MXPA02012263A - 5-aminoalquil-pirazol[4,3-d]pirimidinas. - Google Patents

5-aminoalquil-pirazol[4,3-d]pirimidinas.

Info

Publication number
MXPA02012263A
MXPA02012263A MXPA02012263A MXPA02012263A MXPA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A
Authority
MX
Mexico
Prior art keywords
pyrazolo
phosphodiesterase
pyrimidines
inhibiting effect
aminoalkyl
Prior art date
Application number
MXPA02012263A
Other languages
English (en)
Inventor
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MXPA02012263A publication Critical patent/MXPA02012263A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere a 5-aminoalquil- pirazol [4,3-d]pirimidinas de la Formula general (I) (ver formula) en la cual los radicales R1 a R6 tienen el significado que se indica en el texto. Los compuestos exhiben un efecto inhibidor de la fosfodiesterasa V y pueden ser utilizados para el tratamiento de enfermedades del sistema cardiocirculatorio y para el tratamiento de trastornos de la potencia.
MXPA02012263A 2000-06-29 2001-06-28 5-aminoalquil-pirazol[4,3-d]pirimidinas. MXPA02012263A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10031584A DE10031584A1 (de) 2000-06-29 2000-06-29 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
PCT/EP2001/007378 WO2002000660A1 (de) 2000-06-29 2001-06-28 5-aminoalkyl-pyrazolo[4,3-d]pyrimidine mit phosphodiesterase v inhibierender wirkung

Publications (1)

Publication Number Publication Date
MXPA02012263A true MXPA02012263A (es) 2003-04-25

Family

ID=7647151

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02012263A MXPA02012263A (es) 2000-06-29 2001-06-28 5-aminoalquil-pirazol[4,3-d]pirimidinas.

Country Status (21)

Country Link
US (1) US7060823B2 (es)
EP (1) EP1296986B1 (es)
JP (1) JP4964388B2 (es)
KR (1) KR20030017558A (es)
CN (1) CN1439011A (es)
AR (1) AR028772A1 (es)
AT (1) ATE519761T1 (es)
AU (2) AU2001279700B2 (es)
BR (1) BR0111915A (es)
CA (1) CA2410399C (es)
CZ (1) CZ20024054A3 (es)
DE (1) DE10031584A1 (es)
ES (1) ES2367704T3 (es)
HU (1) HUP0301587A3 (es)
MX (1) MXPA02012263A (es)
NO (1) NO20026247L (es)
PL (1) PL358551A1 (es)
RU (1) RU2271359C2 (es)
SK (1) SK17632002A3 (es)
WO (1) WO2002000660A1 (es)
ZA (1) ZA200209728B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
UA80871C2 (en) * 2003-04-29 2007-11-12 Pfizer Ltd 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the treatment of hypertension
EP1620437B1 (en) 2003-04-29 2009-06-17 Pfizer Limited 5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
ATE417849T1 (de) * 2004-04-07 2009-01-15 Pfizer Pyrazoloä4,3-düpyrimidine
CA2585557C (en) * 2004-10-28 2009-08-18 Pharmacia & Upjohn Company Llc Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors
KR100939890B1 (ko) 2005-05-12 2010-01-29 화이자 인코포레이티드 Ｎ-[1-(2-에톡시에틸)-5-(Ｎ-에틸-Ｎ-메틸아미노)-7-(4-메틸피리딘-2-일-아미노)-1Ｈ-피라졸로[4,3-ｄ]피리미딘-3-카르보닐]메탄술폰아미드의 무수 결정 형태
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
DE102012200360A1 (de) * 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
CA2782774A1 (en) * 2012-07-06 2014-01-06 Pharmascience Inc. Protein kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075310A (en) 1988-07-01 1991-12-24 Smith Kline & French Laboratories, Ltd. Pyrimidone derivatives as bronchodilators
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9423911D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
US5869486A (en) 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19752952A1 (de) 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE19942474A1 (de) 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine

Also Published As

Publication number Publication date
DE10031584A1 (de) 2002-01-10
ES2367704T3 (es) 2011-11-07
AU2001279700B2 (en) 2006-08-24
NO20026247D0 (no) 2002-12-27
SK17632002A3 (sk) 2003-05-02
JP2004501921A (ja) 2004-01-22
PL358551A1 (en) 2004-08-09
KR20030017558A (ko) 2003-03-03
HUP0301587A3 (en) 2005-11-28
RU2271359C2 (ru) 2006-03-10
EP1296986A1 (de) 2003-04-02
EP1296986B1 (de) 2011-08-10
BR0111915A (pt) 2003-05-13
CA2410399C (en) 2010-02-16
AR028772A1 (es) 2003-05-21
AU7970001A (en) 2002-01-08
CA2410399A1 (en) 2002-01-03
CZ20024054A3 (cs) 2003-04-16
ZA200209728B (en) 2004-03-12
NO20026247L (no) 2002-12-27
WO2002000660A1 (de) 2002-01-03
CN1439011A (zh) 2003-08-27
HUP0301587A2 (hu) 2003-09-29
ATE519761T1 (de) 2011-08-15
US7060823B2 (en) 2006-06-13
US20040029900A1 (en) 2004-02-12
JP4964388B2 (ja) 2012-06-27

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