JP2016512198A5 - - Google Patents
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- JP2016512198A5 JP2016512198A5 JP2015561594A JP2015561594A JP2016512198A5 JP 2016512198 A5 JP2016512198 A5 JP 2016512198A5 JP 2015561594 A JP2015561594 A JP 2015561594A JP 2015561594 A JP2015561594 A JP 2015561594A JP 2016512198 A5 JP2016512198 A5 JP 2016512198A5
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- JP
- Japan
- Prior art keywords
- independently selected
- group
- optionally substituted
- hydrogen
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361773779P | 2013-03-06 | 2013-03-06 | |
| US61/773,779 | 2013-03-06 | ||
| PCT/US2014/020700 WO2014138212A1 (en) | 2013-03-06 | 2014-03-05 | CaMKII INHIBITORS AND USES THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512198A JP2016512198A (ja) | 2016-04-25 |
| JP2016512198A5 true JP2016512198A5 (enExample) | 2017-04-06 |
| JP6318180B2 JP6318180B2 (ja) | 2018-04-25 |
Family
ID=51491905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561594A Expired - Fee Related JP6318180B2 (ja) | 2013-03-06 | 2014-03-05 | ＣａＭＫＩＩ阻害剤及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9951061B2 (enExample) |
| EP (1) | EP2964225B1 (enExample) |
| JP (1) | JP6318180B2 (enExample) |
| CN (1) | CN105517549B (enExample) |
| AU (1) | AU2014225889B2 (enExample) |
| CA (1) | CA2901155C (enExample) |
| WO (1) | WO2014138212A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10759792B2 (en) | 2014-09-05 | 2020-09-01 | The Johns Hopkins University | CaMKII inhibitors and uses thereof |
| JP6532737B2 (ja) * | 2015-04-01 | 2019-06-19 | 東ソー・ファインケム株式会社 | ヘテロアセン化合物の製造方法 |
| AR110252A1 (es) * | 2016-11-30 | 2019-03-13 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como inhibidores de la quinasa cam |
| SG11202000007PA (en) * | 2017-07-06 | 2020-01-30 | Childrens Medical Center | Compositions and methods for treating or preventing catecholaminergic polymorphic ventricular tachycardia |
| JP7500426B2 (ja) | 2018-02-21 | 2024-06-17 | ブリストル－マイヤーズ スクイブ カンパニー | Ｃａｍｋ２ｄアンチセンスオリゴヌクレオチドおよびその使用 |
| CN108904532B (zh) * | 2018-08-20 | 2021-07-27 | 上海市第一人民医院 | 一种富勒烯C60纳米晶体联合CaMKII抑制剂的组合物的应用 |
| WO2024197267A1 (en) * | 2023-03-22 | 2024-09-26 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitors of ca 2+/calmodulin-dependent protein kinase ii (camkii) that do not inhibit long-term potentiation (ltp) induction and therapeutic uses thereof |
| TW202535878A (zh) * | 2023-11-07 | 2025-09-16 | 美商卡都瑞恩醫藥公司 | 吡啶基咪唑並［１，２－ｂ］嗒𠯤之多晶型物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE218854T1 (de) | 1997-01-31 | 2002-06-15 | Univ Leland Stanford Junior | Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin- abhängigen protein kinase |
| IL161231A0 (en) | 2001-10-01 | 2004-09-27 | Univ Vanderbilt | Use of calmodulin kinase ii inhibitors to treat myocardial dysfunction in structural heart disease |
| WO2004058764A1 (en) * | 2002-12-27 | 2004-07-15 | Bayer Healthcare Ag | 4-phenyl-pyrimido [4,5-b] indole derivatives |
| WO2006007422A2 (en) * | 2004-06-16 | 2006-01-19 | The Trustees Fo Columbia University In The City Of New York | CaMKII/CALCIUM CHANNEL PHOSPHORYLATION-RELATED COMPOSITIONS AND METHODS |
| WO2006049215A1 (ja) | 2004-11-02 | 2006-05-11 | Dainippon Sumitomo Pharma Co., Ltd. | 自己免疫疾患を治療するための併用薬 |
| CA2608333A1 (en) * | 2005-05-16 | 2006-11-23 | Irm Llc | Pyrrolopyridine derivatives as protein kinase inhibitors |
| EP2354139A1 (en) * | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| JP2008542433A (ja) * | 2005-06-09 | 2008-11-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ＣＤＫ−１インヒビターとしてのα−カルボリン |
| US20070208053A1 (en) * | 2006-01-19 | 2007-09-06 | Arnold Lee D | Fused heterobicyclic kinase inhibitors |
| CL2008001540A1 (es) * | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer. |
| EP2161271A1 (en) * | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
| US8440656B2 (en) | 2009-06-22 | 2013-05-14 | University Of Iowa Research Foundation | Methods of treating pulmonary diseases and disorders by modulating calcium/calmodulin dependent protein kinase II activity |
| US8685969B2 (en) * | 2010-06-16 | 2014-04-01 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
-
2014
- 2014-03-05 AU AU2014225889A patent/AU2014225889B2/en not_active Ceased
- 2014-03-05 WO PCT/US2014/020700 patent/WO2014138212A1/en not_active Ceased
- 2014-03-05 JP JP2015561594A patent/JP6318180B2/ja not_active Expired - Fee Related
- 2014-03-05 CN CN201480012869.6A patent/CN105517549B/zh active Active
- 2014-03-05 CA CA2901155A patent/CA2901155C/en active Active
- 2014-03-05 EP EP14760472.2A patent/EP2964225B1/en active Active
- 2014-03-05 US US14/773,308 patent/US9951061B2/en active Active
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