JP2014532751A5 - - Google Patents
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- JP2014532751A5 JP2014532751A5 JP2014540552A JP2014540552A JP2014532751A5 JP 2014532751 A5 JP2014532751 A5 JP 2014532751A5 JP 2014540552 A JP2014540552 A JP 2014540552A JP 2014540552 A JP2014540552 A JP 2014540552A JP 2014532751 A5 JP2014532751 A5 JP 2014532751A5
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- JP
- Japan
- Prior art keywords
- compound according
- cancer
- der
- independently
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C*(CC1)CC1C(C)=C Chemical compound C*(CC1)CC1C(C)=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161557457P | 2011-11-09 | 2011-11-09 | |
| US61/557,457 | 2011-11-09 | ||
| PCT/GB2012/052786 WO2013068755A1 (en) | 2011-11-09 | 2012-11-09 | 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532751A JP2014532751A (ja) | 2014-12-08 |
| JP2014532751A5 true JP2014532751A5 (enExample) | 2015-12-10 |
| JP6073910B2 JP6073910B2 (ja) | 2017-02-01 |
Family
ID=47178213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540552A Active JP6073910B2 (ja) | 2011-11-09 | 2012-11-09 | ５−（ピリジン−２−イル−アミノ）−ピラジン−２−カルボニトリル化合物及びその治療使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9040540B2 (enExample) |
| EP (1) | EP2776417B1 (enExample) |
| JP (1) | JP6073910B2 (enExample) |
| CN (1) | CN104105696B (enExample) |
| AU (1) | AU2012335409B2 (enExample) |
| BR (1) | BR112014010938A2 (enExample) |
| CA (1) | CA2849566C (enExample) |
| ES (1) | ES2709003T3 (enExample) |
| RU (1) | RU2641693C2 (enExample) |
| WO (1) | WO2013068755A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9040540B2 (en) | 2011-11-09 | 2015-05-26 | Cancer Research Technology Limited | 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use |
| KR20210156333A (ko) | 2012-05-15 | 2021-12-24 | 캔써 리서치 테크놀로지 리미티드 | 5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도 |
| CZ306322B6 (cs) | 2014-12-17 | 2016-11-30 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CN110872277B (zh) * | 2019-11-14 | 2021-06-04 | 浙江大学 | N-取代芳环-2-氨基嘧啶类化合物及用途 |
| CN116917009A (zh) | 2021-02-19 | 2023-10-20 | 美国迈胜医疗系统有限公司 | 用于粒子治疗系统的机架 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773778A (en) | 1972-01-24 | 1973-11-20 | Squibb & Sons Inc | Sulfur derivatives of pyrazolo (3,4-b)pyridines |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| ATE212993T1 (de) | 1995-07-06 | 2002-02-15 | Novartis Erfind Verwalt Gmbh | Pyrolopyrimidine und verfahren zu ihrer herstellung |
| EP1435947B1 (en) | 2001-10-19 | 2007-08-15 | Ortho-McNeil Pharmaceutical, Inc. | 2-phenyl benzimidazoles and imidazo-¬4,5|-pyridines as cds1/chk2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer |
| MXPA04003954A (es) | 2001-10-26 | 2004-11-29 | Aventis Pharma Inc | Bencimidazoles. |
| CA2464934A1 (en) | 2001-10-31 | 2003-05-08 | Bayer Healthcare Ag | Pyrimido [4,5-b] indole derivatives |
| JP4901102B2 (ja) | 2002-05-03 | 2012-03-21 | エクセリクシス， インク． | プロテインキナーゼモジュレーターおよびその使用方法 |
| US7202244B2 (en) | 2002-05-29 | 2007-04-10 | Millennium Pharmaceuticals, Inc. | Chk-1 inhibitors |
| BRPI0413005A (pt) | 2003-07-29 | 2006-09-26 | Irm Llc | compostos e composições como inibidores da proteìna cinase |
| US7449582B2 (en) | 2003-10-08 | 2008-11-11 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| ES2344007T3 (es) | 2003-10-14 | 2010-08-16 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Inhibidores proteina quinasa. |
| MXPA06003607A (es) | 2003-10-16 | 2006-06-05 | Chiron Corp | Quinazolinas, quinoxalinas, quinolinas e isoquinolinas 2.6-disubstituidas como inhibidores de la cinasa raf para el tratamiento del cancer. |
| US20050096324A1 (en) | 2003-11-05 | 2005-05-05 | Zhi-Fu Tao | Macrocyclic kinase inhibitors |
| US7163939B2 (en) | 2003-11-05 | 2007-01-16 | Abbott Laboratories | Macrocyclic kinase inhibitors |
| EP1742935B1 (en) | 2004-04-13 | 2010-02-24 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| JP2008539277A (ja) | 2005-04-28 | 2008-11-13 | スーパージェン， インコーポレイテッド | プロテインキナーゼインヒビター |
| PT1899322E (pt) | 2005-06-28 | 2009-11-09 | Sanofi Aventis | Derivados de isoquinolina como inibidores de rho-cinase |
| PE20070427A1 (es) * | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
| US7776865B2 (en) | 2005-10-06 | 2010-08-17 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| BRPI0721180A2 (pt) | 2006-12-27 | 2014-03-18 | Sanofi Aventis | Derivados de isoquinolina substituídos com cicloalquilamina |
| JP5569956B2 (ja) | 2007-03-16 | 2014-08-13 | ザ スクリプス リサーチ インスティテュート | 接着斑キナーゼのインヒビター |
| WO2008117050A1 (en) | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer |
| WO2009004329A1 (en) | 2007-07-02 | 2009-01-08 | Cancer Research Technology Limited | 9h-pyrimido[4,5-b]indoles, 9h-pyrido[4',3':4,5]pyrrolo[2,3-d]pyridines, and 9h-1,3,6,9-tetraaza-fluorenes as chk1 kinase function inhibitors |
| GB0719644D0 (en) * | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| WO2009151598A1 (en) * | 2008-06-11 | 2009-12-17 | Genentech, Inc. | Diazacarbazoles and methods of use |
| US9040540B2 (en) | 2011-11-09 | 2015-05-26 | Cancer Research Technology Limited | 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use |
| KR20210156333A (ko) | 2012-05-15 | 2021-12-24 | 캔써 리서치 테크놀로지 리미티드 | 5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도 |
-
2012
- 2012-11-09 US US14/356,626 patent/US9040540B2/en active Active
- 2012-11-09 CA CA2849566A patent/CA2849566C/en active Active
- 2012-11-09 JP JP2014540552A patent/JP6073910B2/ja active Active
- 2012-11-09 CN CN201280055367.2A patent/CN104105696B/zh not_active Expired - Fee Related
- 2012-11-09 EP EP12784666.5A patent/EP2776417B1/en active Active
- 2012-11-09 WO PCT/GB2012/052786 patent/WO2013068755A1/en not_active Ceased
- 2012-11-09 BR BR112014010938A patent/BR112014010938A2/pt not_active IP Right Cessation
- 2012-11-09 RU RU2014121334A patent/RU2641693C2/ru active
- 2012-11-09 ES ES12784666T patent/ES2709003T3/es active Active
- 2012-11-09 AU AU2012335409A patent/AU2012335409B2/en not_active Ceased
-
2015
- 2015-04-22 US US14/693,307 patent/US9403797B2/en active Active
-
2016
- 2016-06-24 US US15/191,967 patent/US9765059B2/en not_active Expired - Fee Related
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