JP2013533228A5 - - Google Patents
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- JP2013533228A5 JP2013533228A5 JP2013513651A JP2013513651A JP2013533228A5 JP 2013533228 A5 JP2013533228 A5 JP 2013533228A5 JP 2013513651 A JP2013513651 A JP 2013513651A JP 2013513651 A JP2013513651 A JP 2013513651A JP 2013533228 A5 JP2013533228 A5 JP 2013533228A5
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- Japan
- Prior art keywords
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- Prior art date
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- 0 C*C([C@](C(C)C)NC([C@](C(C)C)NC)=O)=* Chemical compound C*C([C@](C(C)C)NC([C@](C(C)C)NC)=O)=* 0.000 description 15
- XELCRLBPFJTQMS-KDXRVNOWSA-N CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC XELCRLBPFJTQMS-KDXRVNOWSA-N 0.000 description 2
- MWKDAYPCKCUCIO-QWRGUYRKSA-N CC(C)[C@@H](C(C)=O)NC([C@H](C(C)C)NC)=O Chemical compound CC(C)[C@@H](C(C)=O)NC([C@H](C(C)C)NC)=O MWKDAYPCKCUCIO-QWRGUYRKSA-N 0.000 description 1
- GKMGYJQBUYQYBE-BKIBZHPOSA-N CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OC(C2)C22C=CC12)=O)=O)OC)=O)OC)N(C)C([C@H](C)NC([C@H](C(C)C)NC)=O)=O Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OC(C2)C22C=CC12)=O)=O)OC)=O)OC)N(C)C([C@H](C)NC([C@H](C(C)C)NC)=O)=O GKMGYJQBUYQYBE-BKIBZHPOSA-N 0.000 description 1
- NKLNWUSRAQEWFE-UFINBUOZSA-N CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCc2ccccc2C1)=O)=O)OC)=O)OC)/C=C(\C)/CC([C@H](C(C)C)NC([C@H](C(C)=C)NC)=O)=O Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCc2ccccc2C1)=O)=O)OC)=O)OC)/C=C(\C)/CC([C@H](C(C)C)NC([C@H](C(C)=C)NC)=O)=O NKLNWUSRAQEWFE-UFINBUOZSA-N 0.000 description 1
- PRGSRHOCNFFQKN-PRNUUREKSA-N CC[C@H](C)[C@H](CC(C)CC([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CC(C)CC([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC PRGSRHOCNFFQKN-PRNUUREKSA-N 0.000 description 1
- UHSZKRYFCPMXMW-SFXSRNHCSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC UHSZKRYFCPMXMW-SFXSRNHCSA-N 0.000 description 1
- IJKQWIOKVAMDPA-VQYQWNPTSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCN)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CCC[C@@](C1)([C@H]1c1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCN)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CCC[C@@](C1)([C@H]1c1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC IJKQWIOKVAMDPA-VQYQWNPTSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10165550 | 2010-06-10 | ||
| EP10165550.4 | 2010-06-10 | ||
| EP11158464.5 | 2011-03-16 | ||
| EP11158464 | 2011-03-16 | ||
| PCT/EP2011/059300 WO2011154359A1 (de) | 2010-06-10 | 2011-06-06 | Neue auristatin-derivate und ihre verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533228A JP2013533228A (ja) | 2013-08-22 |
| JP2013533228A5 true JP2013533228A5 (enExample) | 2014-07-03 |
| JP5791707B2 JP5791707B2 (ja) | 2015-10-07 |
Family
ID=44275637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513651A Expired - Fee Related JP5791707B2 (ja) | 2010-06-10 | 2011-06-06 | 新規アウリスタチン誘導体およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8722629B2 (enExample) |
| EP (1) | EP2579887B1 (enExample) |
| JP (1) | JP5791707B2 (enExample) |
| CN (1) | CN103200950B (enExample) |
| CA (1) | CA2801971C (enExample) |
| ES (1) | ES2528956T3 (enExample) |
| WO (1) | WO2011154359A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987209B2 (en) | 2010-09-29 | 2015-03-24 | Seattle Genetics, Inc. | N-carboxyalkyl-auristatin and the use thereof |
| ES2543888T3 (es) | 2011-03-16 | 2015-08-25 | Seattle Genetics, Inc. | N-carboxialquil-auristatinas y su utilización |
| SG194567A1 (en) * | 2011-04-21 | 2013-12-30 | Seattle Genetics Inc | Novel binder-drug conjugates (adcs) and their use |
| EP2780039B9 (en) | 2011-11-17 | 2018-04-18 | Pfizer Inc | Cytotoxic peptides and antibody drug conjugates thereof |
