RU2294935C2 - Имидазопиридиновые производные для применения в терапии в качестве лекарственного средства, ингибирующего протонный насос, и промежуточные соединения для их получения - Google Patents
Имидазопиридиновые производные для применения в терапии в качестве лекарственного средства, ингибирующего протонный насос, и промежуточные соединения для их получения Download PDFInfo
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- RU2294935C2 RU2294935C2 RU2004103628/04A RU2004103628A RU2294935C2 RU 2294935 C2 RU2294935 C2 RU 2294935C2 RU 2004103628/04 A RU2004103628/04 A RU 2004103628/04A RU 2004103628 A RU2004103628 A RU 2004103628A RU 2294935 C2 RU2294935 C2 RU 2294935C2
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- Prior art keywords
- alkyl
- hydroxylated
- alkoxy
- compounds
- compound
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- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000001562 ulcerogenic effect Effects 0.000 description 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
- 229940124586 β-lactam antibiotics Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102808A SE0102808D0 (sv) | 2001-08-22 | 2001-08-22 | New compounds |
| SE0102808-3 | 2001-08-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004103628A RU2004103628A (ru) | 2005-06-27 |
| RU2294935C2 true RU2294935C2 (ru) | 2007-03-10 |
Family
ID=20285105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004103628/04A RU2294935C2 (ru) | 2001-08-22 | 2002-08-21 | Имидазопиридиновые производные для применения в терапии в качестве лекарственного средства, ингибирующего протонный насос, и промежуточные соединения для их получения |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20040220209A1 (enExample) |
| EP (1) | EP1421083A1 (enExample) |
| JP (1) | JP2005501870A (enExample) |
| KR (1) | KR20040036723A (enExample) |
| CN (1) | CN100343252C (enExample) |
| AR (1) | AR035465A1 (enExample) |
| BR (1) | BR0211846A (enExample) |
| CA (1) | CA2456350A1 (enExample) |
| HU (1) | HUP0401350A3 (enExample) |
| IL (1) | IL160143A0 (enExample) |
| IS (1) | IS7159A (enExample) |
| MX (1) | MXPA04001402A (enExample) |
| NO (1) | NO20040760L (enExample) |
| NZ (1) | NZ531110A (enExample) |
| PL (1) | PL367971A1 (enExample) |
| RU (1) | RU2294935C2 (enExample) |
| SE (1) | SE0102808D0 (enExample) |
| WO (1) | WO2003018582A1 (enExample) |
| ZA (1) | ZA200401114B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2502737C2 (ru) * | 2009-09-24 | 2013-12-27 | Ф. Хоффманн-Ля Рош Аг | Производные имидазопиридина или имидазопиримидина в качестве ингибиторов фосфодиэстеразы 10а |
| RU2656593C2 (ru) * | 2013-01-31 | 2018-06-06 | Неомед Инститьют | Соединения имидазопиридина, полезные при лечении состояния, связанного с активностью p2x3 и/или p2x2/3 |
| RU2663834C2 (ru) * | 2013-04-30 | 2018-08-10 | Ф. Хоффманн-Ля Рош Аг | Катализируемое палладием сочетание пиразоламидов |
| US12485125B2 (en) | 2019-02-25 | 2025-12-02 | Glaxosmithkline Intellectual Property (No. 3) Limited | Treatment with P2X3 modulators |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301904D0 (sv) | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound II with therapeutic effect |
| US20080280944A1 (en) | 2003-11-03 | 2008-11-13 | Paula Fernstrom | Imidazo[1,2-A]Pyridine Derivatives For The Treatment Of Silent Gastro-Esophageal Reflux |
| US20080033006A1 (en) * | 2004-01-26 | 2008-02-07 | Altana Pharma Ag | 1,2,4-Triazolo[ 1,5-A] Pyridines as Gastric Acid Secretion Inhibitors |
| US20090291977A1 (en) * | 2004-12-17 | 2009-11-26 | Madoka Jinno | Chromane Derivatives Useful As Acid Pump Antagonists |
| GB0513423D0 (en) * | 2005-06-30 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| WO2007107827A1 (en) * | 2006-03-17 | 2007-09-27 | Raqualia Pharma Inc. | Chromane derivatives |
| WO2008059373A1 (en) * | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists |
| KR200449743Y1 (ko) * | 2008-03-11 | 2010-08-05 | 주식회사 보루네오가구 | 파티션용 상부 스크린의 고정구조 |
| FI20086158A0 (fi) | 2008-12-03 | 2008-12-03 | Mikael Dahlstroem | Imidatsopyridiinijohdannaiset |
| CN102470126A (zh) | 2009-07-09 | 2012-05-23 | 拉夸里亚创药株式会社 | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 |
| FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
| CN106279151A (zh) * | 2015-06-26 | 2017-01-04 | 江苏太瑞生诺生物医药科技有限公司 | 5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0033094A1 (en) * | 1980-01-23 | 1981-08-05 | Schering Corporation | Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them |
| RU2136682C1 (ru) * | 1993-02-15 | 1999-09-10 | Бик Гульден Ломберг Хемише Фабрик ГмбХ | Имидазопиридины, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции |
