JP2014526500A5 - - Google Patents
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- Publication number
- JP2014526500A5 JP2014526500A5 JP2014530370A JP2014530370A JP2014526500A5 JP 2014526500 A5 JP2014526500 A5 JP 2014526500A5 JP 2014530370 A JP2014530370 A JP 2014530370A JP 2014530370 A JP2014530370 A JP 2014530370A JP 2014526500 A5 JP2014526500 A5 JP 2014526500A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- trifluoromethyl
- oxadiazol
- halogen atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000623 heterocyclic group Chemical group 0.000 claims 32
- 125000005843 halogen group Chemical group 0.000 claims 31
- 229910052799 carbon Inorganic materials 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 13
- 229910052717 sulfur Inorganic materials 0.000 claims 13
- 125000005842 heteroatom Chemical group 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 7
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 4
- -1 R 14 Chemical compound 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- HNMSYIKEBOLQKV-UHFFFAOYSA-N 2-[5-[3-amino-5,6-bis(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC(C(F)(F)F)=C(C(F)(F)F)N=C1N HNMSYIKEBOLQKV-UHFFFAOYSA-N 0.000 claims 2
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 230000036571 hydration Effects 0.000 claims 2
- 238000006703 hydration reaction Methods 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- GESXZHFWDCTRHG-SNVBAGLBSA-N (2r)-2-[5-[3-amino-4-chloro-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound ClC1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@@](C)(O)C(F)(F)F)=C1N GESXZHFWDCTRHG-SNVBAGLBSA-N 0.000 claims 1
- HNMSYIKEBOLQKV-MRVPVSSYSA-N (2r)-2-[5-[3-amino-5,6-bis(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@](O)(C)C(F)(F)F)=NN=C1C1=NC(C(F)(F)F)=C(C(F)(F)F)N=C1N HNMSYIKEBOLQKV-MRVPVSSYSA-N 0.000 claims 1
- GJICZLZFKWSSBD-SECBINFHSA-N (2r)-2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@](O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N GJICZLZFKWSSBD-SECBINFHSA-N 0.000 claims 1
- HMXVTLCFBUROJI-SNVBAGLBSA-N (2r)-2-[5-[3-amino-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@@](C)(O)C(F)(F)F)=C1N HMXVTLCFBUROJI-SNVBAGLBSA-N 0.000 claims 1
- GESXZHFWDCTRHG-JTQLQIEISA-N (2s)-2-[5-[3-amino-4-chloro-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound ClC1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N GESXZHFWDCTRHG-JTQLQIEISA-N 0.000 claims 1
- CTRQIOYBLMEECE-LBPRGKRZSA-N (2s)-2-[5-[3-amino-4-ethyl-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound COC1=C(C(F)(F)F)C(CC)=C(N)C(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=N1 CTRQIOYBLMEECE-LBPRGKRZSA-N 0.000 claims 1
- HNMSYIKEBOLQKV-QMMMGPOBSA-N (2s)-2-[5-[3-amino-5,6-bis(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@@](O)(C)C(F)(F)F)=NN=C1C1=NC(C(F)(F)F)=C(C(F)(F)F)N=C1N HNMSYIKEBOLQKV-QMMMGPOBSA-N 0.000 claims 1
- GJICZLZFKWSSBD-VIFPVBQESA-N (2s)-2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@@](O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N GJICZLZFKWSSBD-VIFPVBQESA-N 0.000 claims 1
- AIEPIMYPVPRVOQ-INIZCTEOSA-N (2s)-2-[5-[3-amino-6-methoxy-4-phenyl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound NC=1C(C=2C=CC=CC=2)=C(C(F)(F)F)C(OC)=NC=1C1=NN=C([C@](C)(O)C(F)(F)F)O1 AIEPIMYPVPRVOQ-INIZCTEOSA-N 0.000 claims 1
- IPXOIMMPOYXWFR-ZDUSSCGKSA-N (2s)-2-[5-[3-amino-6-methoxy-4-prop-1-en-2-yl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound CC(=C)C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N IPXOIMMPOYXWFR-ZDUSSCGKSA-N 0.000 claims 1
- FDJPJZNPKVAQDQ-ZDUSSCGKSA-N (2s)-2-[5-[3-amino-6-methoxy-4-propan-2-yl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound CC(C)C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N FDJPJZNPKVAQDQ-ZDUSSCGKSA-N 0.000 claims 1
