JP2005502635A5 - - Google Patents
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- JP2005502635A5 JP2005502635A5 JP2003513958A JP2003513958A JP2005502635A5 JP 2005502635 A5 JP2005502635 A5 JP 2005502635A5 JP 2003513958 A JP2003513958 A JP 2003513958A JP 2003513958 A JP2003513958 A JP 2003513958A JP 2005502635 A5 JP2005502635 A5 JP 2005502635A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- och
- medicament
- manufacture
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30581401P | 2001-07-16 | 2001-07-16 | |
| US60/305,814 | 2001-07-16 | ||
| PCT/US2002/022659 WO2003008399A1 (en) | 2001-07-16 | 2002-07-16 | Synthesis of udp-glucose: n-acylsphingosine glucosyltransferase inhibitors |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005112378A Division JP4708073B2 (ja) | 2001-07-16 | 2005-04-08 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2010020146A Division JP5227348B2 (ja) | 2001-07-16 | 2010-02-01 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005502635A JP2005502635A (ja) | 2005-01-27 |
| JP2005502635A5 true JP2005502635A5 (enExample) | 2005-12-22 |
| JP5038582B2 JP5038582B2 (ja) | 2012-10-03 |
Family
ID=23182463
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003513958A Expired - Lifetime JP5038582B2 (ja) | 2001-07-16 | 2002-07-16 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2005112378A Expired - Lifetime JP4708073B2 (ja) | 2001-07-16 | 2005-04-08 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2010020146A Expired - Lifetime JP5227348B2 (ja) | 2001-07-16 | 2010-02-01 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2013041198A Pending JP2013136618A (ja) | 2001-07-16 | 2013-02-13 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2015097734A Pending JP2015180656A (ja) | 2001-07-16 | 2015-04-20 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2016218570A Expired - Lifetime JP6182254B2 (ja) | 2001-07-16 | 2016-11-09 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005112378A Expired - Lifetime JP4708073B2 (ja) | 2001-07-16 | 2005-04-08 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2010020146A Expired - Lifetime JP5227348B2 (ja) | 2001-07-16 | 2010-02-01 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2013041198A Pending JP2013136618A (ja) | 2001-07-16 | 2013-02-13 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2015097734A Pending JP2015180656A (ja) | 2001-07-16 | 2015-04-20 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
| JP2016218570A Expired - Lifetime JP6182254B2 (ja) | 2001-07-16 | 2016-11-09 | Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 |
Country Status (15)
| Country | Link |
|---|---|
| US (11) | US6855830B2 (enExample) |
| EP (3) | EP2266968B1 (enExample) |
| JP (6) | JP5038582B2 (enExample) |
| AT (2) | ATE554082T1 (enExample) |
| BE (1) | BE2015C029I2 (enExample) |
| BR (3) | BR122015016313B8 (enExample) |
| CA (1) | CA2453978C (enExample) |
| CY (1) | CY2015028I1 (enExample) |
| DK (3) | DK2067775T3 (enExample) |
| ES (3) | ES2395122T3 (enExample) |
| FR (1) | FR15C0036I2 (enExample) |
| IL (3) | IL159905A0 (enExample) |
| LU (1) | LU92717I2 (enExample) |
| PT (3) | PT2067775E (enExample) |
| WO (1) | WO2003008399A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1384719A1 (en) * | 1999-07-09 | 2004-01-28 | The Regents of The University of Michigan | Inhibitors of the glucosyl ceramide synthase enzyme useful for the treatment of cancers, sphingolipidosis and microbial infections |
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EP1358172B1 (en) | 2001-01-10 | 2009-11-18 | The Regents of The University of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| US6855830B2 (en) | 2001-07-16 | 2005-02-15 | Genzyme Corporation | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| WO2003045928A1 (en) * | 2001-11-26 | 2003-06-05 | Genzyme Corporation | Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors |
