ES2344655T3 - Inhibidores mif. - Google Patents

Inhibidores mif. Download PDF

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Publication number
ES2344655T3
ES2344655T3 ES05798257T ES05798257T ES2344655T3 ES 2344655 T3 ES2344655 T3 ES 2344655T3 ES 05798257 T ES05798257 T ES 05798257T ES 05798257 T ES05798257 T ES 05798257T ES 2344655 T3 ES2344655 T3 ES 2344655T3
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ES
Spain
Prior art keywords
oxazin
benzo
dihydro
compound
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Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05798257T
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English (en)
Spanish (es)
Inventor
Andreas Billich
Philipp Lehr
Hubert Gstach
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Novartis AG
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Novartis AG
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Filing date
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
ES05798257T 2004-10-21 2005-10-19 Inhibidores mif. Expired - Lifetime ES2344655T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0423405 2004-10-21
GBGB0423405.0A GB0423405D0 (en) 2004-10-21 2004-10-21 Organic compounds

Publications (1)

Publication Number Publication Date
ES2344655T3 true ES2344655T3 (es) 2010-09-02

Family

ID=33484961

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05798257T Expired - Lifetime ES2344655T3 (es) 2004-10-21 2005-10-19 Inhibidores mif.

Country Status (17)

Country Link
US (1) US7378416B2 (enExample)
EP (1) EP1805170B1 (enExample)
JP (1) JP2008517020A (enExample)
KR (1) KR100875767B1 (enExample)
CN (1) CN101035782A (enExample)
AT (1) ATE464307T1 (enExample)
AU (1) AU2005298923B2 (enExample)
BR (1) BRPI0516981A (enExample)
CA (1) CA2581981A1 (enExample)
DE (1) DE602005020666D1 (enExample)
ES (1) ES2344655T3 (enExample)
GB (1) GB0423405D0 (enExample)
MX (1) MX2007004738A (enExample)
PL (1) PL1805170T3 (enExample)
PT (1) PT1805170E (enExample)
RU (1) RU2383541C2 (enExample)
WO (1) WO2006045505A1 (enExample)

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Publication number Priority date Publication date Assignee Title
GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds
CA2623072A1 (en) 2005-09-26 2007-04-05 Avigen, Inc. Use of ibudilast for treating drug and behavioral addictions
US20070281924A1 (en) * 2006-05-31 2007-12-06 Gaeta Federico C MIF inhibitors for treating neuropathic pain and associated syndromes
CA2653345A1 (en) * 2006-05-31 2007-12-13 Avigen, Inc. Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity
EA201170349A1 (ru) 2008-08-18 2011-08-30 Йейл Юниверсити Модуляторы mif
US9643922B2 (en) * 2008-08-18 2017-05-09 Yale University MIF modulators
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
EP2198879A1 (en) 2008-12-11 2010-06-23 Institut Curie CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell
WO2014200872A1 (en) 2013-06-09 2014-12-18 Rjs Biologics Llc Pharmaceutical compounds targeted by mif affinity-tethered moieties
WO2015095052A1 (en) 2013-12-17 2015-06-25 Controlled Chemicals, Inc. Isoindolin-1-ones as macrophage migration inhibitory factor (mif) inhibitors
EP2944310B1 (en) 2014-05-16 2018-03-21 Mifcare MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
US10899739B2 (en) 2017-11-15 2021-01-26 Yale University Macrophage migration inhibitory factor inhibitors, and methods of making and using same
WO2019178480A1 (en) 2018-03-15 2019-09-19 Yale University Pyrazole-containing macrophage migration inhibitory factor inhibitors
US12485178B2 (en) 2018-04-09 2025-12-02 Yale University Bifunctional small molecules to target the selective degradation of circulating proteins
US20230097887A1 (en) 2018-04-09 2023-03-30 Yale University Bi-functional Molecules to Degrade Circulating Proteins
WO2019199634A1 (en) 2018-04-09 2019-10-17 Yale University Bifunctional small molecules to target the selective degradation of circulating proteins
CA3134765A1 (en) * 2018-04-09 2019-10-17 Yale University Bi-functional molecules to degrade circulating proteins
BR112021012113A2 (pt) 2018-12-19 2021-09-08 The Board Of Trustees Of The Leland Stanford Junior University Moléculas bifuncionais para direcionamento lisossomal e composições e métodos relacionados
WO2022093817A1 (en) * 2020-10-26 2022-05-05 Yale University Macrophage migration inhibitory factor inhibitors, and methods of making and using same
EP4237002A4 (en) * 2020-10-28 2025-02-12 University Health Network METHODS OF TREATING SPONDYLOARTHRITIS OR SYMPTOMS THEREOF
CN117957020A (zh) 2021-07-14 2024-04-30 利西亚治疗公司 Asgpr细胞表面受体结合化合物和缀合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6081182A (ja) * 1983-10-12 1985-05-09 Kissei Pharmaceut Co Ltd チオフエン誘導体及びその製造方法
US5696117A (en) * 1995-11-07 1997-12-09 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
JP4403305B2 (ja) * 2001-09-03 2010-01-27 武田薬品工業株式会社 １，３−ベンゾチアジノン誘導体および用途
GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds

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Publication number Publication date
EP1805170B1 (en) 2010-04-14
RU2007118727A (ru) 2008-11-27
MX2007004738A (es) 2007-06-18
US7378416B2 (en) 2008-05-27
EP1805170A1 (en) 2007-07-11
PL1805170T3 (pl) 2010-09-30
KR100875767B1 (ko) 2008-12-26
AU2005298923A1 (en) 2006-05-04
BRPI0516981A (pt) 2008-09-30
JP2008517020A (ja) 2008-05-22
ATE464307T1 (de) 2010-04-15
US20070219189A1 (en) 2007-09-20
DE602005020666D1 (en) 2010-05-27
RU2383541C2 (ru) 2010-03-10
KR20070054253A (ko) 2007-05-28
CN101035782A (zh) 2007-09-12
PT1805170E (pt) 2010-07-12
AU2005298923B2 (en) 2009-12-17
GB0423405D0 (en) 2004-11-24
CA2581981A1 (en) 2006-05-04
WO2006045505A1 (en) 2006-05-04

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