SI1075477T1 - Novel Benzonaphthyridine-N-oxides - Google Patents
Novel Benzonaphthyridine-N-oxidesInfo
- Publication number
- SI1075477T1 SI1075477T1 SI9930279T SI9930279T SI1075477T1 SI 1075477 T1 SI1075477 T1 SI 1075477T1 SI 9930279 T SI9930279 T SI 9930279T SI 9930279 T SI9930279 T SI 9930279T SI 1075477 T1 SI1075477 T1 SI 1075477T1
- Authority
- SI
- Slovenia
- Prior art keywords
- oxides
- hand
- benzonaphthyridine
- novel
- novel benzonaphthyridine
- Prior art date
Links
- JHIGLTFLUVWCGN-UHFFFAOYSA-N 1-oxidobenzo[b][1,8]naphthyridin-1-ium Chemical class C1=CC=C2N=C3[N+]([O-])=CC=CC3=CC2=C1 JHIGLTFLUVWCGN-UHFFFAOYSA-N 0.000 title 1
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
- 101100135868 Dictyostelium discoideum pde3 gene Proteins 0.000 abstract 1
- 101000909851 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) cAMP/cGMP dual specificity phosphodiesterase Rv0805 Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108124 | 1998-05-05 | ||
| EP99922133A EP1075477B1 (de) | 1998-05-05 | 1999-04-27 | Neue Benzonaphtyridin-N-oxide |
| PCT/EP1999/002827 WO1999057118A1 (de) | 1998-05-05 | 1999-04-27 | Neue n-oxide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1075477T1 true SI1075477T1 (en) | 2003-08-31 |
Family
ID=8231880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9930279T SI1075477T1 (en) | 1998-05-05 | 1999-04-27 | Novel Benzonaphthyridine-N-oxides |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6306869B1 (enExample) |
| EP (1) | EP1075477B1 (enExample) |
| JP (1) | JP2002513793A (enExample) |
| AT (1) | ATE234301T1 (enExample) |
| AU (1) | AU3928999A (enExample) |
| CA (1) | CA2330738A1 (enExample) |
| DE (1) | DE59904535D1 (enExample) |
| DK (1) | DK1075477T3 (enExample) |
| ES (1) | ES2195571T3 (enExample) |
| PT (1) | PT1075477E (enExample) |
| SI (1) | SI1075477T1 (enExample) |
| WO (1) | WO1999057118A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5970199A (en) | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
| SI1212089T1 (sl) * | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Sinergisticna kombinacija roflumilasta in salmeterola |
| DE60133879D1 (de) | 2000-01-11 | 2008-06-19 | Nycomed Gmbh | Phenanthridin -n- oxide |
| SI1377574T1 (enExample) * | 2001-02-21 | 2005-08-31 | Altana Pharma Ag | |
| PL373598A1 (en) * | 2002-08-17 | 2005-09-05 | Altana Pharma Ag | Novel benzonaphthyridines |
| AU2003255493B8 (en) * | 2002-08-29 | 2009-03-26 | Takeda Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| JP4587295B2 (ja) * | 2002-08-29 | 2010-11-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての３−ヒドロキシ−６−フェニルフェナントリジン |
| DE60313331T2 (de) * | 2002-09-04 | 2008-01-03 | Nycomed Gmbh | Neue benzonaphthyridine |
| US7470704B2 (en) | 2002-09-04 | 2008-12-30 | Nycomed Gmbh | Benzonaphthyridines |
| IS7839A (is) * | 2002-11-22 | 2004-05-23 | Merck Frosst Canada Ltd. | 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar |
| AU2005212857B2 (en) * | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
| SI2589599T1 (sl) | 2004-03-03 | 2014-10-30 | Takeda Gmbh | Novi hidroksi-6-heteroarilfenantridini in njihova uporaba kot PDE4 inhibitorji |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| WO2005084104A2 (en) * | 2004-03-09 | 2005-09-15 | Altana Pharma Ag | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| JP2007527900A (ja) * | 2004-03-10 | 2007-10-04 | アルタナ ファルマ アクチエンゲゼルシャフト | チオ含有の新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用 |
| AU2005219581A1 (en) * | 2004-03-10 | 2005-09-15 | Nycomed Gmbh | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
| AU2005221832A1 (en) * | 2004-03-10 | 2005-09-22 | Nycomed Gmbh | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
| AU2005223386A1 (en) | 2004-03-17 | 2005-09-29 | Nycomed Gmbh | Novel N- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE3/4 inhibitors |
