JP2008517020A - Ｍｉｆ阻害剤 - Google Patents
Ｍｉｆ阻害剤 Download PDFInfo
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- JP2008517020A JP2008517020A JP2007537198A JP2007537198A JP2008517020A JP 2008517020 A JP2008517020 A JP 2008517020A JP 2007537198 A JP2007537198 A JP 2007537198A JP 2007537198 A JP2007537198 A JP 2007537198A JP 2008517020 A JP2008517020 A JP 2008517020A
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- JP
- Japan
- Prior art keywords
- benzo
- dihydro
- oxazin
- mif
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| PCT/EP2005/011233 WO2006045505A1 (en) | 2004-10-21 | 2005-10-19 | Mif-inhibitors |
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| JP2008517020A true JP2008517020A (ja) | 2008-05-22 |
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Cited By (1)
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| JP2008536841A (ja) * | 2005-04-15 | 2008-09-11 | ノバルティス アクチエンゲゼルシャフト | ３，４−ジヒドロ−ベンゾ［ｅ］［１，３］オキサジン−２−オン |
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| CA2623072A1 (en) | 2005-09-26 | 2007-04-05 | Avigen, Inc. | Use of ibudilast for treating drug and behavioral addictions |
| US20070281924A1 (en) * | 2006-05-31 | 2007-12-06 | Gaeta Federico C | MIF inhibitors for treating neuropathic pain and associated syndromes |
| CA2653345A1 (en) * | 2006-05-31 | 2007-12-13 | Avigen, Inc. | Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity |
| EA201170349A1 (ru) | 2008-08-18 | 2011-08-30 | Йейл Юниверсити | Модуляторы mif |
| US9643922B2 (en) * | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| EP2198879A1 (en) | 2008-12-11 | 2010-06-23 | Institut Curie | CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell |
| WO2014200872A1 (en) | 2013-06-09 | 2014-12-18 | Rjs Biologics Llc | Pharmaceutical compounds targeted by mif affinity-tethered moieties |
| WO2015095052A1 (en) | 2013-12-17 | 2015-06-25 | Controlled Chemicals, Inc. | Isoindolin-1-ones as macrophage migration inhibitory factor (mif) inhibitors |
| EP2944310B1 (en) | 2014-05-16 | 2018-03-21 | Mifcare | MIF inhibitors for the acute or chronic treatment of pulmonary hypertension |
| US10899739B2 (en) | 2017-11-15 | 2021-01-26 | Yale University | Macrophage migration inhibitory factor inhibitors, and methods of making and using same |
| WO2019178480A1 (en) | 2018-03-15 | 2019-09-19 | Yale University | Pyrazole-containing macrophage migration inhibitory factor inhibitors |
| US12485178B2 (en) | 2018-04-09 | 2025-12-02 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| US20230097887A1 (en) | 2018-04-09 | 2023-03-30 | Yale University | Bi-functional Molecules to Degrade Circulating Proteins |
| WO2019199634A1 (en) | 2018-04-09 | 2019-10-17 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| CA3134765A1 (en) * | 2018-04-09 | 2019-10-17 | Yale University | Bi-functional molecules to degrade circulating proteins |
| BR112021012113A2 (pt) | 2018-12-19 | 2021-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Moléculas bifuncionais para direcionamento lisossomal e composições e métodos relacionados |
| WO2022093817A1 (en) * | 2020-10-26 | 2022-05-05 | Yale University | Macrophage migration inhibitory factor inhibitors, and methods of making and using same |
