JP2014526500A5 - - Google Patents
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- Publication number
- JP2014526500A5 JP2014526500A5 JP2014530370A JP2014530370A JP2014526500A5 JP 2014526500 A5 JP2014526500 A5 JP 2014526500A5 JP 2014530370 A JP2014530370 A JP 2014530370A JP 2014530370 A JP2014530370 A JP 2014530370A JP 2014526500 A5 JP2014526500 A5 JP 2014526500A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- trifluoromethyl
- oxadiazol
- halogen atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000623 heterocyclic group Chemical group 0.000 claims 32
- 125000005843 halogen group Chemical group 0.000 claims 31
- 229910052799 carbon Inorganic materials 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 13
- 229910052717 sulfur Inorganic materials 0.000 claims 13
- 125000005842 heteroatom Chemical group 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 7
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 4
- -1 R 14 Chemical compound 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- HNMSYIKEBOLQKV-UHFFFAOYSA-N 2-[5-[3-amino-5,6-bis(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC(C(F)(F)F)=C(C(F)(F)F)N=C1N HNMSYIKEBOLQKV-UHFFFAOYSA-N 0.000 claims 2
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 230000036571 hydration Effects 0.000 claims 2
- 238000006703 hydration reaction Methods 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- GESXZHFWDCTRHG-SNVBAGLBSA-N (2r)-2-[5-[3-amino-4-chloro-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound ClC1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@@](C)(O)C(F)(F)F)=C1N GESXZHFWDCTRHG-SNVBAGLBSA-N 0.000 claims 1
- HNMSYIKEBOLQKV-MRVPVSSYSA-N (2r)-2-[5-[3-amino-5,6-bis(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@](O)(C)C(F)(F)F)=NN=C1C1=NC(C(F)(F)F)=C(C(F)(F)F)N=C1N HNMSYIKEBOLQKV-MRVPVSSYSA-N 0.000 claims 1
- GJICZLZFKWSSBD-SECBINFHSA-N (2r)-2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@](O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N GJICZLZFKWSSBD-SECBINFHSA-N 0.000 claims 1
- HMXVTLCFBUROJI-SNVBAGLBSA-N (2r)-2-[5-[3-amino-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@@](C)(O)C(F)(F)F)=C1N HMXVTLCFBUROJI-SNVBAGLBSA-N 0.000 claims 1
- GESXZHFWDCTRHG-JTQLQIEISA-N (2s)-2-[5-[3-amino-4-chloro-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound ClC1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N GESXZHFWDCTRHG-JTQLQIEISA-N 0.000 claims 1
- CTRQIOYBLMEECE-LBPRGKRZSA-N (2s)-2-[5-[3-amino-4-ethyl-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound COC1=C(C(F)(F)F)C(CC)=C(N)C(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=N1 CTRQIOYBLMEECE-LBPRGKRZSA-N 0.000 claims 1
- HNMSYIKEBOLQKV-QMMMGPOBSA-N (2s)-2-[5-[3-amino-5,6-bis(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@@](O)(C)C(F)(F)F)=NN=C1C1=NC(C(F)(F)F)=C(C(F)(F)F)N=C1N HNMSYIKEBOLQKV-QMMMGPOBSA-N 0.000 claims 1
- GJICZLZFKWSSBD-VIFPVBQESA-N (2s)-2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C([C@@](O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N GJICZLZFKWSSBD-VIFPVBQESA-N 0.000 claims 1
- AIEPIMYPVPRVOQ-INIZCTEOSA-N (2s)-2-[5-[3-amino-6-methoxy-4-phenyl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound NC=1C(C=2C=CC=CC=2)=C(C(F)(F)F)C(OC)=NC=1C1=NN=C([C@](C)(O)C(F)(F)F)O1 AIEPIMYPVPRVOQ-INIZCTEOSA-N 0.000 claims 1
- IPXOIMMPOYXWFR-ZDUSSCGKSA-N (2s)-2-[5-[3-amino-6-methoxy-4-prop-1-en-2-yl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound CC(=C)C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N IPXOIMMPOYXWFR-ZDUSSCGKSA-N 0.000 claims 1
- FDJPJZNPKVAQDQ-ZDUSSCGKSA-N (2s)-2-[5-[3-amino-6-methoxy-4-propan-2-yl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound CC(C)C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N FDJPJZNPKVAQDQ-ZDUSSCGKSA-N 0.000 claims 1
