JP2008520611A5 - - Google Patents
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- Publication number
- JP2008520611A5 JP2008520611A5 JP2007541817A JP2007541817A JP2008520611A5 JP 2008520611 A5 JP2008520611 A5 JP 2008520611A5 JP 2007541817 A JP2007541817 A JP 2007541817A JP 2007541817 A JP2007541817 A JP 2007541817A JP 2008520611 A5 JP2008520611 A5 JP 2008520611A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- formula
- methyl
- compound
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- QTMHVKDZOWDCRB-UHFFFAOYSA-N 4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methyl-6-methylsulfanyl-1,7-naphthyridine-3-carboxamide Chemical compound NC(=O)C1=CN=C2C(C)=NC(SC)=CC2=C1NC1=CC=CC2=C1CCO2 QTMHVKDZOWDCRB-UHFFFAOYSA-N 0.000 claims 1
- HSFLNSPPCNQBMV-UHFFFAOYSA-N 4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methyl-6-methylsulfinyl-1,7-naphthyridine-3-carboxamide Chemical compound NC(=O)C1=CN=C2C(C)=NC(S(C)=O)=CC2=C1NC1=CC=CC2=C1CCO2 HSFLNSPPCNQBMV-UHFFFAOYSA-N 0.000 claims 1
- MJTKGFWCPCSIIO-UHFFFAOYSA-N 4-(2,3-dihydro-1-benzofuran-4-ylamino)-8-methyl-6-methylsulfonyl-1,7-naphthyridine-3-carboxamide Chemical compound NC(=O)C1=CN=C2C(C)=NC(S(C)(=O)=O)=CC2=C1NC1=CC=CC2=C1CCO2 MJTKGFWCPCSIIO-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 150000004703 alkoxides Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0425572.5A GB0425572D0 (en) | 2004-11-19 | 2004-11-19 | 1,7-Naphthyridines |
| PCT/EP2005/012462 WO2006053784A2 (en) | 2004-11-19 | 2005-11-17 | 1,7-naphthyridines as pde4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008520611A JP2008520611A (ja) | 2008-06-19 |
| JP2008520611A5 true JP2008520611A5 (enExample) | 2008-08-07 |
Family
ID=33548592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541817A Pending JP2008520611A (ja) | 2004-11-19 | 2005-11-17 | １，７−ナフチリジン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090270444A1 (enExample) |
| EP (1) | EP1812434A2 (enExample) |
| JP (1) | JP2008520611A (enExample) |
| GB (1) | GB0425572D0 (enExample) |
| WO (1) | WO2006053784A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0505621D0 (en) * | 2005-03-18 | 2005-04-27 | Glaxo Group Ltd | Novel compounds |
| GB0521563D0 (en) * | 2005-10-21 | 2005-11-30 | Glaxo Group Ltd | Novel compounds |
| CN102348707A (zh) | 2009-01-13 | 2012-02-08 | 葛兰素集团有限公司 | 作为syk激酶抑制剂的嘧啶甲酰胺衍生物 |
| PH12012501846A1 (en) * | 2010-04-02 | 2013-02-04 | Firmenich Incorporated | Sweet flavor modifier |
| RU2617700C2 (ru) | 2011-08-12 | 2017-04-26 | Синомикс, Инк. | Производные 4-аминохинолин-3-карбоновой кислоты и содержащие их композиции для усиления сладкого вкуса |
| CA2895209C (en) | 2013-03-14 | 2022-07-19 | Venkataiah Bollu | Substituted pyridine and pyrazine compounds as pde4 inhibitors |
| BR112017008738B1 (pt) | 2014-11-07 | 2021-06-15 | Firmenich Incorporated | Ácidos 4-amino-5-(ciclohexilóxi)quinolina-3-carboxílicos substituídos como modificadores de sabores adoçantes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6576644B2 (en) * | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
| GB0229281D0 (en) * | 2002-12-16 | 2003-01-22 | Novartis Ag | Organic compounds |
| TWI328009B (en) * | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| GB0505621D0 (en) * | 2005-03-18 | 2005-04-27 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-11-19 GB GBGB0425572.5A patent/GB0425572D0/en not_active Ceased
-
2005
- 2005-11-17 US US11/718,892 patent/US20090270444A1/en not_active Abandoned
- 2005-11-17 EP EP05808261A patent/EP1812434A2/en not_active Withdrawn
- 2005-11-17 JP JP2007541817A patent/JP2008520611A/ja active Pending
- 2005-11-17 WO PCT/EP2005/012462 patent/WO2006053784A2/en not_active Ceased