RU2383541C2 - Ингибиторы mif - Google Patents
Ингибиторы mif Download PDFInfo
- Publication number
- RU2383541C2 RU2383541C2 RU2007118727/04A RU2007118727A RU2383541C2 RU 2383541 C2 RU2383541 C2 RU 2383541C2 RU 2007118727/04 A RU2007118727/04 A RU 2007118727/04A RU 2007118727 A RU2007118727 A RU 2007118727A RU 2383541 C2 RU2383541 C2 RU 2383541C2
- Authority
- RU
- Russia
- Prior art keywords
- mif
- compound
- dihydrobenzo
- oxazin
- phenyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 81
- -1 hydroxy, aminosulfonyloxy Chemical group 0.000 claims abstract description 43
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 15
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| GB0423405.0 | 2004-10-21 | ||
| GBGB0423405.0A GB0423405D0 (en) | 2004-10-21 | 2004-10-21 | Organic compounds |
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| RU2007118727A RU2007118727A (ru) | 2008-11-27 |
| RU2383541C2 true RU2383541C2 (ru) | 2010-03-10 |
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| EP2026804A1 (en) * | 2006-05-31 | 2009-02-25 | Avigen, Inc. | Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
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| US20230399303A1 (en) * | 2020-10-26 | 2023-12-14 | Yale University | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same |
| US20230404980A1 (en) * | 2020-10-28 | 2023-12-21 | University Health Network | Methods of treating spondyloarthritis or symptoms thereof |
| JP2024524614A (ja) | 2021-07-14 | 2024-07-05 | ライシア セラピューティクス， インコーポレイテッド | Ａｓｇｐｒ細胞表面受容体結合化合物及びコンジュゲート |
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| RU2191179C2 (ru) * | 1995-11-07 | 2002-10-20 | Орто-Макнейл Фармасьютикал, Инк. | Бензоксазиновые или пиридооксазиновые соединения, способы их получения, промежуточные соединения, фармацевтические композиции, обладающие антибактериальной активностью, способы лечения бактериальных инфекций |
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| JPS6081182A (ja) * | 1983-10-12 | 1985-05-09 | Kissei Pharmaceut Co Ltd | チオフエン誘導体及びその製造方法 |
| JP4403305B2 (ja) * | 2001-09-03 | 2010-01-27 | 武田薬品工業株式会社 | １，３−ベンゾチアジノン誘導体および用途 |
| GB0507695D0 (en) * | 2005-04-15 | 2005-05-25 | Novartis Ag | Organic compounds |
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- 2005-10-19 KR KR1020077008985A patent/KR100875767B1/ko not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2191179C2 (ru) * | 1995-11-07 | 2002-10-20 | Орто-Макнейл Фармасьютикал, Инк. | Бензоксазиновые или пиридооксазиновые соединения, способы их получения, промежуточные соединения, фармацевтические композиции, обладающие антибактериальной активностью, способы лечения бактериальных инфекций |
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| Title |
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| MASAYA ORITA; ET AL JOURNAL OF MEDICINAL CHEMISTRY, 2000.12.30 AMERICAN CHEMICAL SOCIETY, WASHINGTON, Vol:44, Page(s): 540-547. * |
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| EP1805170B1 (en) | 2010-04-14 |
| ES2344655T3 (es) | 2010-09-02 |
| KR20070054253A (ko) | 2007-05-28 |
| EP1805170A1 (en) | 2007-07-11 |
| AU2005298923A1 (en) | 2006-05-04 |
| CA2581981A1 (en) | 2006-05-04 |
| US20070219189A1 (en) | 2007-09-20 |
| PT1805170E (pt) | 2010-07-12 |
| CN101035782A (zh) | 2007-09-12 |
| US7378416B2 (en) | 2008-05-27 |
| PL1805170T3 (pl) | 2010-09-30 |
| KR100875767B1 (ko) | 2008-12-26 |
| MX2007004738A (es) | 2007-06-18 |
| ATE464307T1 (de) | 2010-04-15 |
| GB0423405D0 (en) | 2004-11-24 |
| RU2007118727A (ru) | 2008-11-27 |
| DE602005020666D1 (en) | 2010-05-27 |
| JP2008517020A (ja) | 2008-05-22 |
| AU2005298923B2 (en) | 2009-12-17 |
| WO2006045505A1 (en) | 2006-05-04 |
| BRPI0516981A (pt) | 2008-09-30 |
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