ATE295352T1 - Phenanthridine-n-oxide mit pde-iv hemmender wirkung - Google Patents

Phenanthridine-n-oxide mit pde-iv hemmender wirkung

Info

Publication number
ATE295352T1
ATE295352T1 AT00901089T AT00901089T ATE295352T1 AT E295352 T1 ATE295352 T1 AT E295352T1 AT 00901089 T AT00901089 T AT 00901089T AT 00901089 T AT00901089 T AT 00901089T AT E295352 T1 ATE295352 T1 AT E295352T1
Authority
AT
Austria
Prior art keywords
oxides
phenanthridine
pde
inhibiting effect
compounds
Prior art date
Application number
AT00901089T
Other languages
English (en)
Inventor
Dieter Flockerzi
Hermann Di Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Gutterer
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE295352T1 publication Critical patent/ATE295352T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT00901089T 1999-01-15 2000-01-12 Phenanthridine-n-oxide mit pde-iv hemmender wirkung ATE295352T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100707 1999-01-15
PCT/EP2000/000150 WO2000042017A1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
ATE295352T1 true ATE295352T1 (de) 2005-05-15

Family

ID=8237354

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901089T ATE295352T1 (de) 1999-01-15 2000-01-12 Phenanthridine-n-oxide mit pde-iv hemmender wirkung

Country Status (12)

Country Link
US (1) US6538005B2 (de)
EP (1) EP1147087B1 (de)
JP (1) JP2002534505A (de)
AT (1) ATE295352T1 (de)
AU (1) AU2107700A (de)
CA (1) CA2359404A1 (de)
DE (1) DE60020079T2 (de)
DK (1) DK1147087T3 (de)
ES (1) ES2242594T3 (de)
PT (1) PT1147087E (de)
SI (1) SI1147087T1 (de)
WO (1) WO2000042017A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1152864C (zh) * 1999-01-15 2004-06-09 奥坦纳医药公司 具有pde-iv抑制活性的苯基菲啶类化合物
US6630483B2 (en) 2000-01-11 2003-10-07 Altana Pharma Ag Phenanthridine-N-oxides
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
JP4587295B2 (ja) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての３−ヒドロキシ−６−フェニルフェナントリジン
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
KR101152439B1 (ko) 2004-03-03 2012-07-06 니코메드 게엠베하 신규 히드록시-6-헤테로아릴페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
AU2005221832A1 (en) * 2004-03-10 2005-09-22 Nycomed Gmbh Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors
WO2006027345A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
PT1856093E (pt) 2005-03-02 2010-02-08 Nycomed Gmbh Sal hcl de (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-etoxi- 8-metoxi-1,2,3,4,4a,10b-hexa-hidrofenantridin-2-ol
AU2006221957A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
MX2010003155A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de ciclopropil aril amida y uso de los mismos.
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
ES2184077T3 (es) * 1996-03-26 2003-04-01 Altana Pharma Ag Nuevas fenantridinas sustituidas en la posicion 6.
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
SI0937074T1 (en) * 1996-11-11 2003-08-31 Altana Pharma Ag Benzonaphthyridines as bronchial therapeutics
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
JP2001514640A (ja) 1997-03-07 2001-09-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規のテトラゾール
SI0988302T1 (en) * 1997-06-03 2003-08-31 Altana Pharma Ag Benzonaphthyridines
SI0998460T1 (en) 1997-07-25 2004-08-31 Altana Pharma Ag Novel tetrazole derivatives
IL133825A (en) * 1997-07-25 2005-12-18 Altana Pharma Ag Substituted 6-phenylphenanthridines, medicaments containing same and use thereof in the production of medicaments
WO2000012501A1 (de) 1998-08-31 2000-03-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität

Also Published As

Publication number Publication date
DE60020079T2 (de) 2006-01-19
US6538005B2 (en) 2003-03-25
AU2107700A (en) 2000-08-01
SI1147087T1 (en) 2005-10-31
EP1147087B1 (de) 2005-05-11
EP1147087A1 (de) 2001-10-24
JP2002534505A (ja) 2002-10-15
PT1147087E (pt) 2005-09-30
ES2242594T3 (es) 2005-11-16
DE60020079D1 (de) 2005-06-16
DK1147087T3 (da) 2005-09-05
WO2000042017A1 (en) 2000-07-20
CA2359404A1 (en) 2000-07-20
US20020183350A1 (en) 2002-12-05

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