JP2013540114A5 - - Google Patents
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- JP2013540114A5 JP2013540114A5 JP2013530690A JP2013530690A JP2013540114A5 JP 2013540114 A5 JP2013540114 A5 JP 2013540114A5 JP 2013530690 A JP2013530690 A JP 2013530690A JP 2013530690 A JP2013530690 A JP 2013530690A JP 2013540114 A5 JP2013540114 A5 JP 2013540114A5
- Authority
- JP
- Japan
- Prior art keywords
- solvate
- salt
- formula
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10181966.2 | 2010-09-29 | ||
| EP10181966 | 2010-09-29 | ||
| EP11158466 | 2011-03-16 | ||
| EP11158466.0 | 2011-03-16 | ||
| PCT/EP2011/066658 WO2012041805A1 (de) | 2010-09-29 | 2011-09-26 | N-carboxyalkyl-auristatine und ihre verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540114A JP2013540114A (ja) | 2013-10-31 |
| JP2013540114A5 true JP2013540114A5 (enExample) | 2014-09-18 |
| JP5933562B2 JP5933562B2 (ja) | 2016-06-15 |
Family
ID=44674811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530690A Expired - Fee Related JP5933562B2 (ja) | 2010-09-29 | 2011-09-26 | Ｎ−カルボキシアルキル−アウリスタチンおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8987209B2 (enExample) |
| EP (1) | EP2621508B1 (enExample) |
| JP (1) | JP5933562B2 (enExample) |
| CN (1) | CN103379912B (enExample) |
| CA (1) | CA2813056C (enExample) |
| ES (1) | ES2553874T3 (enExample) |
| WO (1) | WO2012041805A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2553874T3 (es) | 2010-09-29 | 2015-12-14 | Seattle Genetics, Inc. | N-Carboxialquil-auristatinas y su uso |
| JP6023097B2 (ja) * | 2011-03-16 | 2016-11-09 | シアトル ジェネティックス， インコーポレイテッド | Ｎカルボキシアルキルオーリスタチンおよびその使用 |
| AU2012244673A1 (en) * | 2011-04-21 | 2013-11-28 | Seattle Genetics, Inc. | Novel binder-drug conjugates (ADCs) and their use |
| HK1208216A1 (en) | 2012-05-15 | 2016-02-26 | Concortis Biosystems, Corp | Drug-conjugates, conjugation methods, and uses thereof |
| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| AU2014337317A1 (en) | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| US9988420B2 (en) | 2013-12-17 | 2018-06-05 | Novartis Ag | Cytotoxic peptides and conjugates thereof |
| HUE047952T2 (hu) | 2014-04-25 | 2020-05-28 | Pf Medicament | Ellenanyag-drog konjugátum és alkalmazása rák kezelésében történõ alkalmazásra |
| BR112016024619A2 (pt) | 2014-04-25 | 2017-10-10 | Pf Medicament | conjugado de anticorpo ao igf-1r-fármaco e seu uso para o tratamento de câncer |
| SG11201609462RA (en) | 2014-06-13 | 2016-12-29 | Novartis Ag | Auristatin derivatives and conjugates thereof |
| WO2016001485A1 (en) | 2014-06-30 | 2016-01-07 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| WO2016123412A1 (en) | 2015-01-28 | 2016-08-04 | Sorrento Therapeutics, Inc. | Antibody drug conjugates |
| CN106279352B (zh) | 2015-05-29 | 2020-05-22 | 上海新理念生物医药科技有限公司 | 海兔毒素10的衍生物及其应用 |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 |
| EP4667495A3 (en) * | 2017-12-15 | 2026-03-11 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive molecule conjugate, preparation method and use thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| US6620911B1 (en) | 1998-01-09 | 2003-09-16 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Anti-cryptococcal peptides |
| WO2000069472A2 (en) | 1999-05-14 | 2000-11-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Enzyme-activated anti-tumor prodrug compounds |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6737409B2 (en) | 2001-07-19 | 2004-05-18 | Hoffmann-La Roche Inc. | Dolastatin 10 derivatives |
| WO2003026577A2 (en) | 2001-09-24 | 2003-04-03 | Seattle Genetics, Inc. | P-amidobenzylethers in drug delivery agents |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| CN107213469A (zh) | 2003-11-06 | 2017-09-29 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| EP3505191A1 (en) | 2004-11-12 | 2019-07-03 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
| US8871720B2 (en) | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| WO2007008603A1 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
| EP2061814B1 (en) | 2006-10-27 | 2012-06-06 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| CN101573384B (zh) * | 2006-10-27 | 2013-02-20 | 健泰科生物技术公司 | 抗体和免疫偶联物及其用途 |
| JP5394246B2 (ja) * | 2007-03-30 | 2014-01-22 | ジェネンテック， インコーポレイテッド | 抗体及びイムノコンジュゲートとこれらの使用方法 |
| DK2265283T3 (da) | 2008-03-18 | 2014-10-20 | Seattle Genetics Inc | Auristatin-lægemiddel-linker-konjugater |
| CN103200950B (zh) | 2010-06-10 | 2016-03-16 | 西雅图基因公司 | 新颖的耳他汀衍生物及其用途 |
| ES2553874T3 (es) | 2010-09-29 | 2015-12-14 | Seattle Genetics, Inc. | N-Carboxialquil-auristatinas y su uso |
| JP6023097B2 (ja) | 2011-03-16 | 2016-11-09 | シアトル ジェネティックス， インコーポレイテッド | Ｎカルボキシアルキルオーリスタチンおよびその使用 |
| AU2012244673A1 (en) | 2011-04-21 | 2013-11-28 | Seattle Genetics, Inc. | Novel binder-drug conjugates (ADCs) and their use |
| RU2014128467A (ru) | 2011-12-14 | 2016-02-10 | Сиэтл Дженетикс, Инк. | Новые коньюгаты связывающее соединение-активное соединение (adc) и их применение |
-
2011
- 2011-09-26 ES ES11760500.6T patent/ES2553874T3/es active Active
- 2011-09-26 JP JP2013530690A patent/JP5933562B2/ja not_active Expired - Fee Related
- 2011-09-26 CN CN201180057131.8A patent/CN103379912B/zh not_active Expired - Fee Related
- 2011-09-26 EP EP11760500.6A patent/EP2621508B1/de not_active Not-in-force
- 2011-09-26 WO PCT/EP2011/066658 patent/WO2012041805A1/de not_active Ceased
- 2011-09-26 US US13/876,777 patent/US8987209B2/en active Active
- 2011-09-26 CA CA2813056A patent/CA2813056C/en not_active Expired - Fee Related
-
2015
- 2015-02-05 US US14/615,005 patent/US20150148298A1/en not_active Abandoned
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