| EP1791847A2 (en) | 2004-09-08 | 2007-06-06 | Altana Pharma AG | Novel 3-thia-10-aza-phenanthrene derivatives |
| ES2365926T3 (es) * | 2004-09-08 | 2011-10-13 | Nycomed Gmbh | 3-oxa-10-aza-fenantrenos como inhibidores de pde4 o pde3/4. |
| NZ560268A (en) | 2005-03-02 | 2010-12-24 | Nycomed Gmbh | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0247971A3 (en) * | 1986-05-29 | 1990-01-17 | Sandoz Ag | Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin |
| NZ334976A (en) | 1996-11-11 | 2000-10-27 | Byk Gulden Lomberg Chem Fab | Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses |
-
1999
- 1999-04-27 ES ES99922133T patent/ES2195571T3/es not_active Expired - Lifetime
- 1999-04-27 JP JP2000547088A patent/JP2002513793A/ja not_active Withdrawn
- 1999-04-27 WO PCT/EP1999/002827 patent/WO1999057118A1/de not_active Ceased
- 1999-04-27 DK DK99922133T patent/DK1075477T3/da active
- 1999-04-27 AU AU39289/99A patent/AU3928999A/en not_active Abandoned
- 1999-04-27 EP EP99922133A patent/EP1075477B1/de not_active Expired - Lifetime
- 1999-04-27 AT AT99922133T patent/ATE234301T1/de not_active IP Right Cessation
- 1999-04-27 PT PT99922133T patent/PT1075477E/pt unknown
- 1999-04-27 SI SI9930279T patent/SI1075477T1/xx unknown
- 1999-04-27 CA CA002330738A patent/CA2330738A1/en not_active Abandoned
- 1999-04-27 DE DE59904535T patent/DE59904535D1/de not_active Expired - Fee Related
- 1999-04-27 US US09/673,649 patent/US6306869B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1075477E (pt) | 2003-07-31 |
| JP2002513793A (ja) | 2002-05-14 |
| EP1075477A1 (de) | 2001-02-14 |
| AU3928999A (en) | 1999-11-23 |
| US6306869B1 (en) | 2001-10-23 |
| DK1075477T3 (da) | 2003-06-30 |
| EP1075477B1 (de) | 2003-03-12 |
| CA2330738A1 (en) | 1999-11-11 |
| ATE234301T1 (de) | 2003-03-15 |
| DE59904535D1 (de) | 2003-04-17 |
| WO1999057118A1 (de) | 1999-11-11 |
| ES2195571T3 (es) | 2003-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI1075477T1 (en) | Novel Benzonaphthyridine-N-oxides | |
| PL334561A1 (en) | Novel phtalysinones | |
| CA2297911A1 (en) | Substituted 6-phenylphenanthridines | |
| SI1070056T1 (en) | Phthalazinone pde iii/iv inhibitors | |
| ES2195785A1 (es) | Nuevos derivados de piridazin-3(2h)-ona. | |
| TR200400702T4 (tr) | AMP özgü fosfodiesteraz inhibtörleri olarak 3-tiazol-4-il-pirolidin türevleri. | |
| MY135732A (en) | 5,6-trimethylenepyrimidin - 4 - one compounds | |
| YU19499A (sh) | Benzonaftiridini kao bronhijalni terapeutici | |
| WO2002102313A3 (en) | Pyrimidine inhibitors of phosphodiesterase (pde) 7 | |
| WO2004018465A3 (en) | Benzonaphthyridines with pde 3/4 inhibiting activity | |
| PL338339A1 (en) | Novel derivatives of tetrazole | |
| BG105561A (en) | Phenylphenanthridines with pde-iv inhibiting activity | |
| WO2003087088A3 (en) | (condensed) pyrimidone and (condensed) pyridone compounds, processes for their preparation, and pharmaceutical compositions containing them | |
| DK1109810T3 (da) | Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet | |
| WO2002085906A3 (en) | Phthalazinones derivatives useful as pde4/7 inhibitors | |
| WO2001027118A3 (de) | Bicyclische imidazo-5-yl-aminderivate | |
| PL341239A1 (en) | Dihydrobenzofuranes | |
| PT1086096E (pt) | Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4 | |
| DE60019894D1 (de) | Phenantrhridin-n-oxides mit pde-iv hemmender wirkung | |
| AU2107700A (en) | Phenanthridine-n-oxides with pde-iv inhibiting activity | |
| MXPA02012263A (es) | 5-aminoalquil-pirazol[4,3-d]pirimidinas. | |
| WO2002051848A3 (de) | Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer | |
| SI1377574T1 (enExample) | ||
| MXPA02012260A (es) | 2-aminoalquil-tieno[2,3-d]pirimidinas. | |
| SI0937075T1 (en) | New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors. |