| RU2138501C1 (ru) * | 1994-07-28 | 1999-09-27 | Бык Гульден Ломберг Хемише Фабрик Гмбх | Имидазопиридиназолидиноны, их соли и лекарственное средство |
| RU2139288C1 (ru) * | 1993-10-11 | 1999-10-10 | Бык Гульден Ломберг Хемише Фабрик Гмбх | Алкоксиалкилкарбаматы имидазо[1,2-a]пиридинов и лекарственное средство на их основе |
| WO1999055706A1 (en) * | 1998-04-29 | 1999-11-04 | Astrazeneca Ab | Imidazo pyridine derivatives which inhibit gastric acid secretion |
| WO2000011000A2 (en) * | 1998-08-21 | 2000-03-02 | Astrazeneca Ab | New compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| EP0228006A1 (en) * | 1985-12-16 | 1987-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
-
2001
- 2001-08-22 SE SE0102808A patent/SE0102808D0/xx unknown
-
2002
- 2002-08-09 AR ARP020103019A patent/AR035465A1/es not_active Application Discontinuation
- 2002-08-21 RU RU2004103628/04A patent/RU2294935C2/ru not_active IP Right Cessation
- 2002-08-21 HU HU0401350A patent/HUP0401350A3/hu unknown
- 2002-08-21 US US10/487,149 patent/US20040220209A1/en not_active Abandoned
- 2002-08-21 CA CA002456350A patent/CA2456350A1/en not_active Abandoned
- 2002-08-21 KR KR10-2004-7002466A patent/KR20040036723A/ko not_active Ceased
- 2002-08-21 BR BR0211846-7A patent/BR0211846A/pt not_active IP Right Cessation
- 2002-08-21 IL IL16014302A patent/IL160143A0/xx unknown
- 2002-08-21 MX MXPA04001402A patent/MXPA04001402A/es unknown
- 2002-08-21 PL PL02367971A patent/PL367971A1/xx not_active Application Discontinuation
- 2002-08-21 NZ NZ531110A patent/NZ531110A/en unknown
- 2002-08-21 JP JP2003523243A patent/JP2005501870A/ja active Pending
- 2002-08-21 EP EP02759036A patent/EP1421083A1/en not_active Withdrawn
- 2002-08-21 CN CNB028160177A patent/CN100343252C/zh not_active Expired - Fee Related
- 2002-08-21 WO PCT/SE2002/001489 patent/WO2003018582A1/en not_active Ceased
-
2004
- 2004-02-11 ZA ZA200401114A patent/ZA200401114B/en unknown
- 2004-02-20 NO NO20040760A patent/NO20040760L/no not_active Application Discontinuation
- 2004-02-20 IS IS7159A patent/IS7159A/is unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0033094A1 (en) * | 1980-01-23 | 1981-08-05 | Schering Corporation | Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them |
| RU2136682C1 (ru) * | 1993-02-15 | 1999-09-10 | Бик Гульден Ломберг Хемише Фабрик ГмбХ | Имидазопиридины, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции |
| RU2139288C1 (ru) * | 1993-10-11 | 1999-10-10 | Бык Гульден Ломберг Хемише Фабрик Гмбх | Алкоксиалкилкарбаматы имидазо[1,2-a]пиридинов и лекарственное средство на их основе |
| RU2138501C1 (ru) * | 1994-07-28 | 1999-09-27 | Бык Гульден Ломберг Хемише Фабрик Гмбх | Имидазопиридиназолидиноны, их соли и лекарственное средство |
| WO1999055706A1 (en) * | 1998-04-29 | 1999-11-04 | Astrazeneca Ab | Imidazo pyridine derivatives which inhibit gastric acid secretion |
| WO1999055705A1 (en) * | 1998-04-29 | 1999-11-04 | Astrazeneca Ab | Imidazo pyridine derivatives which inhibit gastric acid secretion |
| WO2000011000A2 (en) * | 1998-08-21 | 2000-03-02 | Astrazeneca Ab | New compounds |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2502737C2 (ru) * | 2009-09-24 | 2013-12-27 | Ф. Хоффманн-Ля Рош Аг | Производные имидазопиридина или имидазопиримидина в качестве ингибиторов фосфодиэстеразы 10а |
| RU2656593C2 (ru) * | 2013-01-31 | 2018-06-06 | Неомед Инститьют | Соединения имидазопиридина, полезные при лечении состояния, связанного с активностью p2x3 и/или p2x2/3 |
| RU2663834C2 (ru) * | 2013-04-30 | 2018-08-10 | Ф. Хоффманн-Ля Рош Аг | Катализируемое палладием сочетание пиразоламидов |
| US12485125B2 (en) | 2019-02-25 | 2025-12-02 | Glaxosmithkline Intellectual Property (No. 3) Limited | Treatment with P2X3 modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003018582A1 (en) | 2003-03-06 |
| HUP0401350A3 (en) | 2009-03-02 |
| IS7159A (is) | 2004-02-20 |
| JP2005501870A (ja) | 2005-01-20 |
| PL367971A1 (en) | 2005-03-07 |
| BR0211846A (pt) | 2004-09-08 |
| AR035465A1 (es) | 2004-05-26 |
| US20040220209A1 (en) | 2004-11-04 |
| RU2004103628A (ru) | 2005-06-27 |
| CN1543464A (zh) | 2004-11-03 |
| ZA200401114B (en) | 2005-06-22 |
| HUP0401350A2 (hu) | 2004-12-28 |
| NO20040760L (no) | 2004-02-20 |
| CN100343252C (zh) | 2007-10-17 |
| KR20040036723A (ko) | 2004-04-30 |
| EP1421083A1 (en) | 2004-05-26 |
| CA2456350A1 (en) | 2003-03-06 |
| SE0102808D0 (sv) | 2001-08-22 |
| NZ531110A (en) | 2005-10-28 |
| IL160143A0 (en) | 2004-06-20 |
| MXPA04001402A (es) | 2004-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TK4A | Correction to the publication in the bulletin (patent) |
Free format text: AMENDMENT TO CHAPTER -FG4A- IN JOURNAL: 7-2007 FOR TAG: (57) |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20080822 |