JP4619595B2 - 偏頭痛の処置のための選択的なｉＧｌｕＲ５受容体拮抗薬 - Google Patents
偏頭痛の処置のための選択的なｉＧｌｕＲ５受容体拮抗薬 Download PDFInfo
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- JP4619595B2 JP4619595B2 JP2001507466A JP2001507466A JP4619595B2 JP 4619595 B2 JP4619595 B2 JP 4619595B2 JP 2001507466 A JP2001507466 A JP 2001507466A JP 2001507466 A JP2001507466 A JP 2001507466A JP 4619595 B2 JP4619595 B2 JP 4619595B2
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US60/142,485 | 1999-07-06 | ||
| US15116599P | 1999-08-27 | 1999-08-27 | |
| US60/151,165 | 1999-08-27 | ||
| PCT/US2000/016297 WO2001001972A2 (en) | 1999-07-06 | 2000-06-27 | SELECTIVE iGluR5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE |
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| JP2003503449A JP2003503449A (ja) | 2003-01-28 |
| JP2003503449A5 JP2003503449A5 (enExample) | 2007-08-16 |
| JP4619595B2 true JP4619595B2 (ja) | 2011-01-26 |
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| DE (1) | DE60032905T2 (enExample) |
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| HR (1) | HRP20020013A2 (enExample) |
| HU (1) | HUP0202253A3 (enExample) |
| IL (1) | IL146697A0 (enExample) |
| MX (1) | MXPA01012726A (enExample) |
| MY (1) | MY133503A (enExample) |
| NO (1) | NO20016246L (enExample) |
| NZ (1) | NZ515616A (enExample) |
| PE (1) | PE20010299A1 (enExample) |
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| SK (1) | SK112002A3 (enExample) |
| TR (1) | TR200200066T2 (enExample) |
| WO (1) | WO2001001972A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2574801A (en) * | 1999-12-22 | 2001-07-03 | Eli Lilly And Company | Selective iGLUR5 receptor antagonists |
| CN100548299C (zh) * | 2001-01-05 | 2009-10-14 | 伊莱利利公司 | 兴奋性氨基酸受体拮抗剂 |
| US7205313B2 (en) | 2001-01-05 | 2007-04-17 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| WO2002053139A2 (en) * | 2001-01-05 | 2002-07-11 | Eli Lilly And Company | Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders |
| CZ20031856A3 (cs) * | 2001-01-05 | 2003-09-17 | Eli Lilly And Company | Antagonisté receptorů excitačních aminokyselin |
| US6924294B2 (en) | 2001-01-05 | 2005-08-02 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US6855725B2 (en) * | 2001-01-05 | 2005-02-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| WO2002053555A2 (en) * | 2001-01-05 | 2002-07-11 | Eli Lilly And Company | Pyrrolidinylmethyl- and piperidinyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists |
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| US20040082606A1 (en) * | 2001-12-20 | 2004-04-29 | Khau Vien Van | Excitatory amino acid receptor antagonists |
| PT1511741E (pt) | 2002-04-26 | 2013-02-05 | Lilly Co Eli | Derivados éster de um ácido deca-hidroisoquinolino-3- carboxílico como analgésicos |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| NZ575652A (en) | 2006-08-23 | 2011-08-26 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| KR20090083479A (ko) | 2006-11-28 | 2009-08-03 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체 |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| KR20200035035A (ko) | 2017-07-31 | 2020-04-01 | 노파르티스 아게 | 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도 |
| WO2019171258A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Pharmaceutica Nv | Assays to detect neurodegeneration |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| CA3155812A1 (en) | 2019-11-08 | 2021-05-14 | Cynthia Louise HARDEN | Methods of treating depressive disorders |
| TW202245744A (zh) | 2021-02-09 | 2022-12-01 | 加拿大商再諾製藥公司 | 治療失樂症之方法及用途 |
Family Cites Families (6)
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| US5284957A (en) | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5356902A (en) | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5446051A (en) | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
| US5767117A (en) | 1994-11-18 | 1998-06-16 | The General Hospital Corporation | Method for treating vascular headaches |
| TR199902449T2 (xx) * | 1997-04-07 | 2000-07-21 | Eli Lilly And Company | Farmakolojik etkin maddeler. |
| DE60002733T2 (de) | 1999-07-06 | 2004-03-18 | Eli Lilly And Co., Indianapolis | Diester prodrugs von decahydroischinoline-3-carbonsäure |
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2000
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- 2000-06-27 PT PT00944671T patent/PT1200073E/pt unknown
- 2000-06-27 HU HU0202253A patent/HUP0202253A3/hu unknown
- 2000-06-27 ES ES00944671T patent/ES2278619T3/es not_active Expired - Lifetime
- 2000-06-27 DE DE60032905T patent/DE60032905T2/de not_active Expired - Lifetime
- 2000-06-27 BR BR0012175-4A patent/BR0012175A/pt not_active Application Discontinuation
- 2000-06-27 MX MXPA01012726A patent/MXPA01012726A/es active IP Right Grant
- 2000-06-27 HR HR20020013A patent/HRP20020013A2/hr not_active Application Discontinuation
- 2000-06-27 IL IL14669700A patent/IL146697A0/xx unknown
- 2000-06-27 EA EA200200132A patent/EA004290B1/ru not_active IP Right Cessation
- 2000-06-27 CZ CZ20014488A patent/CZ20014488A3/cs unknown
- 2000-06-27 NZ NZ515616A patent/NZ515616A/en unknown
- 2000-06-27 US US10/009,655 patent/US6566370B1/en not_active Expired - Fee Related
- 2000-06-27 HK HK02107174.1A patent/HK1047036A1/zh unknown
- 2000-06-27 DK DK00944671T patent/DK1200073T3/da active
- 2000-06-27 TR TR2002/00066T patent/TR200200066T2/xx unknown
- 2000-06-27 KR KR1020027000138A patent/KR20020024300A/ko not_active Withdrawn
- 2000-06-27 AU AU58732/00A patent/AU773304B2/en not_active Ceased
- 2000-06-27 CN CNB008096880A patent/CN1230174C/zh not_active Expired - Fee Related
- 2000-06-27 JP JP2001507466A patent/JP4619595B2/ja not_active Expired - Fee Related
- 2000-06-27 EP EP00944671A patent/EP1200073B1/en not_active Expired - Lifetime
- 2000-06-27 CA CA002378613A patent/CA2378613C/en not_active Expired - Fee Related
- 2000-06-27 SK SK11-2002A patent/SK112002A3/sk not_active Application Discontinuation
- 2000-06-27 WO PCT/US2000/016297 patent/WO2001001972A2/en not_active Ceased
- 2000-06-29 AR ARP000103296A patent/AR029373A1/es unknown
- 2000-07-04 MY MYPI20003046 patent/MY133503A/en unknown
- 2000-07-04 PE PE2000000672A patent/PE20010299A1/es not_active Application Discontinuation
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2001
- 2001-12-19 NO NO20016246A patent/NO20016246L/no not_active Application Discontinuation
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2003
- 2003-03-06 US US10/383,296 patent/US6759418B2/en not_active Expired - Fee Related
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2004
- 2004-04-09 US US10/821,698 patent/US6855823B2/en not_active Expired - Fee Related
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2005
- 2005-01-11 US US11/032,759 patent/US7157582B2/en not_active Expired - Fee Related
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