- HMXVTLCFBUROJI-JTQLQIEISA-N (2s)-2-[5-[3-amino-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)[C@](C)(O)C(F)(F)F)=C1N HMXVTLCFBUROJI-JTQLQIEISA-N 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- ZCPYJTVACTXCQN-UHFFFAOYSA-N 2-(5-benzyl-1,3,4-oxadiazol-2-yl)-6-bromo-5-(trifluoromethyl)pyridin-3-amine Chemical compound NC1=CC(C(F)(F)F)=C(Br)N=C1C(O1)=NN=C1CC1=CC=CC=C1 ZCPYJTVACTXCQN-UHFFFAOYSA-N 0.000 claims 1
- QOFCKRKVCJKVJW-SNVBAGLBSA-N 2-[5-[(r)-amino(phenyl)methyl]-1,3,4-oxadiazol-2-yl]-6-bromo-5-(trifluoromethyl)pyridin-3-amine Chemical compound O1C([C@H](N)C=2C=CC=CC=2)=NN=C1C1=NC(Br)=C(C(F)(F)F)C=C1N QOFCKRKVCJKVJW-SNVBAGLBSA-N 0.000 claims 1
- GJICZLZFKWSSBD-UHFFFAOYSA-N 2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N GJICZLZFKWSSBD-UHFFFAOYSA-N 0.000 claims 1
- SLYMSJFTGUGSPB-UHFFFAOYSA-N 2-[5-[3-amino-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-thiadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound S1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC=C(C(F)(F)F)C=C1N SLYMSJFTGUGSPB-UHFFFAOYSA-N 0.000 claims 1
- OBYGNKZCTZZYRW-UHFFFAOYSA-N 2-[5-[3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC(Br)=C(C(F)(F)F)C=C1N OBYGNKZCTZZYRW-UHFFFAOYSA-N 0.000 claims 1
- GXAUSGXVGWVBKQ-UHFFFAOYSA-N 2-[5-[3-amino-6-bromo-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]propan-2-ol Chemical compound O1C(C(C)(O)C)=NN=C1C1=NC(Br)=C(C(F)(F)F)C=C1N GXAUSGXVGWVBKQ-UHFFFAOYSA-N 0.000 claims 1
- GILUBKYXXVYQHQ-UHFFFAOYSA-N 2-[5-[3-amino-6-cyclopropyl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound O1C(C(O)(C)C(F)(F)F)=NN=C1C1=NC(C2CC2)=C(C(F)(F)F)C=C1N GILUBKYXXVYQHQ-UHFFFAOYSA-N 0.000 claims 1
- HMXVTLCFBUROJI-UHFFFAOYSA-N 2-[5-[3-amino-6-methoxy-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(OC)=NC(C=2OC(=NN=2)C(C)(O)C(F)(F)F)=C1N HMXVTLCFBUROJI-UHFFFAOYSA-N 0.000 claims 1
- WIQHUQHSUZPFOM-UHFFFAOYSA-N 2-[5-[3-amino-6-methyl-5-(trifluoromethyl)pyridin-2-yl]-1,3,4-oxadiazol-2-yl]-1,1,1-trifluoropropan-2-ol Chemical compound C1=C(C(F)(F)F)C(C)=NC(C=2OC(=NN=2)C(C)(O)C(F)(F)F)=C1N WIQHUQHSUZPFOM-UHFFFAOYSA-N 0.000 claims 1
- BGYUULQTVSRSJN-UHFFFAOYSA-N 3-(5-benzyl-1,3,4-oxadiazol-2-yl)-5-bromo-6-(trifluoromethyl)pyrazin-2-amine Chemical compound NC1=NC(C(F)(F)F)=C(Br)N=C1C(O1)=NN=C1CC1=CC=CC=C1 BGYUULQTVSRSJN-UHFFFAOYSA-N 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- AVTAXIOQVRBSRX-UHFFFAOYSA-N [5-[3-amino-6-bromo-5-(trifluoromethyl)pyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-phenylmethanone Chemical compound NC1=NC(C(F)(F)F)=C(Br)N=C1C1=NN=C(C(=O)C=2C=CC=CC=2)O1 AVTAXIOQVRBSRX-UHFFFAOYSA-N 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 229940088679 drug related substance Drugs 0.000 claims 1
- 239000002713 epithelial sodium channel blocking agent Substances 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161535560P | 2011-09-16 | 2011-09-16 | |
| US61/535,560 | 2011-09-16 | ||
| PCT/IB2012/054826 WO2013038386A1 (en) | 2011-09-16 | 2012-09-14 | Heterocyclic compounds for the treatment of cystic fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526500A JP2014526500A (ja) | 2014-10-06 |
| JP2014526500A5 true JP2014526500A5 (enExample) | 2014-12-11 |
| JP5886433B2 JP5886433B2 (ja) | 2016-03-16 |
Family
ID=47143988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530370A Expired - Fee Related JP5886433B2 (ja) | 2011-09-16 | 2012-09-14 | 嚢胞性線維症処置のためのヘテロ環式化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9034879B2 (enExample) |
| EP (1) | EP2755967B1 (enExample) |
| JP (1) | JP5886433B2 (enExample) |
| CN (1) | CN103946221B (enExample) |
| ES (1) | ES2558457T3 (enExample) |
| WO (1) | WO2013038386A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN105130948A (zh) | 2010-04-22 | 2015-12-09 | 弗特克斯药品有限公司 | 制备环烷基甲酰胺基-吲哚化合物的方法 |
| ES2882807T3 (es) | 2011-09-16 | 2021-12-02 | Novartis Ag | Heterociclil carboxamidas N-sustituidas |