| EP4237002A4 (en) * | 2020-10-28 | 2025-02-12 | University Health Network | METHODS OF TREATING SPONDYLOARTHRITIS OR SYMPTOMS THEREOF |
| CN117957020A (zh) | 2021-07-14 | 2024-04-30 | 利西亚治疗公司 | Asgpr细胞表面受体结合化合物和缀合物 |
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| US5696117A (en) * | 1995-11-07 | 1997-12-09 | Ortho Pharmaceutical Corporation | Benzoxazine antimicrobial agents |
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2004
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2005
- 2005-10-19 RU RU2007118727/04A patent/RU2383541C2/ru not_active IP Right Cessation
- 2005-10-19 DE DE602005020666T patent/DE602005020666D1/de not_active Expired - Lifetime
- 2005-10-19 PT PT05798257T patent/PT1805170E/pt unknown
- 2005-10-19 KR KR1020077008985A patent/KR100875767B1/ko not_active Expired - Fee Related
- 2005-10-19 AT AT05798257T patent/ATE464307T1/de active
- 2005-10-19 EP EP05798257A patent/EP1805170B1/en not_active Expired - Lifetime
- 2005-10-19 PL PL05798257T patent/PL1805170T3/pl unknown
- 2005-10-19 MX MX2007004738A patent/MX2007004738A/es active IP Right Grant
- 2005-10-19 US US11/576,610 patent/US7378416B2/en not_active Expired - Fee Related
- 2005-10-19 CN CNA2005800342065A patent/CN101035782A/zh active Pending
- 2005-10-19 BR BRPI0516981-0A patent/BRPI0516981A/pt not_active IP Right Cessation
- 2005-10-19 AU AU2005298923A patent/AU2005298923B2/en not_active Expired - Fee Related
- 2005-10-19 CA CA002581981A patent/CA2581981A1/en not_active Abandoned
- 2005-10-19 WO PCT/EP2005/011233 patent/WO2006045505A1/en not_active Ceased
- 2005-10-19 JP JP2007537198A patent/JP2008517020A/ja active Pending
- 2005-10-19 ES ES05798257T patent/ES2344655T3/es not_active Expired - Lifetime
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| JPS6081182A (ja) * | 1983-10-12 | 1985-05-09 | Kissei Pharmaceut Co Ltd | チオフエン誘導体及びその製造方法 |
| JP2004075652A (ja) * | 2001-09-03 | 2004-03-11 | Takeda Chem Ind Ltd | １，３−ベンゾチアジノン誘導体および用途 |
| WO2006108671A1 (en) * | 2005-04-15 | 2006-10-19 | Novartis Ag | 3,4-dihydro-benzo[e][1,3]oxazin-2-ones |
| JP2008536841A (ja) * | 2005-04-15 | 2008-09-11 | ノバルティス アクチエンゲゼルシャフト | ３，４−ジヒドロ−ベンゾ［ｅ］［１，３］オキサジン−２−オン |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008536841A (ja) * | 2005-04-15 | 2008-09-11 | ノバルティス アクチエンゲゼルシャフト | ３，４−ジヒドロ−ベンゾ［ｅ］［１，３］オキサジン−２−オン |
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| ES2344655T3 (es) | 2010-09-02 |
| RU2007118727A (ru) | 2008-11-27 |
| MX2007004738A (es) | 2007-06-18 |
| US7378416B2 (en) | 2008-05-27 |
| EP1805170A1 (en) | 2007-07-11 |
| PL1805170T3 (pl) | 2010-09-30 |
| KR100875767B1 (ko) | 2008-12-26 |
| AU2005298923A1 (en) | 2006-05-04 |
| BRPI0516981A (pt) | 2008-09-30 |
| ATE464307T1 (de) | 2010-04-15 |
| US20070219189A1 (en) | 2007-09-20 |
| DE602005020666D1 (en) | 2010-05-27 |
| RU2383541C2 (ru) | 2010-03-10 |
| KR20070054253A (ko) | 2007-05-28 |
| CN101035782A (zh) | 2007-09-12 |
| PT1805170E (pt) | 2010-07-12 |
| AU2005298923B2 (en) | 2009-12-17 |
| GB0423405D0 (en) | 2004-11-24 |
| CA2581981A1 (en) | 2006-05-04 |
| WO2006045505A1 (en) | 2006-05-04 |
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