ES2448567T3 - Derivados de la tienotriazoldiazepina activos en apo A - Google Patents
Derivados de la tienotriazoldiazepina activos en apo A Download PDFInfo
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- ES2448567T3 ES2448567T3 ES09740899.1T ES09740899T ES2448567T3 ES 2448567 T3 ES2448567 T3 ES 2448567T3 ES 09740899 T ES09740899 T ES 09740899T ES 2448567 T3 ES2448567 T3 ES 2448567T3
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08167982 | 2008-10-30 | ||
| EP08167982 | 2008-10-30 | ||
| PCT/EP2009/064243 WO2010049466A1 (en) | 2008-10-30 | 2009-10-29 | Thienotriazolodiazepine derivatives active on apo a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2448567T3 true ES2448567T3 (es) | 2014-03-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09740899.1T Active ES2448567T3 (es) | 2008-10-30 | 2009-10-29 | Derivados de la tienotriazoldiazepina activos en apo A |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8569288B2 (enExample) |
| EP (1) | EP2362876B1 (enExample) |
| JP (1) | JP5490811B2 (enExample) |
| KR (1) | KR101633742B1 (enExample) |
| CN (1) | CN102292341B (enExample) |
| AU (1) | AU2009309691B2 (enExample) |
| BR (1) | BRPI0914406A2 (enExample) |
| CA (1) | CA2741934C (enExample) |
| EA (1) | EA018620B1 (enExample) |
| ES (1) | ES2448567T3 (enExample) |
| WO (1) | WO2010049466A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2118074E (pt) | 2007-02-01 | 2014-03-20 | Resverlogix Corp | Compostos para a prevenção e tratamento de doenças cardiovasculares |
| KR101913109B1 (ko) | 2009-03-18 | 2018-10-31 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| US9757368B2 (en) | 2009-04-22 | 2017-09-12 | Resverlogix Corp. | Anti-inflammatory agents |
| MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
| EP2571875A4 (en) | 2010-05-14 | 2013-10-30 | Dana Farber Cancer Inst Inc | CONTRACEPTIVE COMPOSITIONS FOR MEN AND METHODS OF USE THEREOF |
| CN103119160B (zh) * | 2010-05-14 | 2016-06-01 | 达那-法伯癌症研究所 | 用于调节代谢的组合物和方法 |
| PL2902030T3 (pl) | 2010-05-14 | 2017-07-31 | Dana-Farber Cancer Institute, Inc. | Związki tienotriazolodiazepinowe do leczenia nowotworu |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| US9975896B2 (en) | 2013-07-25 | 2018-05-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| RU2016122654A (ru) | 2013-11-08 | 2017-12-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка |
| EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| JP2017506666A (ja) | 2014-02-28 | 2017-03-09 | テンシャ セラピューティクス，インコーポレイテッド | 高インスリン血症に関連した症状の処置 |
| PL3157928T3 (pl) | 2014-06-20 | 2019-07-31 | Constellation Pharmaceuticals, Inc. | Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu |
| CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| CN106793775B (zh) | 2014-08-08 | 2020-06-02 | 达纳-法伯癌症研究所股份有限公司 | 二氢碟啶酮衍生物及其用途 |
| KR20170068597A (ko) | 2014-10-27 | 2017-06-19 | 텐샤 세러퓨틱스 인코포레이티드 | 브로모도메인 저해제 |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
| EP3347021A4 (en) | 2015-09-11 | 2019-07-24 | Dana-Farber Cancer Institute, Inc. | CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF |
| MX2018006499A (es) * | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| AU2019284971A1 (en) | 2018-06-13 | 2020-12-03 | Worg Pharmaceuticals (Zhejiang) Co., Ltd. | Preparation of condensed triazepine derivatives and their use as BET inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155913A (en) | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
| DE3435973A1 (de) | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| EP0315698B1 (en) | 1987-05-28 | 1993-03-03 | Yoshitomi Pharmaceutical Industries, Ltd. | Thieno(triazolo)diazepine compounds and medicinal application of the same |
| BR9610390A (pt) | 1995-09-09 | 1999-07-06 | Hoffmann La Roche | O uso de uma tienotriazolodiazepina para aumentar os níveis da apoliproteína a-i |
| US6444664B1 (en) | 1997-04-18 | 2002-09-03 | Nederlandse Organisatie Voor Toegepast - Natuurweten Schappelijk Onderzoek (Tno) | Method for controlling the plasma level of lipoproteins to treat alzheimeris disease |
-
2009
- 2009-10-29 ES ES09740899.1T patent/ES2448567T3/es active Active
- 2009-10-29 US US13/126,600 patent/US8569288B2/en not_active Expired - Fee Related
- 2009-10-29 CN CN200980150891.6A patent/CN102292341B/zh not_active Expired - Fee Related
- 2009-10-29 EP EP09740899.1A patent/EP2362876B1/en not_active Not-in-force
- 2009-10-29 KR KR1020117012290A patent/KR101633742B1/ko not_active Expired - Fee Related
- 2009-10-29 EA EA201100698A patent/EA018620B1/ru not_active IP Right Cessation
- 2009-10-29 BR BRPI0914406A patent/BRPI0914406A2/pt active Search and Examination
- 2009-10-29 CA CA2741934A patent/CA2741934C/en not_active Expired - Fee Related
- 2009-10-29 JP JP2011533714A patent/JP5490811B2/ja not_active Expired - Fee Related
- 2009-10-29 WO PCT/EP2009/064243 patent/WO2010049466A1/en not_active Ceased
- 2009-10-29 AU AU2009309691A patent/AU2009309691B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US8569288B2 (en) | 2013-10-29 |
| KR20110091523A (ko) | 2011-08-11 |
| JP5490811B2 (ja) | 2014-05-14 |
| AU2009309691A1 (en) | 2010-05-06 |
| CA2741934C (en) | 2016-09-13 |
| US20110230460A1 (en) | 2011-09-22 |
| EP2362876B1 (en) | 2013-12-11 |
| EP2362876A1 (en) | 2011-09-07 |
| KR101633742B1 (ko) | 2016-06-27 |
| EA201100698A1 (ru) | 2011-12-30 |
| JP2012506896A (ja) | 2012-03-22 |
| WO2010049466A1 (en) | 2010-05-06 |
| CN102292341A (zh) | 2011-12-21 |
| AU2009309691B2 (en) | 2015-04-02 |
| CN102292341B (zh) | 2014-09-10 |
| EA018620B1 (ru) | 2013-09-30 |
| BRPI0914406A2 (pt) | 2015-10-20 |
| CA2741934A1 (en) | 2010-05-06 |
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