JP2008534572A5 - - Google Patents
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- Publication number
- JP2008534572A5 JP2008534572A5 JP2008503613A JP2008503613A JP2008534572A5 JP 2008534572 A5 JP2008534572 A5 JP 2008534572A5 JP 2008503613 A JP2008503613 A JP 2008503613A JP 2008503613 A JP2008503613 A JP 2008503613A JP 2008534572 A5 JP2008534572 A5 JP 2008534572A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- use according
- group
- propyl
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 18
- -1 aryl alkenyl ketone Chemical class 0.000 claims 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 230000007958 sleep Effects 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 206010041349 Somnolence Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 2
- 208000004547 Hallucinations Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 2
- NNACHAUCXXVJSP-UHFFFAOYSA-N pitolisant Chemical compound C1=CC(Cl)=CC=C1CCCOCCCN1CCCCC1 NNACHAUCXXVJSP-UHFFFAOYSA-N 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- ZBYDMLXPLCXXGZ-UHFFFAOYSA-N 1-[3-(3-phenylpropoxy)propyl]pyrrolidine Chemical compound C1CCCN1CCCOCCCC1=CC=CC=C1 ZBYDMLXPLCXXGZ-UHFFFAOYSA-N 0.000 claims 1
- ARXUNWQEEIWRFV-UHFFFAOYSA-N 1-[6-phenyl-1-(6-phenyl-3-piperidin-1-ylhexoxy)hexan-3-yl]piperidine Chemical compound C=1C=CC=CC=1CCCC(N1CCCCC1)CCOCCC(N1CCCCC1)CCCC1=CC=CC=C1 ARXUNWQEEIWRFV-UHFFFAOYSA-N 0.000 claims 1
- FWWOWPGPERBCNJ-UHFFFAOYSA-N 2-hydroxy-4-(2-hydroxyethoxy)-4-oxobutanoic acid Chemical compound OCCOC(=O)CC(O)C(O)=O FWWOWPGPERBCNJ-UHFFFAOYSA-N 0.000 claims 1
- 208000017164 Chronobiology disease Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 206010040981 Sleep attacks Diseases 0.000 claims 1
- 208000032140 Sleepiness Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 150000001345 alkine derivatives Chemical group 0.000 claims 1
- 230000000648 anti-parkinson Effects 0.000 claims 1
- 229940035678 anti-parkinson drug Drugs 0.000 claims 1
- 239000000939 antiparkinson agent Substances 0.000 claims 1
- 230000006399 behavior Effects 0.000 claims 1
- 229960002802 bromocriptine Drugs 0.000 claims 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- 229960003587 lisuride Drugs 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-M oxalate(1-) Chemical compound OC(=O)C([O-])=O MUBZPKHOEPUJKR-UHFFFAOYSA-M 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000037321 sleepiness Effects 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05290727.6 | 2005-04-01 | ||
| EP05290727A EP1707203A1 (en) | 2005-04-01 | 2005-04-01 | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| US66861805P | 2005-04-06 | 2005-04-06 | |
| US60/668,618 | 2005-04-06 | ||
| PCT/IB2006/000739 WO2006103546A2 (en) | 2005-04-01 | 2006-03-30 | Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000383A Division JP5955872B2 (ja) | 2005-04-01 | 2014-01-06 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008534572A JP2008534572A (ja) | 2008-08-28 |
| JP2008534572A5 true JP2008534572A5 (enExample) | 2010-11-25 |
| JP5546761B2 JP5546761B2 (ja) | 2014-07-09 |
Family
ID=35169680
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503613A Active JP5546761B2 (ja) | 2005-04-01 | 2006-03-30 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2014000383A Active JP5955872B2 (ja) | 2005-04-01 | 2014-01-06 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2016045424A Pending JP2016106142A (ja) | 2005-04-01 | 2016-03-09 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000383A Active JP5955872B2 (ja) | 2005-04-01 | 2014-01-06 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
| JP2016045424A Pending JP2016106142A (ja) | 2005-04-01 | 2016-03-09 | 非イミダゾールアルキルアミンヒスタミンｈ３−受容体リガンドによるパーキンソン病、閉塞性睡眠時無呼吸、レビー小体型認知症、血管性認知症の治療 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8486947B2 (enExample) |
| EP (2) | EP1707203A1 (enExample) |
| JP (3) | JP5546761B2 (enExample) |
| KR (1) | KR101308527B1 (enExample) |
| CN (1) | CN101171009B (enExample) |
| AU (1) | AU2006228413C1 (enExample) |
