CN101035782A - Mif抑制剂 - Google Patents

Mif抑制剂 Download PDF

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Publication number
CN101035782A
CN101035782A CNA2005800342065A CN200580034206A CN101035782A CN 101035782 A CN101035782 A CN 101035782A CN A2005800342065 A CNA2005800342065 A CN A2005800342065A CN 200580034206 A CN200580034206 A CN 200580034206A CN 101035782 A CN101035782 A CN 101035782A
Authority
CN
China
Prior art keywords
benzo
dihydro
oxazin
compound
mif
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800342065A
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English (en)
Chinese (zh)
Inventor
A·比利希
P·莱尔
H·格斯塔西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN101035782A publication Critical patent/CN101035782A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
CNA2005800342065A 2004-10-21 2005-10-19 Mif抑制剂 Pending CN101035782A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0423405.0 2004-10-21
GBGB0423405.0A GB0423405D0 (en) 2004-10-21 2004-10-21 Organic compounds

Publications (1)

Publication Number Publication Date
CN101035782A true CN101035782A (zh) 2007-09-12

Family

ID=33484961

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800342065A Pending CN101035782A (zh) 2004-10-21 2005-10-19 Mif抑制剂

Country Status (17)

Country Link
US (1) US7378416B2 (enExample)
EP (1) EP1805170B1 (enExample)
JP (1) JP2008517020A (enExample)
KR (1) KR100875767B1 (enExample)
CN (1) CN101035782A (enExample)
AT (1) ATE464307T1 (enExample)
AU (1) AU2005298923B2 (enExample)
BR (1) BRPI0516981A (enExample)
CA (1) CA2581981A1 (enExample)
DE (1) DE602005020666D1 (enExample)
ES (1) ES2344655T3 (enExample)
GB (1) GB0423405D0 (enExample)
MX (1) MX2007004738A (enExample)
PL (1) PL1805170T3 (enExample)
PT (1) PT1805170E (enExample)
RU (1) RU2383541C2 (enExample)
WO (1) WO2006045505A1 (enExample)

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GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds
EP1928438B1 (en) 2005-09-26 2013-03-20 Avigen, Inc. Use of ibudilast for treating drug addictions
WO2007142923A1 (en) * 2006-05-31 2007-12-13 Avigen, Inc. Mif inhibitors for treating neuropathic pain and associated syndromes
EP2026804A1 (en) * 2006-05-31 2009-02-25 Avigen, Inc. Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
MX2011001872A (es) * 2008-08-18 2011-05-23 Univ Yale Moduladores de mif.
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
EP2198879A1 (en) 2008-12-11 2010-06-23 Institut Curie CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell
US9549988B2 (en) 2013-06-09 2017-01-24 RJS Biologics Pharmaceutical compounds targeted by MIF affinity-tethered moieties
US9617212B2 (en) 2013-12-17 2017-04-11 Controlled Chemicals, Inc. Isoindolin-1-ones as macrophage migration inhibitory factor (MIF) inhibitors
EP2944310B1 (en) 2014-05-16 2018-03-21 Mifcare MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
US10899739B2 (en) 2017-11-15 2021-01-26 Yale University Macrophage migration inhibitory factor inhibitors, and methods of making and using same
US11465991B2 (en) 2018-03-15 2022-10-11 Yale University Pyrazole-containing macrophage migration inhibitory factor inhibitors
US12697391B2 (en) 2018-04-09 2026-08-04 Yale University Bi-functional molecules to degrade circulating proteins
US12485178B2 (en) 2018-04-09 2025-12-02 Yale University Bifunctional small molecules to target the selective degradation of circulating proteins
CA3134610A1 (en) 2018-04-09 2019-10-17 Yale University Bifunctional small molecules to target the selective degradation of circulating proteins
CA3134765A1 (en) * 2018-04-09 2019-10-17 Yale University Bi-functional molecules to degrade circulating proteins
EP3897747A4 (en) 2018-12-19 2022-12-07 The Board of Trustees of the Leland Stanford Junior University BIFUNCTIONAL MOLECULES FOR LYSOSOMA TARGETING AND RELATED COMPOSITIONS AND METHODS
US20230399303A1 (en) * 2020-10-26 2023-12-14 Yale University Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same
US20230404980A1 (en) * 2020-10-28 2023-12-21 University Health Network Methods of treating spondyloarthritis or symptoms thereof
JP2024524614A (ja) 2021-07-14 2024-07-05 ライシア セラピューティクス， インコーポレイテッド Ａｓｇｐｒ細胞表面受容体結合化合物及びコンジュゲート

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6081182A (ja) * 1983-10-12 1985-05-09 Kissei Pharmaceut Co Ltd チオフエン誘導体及びその製造方法
US5696117A (en) * 1995-11-07 1997-12-09 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
JP4403305B2 (ja) * 2001-09-03 2010-01-27 武田薬品工業株式会社 １，３−ベンゾチアジノン誘導体および用途
GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds

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EP1805170B1 (en) 2010-04-14
ES2344655T3 (es) 2010-09-02
KR20070054253A (ko) 2007-05-28
EP1805170A1 (en) 2007-07-11
AU2005298923A1 (en) 2006-05-04
CA2581981A1 (en) 2006-05-04
US20070219189A1 (en) 2007-09-20
PT1805170E (pt) 2010-07-12
US7378416B2 (en) 2008-05-27
PL1805170T3 (pl) 2010-09-30
KR100875767B1 (ko) 2008-12-26
MX2007004738A (es) 2007-06-18
ATE464307T1 (de) 2010-04-15
GB0423405D0 (en) 2004-11-24
RU2007118727A (ru) 2008-11-27
RU2383541C2 (ru) 2010-03-10
DE602005020666D1 (en) 2010-05-27
JP2008517020A (ja) 2008-05-22
AU2005298923B2 (en) 2009-12-17
WO2006045505A1 (en) 2006-05-04
BRPI0516981A (pt) 2008-09-30

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