JP2002513793A - 新規ｎ−オキシド - Google Patents

新規ｎ−オキシド

Info

Publication number
JP2002513793A
JP2002513793A JP2000547088A JP2000547088A JP2002513793A JP 2002513793 A JP2002513793 A JP 2002513793A JP 2000547088 A JP2000547088 A JP 2000547088A JP 2000547088 A JP2000547088 A JP 2000547088A JP 2002513793 A JP2002513793 A JP 2002513793A
Authority
JP
Japan
Prior art keywords
compound
alkoxy
formula
hydrogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000547088A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002513793A5 (enExample
Inventor
グッテラー ベアテ
アムシュラー ヘルマン
ウルリヒ ヴォルフ−リューディガー
マルティン トーマス
ベール トーマス
ハッツェルマン アルミーン
ボス ヒルデガルト
ボイメ ロルフ
ブントシュー ダニエラ
クライ ハンス−ペーター
フロッケルツィ ディーター
Original Assignee
ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング filed Critical ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング
Publication of JP2002513793A publication Critical patent/JP2002513793A/ja
Publication of JP2002513793A5 publication Critical patent/JP2002513793A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
JP2000547088A 1998-05-05 1999-04-27 新規ｎ−オキシド Withdrawn JP2002513793A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98108124.3 1998-05-05
EP98108124 1998-05-05
PCT/EP1999/002827 WO1999057118A1 (de) 1998-05-05 1999-04-27 Neue n-oxide

Publications (2)

Publication Number Publication Date
JP2002513793A true JP2002513793A (ja) 2002-05-14
JP2002513793A5 JP2002513793A5 (enExample) 2006-06-22

Family

ID=8231880

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000547088A Withdrawn JP2002513793A (ja) 1998-05-05 1999-04-27 新規ｎ−オキシド

Country Status (12)

Country Link
US (1) US6306869B1 (enExample)
EP (1) EP1075477B1 (enExample)
JP (1) JP2002513793A (enExample)
AT (1) ATE234301T1 (enExample)
AU (1) AU3928999A (enExample)
CA (1) CA2330738A1 (enExample)
DE (1) DE59904535D1 (enExample)
DK (1) DK1075477T3 (enExample)
ES (1) ES2195571T3 (enExample)
PT (1) PT1075477E (enExample)
SI (1) SI1075477T1 (enExample)
WO (1) WO1999057118A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005539055A (ja) * 2002-09-04 2005-12-22 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のベンゾナフチリジン
JP2007523130A (ja) * 2004-02-18 2007-08-16 アルタナ　ファルマ　アクチエンゲゼルシャフト 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
JP2007526283A (ja) * 2004-03-03 2007-09-13 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のヒドロキシ−６−ヘテロアリールフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
JP2008512367A (ja) * 2004-09-08 2008-04-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−チア−１０−アザ−フェナントレン誘導体

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity
SI1212089T1 (sl) * 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
DE60133879D1 (de) 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
SI1377574T1 (enExample) * 2001-02-21 2005-08-31 Altana Pharma Ag
PL373598A1 (en) * 2002-08-17 2005-09-05 Altana Pharma Ag Novel benzonaphthyridines
AU2003255493B8 (en) * 2002-08-29 2009-03-26 Takeda Gmbh 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors
JP4587295B2 (ja) * 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての３−ヒドロキシ−６−フェニルフェナントリジン
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
IS7839A (is) * 2002-11-22 2004-05-23 Merck Frosst Canada Ltd. 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
WO2005084104A2 (en) * 2004-03-09 2005-09-15 Altana Pharma Ag Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
JP2007527900A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト チオ含有の新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
AU2005219581A1 (en) * 2004-03-10 2005-09-15 Nycomed Gmbh Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
AU2005221832A1 (en) * 2004-03-10 2005-09-22 Nycomed Gmbh Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
AU2005223386A1 (en) 2004-03-17 2005-09-29 Nycomed Gmbh Novel N- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE3/4 inhibitors
ES2365926T3 (es) * 2004-09-08 2011-10-13 Nycomed Gmbh 3-oxa-10-aza-fenantrenos como inhibidores de pde4 o pde3/4.
NZ560268A (en) 2005-03-02 2010-12-24 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP1942879A1 (en) 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
NZ334976A (en) 1996-11-11 2000-10-27 Byk Gulden Lomberg Chem Fab Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005539055A (ja) * 2002-09-04 2005-12-22 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のベンゾナフチリジン
JP2007523130A (ja) * 2004-02-18 2007-08-16 アルタナ　ファルマ　アクチエンゲゼルシャフト 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
JP2007526283A (ja) * 2004-03-03 2007-09-13 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のヒドロキシ−６−ヘテロアリールフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
JP2008512367A (ja) * 2004-09-08 2008-04-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の３−チア−１０−アザ−フェナントレン誘導体

Also Published As

Publication number Publication date
PT1075477E (pt) 2003-07-31
EP1075477A1 (de) 2001-02-14
AU3928999A (en) 1999-11-23
US6306869B1 (en) 2001-10-23
DK1075477T3 (da) 2003-06-30
EP1075477B1 (de) 2003-03-12
CA2330738A1 (en) 1999-11-11
SI1075477T1 (en) 2003-08-31
ATE234301T1 (de) 2003-03-15
DE59904535D1 (de) 2003-04-17
WO1999057118A1 (de) 1999-11-11
ES2195571T3 (es) 2003-12-01

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