| BR (1) | BRPI0612216B1 (enExample) |
| CA (1) | CA2603656C (enExample) |
| CY (1) | CY1114636T1 (enExample) |
| DK (1) | DK1863487T4 (enExample) |
| EA (1) | EA016007B1 (enExample) |
| ES (1) | ES2426008T5 (enExample) |
| HR (1) | HRP20130748T4 (enExample) |
| MA (1) | MA29353B1 (enExample) |
| ME (1) | ME01713B (enExample) |
| MX (1) | MX2007012162A (enExample) |
| NO (1) | NO343603B1 (enExample) |
| NZ (1) | NZ561940A (enExample) |
| PL (1) | PL1863487T5 (enExample) |
| PT (1) | PT1863487E (enExample) |
| RS (1) | RS52911B2 (enExample) |
| SG (1) | SG147415A1 (enExample) |
| SI (1) | SI1863487T2 (enExample) |
| TN (1) | TNSN07365A1 (enExample) |
| UA (1) | UA94902C2 (enExample) |
| WO (1) | WO2006103546A2 (enExample) |
| ZA (1) | ZA200708086B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8829041B2 (en) | 2006-06-23 | 2014-09-09 | Abbvie Inc. | Cyclopropyl amine derivatives |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| FR2903904A1 (fr) * | 2006-07-21 | 2008-01-25 | Bioprojet Soc Civ Ile | Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3 |
| JP5335675B2 (ja) | 2006-07-25 | 2013-11-06 | セファロン、インク． | ピリジジノン誘導体 |
| US8153813B2 (en) | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| ES2390004T3 (es) | 2008-01-30 | 2012-11-05 | Cephalon, Inc. | Derivados sustituidos de piperidina espirocíclica como ligandos del receptor de la histamina 3(H3) |
| FR2932479A1 (fr) | 2008-06-13 | 2009-12-18 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US9181275B2 (en) | 2011-08-11 | 2015-11-10 | Abbvie Inc. | Mercaptoamidine derivatives and methods of use |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| CA2886785C (en) * | 2012-10-05 | 2022-06-07 | Transtech Pharma, Llc | Treatment of mild and moderate alzheimer's disease |
| EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
| US11266837B2 (en) | 2019-03-06 | 2022-03-08 | Medtronic Xomed, Inc. | Position sensitive lingual muscle simulation system for obstructive sleep apnea |
| EP4248969A1 (en) | 2022-03-23 | 2023-09-27 | Bioprojet | Use of pitolisant for treating severe fatigue |
| KR20250165426A (ko) | 2023-03-31 | 2025-11-25 | 바이오프로제 파르마 | 피톨리산트 염산염의 다형(多形) 형태 |
| WO2025082972A1 (en) | 2023-10-16 | 2025-04-24 | Bioprojet Pharma | Enteric coated pitolisant formulations and methods of use |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815945A (ja) * | 1981-07-21 | 1983-01-29 | Teikoku Hormone Mfg Co Ltd | 新規なフエノキシアルキルアミン誘導体 |
| FR2579596B1 (fr) | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
| FR2671083B1 (fr) | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
| ES2108107T3 (es) | 1991-02-27 | 1997-12-16 | Seed Capital Investments | Derivados de imidazol que tienen actividad antagonista en el receptor h3 de histamina. |
| DE69212164T2 (de) | 1991-12-18 | 1996-12-05 | Schering Corp., Kenilworth, N.J. | Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring |
| DK0618913T3 (da) | 1991-12-18 | 1996-10-14 | Schering Corp | Imidazolyl eller imidazoylalkyl substitueret med en 4- eller 5-leddet nitrogenholdig heterocyclisk ring |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
| US5639775A (en) | 1992-04-01 | 1997-06-17 | The University Of Toledo | 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof |
| US5380858A (en) | 1992-04-01 | 1995-01-10 | The University Of Toledo | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists |
| EP0680960A4 (en) | 1993-01-25 | 1997-05-14 | Green Cross Corp | IMIDAZOLE COMPOUND. |
| JP3522790B2 (ja) | 1993-06-08 | 2004-04-26 | 花王株式会社 | Ｈ３−レセプター刺激薬 |
| WO1995006037A1 (en) | 1993-08-27 | 1995-03-02 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
| NZ330898A (en) | 1993-11-15 | 2000-01-28 | Schering Corp | Phenyl-alkyl imidazoles as H3-receptor antagonists in particular for the treatment of inflammation |
| GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| AU721325B2 (en) | 1995-05-30 | 2000-06-29 | Gliatech Inc. | 1H-4(5)-substituted imidazole derivatives |
