TNSN07365A1 - Traitement de la maladie de parkinson, de l'apnee obstructive du sommeil, de la demence a corps de lewy, de la demence vasculaire, avec des ligands du recepteur h3 de l'histamine non-imidazole-alkylamines - Google Patents
Traitement de la maladie de parkinson, de l'apnee obstructive du sommeil, de la demence a corps de lewy, de la demence vasculaire, avec des ligands du recepteur h3 de l'histamine non-imidazole-alkylaminesInfo
- Publication number
- TNSN07365A1 TNSN07365A1 TNP2007000365A TNSN07365A TNSN07365A1 TN SN07365 A1 TNSN07365 A1 TN SN07365A1 TN P2007000365 A TNP2007000365 A TN P2007000365A TN SN07365 A TNSN07365 A TN SN07365A TN SN07365 A1 TNSN07365 A1 TN SN07365A1
- Authority
- TN
- Tunisia
- Prior art keywords
- dementia
- parkinson
- disease
- treatment
- sleep apnea
- Prior art date
Links
- 208000009829 Lewy Body Disease Diseases 0.000 title abstract 2
- 201000002832 Lewy body dementia Diseases 0.000 title abstract 2
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- 201000004810 Vascular dementia Diseases 0.000 title abstract 2
- 208000001797 obstructive sleep apnea Diseases 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05290727A EP1707203A1 (en) | 2005-04-01 | 2005-04-01 | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| US66861805P | 2005-04-06 | 2005-04-06 | |
| PCT/IB2006/000739 WO2006103546A2 (en) | 2005-04-01 | 2006-03-30 | Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN07365A1 true TNSN07365A1 (fr) | 2008-12-31 |
Family
ID=35169680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2007000365A TNSN07365A1 (fr) | 2005-04-01 | 2007-09-26 | Traitement de la maladie de parkinson, de l'apnee obstructive du sommeil, de la demence a corps de lewy, de la demence vasculaire, avec des ligands du recepteur h3 de l'histamine non-imidazole-alkylamines |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8486947B2 (enExample) |
| EP (2) | EP1707203A1 (enExample) |
| JP (3) | JP5546761B2 (enExample) |
| KR (1) | KR101308527B1 (enExample) |
| CN (1) | CN101171009B (enExample) |
| AU (1) | AU2006228413C1 (enExample) |
| BR (1) | BRPI0612216B1 (enExample) |
| CA (1) | CA2603656C (enExample) |
| CY (1) | CY1114636T1 (enExample) |
| DK (1) | DK1863487T4 (enExample) |
| EA (1) | EA016007B1 (enExample) |
| ES (1) | ES2426008T5 (enExample) |
| HR (1) | HRP20130748T4 (enExample) |
| MA (1) | MA29353B1 (enExample) |
| ME (1) | ME01713B (enExample) |
| MX (1) | MX2007012162A (enExample) |
| NO (1) | NO343603B1 (enExample) |
| NZ (1) | NZ561940A (enExample) |
| PL (1) | PL1863487T5 (enExample) |
| PT (1) | PT1863487E (enExample) |
| RS (1) | RS52911B2 (enExample) |
| SG (1) | SG147415A1 (enExample) |
| SI (1) | SI1863487T2 (enExample) |
| TN (1) | TNSN07365A1 (enExample) |
| UA (1) | UA94902C2 (enExample) |
| WO (1) | WO2006103546A2 (enExample) |
| ZA (1) | ZA200708086B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| CA2655604C (en) | 2006-06-23 | 2016-08-09 | Abbott Laboratories | Cyclopropyl amine derivatives |
| FR2903904A1 (fr) * | 2006-07-21 | 2008-01-25 | Bioprojet Soc Civ Ile | Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3 |
| MX2009000884A (es) | 2006-07-25 | 2009-06-05 | Cephalon Inc | Derivados de piridizinona. |
| US8153813B2 (en) | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| EP2250176B1 (en) | 2008-01-30 | 2012-08-01 | Cephalon, Inc. | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands |
| FR2932479A1 (fr) * | 2008-06-13 | 2009-12-18 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US9181275B2 (en) | 2011-08-11 | 2015-11-10 | Abbvie Inc. | Mercaptoamidine derivatives and methods of use |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| AU2013327450B2 (en) * | 2012-10-05 | 2018-07-12 | Vtv Therapeutics Llc | Treatment of mild and moderate Alzheimer's disease |
| EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
| US11266837B2 (en) | 2019-03-06 | 2022-03-08 | Medtronic Xomed, Inc. | Position sensitive lingual muscle simulation system for obstructive sleep apnea |
| EP4248969A1 (en) | 2022-03-23 | 2023-09-27 | Bioprojet | Use of pitolisant for treating severe fatigue |
| CN121175294A (zh) | 2023-03-31 | 2025-12-19 | 生物计划制药公司 | 盐酸替洛利生的多晶型形式 |
