 2009-10-29 对apo a有活性的噻吩并三唑并二氮杂*衍生物 Expired - Fee Related CN102292341B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08167982.1 2008-10-30
EP08167982 2008-10-30
PCT/EP2009/064243 WO2010049466A1 (en) 2008-10-30 2009-10-29 Thienotriazolodiazepine derivatives active on apo a

Publications (2)

Publication Number Publication Date
CN102292341A CN102292341A (zh) 2011-12-21
CN102292341B true CN102292341B (zh) 2014-09-10

Family

ID=40380148

Family Applications (1)

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CN200980150891.6A Expired - Fee Related CN102292341B (zh) 2008-10-30 2009-10-29 对apo a有活性的噻吩并三唑并二氮杂*衍生物

Country Status (11)

Country Link
US (1) US8569288B2 (enExample)
EP (1) EP2362876B1 (enExample)
JP (1) JP5490811B2 (enExample)
KR (1) KR101633742B1 (enExample)
CN (1) CN102292341B (enExample)
AU (1) AU2009309691B2 (enExample)
BR (1) BRPI0914406A2 (enExample)
CA (1) CA2741934C (enExample)
EA (1) EA018620B1 (enExample)
ES (1) ES2448567T3 (enExample)
WO (1) WO2010049466A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5236664B2 (ja) 2007-02-01 2013-07-17 レスバーロジックス コーポレイション 心血管疾患を予防および治療するための化合物
MX392179B (es) 2009-03-18 2025-03-21 Resverlogix Corp Nuevos agentes anti-inflamatorios.
AU2010239266B2 (en) 2009-04-22 2015-01-22 Resverlogix Corp. Novel anti-inflammatory agents
CA2799381A1 (en) * 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Male contraceptive compositions and methods of use
MX354217B (es) 2010-05-14 2018-02-19 Dana Farber Cancer Inst Inc Composiciones y metodos para el tratamiento de leucemia.
PL2571503T3 (pl) 2010-05-14 2015-06-30 Dana Farber Cancer Inst Inc Kompozycje i sposoby leczenia nowotworu, choroby zapalnej i innych zaburzeń
EP2569429A4 (en) * 2010-05-14 2013-09-25 Dana Farber Cancer Inst Inc COMPOSITIONS AND METHODS FOR MODULATING METABOLISM
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
WO2012151512A2 (en) 2011-05-04 2012-11-08 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
MX2016001037A (es) 2013-07-25 2016-11-10 Dana Farber Cancer Inst Inc Inhibidores de factores de transcripción y usos.
MX379463B (es) 2013-11-08 2025-03-10 Dana Farber Cancer Inst Inc Terapia de combinación para el cáncer usando inhibidores de la proteína bromodominio y extra-terminal.
EP3099693A4 (en) 2014-01-31 2017-08-16 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
US10150756B2 (en) 2014-01-31 2018-12-11 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
JP2017506666A (ja) 2014-02-28 2017-03-09 テンシャ セラピューティクス，インコーポレイテッド 高インスリン血症に関連した症状の処置
HUE043441T2 (hu) 2014-06-20 2019-08-28 Constellation Pharmaceuticals Inc 2-((4S)-6-(4-klórfenil)-l-metil-4H-benzo[c]izoxazolo[4,5-e]azepin-4-il)acetamid kristályos formái
WO2016022970A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Dihydropteridinone derivatives and uses thereof
RU2017104897A (ru) 2014-08-08 2018-09-10 Дана-Фарбер Кэнсер Инститьют, Инк. Производные диазепана и их применения
EP3212654B1 (en) 2014-10-27 2020-04-08 Tensha Therapeutics, Inc. Bromodomain inhibitors
JP6903585B2 (ja) 2015-03-13 2021-07-14 レスバーロジックス コーポレイション 補体関連疾患の治療のための組成物および治療方法
CA2986441A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
RU2018112953A (ru) 2015-09-11 2019-10-14 Дана-Фарбер Кэнсер Инститьют, Инк. Ацетамидтиенотриазолодиазепины и пути их применения
PE20181287A1 (es) 2015-09-11 2018-08-07 Dana Farber Cancer Inst Inc Ciano tienotriazolpirazinas y usos de las mismas
US10913752B2 (en) * 2015-11-25 2021-02-09 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibitors and uses thereof
EA202092635A1 (ru) 2018-06-13 2021-03-23 Дибли Аг Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4155913A (en) * 1973-02-08 1979-05-22 Hoffmann-La Roche Inc. Thienotriazolodiazepine derivatives
US4621083A (en) * 1984-10-01 1986-11-04 Boehringer Ingelheim Kg PAF-antagonistic diazepines
US4960770A (en) * 1987-05-28 1990-10-02 Yoshitomi Pharmaceutical Industries, Ltd. 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses thereof
CN1195989A (zh) * 1995-09-09 1998-10-14 弗·哈夫曼-拉罗切有限公司 噻吩并三唑并二氮杂䓬增加载脂蛋白a－i含量的用途
US6444664B1 (en) * 1997-04-18 2002-09-03 Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) Method for controlling the plasma level of lipoproteins to treat alzheimeris disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4155913A (en) * 1973-02-08 1979-05-22 Hoffmann-La Roche Inc. Thienotriazolodiazepine derivatives
US4621083A (en) * 1984-10-01 1986-11-04 Boehringer Ingelheim Kg PAF-antagonistic diazepines
US4960770A (en) * 1987-05-28 1990-10-02 Yoshitomi Pharmaceutical Industries, Ltd. 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses thereof
CN1195989A (zh) * 1995-09-09 1998-10-14 弗·哈夫曼-拉罗切有限公司 噻吩并三唑并二氮杂䓬增加载脂蛋白a－i含量的用途
US6444664B1 (en) * 1997-04-18 2002-09-03 Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) Method for controlling the plasma level of lipoproteins to treat alzheimeris disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer’s disease;A Merched，等;《Neurobiology of Aging》;20000229;第21卷(第1期);第27-30页，参见第27页摘要 *

Also Published As

Publication number Publication date
EA201100698A1 (ru) 2011-12-30
ES2448567T3 (es) 2014-03-14
KR20110091523A (ko) 2011-08-11
AU2009309691B2 (en) 2015-04-02
EP2362876B1 (en) 2013-12-11
US8569288B2 (en) 2013-10-29
CA2741934C (en) 2016-09-13
JP2012506896A (ja) 2012-03-22
AU2009309691A1 (en) 2010-05-06
EA018620B1 (ru) 2013-09-30
KR101633742B1 (ko) 2016-06-27
US20110230460A1 (en) 2011-09-22
BRPI0914406A2 (pt) 2015-10-20
CN102292341A (zh) 2011-12-21
EP2362876A1 (en) 2011-09-07
WO2010049466A1 (en) 2010-05-06
CA2741934A1 (en) 2010-05-06
JP5490811B2 (ja) 2014-05-14

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Granted publication date: 20140910

Termination date: 20181029