| US5652258A (en) | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| ES2184876T3 (es) | 1995-06-07 | 2003-04-16 | Gliatech Inc | Derivados de imidazol sustituidos en 1h-4(5). |
| CA2244745A1 (en) | 1996-02-09 | 1997-08-14 | James Black Foundation Limited | Histamine h3 receptor ligands |
| JP3925579B2 (ja) | 1998-02-03 | 2007-06-06 | 日本精工株式会社 | 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置 |
| EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| US6797726B1 (en) | 1999-06-11 | 2004-09-28 | Toyama Chemical Co., Ltd. | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same |
| GB9924941D0 (en) | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| US6620839B2 (en) * | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| WO2002012214A2 (en) | 2000-08-08 | 2002-02-14 | Ortho Mcneil Pharmaceutical Inc. | Non-imidazole aryloxyalkylamines as h3 receptor ligands |
| US6794405B2 (en) | 2000-08-17 | 2004-09-21 | Merck & Co., Inc. | Alicyclic imidazoles as H3 agents |
| AU2001283573A1 (en) * | 2000-08-21 | 2002-03-04 | Gliatech, Inc. | The use of histamine H3 receptor inverse agonists for the control of appetite and treatment of obesity |
| DK1373218T3 (da) | 2001-03-29 | 2008-05-19 | Ortho Mcneil Pharm Inc | Imidazolylderivater til anvendelse som histamin H3-receptorligander |
| WO2003044059A1 (en) * | 2001-11-15 | 2003-05-30 | Ortho-Mcneil Pharmaceutical, Inc. | Agonists of recombinant human histamine h3 receptor |
| DK1451167T3 (da) * | 2001-12-10 | 2006-07-03 | Ortho Mcneil Pharm Inc | Phenylalkyner |
| JP2006505590A (ja) * | 2002-10-23 | 2006-02-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンｈ３受容体調節物質としてのフェニルピペリジンおよびフェニルピロリジン |
| JP4735261B2 (ja) | 2003-06-27 | 2011-07-27 | Ｍｓｄ株式会社 | ヘテロアリールオキシ含窒素飽和ヘテロ環誘導体 |
| FR2856596B1 (fr) | 2003-06-27 | 2007-04-27 | Bioprojet Soc Civ | Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes. |
| SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
| US7547693B2 (en) | 2003-09-22 | 2009-06-16 | Banyu Pharmaceutical Co. Ltd. | Piperidine derivative |
-
2005
- 2005-04-01 EP EP05290727A patent/EP1707203A1/en not_active Withdrawn
-
2006
- 2006-03-29 AU AU2006228413A patent/AU2006228413C1/en active Active
- 2006-03-30 DK DK06744466.1T patent/DK1863487T4/da active
- 2006-03-30 SG SG200807447-8A patent/SG147415A1/en unknown
- 2006-03-30 US US11/909,778 patent/US8486947B2/en active Active
- 2006-03-30 MX MX2007012162A patent/MX2007012162A/es active IP Right Grant
- 2006-03-30 ME MEP-2013-98A patent/ME01713B/me unknown
- 2006-03-30 PT PT67444661T patent/PT1863487E/pt unknown
- 2006-03-30 BR BRPI0612216-7A patent/BRPI0612216B1/pt active IP Right Grant
- 2006-03-30 CA CA2603656A patent/CA2603656C/en active Active
- 2006-03-30 KR KR1020077025126A patent/KR101308527B1/ko active Active
- 2006-03-30 PL PL06744466T patent/PL1863487T5/pl unknown
- 2006-03-30 CN CN2006800157656A patent/CN101171009B/zh active Active
- 2006-03-30 ES ES06744466T patent/ES2426008T5/es active Active
- 2006-03-30 NZ NZ561940A patent/NZ561940A/en unknown
- 2006-03-30 RS RS20130359 patent/RS52911B2/sr unknown
- 2006-03-30 UA UAA200710712A patent/UA94902C2/ru unknown
- 2006-03-30 WO PCT/IB2006/000739 patent/WO2006103546A2/en not_active Ceased
- 2006-03-30 SI SI200631636T patent/SI1863487T2/sl unknown
- 2006-03-30 HR HRP20130748T patent/HRP20130748T4/hr unknown
- 2006-03-30 EA EA200702135A patent/EA016007B1/ru not_active IP Right Cessation
- 2006-03-30 JP JP2008503613A patent/JP5546761B2/ja active Active
- 2006-03-30 EP EP06744466.1A patent/EP1863487B2/en active Active
-
2007
- 2007-09-20 ZA ZA200708086A patent/ZA200708086B/xx unknown
- 2007-09-26 TN TNP2007000365A patent/TNSN07365A1/fr unknown
- 2007-09-27 MA MA30254A patent/MA29353B1/fr unknown
- 2007-10-09 NO NO20075086A patent/NO343603B1/no unknown
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2013
- 2013-08-14 CY CY20131100705T patent/CY1114636T1/el unknown
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2014
- 2014-01-06 JP JP2014000383A patent/JP5955872B2/ja active Active
-
2016
- 2016-03-09 JP JP2016045424A patent/JP2016106142A/ja active Pending