| US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| JP4195411B2 (ja) * | 2004-04-12 | 2008-12-10 | セイコーエプソン株式会社 | 有機エレクトロルミネッセンス装置の製造方法 |
| BRPI0517701A8 (pt) * | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| PL383715A1 (pl) * | 2005-01-26 | 2008-05-12 | Allergan, Inc. | Amidy kwasu 3-arylo-3-hydroksy-2-amino-propionowego, amidy kwasu 3-heteroarylo-3-hydroksy-2-amino-propionowego i ich związki pokrewne posiadające aktywność przeciwbólową i/lub pobudzającą odporność |
| ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
| CN102978185B (zh) | 2007-01-18 | 2015-02-11 | 建新公司 | 包含氨基氧基基团的寡糖及其轭合物 |
| US8173683B2 (en) | 2007-03-06 | 2012-05-08 | Allergan, Inc. | Methods for treating cognitive disorders |
| WO2008109610A1 (en) * | 2007-03-06 | 2008-09-12 | Allergan, Inc. | Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| US20140179925A1 (en) | 2009-09-04 | 2014-06-26 | Allergan, Inc. | Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| US9314466B2 (en) | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| EP2594565B1 (en) | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| KR101640263B1 (ko) | 2007-10-05 | 2016-07-15 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
| US8168631B2 (en) | 2008-02-05 | 2012-05-01 | Allergan, Inc. | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity |
| JP2011529500A (ja) * | 2008-07-28 | 2011-12-08 | ジェンザイム コーポレーション | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
| CN102271678B (zh) * | 2008-10-03 | 2017-06-30 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂 |
| EP3608330B1 (en) | 2008-12-16 | 2022-11-09 | Genzyme Corporation | Synthetic intermediates for preparing oligosaccharide-protein conjugates |
| MY192644A (en) * | 2009-11-27 | 2022-08-29 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| EP3236686A1 (en) | 2010-04-16 | 2017-10-25 | Kyocera Corporation | Radio communication system, high-power base station, low-power base station, and communication control method |
| SG10201605874TA (en) | 2011-04-22 | 2016-09-29 | Genzyme Corp | Modified acid alpha glucosidase with accelerated processing |
| US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| WO2014150043A1 (en) * | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| CN110372636B (zh) | 2013-09-20 | 2023-03-28 | 生物马林药物股份有限公司 | 用于治疗疾病的葡萄糖神经酰胺合成酶抑制剂 |
| WO2015059679A1 (en) * | 2013-10-25 | 2015-04-30 | Dr. Reddy's Laboratories Limited | Improved process for the preparation of eliglustat |
| EP3063141B1 (en) | 2013-10-29 | 2018-02-28 | BioMarin Pharmaceutical Inc. | N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors |
| ES2856898T3 (es) | 2015-02-02 | 2021-09-28 | Univ Michigan Regents | Inhibidores de glucosilceramida sintasa y métodos terapéuticos que usan los mismos |
| CN104557851B (zh) * | 2015-02-10 | 2017-04-05 | 苏州明锐医药科技有限公司 | 依鲁司他的制备方法 |
| EP3283483B1 (en) | 2015-04-14 | 2018-12-19 | Sandoz AG | Crystalline eliglustat hydrochloride |
| WO2017068496A1 (en) * | 2015-10-20 | 2017-04-27 | Dr. Reddy' S Laboratories Limited | Improved process for the preparation of eliglustat and its salts |
| CN105646442A (zh) * | 2015-10-27 | 2016-06-08 | 北京凯莱天成医药科技有限公司 | 一种依利格鲁司他的制备方法 |
| US20190142782A1 (en) | 2016-04-11 | 2019-05-16 | Spedding Research Solutions | Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units |
| CN106349210A (zh) * | 2016-08-24 | 2017-01-25 | 北京阳光诺和药物研究有限公司 | 一种制备酒石酸艾力骨司坦的方法 |
| CN106967042B (zh) * | 2017-03-21 | 2020-08-14 | 浙江奥翔药业股份有限公司 | 依利格鲁司他的合成方法及其中间体化合物 |
| CN108822072B (zh) * | 2017-04-11 | 2021-01-12 | 中国医学科学院药物研究所 | 一种制备伊力格鲁司他的方法 |
| WO2018193090A2 (en) | 2017-04-21 | 2018-10-25 | Amneal Pharmaceuticals Company Gmbh | Process for preparation of eliglustat hemitartrate and intermediates thereof |
