ES2278619T3 - Antagonistas selectivos del receptor iglur 5 para el tratamiento de la migraña. - Google Patents
Antagonistas selectivos del receptor iglur 5 para el tratamiento de la migraña. Download PDFInfo
- Publication number
- ES2278619T3 ES2278619T3 ES00944671T ES00944671T ES2278619T3 ES 2278619 T3 ES2278619 T3 ES 2278619T3 ES 00944671 T ES00944671 T ES 00944671T ES 00944671 T ES00944671 T ES 00944671T ES 2278619 T3 ES2278619 T3 ES 2278619T3
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- Prior art keywords
- compound
- alkyl
- acid
- migraine
- methyl
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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Landscapes
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14248599P | 1999-07-06 | 1999-07-06 | |
| US142485P | 1999-07-06 | ||
| US15116599P | 1999-08-27 | 1999-08-27 | |
| US151165P | 1999-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2278619T3 true ES2278619T3 (es) | 2007-08-16 |
Family
ID=26840135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00944671T Expired - Lifetime ES2278619T3 (es) | 1999-07-06 | 2000-06-27 | Antagonistas selectivos del receptor iglur 5 para el tratamiento de la migraña. |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US6566370B1 (enExample) |
| EP (1) | EP1200073B1 (enExample) |
| JP (1) | JP4619595B2 (enExample) |
| KR (1) | KR20020024300A (enExample) |
| CN (1) | CN1230174C (enExample) |
| AR (1) | AR029373A1 (enExample) |
| AU (1) | AU773304B2 (enExample) |
| BR (1) | BR0012175A (enExample) |
| CA (1) | CA2378613C (enExample) |
| CZ (1) | CZ20014488A3 (enExample) |
| DE (1) | DE60032905T2 (enExample) |
| DK (1) | DK1200073T3 (enExample) |
| DZ (1) | DZ3209A1 (enExample) |
| EA (1) | EA004290B1 (enExample) |
| ES (1) | ES2278619T3 (enExample) |
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| HR (1) | HRP20020013A2 (enExample) |
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Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1257545A1 (en) * | 1999-12-22 | 2002-11-20 | Eli Lilly And Company | SELECTIVE iGLUR 5? RECEPTOR ANTAGONISTS |
| AU2002227020A1 (en) * | 2001-01-05 | 2002-07-16 | Eli Lilly And Company | Pyrrolidinylmethyl- and piperidinyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists |
| MXPA03005981A (es) * | 2001-01-05 | 2003-09-10 | Lilly Co Eli | Antagonistas de receptores de aminoacidos excitatorios. |
| AU2002241565A1 (en) * | 2001-01-05 | 2002-07-16 | Eli Lilly And Company | Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders |
| US6924294B2 (en) | 2001-01-05 | 2005-08-02 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| DK1368032T3 (da) * | 2001-01-05 | 2008-09-29 | Lilly Co Eli | Exitatoriske aminosyrereceptorantagonister |
| US7205313B2 (en) | 2001-01-05 | 2007-04-17 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US6855725B2 (en) * | 2001-01-05 | 2005-02-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| US20040082606A1 (en) * | 2001-12-20 | 2004-04-29 | Khau Vien Van | Excitatory amino acid receptor antagonists |
| BR0308911A (pt) | 2002-04-26 | 2005-01-04 | Lilly Co Eli | Composto, composição farmacêutica, métodos de tratamento de dor e de enxaqueca, e, uso de um composto |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| MX2009002002A (es) | 2006-08-23 | 2009-07-22 | Valeant Pharmaceuticals Int | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potasio. |
| US8722929B2 (en) | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| US8030518B2 (en) | 2006-11-28 | 2011-10-04 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| KR20200035035A (ko) | 2017-07-31 | 2020-04-01 | 노파르티스 아게 | 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도 |
| JP7399096B2 (ja) | 2018-03-05 | 2023-12-15 | ヤンセン ファーマシューティカ エヌ．ベー． | 神経変性を検出するためのアッセイ |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| MA56607A1 (fr) | 2019-11-08 | 2022-10-31 | Xenon Pharmaceuticals Inc | Méthodes de traitement de troubles dépressifs |
| JP2024508660A (ja) | 2021-02-09 | 2024-02-28 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5356902A (en) | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5446051A (en) | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
| US5767117A (en) * | 1994-11-18 | 1998-06-16 | The General Hospital Corporation | Method for treating vascular headaches |
| KR20010006075A (ko) | 1997-04-07 | 2001-01-15 | 피터 지. 스트링거 | 약제 |
| US6486175B1 (en) * | 1999-07-06 | 2002-11-26 | Eli Lilly And Company | Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid |
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2000
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- 2000-06-27 DZ DZ003209A patent/DZ3209A1/xx active
- 2000-06-27 SK SK11-2002A patent/SK112002A3/sk not_active Application Discontinuation
- 2000-06-27 HU HU0202253A patent/HUP0202253A3/hu unknown
- 2000-06-27 CA CA002378613A patent/CA2378613C/en not_active Expired - Fee Related
- 2000-06-27 BR BR0012175-4A patent/BR0012175A/pt not_active Application Discontinuation
- 2000-06-27 WO PCT/US2000/016297 patent/WO2001001972A2/en not_active Ceased
- 2000-06-27 IL IL14669700A patent/IL146697A0/xx unknown
- 2000-06-27 PT PT00944671T patent/PT1200073E/pt unknown
- 2000-06-27 US US10/009,655 patent/US6566370B1/en not_active Expired - Fee Related
- 2000-06-27 EA EA200200132A patent/EA004290B1/ru not_active IP Right Cessation
- 2000-06-27 NZ NZ515616A patent/NZ515616A/en unknown
- 2000-06-27 HR HR20020013A patent/HRP20020013A2/hr not_active Application Discontinuation
- 2000-06-27 DE DE60032905T patent/DE60032905T2/de not_active Expired - Lifetime
- 2000-06-27 HK HK02107174.1A patent/HK1047036A1/zh unknown
- 2000-06-27 ES ES00944671T patent/ES2278619T3/es not_active Expired - Lifetime
- 2000-06-27 CN CNB008096880A patent/CN1230174C/zh not_active Expired - Fee Related
- 2000-06-27 EP EP00944671A patent/EP1200073B1/en not_active Expired - Lifetime
- 2000-06-27 DK DK00944671T patent/DK1200073T3/da active
- 2000-06-27 AU AU58732/00A patent/AU773304B2/en not_active Ceased
- 2000-06-27 CZ CZ20014488A patent/CZ20014488A3/cs unknown
- 2000-06-27 JP JP2001507466A patent/JP4619595B2/ja not_active Expired - Fee Related
- 2000-06-29 AR ARP000103296A patent/AR029373A1/es unknown
- 2000-07-04 PE PE2000000672A patent/PE20010299A1/es not_active Application Discontinuation
- 2000-07-04 MY MYPI20003046 patent/MY133503A/en unknown
-
2001
- 2001-12-19 NO NO20016246A patent/NO20016246L/no not_active Application Discontinuation
-
2003
- 2003-03-06 US US10/383,296 patent/US6759418B2/en not_active Expired - Fee Related
-
2004
- 2004-04-09 US US10/821,698 patent/US6855823B2/en not_active Expired - Fee Related
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2005
- 2005-01-11 US US11/032,759 patent/US7157582B2/en not_active Expired - Fee Related
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