DK1147087T3 - Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet - Google Patents

Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet

Info

Publication number
DK1147087T3
DK1147087T3 DK00901089T DK00901089T DK1147087T3 DK 1147087 T3 DK1147087 T3 DK 1147087T3 DK 00901089 T DK00901089 T DK 00901089T DK 00901089 T DK00901089 T DK 00901089T DK 1147087 T3 DK1147087 T3 DK 1147087T3
Authority
DK
Denmark
Prior art keywords
oxides
phenanthridine
pde
inhibitory activity
compounds
Prior art date
Application number
DK00901089T
Other languages
English (en)
Inventor
Dieter Flockerzi
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Gutterer
Hermann Di Amschler
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK1147087T3 publication Critical patent/DK1147087T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK00901089T 1999-01-15 2000-01-12 Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet DK1147087T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100707 1999-01-15
PCT/EP2000/000150 WO2000042017A1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity
EP00901089A EP1147087B1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
DK1147087T3 true DK1147087T3 (da) 2005-09-05

Family

ID=8237354

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00901089T DK1147087T3 (da) 1999-01-15 2000-01-12 Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet

Country Status (12)

Country Link
US (1) US6538005B2 (da)
EP (1) EP1147087B1 (da)
JP (1) JP2002534505A (da)
AT (1) ATE295352T1 (da)
AU (1) AU2107700A (da)
CA (1) CA2359404A1 (da)
DE (1) DE60020079T2 (da)
DK (1) DK1147087T3 (da)
ES (1) ES2242594T3 (da)
PT (1) PT1147087E (da)
SI (1) SI1147087T1 (da)
WO (1) WO2000042017A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042020A1 (en) * 1999-01-15 2000-07-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenylphenanthridines with pde-iv inhibiting activity
DE60133879D1 (de) 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
AU2001269126A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Phenanthridine n-oxides
DE60108758T2 (de) 2000-07-14 2006-04-27 Altana Pharma Ag 6-heteroarylphenanthridine
ES2281658T3 (es) 2002-08-29 2007-10-01 Nycomed Gmbh 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
JP4728259B2 (ja) 2004-02-18 2011-07-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
WO2005085225A1 (en) 2004-03-03 2005-09-15 Altana Pharma Ag Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
EP1725534A1 (en) * 2004-03-10 2006-11-29 Altana Pharma AG Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
US7589205B2 (en) * 2004-09-08 2009-09-15 Nycomed Gmbh 3-thia-10-aza-phenanthrene derivatives
NZ560268A (en) 2005-03-02 2010-12-24 Nycomed Gmbh Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
CA2599368A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
JP5362729B2 (ja) 2007-10-04 2013-12-11 エフ．ホフマン−ラ ロシュ アーゲー シクロプロピルアリールアミド誘導体及びその使用
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
PT882021E (pt) * 1996-01-31 2003-07-31 Altana Pharma Ag Novas fenantridinas
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
CA2250569C (en) * 1996-03-26 2005-05-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel phenanthridines substituted in the 6 position
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
ES2195189T3 (es) * 1996-11-11 2003-12-01 Altana Pharma Ag Benzonaftiridinas como agentes terapeuticos bronquiales.
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
US6143759A (en) 1997-03-07 2000-11-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazoles
WO1998055481A1 (en) * 1997-06-03 1998-12-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
CA2297911C (en) * 1997-07-25 2007-09-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 6-phenylphenanthridines
SI0998460T1 (en) 1997-07-25 2004-08-31 Altana Pharma Ag Novel tetrazole derivatives
DK1109810T3 (da) 1998-08-31 2004-10-18 Altana Pharma Ag Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet

Also Published As

Publication number Publication date
EP1147087A1 (en) 2001-10-24
US20020183350A1 (en) 2002-12-05
JP2002534505A (ja) 2002-10-15
DE60020079D1 (de) 2005-06-16
ES2242594T3 (es) 2005-11-16
DE60020079T2 (de) 2006-01-19
ATE295352T1 (de) 2005-05-15
PT1147087E (pt) 2005-09-30
SI1147087T1 (en) 2005-10-31
CA2359404A1 (en) 2000-07-20
US6538005B2 (en) 2003-03-25
WO2000042017A1 (en) 2000-07-20
AU2107700A (en) 2000-08-01
EP1147087B1 (en) 2005-05-11

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