- HMXVTLCFBUROJI-JTQLQIEISA-N (2s)-2-[5-[3-amino-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N HMXVTLCFBUROJI-JTQLQIEISA-N 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- ZCPYJTVACTXCQN-UHFFFAOYSA-N 2-(5-benzyl-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine Chemical compound NC1=CC(C(F)(F)F)=C(Br)N=C1C(O1)=NN=C1CC1=CC=CC=C1 ZCPYJTVACTXCQN-UHFFFAOYSA-N 0.000 claims 1
- QOFCKRKVCJKVJW-SNVBAGLBSA-N 2-[5-[(r)-amino(phenyl)methyl]-1,3,4-oxadiazol-2-yl]-6-bromo-5-(trifluoromethyl)pyridin-3-amine Chemical compound O1C([C@H](N)C=2C=CC=CC=2)=NN=C1C1=NC(Br)=C(C(F)(F)F)C=C1N QOFCKRKVCJKVJW-SNVBAGLBSA-N 0.000 claims 1
- GJICZLZFKWSSBD-UHFFFAOYSA-N 2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N GJICZLZFKWSSBD-UHFFFAOYSA-N 0.000 claims 1
- SLYMSJFTGUGSPB-UHFFFAOYSA-N 2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-thiadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound S1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N SLYMSJFTGUGSPB-UHFFFAOYSA-N 0.000 claims 1
- OBYGNKZCTZZYRW-UHFFFAOYSA-N 2-[5-[3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC(Br)=C(C(F)(F)F)C=C1N OBYGNKZCTZZYRW-UHFFFAOYSA-N 0.000 claims 1
- GXAUSGXVGWVBKQ-UHFFFAOYSA-N 2-[5-[3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]propan-2-ol Chemical compound O1C(C(C)(O)C)=NN=C1C1=NC(Br)=C(C(F)(F)F)C=C1N GXAUSGXVGWVBKQ-UHFFFAOYSA-N 0.000 claims 1
- GILUBKYXXVYQHQ-UHFFFAOYSA-N 2-[5-[3-amino-6-cyclopropyl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC(C2CC2)=C(C(F)(F)F)C=C1N GILUBKYXXVYQHQ-UHFFFAOYSA-N 0.000 claims 1
- HMXVTLCFBUROJI-UHFFFAOYSA-N 2-[5-[3-amino-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)C(C)(O)C(F)(F)F)=C1N HMXVTLCFBUROJI-UHFFFAOYSA-N 0.000 claims 1
- WIQHUQHSUZPFOM-UHFFFAOYSA-N 2-[5-[3-amino-6-methyl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(C)=NC(C=2OC(=NN=2)C(C)(O)C(F)(F)F)=C1N WIQHUQHSUZPFOM-UHFFFAOYSA-N 0.000 claims 1
- BGYUULQTVSRSJN-UHFFFAOYSA-N 3-(5-benzyl-1,3,4-oxadiazol-2-yl)-5-bromo-6-(trifluoromethyl)pyrazin-2-amine Chemical compound NC1=NC(C(F)(F)F)=C(Br)N=C1C(O1)=NN=C1CC1=CC=CC=C1 BGYUULQTVSRSJN-UHFFFAOYSA-N 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- AVTAXIOQVRBSRX-UHFFFAOYSA-N [5-[3-amino-6-bromo-5-(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-phenylmethanone Chemical compound NC1=NC(C(F)(F)F)=C(Br)N=C1C1=NN=C(C(=O)C=2C=CC=CC=2)O1 AVTAXIOQVRBSRX-UHFFFAOYSA-N 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 229940088679 drug related substance Drugs 0.000 claims 1
- 239000002713 epithelial sodium channel blocking agent Substances 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161535560P | 2011-09-16 | 2011-09-16 | |
| US61/535,560 | 2011-09-16 | ||
| PCT/IB2012/054826 WO2013038386A1 (en) | 2011-09-16 | 2012-09-14 | Heterocyclic compounds for the treatment of cystic fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526500A JP2014526500A (ja) | 2014-10-06 |
| JP2014526500A5 true JP2014526500A5 (enExample) | 2014-12-11 |
| JP5886433B2 JP5886433B2 (ja) | 2016-03-16 |
Family
ID=47143988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530370A Expired - Fee Related JP5886433B2 (ja) | 2011-09-16 | 2012-09-14 | 嚢胞性線維症処置のためのヘテロ環式化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9034879B2 (enExample) |
| EP (1) | EP2755967B1 (enExample) |
| JP (1) | JP5886433B2 (enExample) |
| CN (1) | CN103946221B (enExample) |
| ES (1) | ES2558457T3 (enExample) |
| WO (1) | WO2013038386A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| JP6165733B2 (ja) | 2011-09-16 | 2017-07-19 | ノバルティス アーゲー | Ｎ−置換ヘテロシクリルカルボキサミド類 |
| PL3925607T5 (pl) | 2014-04-15 | 2026-06-01 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa |
| EP3157917B1 (en) | 2014-06-19 | 2020-03-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| TW202140422A (zh) | 2014-10-06 | 2021-11-01 | 美商維泰克斯製藥公司 | 囊腫纖維化症跨膜傳導調節蛋白之調節劑 |
| CA2966023A1 (en) | 2014-10-31 | 2016-05-06 | Abbvie S.A.R.L. | Substituted tetrahydropyrans and method of use |