| WO2018225085A1 (en) | 2017-06-05 | 2018-12-13 | Cipla Limited | Stable solid dispersions of eliglustat hemitartrate |
| IL275091B2 (en) | 2017-12-15 | 2024-09-01 | Genzyme Corp | Methods for treating gaucher disease |
| WO2019123476A1 (en) | 2017-12-20 | 2019-06-27 | Sarudbhava Formulations Private Limited | Stable amorphous eliglustat premix and process for the preparation thereof |
| CN111217791B (zh) * | 2018-11-27 | 2024-02-02 | 广东东阳光药业股份有限公司 | 依鲁司他中间体及其制备方法 |
| US12398114B2 (en) | 2019-03-22 | 2025-08-26 | Piramal Pharma Limited | Process for the preparation of ELIGLUSTAT and its intermediate |
| WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
| US11220479B2 (en) | 2019-10-23 | 2022-01-11 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| WO2021214771A1 (en) | 2020-04-23 | 2021-10-28 | The Israel Institute of Biological Research (IIBR) | Glucosylceramide synthase inhibitors for prevention and treatment of viral diseases |
| WO2021221953A1 (en) | 2020-04-28 | 2021-11-04 | The Regents Of The University Of Michigan | Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same |
| CN116120274A (zh) | 2021-11-12 | 2023-05-16 | 曙方(上海)医药科技有限公司 | 依利格鲁司他可药用盐及其晶型 |
| EP4201403A1 (en) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses |
| WO2026006099A1 (en) | 2024-06-24 | 2026-01-02 | Genzyme Corporation | Eliglustat for the treatment of gaucher disease |
| EP4725474A1 (en) | 2024-10-11 | 2026-04-15 | Genepharm S.A. | A solid composition of eliglustat |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
| DE3522475A1 (de) | 1985-06-22 | 1987-01-02 | Kali Chemie Pharma Gmbh | Neue aromatische verbindungen, ihre herstellung und verwendung |
| JPH0416856A (ja) | 1990-05-10 | 1992-01-21 | Canon Inc | 正帯電性非磁性トナー |
| ZA929008B (en) | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
| CN1128951A (zh) * | 1993-08-13 | 1996-08-14 | 生化学工业株式会社 | 治疗神经元疾病的药物 |
| ES2149350T3 (es) | 1994-02-02 | 2000-11-01 | Liposome Co Inc | Compuestos y liposomas farmaceuticamente activos y metodos para su utilizacion. |
| CA2192555C (en) * | 1994-06-10 | 2005-01-11 | Jinichi Inokuchi | 2-acylaminopropanol compound and medicinal composition |
| FR2734819B1 (fr) | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US20030073680A1 (en) | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6255336B1 (en) * | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US5916911A (en) * | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
| WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| JP3993908B2 (ja) * | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
| NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
| JP4140984B2 (ja) | 1995-12-20 | 2008-08-27 | 生化学工業株式会社 | 分化誘導作用を有する薬剤 |
| US5916802A (en) * | 1997-02-19 | 1999-06-29 | Fritz Berthold | Device for measuring ATP |
| US5972928A (en) | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
| JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
| US6511979B1 (en) | 1998-07-27 | 2003-01-28 | Johns Hopkins University | Methods for treating conditions modulated by lactosylceramide |
| EP1384719A1 (en) | 1999-07-09 | 2004-01-28 | The Regents of The University of Michigan | Inhibitors of the glucosyl ceramide synthase enzyme useful for the treatment of cancers, sphingolipidosis and microbial infections |
| US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| EP1358172B1 (en) | 2001-01-10 | 2009-11-18 | The Regents of The University of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20020198240A1 (en) | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
| US6855830B2 (en) | 2001-07-16 | 2005-02-15 | Genzyme Corporation | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| US6916802B2 (en) | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| ES2546181T3 (es) * | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
