JP2013533228A5 - - Google Patents
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- JP2013533228A5 JP2013533228A5 JP2013513651A JP2013513651A JP2013533228A5 JP 2013533228 A5 JP2013533228 A5 JP 2013533228A5 JP 2013513651 A JP2013513651 A JP 2013513651A JP 2013513651 A JP2013513651 A JP 2013513651A JP 2013533228 A5 JP2013533228 A5 JP 2013533228A5
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- Japan
- Prior art keywords
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- Prior art date
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- 0 C*C([C@](C(C)C)NC([C@](C(C)C)NC)=O)=* Chemical compound C*C([C@](C(C)C)NC([C@](C(C)C)NC)=O)=* 0.000 description 15
- XELCRLBPFJTQMS-KDXRVNOWSA-N CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](C)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC XELCRLBPFJTQMS-KDXRVNOWSA-N 0.000 description 2
- MWKDAYPCKCUCIO-QWRGUYRKSA-N CC(C)[C@@H](C(C)=O)NC([C@H](C(C)C)NC)=O Chemical compound CC(C)[C@@H](C(C)=O)NC([C@H](C(C)C)NC)=O MWKDAYPCKCUCIO-QWRGUYRKSA-N 0.000 description 1
- GKMGYJQBUYQYBE-BKIBZHPOSA-N CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OC(C2)C22C=CC12)=O)=O)OC)=O)OC)N(C)C([C@H](C)NC([C@H](C(C)C)NC)=O)=O Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OC(C2)C22C=CC12)=O)=O)OC)=O)OC)N(C)C([C@H](C)NC([C@H](C(C)C)NC)=O)=O GKMGYJQBUYQYBE-BKIBZHPOSA-N 0.000 description 1
- NKLNWUSRAQEWFE-UFINBUOZSA-N CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCc2ccccc2C1)=O)=O)OC)=O)OC)/C=C(\C)/CC([C@H](C(C)C)NC([C@H](C(C)=C)NC)=O)=O Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCc2ccccc2C1)=O)=O)OC)=O)OC)/C=C(\C)/CC([C@H](C(C)C)NC([C@H](C(C)=C)NC)=O)=O NKLNWUSRAQEWFE-UFINBUOZSA-N 0.000 description 1
- PRGSRHOCNFFQKN-PRNUUREKSA-N CC[C@H](C)[C@H](CC(C)CC([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CC(C)CC([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC PRGSRHOCNFFQKN-PRNUUREKSA-N 0.000 description 1
- UHSZKRYFCPMXMW-SFXSRNHCSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(O)=O)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC UHSZKRYFCPMXMW-SFXSRNHCSA-N 0.000 description 1
- IJKQWIOKVAMDPA-VQYQWNPTSA-N CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCN)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CCC[C@@](C1)([C@H]1c1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC Chemical compound CC[C@H](C)[C@H](CCC(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCN)=O)=O)[C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(CCC[C@@](C1)([C@H]1c1ccccc1)C(N1OCCCC1)=O)=O)OC)=O)OC IJKQWIOKVAMDPA-VQYQWNPTSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10165550.4 | 2010-06-10 | ||
| EP10165550 | 2010-06-10 | ||
| EP11158464 | 2011-03-16 | ||
| EP11158464.5 | 2011-03-16 | ||
| PCT/EP2011/059300 WO2011154359A1 (de) | 2010-06-10 | 2011-06-06 | Neue auristatin-derivate und ihre verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533228A JP2013533228A (ja) | 2013-08-22 |
| JP2013533228A5 true JP2013533228A5 (enExample) | 2014-07-03 |
| JP5791707B2 JP5791707B2 (ja) | 2015-10-07 |
Family
ID=44275637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513651A Active JP5791707B2 (ja) | 2010-06-10 | 2011-06-06 | 新規アウリスタチン誘導体およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8722629B2 (enExample) |
| EP (1) | EP2579887B1 (enExample) |
| JP (1) | JP5791707B2 (enExample) |
| CN (1) | CN103200950B (enExample) |
| CA (1) | CA2801971C (enExample) |
| ES (1) | ES2528956T3 (enExample) |
| WO (1) | WO2011154359A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2553874T3 (es) | 2010-09-29 | 2015-12-14 | Seattle Genetics, Inc. | N-Carboxialquil-auristatinas y su uso |
| CA2829736C (en) | 2011-03-16 | 2020-07-21 | Seattle Genetics, Inc. | N-carboxyalkylauristatins and use thereof |
| EP3501546A3 (de) * | 2011-04-21 | 2019-09-18 | Seattle Genetics, Inc. | Cystein-wirkstoff konjugate und ihre verwendung |
