JP2014532751A5 - - Google Patents
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- Publication number
- JP2014532751A5 JP2014532751A5 JP2014540552A JP2014540552A JP2014532751A5 JP 2014532751 A5 JP2014532751 A5 JP 2014532751A5 JP 2014540552 A JP2014540552 A JP 2014540552A JP 2014540552 A JP2014540552 A JP 2014540552A JP 2014532751 A5 JP2014532751 A5 JP 2014532751A5
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- JP
- Japan
- Prior art keywords
- compound according
- cancer
- der
- independently
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C*(CC1)CC1C(C)=C Chemical compound C*(CC1)CC1C(C)=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161557457P | 2011-11-09 | 2011-11-09 | |
| US61/557,457 | 2011-11-09 | ||
| PCT/GB2012/052786 WO2013068755A1 (en) | 2011-11-09 | 2012-11-09 | 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532751A JP2014532751A (ja) | 2014-12-08 |
| JP2014532751A5 true JP2014532751A5 (enExample) | 2015-12-10 |
| JP6073910B2 JP6073910B2 (ja) | 2017-02-01 |
Family
ID=47178213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540552A Active JP6073910B2 (ja) | 2011-11-09 | 2012-11-09 | ５−（ピリジン−２−イル−アミノ）−ピラジン−２−カルボニトリル化合物及びその治療使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9040540B2 (enExample) |
| EP (1) | EP2776417B1 (enExample) |
| JP (1) | JP6073910B2 (enExample) |
| CN (1) | CN104105696B (enExample) |
| AU (1) | AU2012335409B2 (enExample) |
| BR (1) | BR112014010938A2 (enExample) |
| CA (1) | CA2849566C (enExample) |
| ES (1) | ES2709003T3 (enExample) |
| RU (1) | RU2641693C2 (enExample) |
| WO (1) | WO2013068755A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014010938A2 (pt) | 2011-11-09 | 2017-05-16 | Cancer Res Tech Ltd | compostos de 5-(piridin-2-il-amino)-pirazina-2-carbonitrila e seu uso terapêutico |
| MX358819B (es) | 2012-05-15 | 2018-09-05 | Cancer Research Tech Ltd | 5-[[4-[[morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]am ino]pirazina-2-carbonitrilo y usos terapeuticos del mismo. |
| CZ306322B6 (cs) | 2014-12-17 | 2016-11-30 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| CN110872277B (zh) * | 2019-11-14 | 2021-06-04 | 浙江大学 | N-取代芳环-2-氨基嘧啶类化合物及用途 |
| CN116917009A (zh) | 2021-02-19 | 2023-10-20 | 美国迈胜医疗系统有限公司 | 用于粒子治疗系统的机架 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773778A (en) | 1972-01-24 | 1973-11-20 | Squibb & Sons Inc | Sulfur derivatives of pyrazolo (3,4-b)pyridines |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| NZ312665A (en) | 1995-07-06 | 1999-08-30 | Novartis Ag | Rrolopyrimidines(7h-pyrrolo[2,3-d]pyrimidine and preparation of these |
| DE60221866T2 (de) | 2001-10-19 | 2008-05-29 | Ortho-Mcneil Pharmaceutical, Inc. | 2-PHENYL BENZIMIDAZOLE UND IMIDAZO-i4,5ö-PYRIDINE ALS CDS1/CHK2-INHIBITOREN UND ADJUVANTIEN IN DER CHEMOTHERAPIE ODER STRAHLUNGSTHERAPIE ZUR BEHANDLUNG VON KREBS |
| IL161576A0 (en) | 2001-10-26 | 2004-09-27 | Aventis Pharma Inc | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| JP2005515173A (ja) | 2001-10-31 | 2005-05-26 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ピリミド［４，５−ｂ］インドール誘導体 |
| CA2484209C (en) | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| WO2003101444A1 (en) | 2002-05-29 | 2003-12-11 | Millennium Pharmaceuticals, Inc. | Diarylurea compounds and derivatives as chk-1 inhibitors for the treatment of cancer |