-
2002
- 2002-07-16 US US10/197,227 patent/US6855830B2/en not_active Expired - Lifetime
- 2002-07-16 CA CA2453978A patent/CA2453978C/en not_active Expired - Lifetime
- 2002-07-16 PT PT09003291T patent/PT2067775E/pt unknown
- 2002-07-16 DK DK09003291.3T patent/DK2067775T3/da active
- 2002-07-16 ES ES02750099T patent/ES2395122T3/es not_active Expired - Lifetime
- 2002-07-16 ES ES09003291T patent/ES2395463T3/es not_active Expired - Lifetime
- 2002-07-16 PT PT100754290T patent/PT2266968E/pt unknown
- 2002-07-16 IL IL15990502A patent/IL159905A0/xx unknown
- 2002-07-16 BR BR122015016313A patent/BR122015016313B8/pt not_active IP Right Cessation
- 2002-07-16 DK DK10075429.0T patent/DK2266968T3/da active
- 2002-07-16 BR BRPI0211379-1 patent/BRPI0211379B8/pt active IP Right Grant
- 2002-07-16 EP EP10075429A patent/EP2266968B1/en not_active Expired - Lifetime
- 2002-07-16 BR BR122015016314A patent/BR122015016314B8/pt not_active IP Right Cessation
- 2002-07-16 DK DK02750099.0T patent/DK1409467T3/da active
- 2002-07-16 EP EP02750099A patent/EP1409467B1/en not_active Expired - Lifetime
- 2002-07-16 EP EP09003291A patent/EP2067775B1/en not_active Expired - Lifetime
- 2002-07-16 PT PT02750099T patent/PT1409467E/pt unknown
- 2002-07-16 WO PCT/US2002/022659 patent/WO2003008399A1/en not_active Ceased
- 2002-07-16 AT AT02750099T patent/ATE554082T1/de active
- 2002-07-16 AT AT09003291T patent/ATE555102T1/de active
- 2002-07-16 JP JP2003513958A patent/JP5038582B2/ja not_active Expired - Lifetime
- 2002-07-16 ES ES10075429T patent/ES2399323T3/es not_active Expired - Lifetime
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2004
- 2004-01-16 IL IL159905A patent/IL159905A/en active Protection Beyond IP Right Term
- 2004-08-12 US US10/916,824 patent/US7265228B2/en not_active Expired - Lifetime
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2005
- 2005-03-28 US US11/091,836 patent/US7196205B2/en active Active
- 2005-04-08 JP JP2005112378A patent/JP4708073B2/ja not_active Expired - Lifetime
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2007
- 2007-02-05 US US11/702,425 patent/US7615573B2/en not_active Expired - Lifetime
- 2007-08-24 US US11/895,632 patent/US7763738B2/en not_active Expired - Lifetime
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2008
- 2008-08-05 IL IL193244A patent/IL193244A0/en unknown
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2010
- 2010-02-01 JP JP2010020146A patent/JP5227348B2/ja not_active Expired - Lifetime
- 2010-07-06 US US12/830,962 patent/US8138353B2/en not_active Expired - Fee Related
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2012
- 2012-03-14 US US13/420,108 patent/US8779163B2/en not_active Expired - Fee Related
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2013
- 2013-02-13 JP JP2013041198A patent/JP2013136618A/ja active Pending
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2014
- 2014-06-26 US US14/315,453 patent/US9546161B2/en not_active Expired - Fee Related
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2015
- 2015-04-20 JP JP2015097734A patent/JP2015180656A/ja active Pending
- 2015-05-12 BE BE2015C029C patent/BE2015C029I2/fr unknown
- 2015-05-13 LU LU92717C patent/LU92717I2/xx unknown
- 2015-05-13 FR FR15C0036C patent/FR15C0036I2/fr active Active
- 2015-07-08 CY CY2015028C patent/CY2015028I1/el unknown
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2016
- 2016-11-09 JP JP2016218570A patent/JP6182254B2/ja not_active Expired - Lifetime
- 2016-12-30 US US15/395,329 patent/US20170334888A1/en not_active Abandoned
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2018
- 2018-11-21 US US16/198,258 patent/US20190322649A1/en not_active Abandoned
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2020
- 2020-07-23 US US16/937,437 patent/US20210171507A1/en not_active Abandoned