DK1303506T3 - 6-heteroarylphenanthridiner - Google Patents
6-heteroarylphenanthridinerInfo
- Publication number
- DK1303506T3 DK1303506T3 DK01962844T DK01962844T DK1303506T3 DK 1303506 T3 DK1303506 T3 DK 1303506T3 DK 01962844 T DK01962844 T DK 01962844T DK 01962844 T DK01962844 T DK 01962844T DK 1303506 T3 DK1303506 T3 DK 1303506T3
- Authority
- DK
- Denmark
- Prior art keywords
- heteroatoms
- unsubstituted
- radical
- substituted
- pyradazinyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00115352 | 2000-07-14 | ||
| PCT/EP2001/007818 WO2002006270A1 (en) | 2000-07-14 | 2001-07-07 | Novel 6-heteroarylphenanthridines |
| EP01962844A EP1303506B1 (en) | 2000-07-14 | 2001-07-07 | 6-heteroarylphenanthridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1303506T3 true DK1303506T3 (da) | 2005-05-30 |
Family
ID=8169276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01962844T DK1303506T3 (da) | 2000-07-14 | 2001-07-07 | 6-heteroarylphenanthridiner |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6884802B2 (da) |
| EP (1) | EP1303506B1 (da) |
| JP (1) | JP2004504316A (da) |
| AT (1) | ATE288430T1 (da) |
| AU (2) | AU2001283935B2 (da) |
| CA (1) | CA2415935A1 (da) |
| DE (1) | DE60108758T2 (da) |
| DK (1) | DK1303506T3 (da) |
| ES (1) | ES2236288T3 (da) |
| PT (1) | PT1303506E (da) |
| SI (1) | SI1303506T1 (da) |
| WO (1) | WO2002006270A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL374014A1 (en) * | 2002-08-17 | 2005-09-19 | Altana Pharma Ag | Novel phenanthridines having pde 3/4 inhibiting properties |
| ES2281658T3 (es) | 2002-08-29 | 2007-10-01 | Nycomed Gmbh | 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4. |
| AU2005206437B2 (en) | 2004-01-23 | 2010-08-12 | Mitsui Chemicals Agro, Inc. | 3-(dihydro(tetrahydro)isoquinolin-1-yl)quinolines |
| EP1720835B1 (en) | 2004-02-18 | 2012-12-12 | Nycomed GmbH | Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors |
| ES2427256T3 (es) * | 2004-03-03 | 2013-10-30 | Takeda Gmbh | Nuevas hidroxi-6-heteroaril-fenantridinas y su uso como agentes inhibidores de la PDE4 |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| BRPI0508481A (pt) * | 2004-03-10 | 2007-07-31 | Altana Pharma Ag | hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4 |
| ES2337083T3 (es) | 2005-03-02 | 2010-04-20 | Nycomed Gmbh | (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1. |
| EP1856092A1 (en) * | 2005-03-02 | 2007-11-21 | Nycomed GmbH | 6-heteroaryl-1,2,3,4,4a,10b-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders |
| ATE525375T1 (de) * | 2007-03-13 | 2011-10-15 | Merck Sharp & Dohme | Hemmer von janus-kinasen und/oder 3- phosphoinositid-abhängiger protein-kinase 1 |
| NO340563B1 (no) * | 2016-09-05 | 2017-05-15 | Takeda Gmbh | Nye salter av 6-heterocyklylsubstituerte heksahydrofenantridinderivater |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE03523B1 (et) | 1996-01-31 | 2001-10-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine |
| DE59708265D1 (de) * | 1996-03-26 | 2002-10-24 | Altana Pharma Ag | Neue in 6-position substituierte phenanthridine |
| US6121279A (en) * | 1997-07-25 | 2000-09-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted 6-phenylphenanthridines |
| HUP0002510A3 (en) | 1997-07-25 | 2002-10-28 | Altana Pharma Ag | Tetrazole derivatives and pharmaceutical compositions containing them |
| DE69808099T2 (de) | 1997-07-25 | 2003-05-15 | Altana Pharma Ag | Substituierte 6-alkylphenanthridine |
| DK1147103T3 (da) | 1999-01-15 | 2005-08-29 | Altana Pharma Ag | Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet |
| AU2904300A (en) | 1999-01-15 | 2000-08-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity |
| AU2107700A (en) | 1999-01-15 | 2000-08-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| US6479505B1 (en) | 1999-01-15 | 2002-11-12 | Altana Pharma Ag | 6-arylphenanthridines with PDE-IV inhibiting activity |
| EP1250325B1 (en) | 2000-01-11 | 2008-05-07 | Nycomed GmbH | Phenanthridine-n-oxides |
-
2001
- 2001-07-07 EP EP01962844A patent/EP1303506B1/en not_active Expired - Lifetime
- 2001-07-07 DK DK01962844T patent/DK1303506T3/da active
- 2001-07-07 JP JP2002512173A patent/JP2004504316A/ja active Pending
- 2001-07-07 ES ES01962844T patent/ES2236288T3/es not_active Expired - Lifetime
- 2001-07-07 US US10/297,765 patent/US6884802B2/en not_active Expired - Fee Related
- 2001-07-07 WO PCT/EP2001/007818 patent/WO2002006270A1/en active IP Right Grant
- 2001-07-07 DE DE60108758T patent/DE60108758T2/de not_active Expired - Fee Related
- 2001-07-07 CA CA002415935A patent/CA2415935A1/en not_active Abandoned
- 2001-07-07 AU AU2001283935A patent/AU2001283935B2/en not_active Ceased
- 2001-07-07 SI SI200130330T patent/SI1303506T1/xx unknown
- 2001-07-07 PT PT01962844T patent/PT1303506E/pt unknown
- 2001-07-07 AU AU8393501A patent/AU8393501A/xx active Pending
- 2001-07-07 AT AT01962844T patent/ATE288430T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002006270A1 (en) | 2002-01-24 |
| CA2415935A1 (en) | 2002-01-24 |
| US20040038979A1 (en) | 2004-02-26 |
| JP2004504316A (ja) | 2004-02-12 |
| EP1303506A1 (en) | 2003-04-23 |
| DE60108758T2 (de) | 2006-04-27 |
| AU2001283935B2 (en) | 2006-07-13 |
| PT1303506E (pt) | 2005-06-30 |
| SI1303506T1 (en) | 2005-06-30 |
| ES2236288T3 (es) | 2005-07-16 |
| US6884802B2 (en) | 2005-04-26 |
| AU8393501A (en) | 2002-01-30 |
| ATE288430T1 (de) | 2005-02-15 |
| DE60108758D1 (de) | 2005-03-10 |
| EP1303506B1 (en) | 2005-02-02 |
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