| MX2014007121A (es) * | 2011-12-14 | 2014-09-04 | Seattle Genetics Inc | Nuevos conjugados de principio activo-ligante (adc) y su uso. |
| US10226535B2 (en) | 2012-12-10 | 2019-03-12 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| HK1220626A1 (zh) | 2013-03-15 | 2017-05-12 | The Centre For Drug Research And Development | 具细胞毒性和抗有丝分裂的化合物以及其使用方法 |
| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| MX2016008448A (es) | 2013-12-27 | 2017-01-09 | Zymeworks Inc | Conjugados de var2csa-farmaco. |
| KR102384740B1 (ko) | 2013-12-27 | 2022-04-07 | 자임워크스 인코포레이티드 | 약물 접합체를 위한 설폰아마이드-함유 연결 시스템 |
| MX378281B (es) | 2014-04-25 | 2025-03-10 | Pf Medicament | Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer. |
| MA39909B1 (fr) | 2014-04-25 | 2019-05-31 | Pf Medicament | Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer |
| ES2905569T3 (es) * | 2014-09-17 | 2022-04-11 | Zymeworks Inc | Compuestos citotóxicos y antimitóticos y métodos para utilizarlos |
| CN106279352B (zh) | 2015-05-29 | 2020-05-22 | 上海新理念生物医药科技有限公司 | 海兔毒素10的衍生物及其应用 |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| CN108690119B (zh) * | 2018-06-04 | 2022-04-19 | 莎穆(上海)生物科技有限公司 | 一种伊文思蓝修饰的多肽类前药及其制备和应用 |
| WO2022217022A1 (en) | 2021-04-10 | 2022-10-13 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| CA3216459A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CA3230737A1 (en) | 2021-09-03 | 2023-03-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
| TW202547866A (zh) | 2024-01-10 | 2025-12-16 | 丹麥商珍美寶股份有限公司 | Ｓｌｉｔｒｋ６結合劑、其共軛物及使用彼之方法 |
| WO2025181219A1 (en) | 2024-02-29 | 2025-09-04 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663149A (en) * | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| ATE284412T1 (de) * | 1998-01-09 | 2004-12-15 | Univ Arizona State | Anti-kryptokokkus peptide |
| MXPA01011502A (es) | 1999-05-14 | 2003-08-20 | Boehringer Ingelheim Pharma | Compuestos de tipo profarmaco anti-tumorigenos, activados por enzimas. |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6737409B2 (en) | 2001-07-19 | 2004-05-18 | Hoffmann-La Roche Inc. | Dolastatin 10 derivatives |
| WO2003026577A2 (en) | 2001-09-24 | 2003-04-03 | Seattle Genetics, Inc. | P-amidobenzylethers in drug delivery agents |
| EP1537140B1 (en) * | 2001-11-07 | 2013-01-02 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 161p2f10b useful in treatment and detection of cancer |
| ES2369542T3 (es) | 2002-07-31 | 2011-12-01 | Seattle Genetics, Inc. | Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa. |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| JP2008519863A (ja) | 2004-11-12 | 2008-06-12 | シアトル ジェネティクス インコーポレイティッド | Ｎ末端にアミノ安息香酸単位を有するオーリスタチン |
| ES2708763T3 (es) | 2005-07-07 | 2019-04-11 | Seattle Genetics Inc | Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C |
| WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| PT2845866T (pt) | 2006-10-27 | 2017-08-09 | Genentech Inc | Anticorpos e imunoconjugados e utilizações dos mesmos |
| WO2009117531A1 (en) | 2008-03-18 | 2009-09-24 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| SG194567A1 (en) * | 2011-04-21 | 2013-12-30 | Seattle Genetics Inc | Novel binder-drug conjugates (adcs) and their use |
-
2011
- 2011-06-06 CN CN201180037305.4A patent/CN103200950B/zh not_active Expired - Fee Related
- 2011-06-06 WO PCT/EP2011/059300 patent/WO2011154359A1/de not_active Ceased
- 2011-06-06 JP JP2013513651A patent/JP5791707B2/ja not_active Expired - Fee Related
- 2011-06-06 US US13/702,881 patent/US8722629B2/en not_active Expired - Fee Related
- 2011-06-06 EP EP11725412.8A patent/EP2579887B1/de not_active Not-in-force
- 2011-06-06 ES ES11725412.8T patent/ES2528956T3/es active Active
- 2011-06-06 CA CA2801971A patent/CA2801971C/en active Active