ATE294793T1 - Phenantrhridin-n-oxides mit pde-iv hemmender wirkung - Google Patents

Phenantrhridin-n-oxides mit pde-iv hemmender wirkung

Info

Publication number
ATE294793T1
ATE294793T1 AT00901539T AT00901539T ATE294793T1 AT E294793 T1 ATE294793 T1 AT E294793T1 AT 00901539 T AT00901539 T AT 00901539T AT 00901539 T AT00901539 T AT 00901539T AT E294793 T1 ATE294793 T1 AT E294793T1
Authority
AT
Austria
Prior art keywords
oxides
phenantrhridine
pde
inhibiting effect
compounds
Prior art date
Application number
AT00901539T
Other languages
English (en)
Inventor
Dieter Flockerzi
Hermann Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE294793T1 publication Critical patent/ATE294793T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT00901539T 1999-01-15 2000-01-13 Phenantrhridin-n-oxides mit pde-iv hemmender wirkung ATE294793T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15
PCT/EP2000/000192 WO2000042034A1 (en) 1999-01-15 2000-01-13 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
ATE294793T1 true ATE294793T1 (de) 2005-05-15

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901539T ATE294793T1 (de) 1999-01-15 2000-01-13 Phenantrhridin-n-oxides mit pde-iv hemmender wirkung

Country Status (12)

Country Link
US (1) US6534519B1 (de)
EP (1) EP1147103B1 (de)
JP (1) JP2003502278A (de)
AT (1) ATE294793T1 (de)
AU (1) AU2290000A (de)
CA (1) CA2359449A1 (de)
DE (1) DE60019894T2 (de)
DK (1) DK1147103T3 (de)
ES (1) ES2241571T3 (de)
PT (1) PT1147103E (de)
SI (1) SI1147103T1 (de)
WO (1) WO2000042034A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1147089T1 (sl) * 1999-01-15 2006-04-30 Altana Pharma Ag Fenilfenantridini z inhibirajoco aktivnostjo za PDE-IV
DE60133879D1 (de) 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
DK1303506T3 (da) 2000-07-14 2005-05-30 Altana Pharma Ag 6-heteroarylphenanthridiner
ES2281658T3 (es) 2002-08-29 2007-10-01 Nycomed Gmbh 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
WO2004019944A1 (en) * 2002-08-29 2004-03-11 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
JP2007500686A (ja) * 2003-07-31 2007-01-18 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規の６−フェニルフェナントリジン
EP1658270A1 (de) * 2003-07-31 2006-05-24 ALTANA Pharma AG Neue 6-phenylphenantridine
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
CA2537230A1 (en) * 2003-09-05 2005-03-17 Altana Pharma Ag Use of pde4 inhibitors for the treatment of diabetes mellitus
EP1720835B1 (de) 2004-02-18 2012-12-12 Nycomed GmbH Neue guanidinylsubstituierte hydroxy-6-phenylphenanthridine als wirksame phosphodiesterase-(pde-)4-inhibitoren
ES2505473T3 (es) 2004-03-03 2014-10-10 Takeda Gmbh Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la PDE4
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
AU2005221832A1 (en) * 2004-03-10 2005-09-22 Nycomed Gmbh Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
NZ560268A (en) * 2005-03-02 2010-12-24 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
CN102600144A (zh) 2005-03-08 2012-07-25 奈科明有限责任公司 治疗糖尿病的罗氟司特
CA2699625C (en) 2007-10-04 2016-02-02 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof
EP2804603A1 (de) 2012-01-10 2014-11-26 President and Fellows of Harvard College Betazellen-replikation für promoterverbindungen und verwendungsverfahren dafür

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
BR9707233A (pt) * 1996-01-31 1999-07-20 Byk Gulden Lomberg Chem Fab Fenantridinas
JP4141501B2 (ja) * 1996-03-26 2008-08-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の６位置換フェナントリジン
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
SK283269B6 (sk) 1996-11-11 2003-04-01 Altana Pharma Ag Benzonaftyridíny, farmaceutický prostriedok s ich obsahom a ich použitie
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
US6143759A (en) 1997-03-07 2000-11-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazoles
PT988302E (pt) 1997-06-03 2003-07-31 Altana Pharma Ag Benzonaftiridinas
PL190685B1 (pl) 1997-07-25 2005-12-30 Altana Pharma Ag Nowe pochodne tetrazolu, środek farmaceutyczny oraz zastosowanie
DK1109810T3 (da) 1998-08-31 2004-10-18 Altana Pharma Ag Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet

Also Published As

Publication number Publication date
DK1147103T3 (da) 2005-08-29
DE60019894D1 (de) 2005-06-09
PT1147103E (pt) 2005-08-31
JP2003502278A (ja) 2003-01-21
WO2000042034A1 (en) 2000-07-20
ES2241571T3 (es) 2005-11-01
DE60019894T2 (de) 2006-01-12
US6534519B1 (en) 2003-03-18
EP1147103B1 (de) 2005-05-04
EP1147103A1 (de) 2001-10-24
AU2290000A (en) 2000-08-01
CA2359449A1 (en) 2000-07-20
SI1147103T1 (en) 2005-10-31

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