| BRPI0413005A (pt) | 2003-07-29 | 2006-09-26 | Irm Llc | compostos e composições como inibidores da proteìna cinase |
| EP1673343A4 (en) | 2003-10-08 | 2008-09-10 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS |
| DK1678166T3 (da) | 2003-10-14 | 2009-11-09 | Univ Arizona State | Proteinkinaseinhibitorer |
| KR20070029110A (ko) | 2003-10-16 | 2007-03-13 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 암의 치료를 위한 ｒａｆ 키나아제의 저해제로서2,6-디치환 퀴나졸린, 퀴녹살린, 퀴놀린 및 아이소퀴놀린 |
| US20050096324A1 (en) | 2003-11-05 | 2005-05-05 | Zhi-Fu Tao | Macrocyclic kinase inhibitors |
| US7163939B2 (en) | 2003-11-05 | 2007-01-16 | Abbott Laboratories | Macrocyclic kinase inhibitors |
| CA2561831A1 (en) | 2004-04-13 | 2005-12-22 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| MX2007013624A (es) | 2005-04-28 | 2008-02-12 | Supergen Inc | Inhibidores de proteina cinasa. |
| KR101327780B1 (ko) | 2005-06-28 | 2013-11-11 | 사노피 | Ｒｈｏ 키나제 억제제로서의 이소퀴놀린 유도체 |
| TW200804345A (en) * | 2005-08-30 | 2008-01-16 | Novartis Ag | Substituted benzimidazoles and methods of preparation |
| AR056206A1 (es) | 2005-10-06 | 2007-09-26 | Schering Corp | Pirazolpirimidinas como inhibidores de protein quinasas |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CN101611012B (zh) | 2006-12-27 | 2012-11-14 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹啉衍生物 |
| CN103588704B (zh) | 2007-03-16 | 2016-09-14 | 斯克里普斯研究学院 | 粘着斑激酶抑制剂 |
| WO2008117050A1 (en) | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer |
| WO2009004329A1 (en) | 2007-07-02 | 2009-01-08 | Cancer Research Technology Limited | 9h-pyrimido[4,5-b]indoles, 9h-pyrido[4',3':4,5]pyrrolo[2,3-d]pyridines, and 9h-1,3,6,9-tetraaza-fluorenes as chk1 kinase function inhibitors |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB0803018D0 (en) * | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| CN102119163A (zh) * | 2008-06-11 | 2011-07-06 | 健泰科生物技术公司 | 二氮杂咔唑和使用方法 |
| BR112014010938A2 (pt) | 2011-11-09 | 2017-05-16 | Cancer Res Tech Ltd | compostos de 5-(piridin-2-il-amino)-pirazina-2-carbonitrila e seu uso terapêutico |
| MX358819B (es) | 2012-05-15 | 2018-09-05 | Cancer Research Tech Ltd | 5-[[4-[[morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]am ino]pirazina-2-carbonitrilo y usos terapeuticos del mismo. |
-
2012
- 2012-11-09 BR BR112014010938A patent/BR112014010938A2/pt not_active IP Right Cessation
- 2012-11-09 JP JP2014540552A patent/JP6073910B2/ja active Active
- 2012-11-09 AU AU2012335409A patent/AU2012335409B2/en not_active Ceased
- 2012-11-09 CA CA2849566A patent/CA2849566C/en active Active
- 2012-11-09 EP EP12784666.5A patent/EP2776417B1/en active Active
- 2012-11-09 WO PCT/GB2012/052786 patent/WO2013068755A1/en not_active Ceased
- 2012-11-09 RU RU2014121334A patent/RU2641693C2/ru active
- 2012-11-09 ES ES12784666T patent/ES2709003T3/es active Active
- 2012-11-09 CN CN201280055367.2A patent/CN104105696B/zh not_active Expired - Fee Related
- 2012-11-09 US US14/356,626 patent/US9040540B2/en active Active
-
2015
- 2015-04-22 US US14/693,307 patent/US9403797B2/en active Active
-
2016
- 2016-06-24 US US15/191,967 patent/US9765059B2/en not_active Expired - Fee Related
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