| JP6543268B2 (ja) | 2014-04-15 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 |
| EP3157917B1 (en) | 2014-06-19 | 2020-03-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| RS60906B1 (sr) | 2014-10-06 | 2020-11-30 | Vertex Pharma | Modulatori regulatora transmembranske provodljivosti za cističnu fibrozu |
| US9567322B2 (en) | 2014-10-31 | 2017-02-14 | Abbvie S.Á.R.L. | Substituted tetrahydropyrans and method of use |
| WO2016105468A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| CA2971850A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylthiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| KR20180029204A (ko) | 2015-06-02 | 2018-03-20 | 애브비 에스.에이.알.엘. | 치환된 피리딘 및 사용 방법 |
| US9840513B2 (en) | 2015-07-16 | 2017-12-12 | Abbvie S.Á.R.L. | Substituted tricyclics and method of use |
| US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
| WO2017062581A1 (en) | 2015-10-06 | 2017-04-13 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating cftr |
| WO2017060879A1 (en) | 2015-10-09 | 2017-04-13 | AbbVie S.à.r.l. | Novel compounds for treatment of cystic fibrosis |
| PL3359541T3 (pl) | 2015-10-09 | 2021-01-11 | AbbVie Overseas S.à r.l. | N-SULFONYLOWANE PIRAZOLO[3,4-b]PIRYDYNO-6-KARBOKSAMIDY I SPOSÓB ZASTOSOWANIA |
| EP3359539A1 (en) | 2015-10-09 | 2018-08-15 | AbbVie S.À.R.L. | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and their use |
| US10662207B2 (en) | 2016-04-07 | 2020-05-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
| AU2017256172A1 (en) | 2016-04-26 | 2018-09-06 | AbbVie S.à.r.l. | Modulators of cystic fibrosis transmembrane conductance regulator protein |
| US10138227B2 (en) | 2016-06-03 | 2018-11-27 | Abbvie S.Á.R.L. | Heteroaryl substituted pyridines and methods of use |
| US10899751B2 (en) | 2016-06-21 | 2021-01-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
| US10399940B2 (en) | 2016-10-07 | 2019-09-03 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| US9981910B2 (en) | 2016-10-07 | 2018-05-29 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| US20190256474A1 (en) | 2016-10-26 | 2019-08-22 | Proteostasis Therapeutics, Inc. | N-phenyl-2-(3-phenyl-6-oxo-1,6-dihydropyridazin-1-yl)acetamide derivatives for treating cystic fibrosis |
| WO2018081378A1 (en) | 2016-10-26 | 2018-05-03 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating cftr |
| EP3532467A1 (en) | 2016-10-26 | 2019-09-04 | Proteostasis Therapeutics, Inc. | Pyridazine derivatives, compositions and methods for modulating cftr |
| PT3551622T (pt) | 2016-12-09 | 2020-11-12 | Vertex Pharma | Modulador do regulador da condutância transmembrana da fibrose quística, composições farmacêuticas, métodos de tratamento e processo de fabrico do modulador |
| ES2891527T3 (es) | 2016-12-19 | 2022-01-28 | Novartis Ag | Nuevos derivados de ácido picolínico y su uso como intermedios |
| WO2018116185A1 (en) | 2016-12-20 | 2018-06-28 | AbbVie S.à.r.l. | Deuterated cftr modulators and methods of use |
| TW201831471A (zh) | 2017-02-24 | 2018-09-01 | 盧森堡商艾伯維公司 | 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法 |
| US20200055844A1 (en) | 2017-04-28 | 2020-02-20 | Proteostasis Therapeutics, Inc. | 4-sulfonylaminocarbonylquinoline derivatives for increasing cftr activity |
| WO2019018395A1 (en) | 2017-07-17 | 2019-01-24 | Vertex Pharmaceuticals Incorporated | METHODS OF TREATING CYSTIC FIBROSIS |
| US10988454B2 (en) | 2017-09-14 | 2021-04-27 | Abbvie Overseas S.À.R.L. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| AU2018346602B2 (en) | 2017-10-06 | 2024-10-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods for increasing CFTR activity |
| CA3085006A1 (en) | 2017-12-08 | 2019-06-13 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
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