PT882021E - Novas fenantridinas - Google Patents

Novas fenantridinas

Info

Publication number
PT882021E
PT882021E PT97904354T PT97904354T PT882021E PT 882021 E PT882021 E PT 882021E PT 97904354 T PT97904354 T PT 97904354T PT 97904354 T PT97904354 T PT 97904354T PT 882021 E PT882021 E PT 882021E
Authority
PT
Portugal
Prior art keywords
new
phenantridines
compounds
formula
description
Prior art date
Application number
PT97904354T
Other languages
English (en)
Inventor
Rolf Beume
Dietrich Hafner
Hans-Peter Kley
Thomas Bar
Thomas Martin
Wolf-Rudiger Ulrich
Dieter Flockerzi
Beate Schmidt
Armin Hatzelmann
Hildegard Boss
Hermann Amschler
Karl-Josef Goebel
Christian Schudt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19603321A external-priority patent/DE19603321A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of PT882021E publication Critical patent/PT882021E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
PT97904354T 1996-01-31 1997-01-30 Novas fenantridinas PT882021E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19603321A DE19603321A1 (de) 1996-01-31 1996-01-31 Neue Phenanthridine
EP96101791 1996-02-08

Publications (1)

Publication Number Publication Date
PT882021E true PT882021E (pt) 2003-07-31

Family

ID=26022482

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97904354T PT882021E (pt) 1996-01-31 1997-01-30 Novas fenantridinas

Country Status (19)

Country Link
US (1) US6191138B1 (pt)
EP (1) EP0882021B1 (pt)
JP (1) JP4138003B2 (pt)
KR (1) KR100454781B1 (pt)
AT (1) ATE233735T1 (pt)
BR (1) BR9707233A (pt)
CA (1) CA2245142C (pt)
CY (1) CY2473B1 (pt)
CZ (1) CZ289340B6 (pt)
DE (1) DE59709437D1 (pt)
DK (1) DK0882021T3 (pt)
EA (1) EA001205B1 (pt)
EE (1) EE03523B1 (pt)
ES (1) ES2194180T3 (pt)
HU (1) HU221380B1 (pt)
PT (1) PT882021E (pt)
SI (1) SI0882021T1 (pt)
UA (1) UA48216C2 (pt)
WO (1) WO1997028131A1 (pt)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0882021T3 (da) * 1996-01-31 2003-06-23 Altana Pharma Ag Nye phenanthridiner
ATE260899T1 (de) * 1997-07-25 2004-03-15 Altana Pharma Ag Neue tetrazolderivate
CA2297911C (en) * 1997-07-25 2007-09-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 6-phenylphenanthridines
GB9828340D0 (en) * 1998-12-22 1999-02-17 Novartis Ag Organic compounds
KR100720906B1 (ko) * 1999-01-15 2007-05-25 알타나 파마 아게 Ｐｄｅ-ｉｖ 억제 활성을 갖는 페닐페난트리딘
WO2000042017A1 (en) * 1999-01-15 2000-07-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides with pde-iv inhibiting activity
WO2000042018A1 (en) * 1999-01-15 2000-07-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
PT1147088E (pt) * 1999-01-15 2006-05-31 Altana Pharma Ag 6-arilfenantridinas com actividade inibitoria da pde-iv
ATE294793T1 (de) 1999-01-15 2005-05-15 Altana Pharma Ag Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
PT1212089E (pt) 1999-08-21 2006-08-31 Altana Pharma Ag Combinacao sinergica de roflumilast e salmeterol
WO2001051470A1 (en) * 2000-01-11 2001-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides
AU2001267589A1 (en) * 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
DK1303506T3 (da) * 2000-07-14 2005-05-30 Altana Pharma Ag 6-heteroarylphenanthridiner
WO2002005616A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines
EP1316316B1 (en) * 2000-09-06 2012-04-04 Mitsubishi Tanabe Pharma Corporation Preparations for oral administration
CA2437754C (en) * 2001-02-15 2010-05-18 Tanabe Seiyaku Co., Ltd. Tablets quickly disintegrated in oral cavity
JP2005537312A (ja) * 2002-08-17 2005-12-08 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のフェナントリジン
JP4587294B2 (ja) 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
WO2005012253A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenanthridines
EP1658270A1 (en) * 2003-07-31 2006-05-24 ALTANA Pharma AG Novel 6-phenylphenantridines
MXPA06002521A (es) * 2003-09-05 2006-06-20 Altana Pharma Ag Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus.
AU2005212857B2 (en) 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
BRPI0508321B1 (pt) 2004-03-03 2018-02-06 Takeda Gmbh Hidróxi-6-heteroarilfenantridinas, seu uso e composições farmacêuticas que as compreende
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
US20070191414A1 (en) * 2004-03-09 2007-08-16 Altana Pharma Ag Novel isoamido-substituted hydroxy-6-phenylphenanthridines
WO2005085203A1 (en) * 2004-03-10 2005-09-15 Altana Pharma Ag Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
MXPA06009892A (es) * 2004-03-10 2007-03-01 Altana Pharma Ag Nuevas hidroxi-6-fenilfenantridinas sustituidas con amido y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4).
US20080161339A1 (en) * 2004-03-10 2008-07-03 Altana Pharma Ag Novel Thio-Containing Hydroxy-6-Phenylphenanthridines and their Use as Pde4 Inhibitors
AU2005281703B2 (en) * 2004-09-08 2011-11-17 Takeda Gmbh Novel 3-thia-10-aza-phenanthrene derivatives
WO2006027344A2 (en) 2004-09-08 2006-03-16 Altana Pharma Ag 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors
US7411093B2 (en) 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
KR101421914B1 (ko) 2005-03-02 2014-07-22 다케다 게엠베하 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염
JP5091106B2 (ja) 2005-03-08 2012-12-05 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 真性糖尿病の治療のためのロフルミラスト
EA200701813A1 (ru) * 2005-03-09 2008-06-30 Никомед Гмбх Новые амидозамещенные 6-фенилфенантридины
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP1942879A1 (en) 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP1991212A1 (en) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
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CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
BRPI0716604A2 (pt) * 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
CA2663347A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. Ppar mediated modulation of neurogenesis
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AU2008259841B2 (en) 2007-05-31 2015-02-05 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
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KR101067069B1 (ko) * 2009-03-09 2011-09-22 부경대학교 산학협력단 트리플루오로아세트산을 이용한 페난트리딘 유도체의 제조방법
CN102179655B (zh) * 2011-06-01 2013-09-04 柳州市久日工程机械有限公司 履带梁拼搭气动工装
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JP7234470B2 (ja) 2015-10-30 2023-03-08 トーヨーカネツ株式会社 立体自動倉庫