| WO2016105477A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc | Derivatives of 5-phenyl- or 5-heteroarylthiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| WO2016105468A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10047051B2 (en) | 2015-06-02 | 2018-08-14 | Abbvie S.Á.R.L. | Substituted pyridines and method of use |
| US9840513B2 (en) | 2015-07-16 | 2017-12-12 | Abbvie S.Á.R.L. | Substituted tricyclics and method of use |
| US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
| SG11201802798WA (en) * | 2015-10-06 | 2018-05-30 | Proteostasis Therapeutics Inc | Compounds, compositions, and methods for modulating cftr |
| AU2016333855A1 (en) | 2015-10-09 | 2018-04-26 | AbbVie S.à.r.l. | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and their use |
| CN108602816A (zh) | 2015-10-09 | 2018-09-28 | 艾伯维公司 | 用于治疗囊性纤维化的新颖化合物 |
| PL3359541T3 (pl) | 2015-10-09 | 2021-01-11 | AbbVie Overseas S.à r.l. | N-SULFONYLOWANE PIRAZOLO[3,4-b]PIRYDYNO-6-KARBOKSAMIDY I SPOSÓB ZASTOSOWANIA |
| WO2017177124A1 (en) | 2016-04-07 | 2017-10-12 | Proteostasis Therapeutics, Inc. | Silicone atoms containing ivacaftor analogues |
| AU2017256172A1 (en) | 2016-04-26 | 2018-09-06 | AbbVie S.à.r.l. | Modulators of cystic fibrosis transmembrane conductance regulator protein |
| US10138227B2 (en) * | 2016-06-03 | 2018-11-27 | Abbvie S.Á.R.L. | Heteroaryl substituted pyridines and methods of use |
| ES2954658T3 (es) | 2016-06-21 | 2023-11-23 | Proteostasis Therapeutics Inc | Compuestos, composiciones y procedimientos para aumentar la actividad de CFTR |
| US9981910B2 (en) | 2016-10-07 | 2018-05-29 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| US10399940B2 (en) | 2016-10-07 | 2019-09-03 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| CA3041676A1 (en) | 2016-10-26 | 2018-05-03 | Daniel Parks | Pyridazine derivatives, compositions and methods for modulating cftr |
| US20190248779A1 (en) | 2016-10-26 | 2019-08-15 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| EP3532461A1 (en) | 2016-10-26 | 2019-09-04 | Proteostasis Therapeutics, Inc. | N-phenyl-2-(3-phenyl-6-oxo-1,6-dihydropyridazin-1-yl)acetamide derivatives for treating cystic fibrosis |
| EA202192783A1 (ru) | 2016-12-09 | 2022-02-24 | Вертекс Фармасьютикалз Инкорпорейтед | Модулятор регулятора трансмембранной проводимости при муковисцидозе, фармацевтические композиции, способы лечения и способ получения указанного модулятора |
| CA3044366A1 (en) | 2016-12-19 | 2018-06-28 | Novartis Ag | New picolinic acid derivatives and their use as intermediates |
| WO2018116185A1 (en) | 2016-12-20 | 2018-06-28 | AbbVie S.à.r.l. | Deuterated cftr modulators and methods of use |
| TW201831471A (zh) | 2017-02-24 | 2018-09-01 | 盧森堡商艾伯維公司 | 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法 |
| CA3061476A1 (en) | 2017-04-28 | 2018-11-01 | Proteostasis Therapeutics, Inc. | 4-sulfonylaminocarbonylquinoline derivatives for increasing cftr activity |
| IL272032B2 (en) | 2017-07-17 | 2026-04-01 | Vertex Pharma | Combination therapy for the treatment of cystic fibrosis including N-(1,3-DIMETHYLPYRAZOL-4-YL)SULFONYL-6-[3-(3,3,3-TRIFLUORO-2,2- DIMETHYL-PROPOXY)PYRAZOL-1-YL]-2-[(4S)-2,2,4- TRIMETHYLPYRROLIDIN-1-YL]PYRIDINE-3-CARBOXAMIDE and |
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2012
- 2012-09-14 CN CN201280056105.8A patent/CN103946221B/zh not_active Expired - Fee Related
- 2012-09-14 US US14/343,861 patent/US9034879B2/en active Active
- 2012-09-14 EP EP12783308.5A patent/EP2755967B1/en not_active Not-in-force
- 2012-09-14 ES ES12783308.5T patent/ES2558457T3/es active Active
- 2012-09-14 JP JP2014530370A patent/JP5886433B2/ja not_active Expired - Fee Related
- 2012-09-14 WO PCT/IB2012/054826 patent/WO2013038386A1/en not_active Ceased
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