PT1147103E - Fenantridina-n-oxidos com actividade inibitoria de pde-iv - Google Patents

Fenantridina-n-oxidos com actividade inibitoria de pde-iv

Info

Publication number
PT1147103E
PT1147103E PT00901539T PT00901539T PT1147103E PT 1147103 E PT1147103 E PT 1147103E PT 00901539 T PT00901539 T PT 00901539T PT 00901539 T PT00901539 T PT 00901539T PT 1147103 E PT1147103 E PT 1147103E
Authority
PT
Portugal
Prior art keywords
fenantridine
pde
oxides
inhibitors activity
inhibitors
Prior art date
Application number
PT00901539T
Other languages
English (en)
Inventor
Rolf Beume
Hildegard Boss
Dieter Flockerzi
Beate Schmidt
Armin Hatzelmann
Hermann Amschler
Kley Hans-Peter
Bundschuh Daniela
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP99100693 priority Critical
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of PT1147103E publication Critical patent/PT1147103E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PT00901539T 1999-01-15 2000-01-13 Fenantridina-n-oxidos com actividade inibitoria de pde-iv PT1147103E (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15

Publications (1)

Publication Number Publication Date
PT1147103E true PT1147103E (pt) 2005-08-31

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00901539T PT1147103E (pt) 1999-01-15 2000-01-13 Fenantridina-n-oxidos com actividade inibitoria de pde-iv

Country Status (12)

Country Link
US (1) US6534519B1 (pt)
EP (1) EP1147103B1 (pt)
JP (1) JP2003502278A (pt)
AT (1) AT294793T (pt)
AU (1) AU2290000A (pt)
CA (1) CA2359449A1 (pt)
DE (1) DE60019894T2 (pt)
DK (1) DK1147103T3 (pt)
ES (1) ES2241571T3 (pt)
PT (1) PT1147103E (pt)
SI (1) SI1147103T1 (pt)
WO (1) WO2000042034A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ300366B6 (cs) * 1999-01-15 2009-05-06 Nycomed Gmbh Fenylfenanthridinová sloucenina, farmaceutický prostredek s jejím obsahem a její použití
DE60133879D1 (de) 2000-01-11 2008-06-19 Nycomed Gmbh Phenanthridin -n- oxide
AT288430T (de) 2000-07-14 2005-02-15 Altana Pharma Ag 6-heteroarylphenanthridine
DE60311662T2 (de) 2002-08-29 2007-10-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
JP4587294B2 (ja) * 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツングNycomed GmbH Pde4インヒビターとしての2−ヒドロキシ−6−フェニルフェナントリジン
CA2533635A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenantridines
WO2005012253A1 (en) * 2003-07-31 2005-02-10 Altana Pharma Ag Novel 6-phenylphenanthridines
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
US7776893B2 (en) 2003-09-05 2010-08-17 Nycomed Gmbh Use of PDE4 inhibitors for the treatment of diabetes mellitus
ES2400823T3 (es) 2004-02-18 2013-04-12 Takeda Gmbh Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
CA2557752C (en) 2004-03-03 2012-10-02 Altana Pharma Ag Hydroxy-6-heteroaryl-phenanthridines and their use as pde4 inhibitors
BRPI0508481A (pt) * 2004-03-10 2007-07-31 Altana Pharma Ag hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4
KR101421914B1 (ko) 2005-03-02 2014-07-22 다케다 게엠베하 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염
CA2599376C (en) 2005-03-08 2014-05-13 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
WO2009043784A1 (en) 2007-10-04 2009-04-09 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
BR9707233A (pt) 1996-01-31 1999-07-20 Byk Gulden Lomberg Chem Fab Fenantridinas
EP0889886B1 (de) * 1996-03-26 2002-09-18 ALTANA Pharma AG Neue in 6-position substituierte phenanthridine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
AU733129B2 (en) 1996-11-11 2001-05-10 Takeda Gmbh Benzonaphthyridines as bronchial therapeutics
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
US6143759A (en) 1997-03-07 2000-11-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazoles
DE69811492T2 (de) 1997-06-03 2004-02-05 Altana Pharma Ag Benzonaphthyridine
US6410551B1 (en) 1997-07-25 2002-06-25 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrazole derivatives
US6436952B1 (en) 1998-08-31 2002-08-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-N-oxides comprising a PDE3 and PDE4 inhibiting activity

Also Published As

Publication number Publication date
CA2359449A1 (en) 2000-07-20
AU2290000A (en) 2000-08-01
DK1147103T3 (da) 2005-08-29
AT294793T (de) 2005-05-15
EP1147103B1 (en) 2005-05-04
ES2241571T3 (es) 2005-11-01
JP2003502278A (ja) 2003-01-21
WO2000042034A1 (en) 2000-07-20
DE60019894D1 (de) 2005-06-09
EP1147103A1 (en) 2001-10-24
DE60019894T2 (de) 2006-01-12
SI1147103T1 (en) 2005-10-31
US6534519B1 (en) 2003-03-18

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