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Publication number Priority date Publication date Assignee Title
BE786031A (fr) * 1971-07-08 1973-01-08 Rhone Poulenc Sa Nouveaux derives de la phenanthridine, leur preparation et les compositions medicinales qui les contiennent
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof
DK0882021T3 (da) * 1996-01-31 2003-06-23 Altana Pharma Ag Nye phenanthridiner

Also Published As

Publication number Publication date
HU221380B1 (en) 2002-09-28
EA199800667A1 (ru) 1999-02-25
EP0882021B1 (de) 2003-03-05
KR100454781B1 (ko) 2005-04-08
DE59709437D1 (de) 2003-04-10
DK0882021T3 (da) 2003-06-23
KR19990082143A (ko) 1999-11-15
UA48216C2 (uk) 2002-08-15
HUP9900666A2 (hu) 1999-06-28
CZ289340B6 (cs) 2002-01-16
CZ241498A3 (cs) 1998-12-16
WO1997028131A1 (de) 1997-08-07
ATE233735T1 (de) 2003-03-15
EA001205B1 (ru) 2000-12-25
JP2000503996A (ja) 2000-04-04
CY2473B1 (en) 2005-06-03
HUP9900666A3 (en) 2000-04-28
EE9800223A (et) 1998-12-15
SI0882021T1 (en) 2003-10-31
CA2245142A1 (en) 1997-08-07
US6191138B1 (en) 2001-02-20
EP0882021A1 (de) 1998-12-09
BR9707233A (pt) 1999-07-20
ES2194180T3 (es) 2003-11-16
CA2245142C (en) 2004-11-30
JP4138003B2 (ja) 2008-08-20
EE03523B1 (et) 2001-10-15

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