JP2005501870A5 - - Google Patents
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- Publication number
- JP2005501870A5 JP2005501870A5 JP2003523243A JP2003523243A JP2005501870A5 JP 2005501870 A5 JP2005501870 A5 JP 2005501870A5 JP 2003523243 A JP2003523243 A JP 2003523243A JP 2003523243 A JP2003523243 A JP 2003523243A JP 2005501870 A5 JP2005501870 A5 JP 2005501870A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- salt
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 27
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- -1 nitro, amino Chemical group 0.000 claims 6
- 229910052717 sulfur Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 239000012442 inert solvent Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 2
- 206010019375 Helicobacter infections Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000027119 gastric acid secretion Effects 0.000 claims 2
- 210000001156 gastric mucosa Anatomy 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000003235 pyrrolidines Chemical class 0.000 claims 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- JXDIFRRRYRQRPX-UHFFFAOYSA-N 8-[(2,4-dimethylthiophen-3-yl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide Chemical compound CC1=CSC(C)=C1CNC1=CC(C(N)=O)=CN2C1=NC(C)=C2C JXDIFRRRYRQRPX-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000002841 Lewis acid Substances 0.000 claims 1
- 239000012317 TBTU Substances 0.000 claims 1
- CLZISMQKJZCZDN-UHFFFAOYSA-N [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium Chemical compound C1=CC=C2N(OC(N(C)C)=[N+](C)C)N=NC2=C1 CLZISMQKJZCZDN-UHFFFAOYSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 150000007517 lewis acids Chemical class 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940126409 proton pump inhibitor Drugs 0.000 claims 1
- 239000000612 proton pump inhibitor Substances 0.000 claims 1
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 1
- 239000012279 sodium borohydride Substances 0.000 claims 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
- 235000005074 zinc chloride Nutrition 0.000 claims 1
- 239000011592 zinc chloride Substances 0.000 claims 1
- 0 *c1c(*)nc(c(N)c2)[n]1cc2C(N(*)*=C)=O Chemical compound *c1c(*)nc(c(N)c2)[n]1cc2C(N(*)*=C)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102808A SE0102808D0 (sv) | 2001-08-22 | 2001-08-22 | New compounds |
| PCT/SE2002/001489 WO2003018582A1 (en) | 2001-08-22 | 2002-08-21 | Novel imidazopyridine compounds with therapeutic effect |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501870A JP2005501870A (ja) | 2005-01-20 |
| JP2005501870A5 true JP2005501870A5 (enExample) | 2006-01-05 |
Family
ID=20285105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003523243A Pending JP2005501870A (ja) | 2001-08-22 | 2002-08-21 | 治療効果を有する新規なイミダゾピリジン化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040220209A1 (enExample) |
| EP (1) | EP1421083A1 (enExample) |
| JP (1) | JP2005501870A (enExample) |
| KR (1) | KR20040036723A (enExample) |
| CN (1) | CN100343252C (enExample) |
| AR (1) | AR035465A1 (enExample) |
| BR (1) | BR0211846A (enExample) |
| CA (1) | CA2456350A1 (enExample) |
| HU (1) | HUP0401350A3 (enExample) |
| IL (1) | IL160143A0 (enExample) |
| IS (1) | IS7159A (enExample) |
| MX (1) | MXPA04001402A (enExample) |
| NO (1) | NO20040760L (enExample) |
| NZ (1) | NZ531110A (enExample) |
| PL (1) | PL367971A1 (enExample) |
| RU (1) | RU2294935C2 (enExample) |
| SE (1) | SE0102808D0 (enExample) |
| WO (1) | WO2003018582A1 (enExample) |
| ZA (1) | ZA200401114B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301904D0 (sv) | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound II with therapeutic effect |
| EP1974730A1 (en) | 2003-11-03 | 2008-10-01 | AstraZeneca AB | Imidazo[1,2-a]pyridine derivatives for use in the treatment of sleep disturbance due to silent gastro-esophageal reflux |