| TWI589592B (zh) | 2011-11-17 | 2017-07-01 | 輝瑞股份有限公司 | 胞毒性肽類以及其抗體藥物共軛體 |
| MX2014007121A (es) * | 2011-12-14 | 2014-09-04 | Seattle Genetics Inc | Nuevos conjugados de principio activo-ligante (adc) y su uso. |
| WO2014093379A1 (en) | 2012-12-10 | 2014-06-19 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| US9522876B2 (en) | 2013-03-15 | 2016-12-20 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| ES2916722T3 (es) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sistemas de enlace que contienen sulfonamida para conjugados de fármacos |
| SG11201605260VA (en) | 2013-12-27 | 2016-07-28 | Zymeworks Inc | Var2csa-drug conjugates |
| EP3134124B1 (en) | 2014-04-25 | 2019-02-20 | Pierre Fabre Medicament | Igf-1r antibody-drug-conjugate and its use for the treatment of cancer |
| CN106470708B (zh) | 2014-04-25 | 2019-12-31 | 皮埃尔法布雷医药公司 | 抗体-药物-缀合物和其用于治疗癌症的用途 |
| EP3194421B1 (en) | 2014-09-17 | 2021-11-03 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| CN106279352B (zh) | 2015-05-29 | 2020-05-22 | 上海新理念生物医药科技有限公司 | 海兔毒素10的衍生物及其应用 |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| CN108690119B (zh) * | 2018-06-04 | 2022-04-19 | 莎穆(上海)生物科技有限公司 | 一种伊文思蓝修饰的多肽类前药及其制备和应用 |
| EP4319820A1 (en) | 2021-04-10 | 2024-02-14 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| JP7742892B2 (ja) | 2021-04-23 | 2025-09-22 | ジェンマブ エー／エス | 抗ｃｄ７０抗体、そのコンジュゲートおよびこれを使用する方法 |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| EP4400121A1 (en) | 2021-09-03 | 2024-07-17 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| WO2025072406A1 (en) | 2023-09-26 | 2025-04-03 | Profoundbio Us Co. | Ptk7 binding agents, conjugates thereof and methods of using the same |
| TW202547866A (zh) | 2024-01-10 | 2025-12-16 | 丹麥商珍美寶股份有限公司 | Ｓｌｉｔｒｋ６結合劑、其共軛物及使用彼之方法 |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| CA2315230C (en) | 1998-01-09 | 2004-06-29 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Anti-cryptococcal peptides |
| MXPA01011502A (es) | 1999-05-14 | 2003-08-20 | Boehringer Ingelheim Pharma | Compuestos de tipo profarmaco anti-tumorigenos, activados por enzimas. |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6737409B2 (en) | 2001-07-19 | 2004-05-18 | Hoffmann-La Roche Inc. | Dolastatin 10 derivatives |
| WO2003026577A2 (en) | 2001-09-24 | 2003-04-03 | Seattle Genetics, Inc. | P-amidobenzylethers in drug delivery agents |
| EP1537140B1 (en) * | 2001-11-07 | 2013-01-02 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 161p2f10b useful in treatment and detection of cancer |
| ES2544527T3 (es) | 2002-07-31 | 2015-09-01 | Seattle Genetics, Inc. | Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| JP2008519863A (ja) | 2004-11-12 | 2008-06-12 | シアトル ジェネティクス インコーポレイティッド | Ｎ末端にアミノ安息香酸単位を有するオーリスタチン |
| WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| JP5171621B2 (ja) | 2005-07-07 | 2013-03-27 | シアトル ジェネティックス， インコーポレイテッド | フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物 |
| AU2007308792B2 (en) | 2006-10-27 | 2013-01-24 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| EP2265283B1 (en) | 2008-03-18 | 2014-09-03 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| EP3501546A3 (de) * | 2011-04-21 | 2019-09-18 | Seattle Genetics, Inc. | Cystein-wirkstoff konjugate und ihre verwendung |
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2011
- 2011-06-06 CA CA2801971A patent/CA2801971C/en active Active
- 2011-06-06 ES ES11725412.8T patent/ES2528956T3/es active Active
- 2011-06-06 EP EP11725412.8A patent/EP2579887B1/de active Active
- 2011-06-06 CN CN201180037305.4A patent/CN103200950B/zh active Active
- 2011-06-06 WO PCT/EP2011/059300 patent/WO2011154359A1/de not_active Ceased
- 2011-06-06 US US13/702,881 patent/US8722629B2/en active Active
- 2011-06-06 JP JP2013513651A patent/JP5791707B2/ja active Active