DK1109810T3 - Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet - Google Patents

Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet

Info

Publication number
DK1109810T3
DK1109810T3 DK99968237T DK99968237T DK1109810T3 DK 1109810 T3 DK1109810 T3 DK 1109810T3 DK 99968237 T DK99968237 T DK 99968237T DK 99968237 T DK99968237 T DK 99968237T DK 1109810 T3 DK1109810 T3 DK 1109810T3
Authority
DK
Denmark
Prior art keywords
benzonaphthydine
pde3
oxides
inhibitory activity
pde4 inhibitory
Prior art date
Application number
DK99968237T
Other languages
English (en)
Inventor
Beate Schmidt
Thomas Baer
Armin Hatzelmann
Rolf Beume
Hans-Peter Kley
Dieter Flockerzi
Hermann Amschler
Wolf-Ruediger Ulrich
Thomas Martin
Hildegard Boss
Daniela Bundschuh
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK1109810T3 publication Critical patent/DK1109810T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
DK99968237T 1998-08-31 1999-08-21 Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet DK1109810T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98116416 1998-08-31
EP99968237A EP1109810B1 (de) 1998-08-31 1999-08-21 Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität

Publications (1)

Publication Number Publication Date
DK1109810T3 true DK1109810T3 (da) 2004-10-18

Family

ID=8232548

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99968237T DK1109810T3 (da) 1998-08-31 1999-08-21 Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet

Country Status (11)

Country Link
US (1) US6436952B1 (da)
EP (1) EP1109810B1 (da)
JP (1) JP2002523505A (da)
AT (1) ATE269331T1 (da)
AU (1) AU5970199A (da)
CA (1) CA2342245A1 (da)
DE (1) DE59909760D1 (da)
DK (1) DK1109810T3 (da)
ES (1) ES2224745T3 (da)
SI (1) SI1109810T1 (da)
WO (1) WO2000012501A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042018A1 (en) 1999-01-15 2000-07-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
SI1147087T1 (en) 1999-01-15 2005-10-31 Altana Pharma Ag Phenanthridine-n-oxides with pde-iv inhibiting activity
ATE294793T1 (de) 1999-01-15 2005-05-15 Altana Pharma Ag Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
JP2003519686A (ja) 2000-01-11 2003-06-24 アルタナ ファルマ アクチエンゲゼルシャフト フェナントリジン−ｎ−オキシド
WO2002066476A1 (en) * 2001-02-21 2002-08-29 Altana Pharma Ag 6-phenylbenzonaphthyridines
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CN1671662A (zh) * 2002-05-31 2005-09-21 武田药品工业株式会社 哌啶衍生物及其制备方法和用途
PL373598A1 (en) * 2002-08-17 2005-09-05 Altana Pharma Ag Novel benzonaphthyridines
US7470704B2 (en) 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
CN104817534A (zh) 2004-03-03 2015-08-05 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
US7671068B2 (en) 2004-03-17 2010-03-02 Nycomed Gmbh N-(alkoxyalkyl) carbamoyl-substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE ¾ inhibitors
US7589205B2 (en) 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
WO2006027344A2 (en) 2004-09-08 2006-03-16 Altana Pharma Ag 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors
JPWO2006030975A1 (ja) * 2004-09-17 2008-05-15 武田薬品工業株式会社 ピペリジン誘導体およびその用途
AU2005318597A1 (en) * 2004-12-20 2006-06-29 F. Hoffmann-La Roche Ag 4-aminopiperidine derivatives
NZ560268A (en) 2005-03-02 2010-12-24 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
JP5383183B2 (ja) 2005-03-16 2014-01-08 タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング ロフルミラストを含有する矯味された剤形
WO2013109738A1 (en) 2012-01-17 2013-07-25 The Trustees Of Columbia University In The City Of New York Novel phosphodiesterase inhibitors and uses thereof
US10899756B2 (en) 2013-07-17 2021-01-26 The Trustees Of Columbia University In The City Of New York Phosphodiesterase inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
BR9713338B1 (pt) 1996-11-11 2009-12-01 benzonaftiridinas, medicamento, bem como seu uso como terapêuticos brÈnquicos.
JP2001514640A (ja) * 1997-03-07 2001-09-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規のテトラゾール
ES2195571T3 (es) 1998-05-05 2003-12-01 Altana Pharma Ag Nuevos benzonaftiridin-n-oxidos.

Also Published As

Publication number Publication date
DE59909760D1 (de) 2004-07-22
AU5970199A (en) 2000-03-21
WO2000012501A1 (de) 2000-03-09
EP1109810A1 (de) 2001-06-27
EP1109810B1 (de) 2004-06-16
US6436952B1 (en) 2002-08-20
ES2224745T3 (es) 2005-03-01
SI1109810T1 (en) 2004-12-31
JP2002523505A (ja) 2002-07-30
CA2342245A1 (en) 2000-03-09
ATE269331T1 (de) 2004-07-15

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