| WO2005070927A2 (en) * | 2004-01-26 | 2005-08-04 | Altana Pharma Ag | 1,2,4-triazolo[1,5-a] pyridines as gastric acid secretion inhibitors |
| BRPI0519598A2 (pt) * | 2004-12-17 | 2009-03-10 | Pfizer | derivados de cromano éteis como antagonistas de bomba de Ácido, composiÇço farmacÊutica e uso dos mesmos |
| GB0513423D0 (en) * | 2005-06-30 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| WO2007107827A1 (en) * | 2006-03-17 | 2007-09-27 | Raqualia Pharma Inc. | Chromane derivatives |
| WO2008059373A1 (en) * | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists |
| KR200449743Y1 (ko) * | 2008-03-11 | 2010-08-05 | 주식회사 보루네오가구 | 파티션용 상부 스크린의 고정구조 |
| FI20086158A0 (fi) | 2008-12-03 | 2008-12-03 | Mikael Dahlstroem | Imidatsopyridiinijohdannaiset |
| KR101605063B1 (ko) | 2009-07-09 | 2016-03-21 | 라퀄리아 파마 인코포레이티드 | 소화관 운동이상이 관여하는 질환의 치료용 산 펌프 길항제 |
| CA2770087C (en) * | 2009-09-24 | 2014-09-09 | F. Hoffmann-La Roche Ag | Imidazopyridine or imidazopyrimidine derivatives as phosphodiesterase 1oa inhibitors |
| FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
| WO2014117274A1 (en) * | 2013-01-31 | 2014-08-07 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| JP2016520047A (ja) * | 2013-04-30 | 2016-07-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピラゾールアミドのＰｄ触媒カップリング |
| CN106279151A (zh) * | 2015-06-26 | 2017-01-04 | 江苏太瑞生诺生物医药科技有限公司 | 5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法 |
| CN113727716A (zh) | 2019-02-25 | 2021-11-30 | 贝卢斯医疗咳嗽病公司 | 采用p2x3调节剂的治疗 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA81219B (en) * | 1980-01-23 | 1982-01-27 | Schering Corp | Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them |
| DE3269604D1 (en) * | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| EP0228006A1 (en) * | 1985-12-16 | 1987-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
| IL108520A (en) * | 1993-02-15 | 1997-09-30 | Byk Gulden Lomberg Chem Fab | 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| UA48122C2 (uk) * | 1993-10-11 | 2002-08-15 | Бік Гульден Ломберг Хеміше Фабрік Гмбх | АЛКОКСІАЛКІЛКАРБАМАТИ ІМІДАЗО[1,2-а]ПІРИДИНІВ, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ |
| JPH10505333A (ja) * | 1994-07-28 | 1998-05-26 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | イミダゾピリジン−アゾリジノン |
| SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
-
2001
- 2001-08-22 SE SE0102808A patent/SE0102808D0/xx unknown
-
2002
- 2002-08-09 AR ARP020103019A patent/AR035465A1/es not_active Application Discontinuation
- 2002-08-21 CA CA002456350A patent/CA2456350A1/en not_active Abandoned
- 2002-08-21 WO PCT/SE2002/001489 patent/WO2003018582A1/en not_active Ceased
- 2002-08-21 CN CNB028160177A patent/CN100343252C/zh not_active Expired - Fee Related
- 2002-08-21 IL IL16014302A patent/IL160143A0/xx unknown
- 2002-08-21 EP EP02759036A patent/EP1421083A1/en not_active Withdrawn
- 2002-08-21 RU RU2004103628/04A patent/RU2294935C2/ru not_active IP Right Cessation
- 2002-08-21 JP JP2003523243A patent/JP2005501870A/ja active Pending
- 2002-08-21 BR BR0211846-7A patent/BR0211846A/pt not_active IP Right Cessation
- 2002-08-21 US US10/487,149 patent/US20040220209A1/en not_active Abandoned
- 2002-08-21 NZ NZ531110A patent/NZ531110A/en unknown
- 2002-08-21 PL PL02367971A patent/PL367971A1/xx not_active Application Discontinuation
- 2002-08-21 KR KR10-2004-7002466A patent/KR20040036723A/ko not_active Ceased
- 2002-08-21 MX MXPA04001402A patent/MXPA04001402A/es unknown
- 2002-08-21 HU HU0401350A patent/HUP0401350A3/hu unknown
-
2004
- 2004-02-11 ZA ZA200401114A patent/ZA200401114B/en unknown
- 2004-02-20 NO NO20040760A patent/NO20040760L/no not_active Application Discontinuation
- 2004-02-20 IS IS7159A patent/IS7159A/is unknown
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