JP2008531537A5 - - Google Patents

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Publication number
JP2008531537A5
JP2008531537A5 JP2007556664A JP2007556664A JP2008531537A5 JP 2008531537 A5 JP2008531537 A5 JP 2008531537A5 JP 2007556664 A JP2007556664 A JP 2007556664A JP 2007556664 A JP2007556664 A JP 2007556664A JP 2008531537 A5 JP2008531537 A5 JP 2008531537A5
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JP
Japan
Prior art keywords
group
compound according
composition according
halo
carbon atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007556664A
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English (en)
Japanese (ja)
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JP2008531537A (ja
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Publication date
Priority claimed from GBGB0503962.3A external-priority patent/GB0503962D0/en
Application filed filed Critical
Priority claimed from PCT/GB2006/000668 external-priority patent/WO2006090167A2/en
Publication of JP2008531537A publication Critical patent/JP2008531537A/ja
Publication of JP2008531537A5 publication Critical patent/JP2008531537A5/ja
Pending legal-status Critical Current

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JP2007556664A 2005-02-25 2006-02-24 化合物 Pending JP2008531537A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65619305P 2005-02-25 2005-02-25
GBGB0503962.3A GB0503962D0 (en) 2005-02-25 2005-02-25 Compounds
PCT/GB2006/000668 WO2006090167A2 (en) 2005-02-25 2006-02-24 Hydrazinomethyl, hydr zonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents

Publications (2)

Publication Number Publication Date
JP2008531537A JP2008531537A (ja) 2008-08-14
JP2008531537A5 true JP2008531537A5 (enExample) 2009-04-09

Family

ID=36729293

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007556664A Pending JP2008531537A (ja) 2005-02-25 2006-02-24 化合物

Country Status (10)

Country Link
US (1) US20100130473A1 (enExample)
EP (1) EP1877388A2 (enExample)
JP (1) JP2008531537A (enExample)
KR (1) KR20070108916A (enExample)
AU (1) AU2006217742A1 (enExample)
CA (1) CA2599320A1 (enExample)
IL (1) IL184900A0 (enExample)
MX (1) MX2007010404A (enExample)
NO (1) NO20074071L (enExample)
WO (1) WO2006090167A2 (enExample)

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HUE033894T2 (en) * 2006-08-23 2018-01-29 Kudos Pharm Ltd 2-Methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as MTOR inhibitors
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US9029411B2 (en) 2008-01-25 2015-05-12 Millennium Pharmaceuticals, Inc. Thiophenes and uses thereof
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UY32470A (es) 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
US8242260B2 (en) 2009-08-28 2012-08-14 Novartis Ag Compounds and compositions as protein kinase inhibitors
WO2011067356A2 (en) 2009-12-03 2011-06-09 Novartis Ag Polymorphs of a mek inhibitor
WO2011067348A2 (en) 2009-12-03 2011-06-09 Novartis Ag Mek inhibitor salts and solvates thereof
EP2992878A1 (en) 2010-02-03 2016-03-09 Signal Pharmaceuticals, LLC Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors
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WO2011120911A1 (en) 2010-03-30 2011-10-06 Novartis Ag Pkc inhibitors for the treatment of b-cell lymphoma having chronic active b-cell-receptor signalling
ES2689177T3 (es) 2010-04-13 2018-11-08 Novartis Ag Combinación que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclina (CDK4/6) y un inhibidor de mTOR para tratar cáncer
KR20130048293A (ko) 2010-06-25 2013-05-09 노파르티스 아게 단백질 키나제 억제제로서의 헤테로아릴 화합물 및 조성물
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US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
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AU2012290056B2 (en) 2011-08-03 2015-03-19 Signal Pharmaceuticals, Llc Identification of gene expression profile as a predictive biomarker for LKB1 status
JP6026544B2 (ja) 2011-09-27 2016-11-16 ノバルティス アーゲー 変異体idhの阻害剤としての3−ピリミジン−4−イル−オキサゾリジン−2−オン類
ES2694413T3 (es) * 2011-12-02 2018-12-20 Signal Pharmaceuticals, Llc Composiciones farmacéuticas de 7-(6-(2-hidroxipropan-2-il)piridin-3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino [2,3-b]pirazin-2(1H)-ona, una forma sólida de la misma y métodos para su uso
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
JP6120311B2 (ja) * 2013-02-12 2017-04-26 学校法人銀杏学園 ポリフェノール化合物
GEP201706699B (en) 2013-03-14 2017-07-10 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
WO2014172432A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
SG11201508527VA (en) 2013-04-17 2015-11-27 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
MX364101B (es) 2013-04-17 2019-04-12 Signal Pharm Llc Terapia de combinación que comprende un compuesto de dihidropirazino-pirazina y un antagonista de receptor de andrógenos para tratar cáncer de próstata.
EA030808B1 (ru) 2013-04-17 2018-09-28 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи ПРИМЕНЕНИЕ 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1Н-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА В ЛЕЧЕНИИ МУЛЬТИФОРМНОЙ ГЛИОБЛАСТОМЫ
HK1221174A1 (zh) 2013-04-17 2017-05-26 西格诺药品有限公司 用於治疗癌症的包括tor激酶抑制剂和5-取代喹唑啉酮化合物的组合疗法
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HK1221150A1 (zh) 2013-04-17 2017-05-26 西格诺药品有限公司 用二氢吡嗪并-吡嗪类对癌症的治疗
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JP2017505787A (ja) * 2014-02-14 2017-02-23 ザ ユニバーシティ オブ ブリティッシュ コロンビア 治療薬としてのヒトアンドロゲン受容体dna結合ドメイン(dbd)化合物およびそれらを使用する方法
WO2015160880A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
MY198676A (en) 2017-06-22 2023-09-15 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
EP4161926A4 (en) * 2020-06-03 2024-06-19 Yumanity Therapeutics, Inc. PYRIDOPYRIMIDINES AND THEIR METHODS OF USE
WO2025012643A1 (en) 2023-07-11 2025-01-16 Tay Therapeutics Limited Compounds comprising a naphthyridine or pyridopyrimidine core as ptc read-through agents

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JP3385387B2 (ja) * 1992-05-29 2003-03-10 大塚製薬株式会社 チアゾール誘導体
WO1993024472A1 (fr) * 1992-05-29 1993-12-09 Otsuka Pharmaceutical Co., Ltd. Derive de thiazole
US7495018B2 (en) * 2000-03-30 2009-02-24 Takeda Pharmaceutical Company Limited Substituted 1,3-thiazole compounds, their production and use
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WO2003075828A2 (en) * 2002-03-11 2003-09-18 Zetiq Technologies Ltd. Compounds useful in the treatment of cancer
US8053477B2 (en) * 2002-03-29 2011-11-08 University Of Maryland, Baltimore Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
JP2007500241A (ja) * 2003-05-29 2007-01-11 シンタ ファーマシューティカルズ コーポレーション 過度の骨量減少に関連する疾患の予防及び治療用の複素環化合物

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