AR028772A1 - 5-aminoalquil-pirazol[4,3-d] pirimidinas - Google Patents

5-aminoalquil-pirazol[4,3-d] pirimidinas

Info

Publication number
AR028772A1
AR028772A1 ARP010103144A ARP010103144A AR028772A1 AR 028772 A1 AR028772 A1 AR 028772A1 AR P010103144 A ARP010103144 A AR P010103144A AR P010103144 A ARP010103144 A AR P010103144A AR 028772 A1 AR028772 A1 AR 028772A1
Authority
AR
Argentina
Prior art keywords
aminoalquil
pyrimidins
pirazol
treatment
pyrimidines
Prior art date
Application number
ARP010103144A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR028772A1 publication Critical patent/AR028772A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

5-aminometil-pirazol[4,3-d] pirimidinas de formula general (1), donde los radicales R1 a R6 tienen el significado que se indica en el texto. Los compuestos son inhibidores-V de la fosfodiesterasa y pueden ser utilizados para el tratamiento de enfermedades del sistema cardiocirculatorio y para el tratamiento de trastornos de la potencia.
ARP010103144A 2000-06-29 2001-06-29 5-aminoalquil-pirazol[4,3-d] pirimidinas AR028772A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10031584A DE10031584A1 (de) 2000-06-29 2000-06-29 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine

Publications (1)

Publication Number Publication Date
AR028772A1 true AR028772A1 (es) 2003-05-21

Family

ID=7647151

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103144A AR028772A1 (es) 2000-06-29 2001-06-29 5-aminoalquil-pirazol[4,3-d] pirimidinas

Country Status (21)

Country Link
US (1) US7060823B2 (es)
EP (1) EP1296986B1 (es)
JP (1) JP4964388B2 (es)
KR (1) KR20030017558A (es)
CN (1) CN1439011A (es)
AR (1) AR028772A1 (es)
AT (1) ATE519761T1 (es)
AU (2) AU7970001A (es)
BR (1) BR0111915A (es)
CA (1) CA2410399C (es)
CZ (1) CZ20024054A3 (es)
DE (1) DE10031584A1 (es)
ES (1) ES2367704T3 (es)
HU (1) HUP0301587A3 (es)
MX (1) MXPA02012263A (es)
NO (1) NO20026247L (es)
PL (1) PL358551A1 (es)
RU (1) RU2271359C2 (es)
SK (1) SK17632002A3 (es)
WO (1) WO2002000660A1 (es)
ZA (1) ZA200209728B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
OA13050A (en) 2003-04-29 2006-11-10 Pfizer Ltd 5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension.
UA80871C2 (en) * 2003-04-29 2007-11-12 Pfizer Ltd 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the treatment of hypertension
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
EP1742950B1 (en) * 2004-04-07 2008-12-17 Pfizer Limited Pyrazolo[4,3-d] pyrimidines
CA2585557C (en) * 2004-10-28 2009-08-18 Pharmacia & Upjohn Company Llc Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors
NZ564187A (en) 2005-05-12 2010-03-26 Pfizer Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
DE102012200360A1 (de) * 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
CA2782774A1 (en) * 2012-07-06 2014-01-06 Pharmascience Inc. Protein kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075310A (en) * 1988-07-01 1991-12-24 Smith Kline & French Laboratories, Ltd. Pyrimidone derivatives as bronchodilators
JP2657760B2 (ja) 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
GB9423911D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19752952A1 (de) 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine

Also Published As

Publication number Publication date
HUP0301587A3 (en) 2005-11-28
HUP0301587A2 (hu) 2003-09-29
AU2001279700B2 (en) 2006-08-24
NO20026247D0 (no) 2002-12-27
JP4964388B2 (ja) 2012-06-27
US20040029900A1 (en) 2004-02-12
CZ20024054A3 (cs) 2003-04-16
CN1439011A (zh) 2003-08-27
KR20030017558A (ko) 2003-03-03
CA2410399C (en) 2010-02-16
CA2410399A1 (en) 2002-01-03
MXPA02012263A (es) 2003-04-25
ATE519761T1 (de) 2011-08-15
NO20026247L (no) 2002-12-27
RU2271359C2 (ru) 2006-03-10
US7060823B2 (en) 2006-06-13
AU7970001A (en) 2002-01-08
ZA200209728B (en) 2004-03-12
SK17632002A3 (sk) 2003-05-02
PL358551A1 (en) 2004-08-09
JP2004501921A (ja) 2004-01-22
ES2367704T3 (es) 2011-11-07
BR0111915A (pt) 2003-05-13
EP1296986A1 (de) 2003-04-02
WO2002000660A1 (de) 2002-01-03
DE10031584A1 (de) 2002-01-10
EP1296986B1 (de) 2011-08-10

Similar Documents

Publication Publication Date Title
UY26958A1 (es) Nuevos agentes anticolinérgicos que se pueden emplear como medicamentos así como procedimiento para su preparación
ES2192213T3 (es) Arilalquil-diazinonas como inhibidores de fosfodiesterasa iv.
UY26981A1 (es) Inhibidores de metaloproteinasa del tipo pirimidin-2,4,6-triona
UY26957A1 (es) Nuevos agentes anticolinérgicos que se pueden emplear como medicamentos así como procedimiento para su preparación
AR027355A1 (es) Acidos tiazolidincarboxilicos
AR028772A1 (es) 5-aminoalquil-pirazol[4,3-d] pirimidinas
CR6565A (es) Pirimidina-2,4,6-trionas inhibidores de metloproteinas
ECSP034774A (es) Pirazolopirimmidinas como agentes terapeuticos
ECSP034773A (es) Pirazolopirimmidinas como agentes terapeuticos
ES2191192T3 (es) Tienopirimidinas.
ECSP045081A (es) Derivados de 1,8-naftiridina y su uso para el tratamiento de la diabetes y trastornos relacionados
ECSP044992A (es) Inhibidores de la alquín-aril fosfodiesterasa-4
PE20020521A1 (es) Compuestos heterociclicos sustituidos para tratar la resistencia a multiples drogas
ATE407676T1 (de) Topoisomerasehemmern zur behandlung von chirurgischen verklebungen
ATE461217T1 (de) Glp-1-verbindungen
ECSP045153A (es) Metodo y composición para aumentar la potencia de un analgésico de narcotico.
ES2191070T3 (es) Arilalquil-piridazinonas.
PE20030061A1 (es) 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4
AR024380A1 (es) Tienopirimidinas
SE9802208D0 (sv) Novel compounds
EA200200742A1 (ru) 1,2-диарилбензимидазолы для лечения заболеваний, связанных с активацией микроглии
TR200400228T4 (tr) Psöryazinin tedavisinde kullanılacak maddeler
DE60115466D1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
DE60127131D1 (de) Tricyclische imidazopyridine
AR020563A1 (es) Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion

Legal Events

Date Code Title Description
FB Suspension of granting procedure