| TW202535386A (zh) | 2023-10-16 | 2025-09-16 | 法商拜爾普羅傑特醫藥有限公司 | 腸溶包衣必托里賽(pitolisant)調配物及使用方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815945A (ja) * | 1981-07-21 | 1983-01-29 | Teikoku Hormone Mfg Co Ltd | 新規なフエノキシアルキルアミン誘導体 |
| FR2579596B1 (fr) | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
| FR2671083B1 (fr) | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
| EP0573542B1 (en) | 1991-02-27 | 1997-10-15 | Seed Capital Investments( Sci) B.V. | Imidazole-derivatives having antagonistic activity on the histamine h3-receptor |
| KR0142801B1 (en) | 1991-12-18 | 1998-07-15 | Schering Corp | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring t |
| NZ246441A (en) | 1991-12-18 | 1996-02-27 | Schering Corp | Imidazol or imidazolalkyl substituted with a 4 or 5 membered nitrogen containing heterocycle, preparation and pharmaceutical compositions thereof |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
| US5380858A (en) | 1992-04-01 | 1995-01-10 | The University Of Toledo | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists |
| US5639775A (en) | 1992-04-01 | 1997-06-17 | The University Of Toledo | 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof |
| EP0680960A4 (en) | 1993-01-25 | 1997-05-14 | Green Cross Corp | IMIDAZOLE CONNECTION. |
| JP3522790B2 (ja) | 1993-06-08 | 2004-04-26 | 花王株式会社 | H3−レセプター刺激薬 |
| AU7823894A (en) | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
| NZ276883A (en) | 1993-11-15 | 1998-08-26 | Schering Corp | 1h-imidazol-4-yl)alkyl]benzene derivatives |
| GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| PT841922E (pt) | 1995-05-30 | 2002-07-31 | Gliatech Inc | Derivados de ih-imidazole 4(5)-substituidos |
| US5652258A (en) | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| ES2184876T3 (es) | 1995-06-07 | 2003-04-16 | Gliatech Inc | Derivados de imidazol sustituidos en 1h-4(5). |
| AU709611B2 (en) | 1996-02-09 | 1999-09-02 | James Black Foundation Limited | Histamine h3 receptor ligands |
| JP3925579B2 (ja) * | 1998-02-03 | 2007-06-06 | 日本精工株式会社 | 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置 |
| EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| AU770234B2 (en) * | 1999-06-11 | 2004-02-19 | Toyama Chemical Co. Ltd. | N-alkoxyalkyl-N, N-dialkylamine derivatives or salts thereof and agents for treating neurodegenerative diseases comprising the same |
| GB9924941D0 (en) * | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| US6620839B2 (en) * | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| ATE319696T1 (de) * | 2000-08-08 | 2006-03-15 | Ortho Mcneil Pharm Inc | Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden |
| CA2419073A1 (en) * | 2000-08-17 | 2002-02-21 | Gliatech, Inc. | Novel alicyclic imidazoles as h3 agents |
| AU2001283573A1 (en) * | 2000-08-21 | 2002-03-04 | Gliatech, Inc. | The use of histamine H3 receptor inverse agonists for the control of appetite and treatment of obesity |
| CA2442326C (en) * | 2001-03-29 | 2012-05-22 | Ortho-Mcneil Pharmaceutical, Inc. | Imidazolyl derivatives useful as histamine h3 receptor ligands |
| AU2002228698A1 (en) * | 2001-11-15 | 2003-06-10 | Ortho-Mcneil Pharmaceutical, Inc. | Agonists of recombinant human histamine h3 receptor |
| CA2469893A1 (en) * | 2001-12-10 | 2003-06-19 | Ortho-Mcneil Pharmaceutical, Inc. | Phenylalkynes |
| EP1556046A1 (en) * | 2002-10-23 | 2005-07-27 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| FR2856596B1 (fr) * | 2003-06-27 | 2007-04-27 | Bioprojet Soc Civ | Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes. |
| CA2529790A1 (en) * | 2003-06-27 | 2005-01-27 | Banyu Pharmaceutical Co., Ltd. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
| SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
| JP4765627B2 (ja) * | 2003-09-22 | 2011-09-07 | Msd株式会社 | 新規ピペリジン誘導体 |
-
2005
- 2005-04-01 EP EP05290727A patent/EP1707203A1/en not_active Withdrawn
-
2006
- 2006-03-29 AU AU2006228413A patent/AU2006228413C1/en not_active Expired
- 2006-03-30 JP JP2008503613A patent/JP5546761B2/ja not_active Expired - Lifetime
- 2006-03-30 ES ES06744466T patent/ES2426008T5/es not_active Expired - Lifetime
- 2006-03-30 KR KR1020077025126A patent/KR101308527B1/ko not_active Expired - Lifetime
- 2006-03-30 ME MEP-2013-98A patent/ME01713B/me unknown
- 2006-03-30 SG SG200807447-8A patent/SG147415A1/en unknown
- 2006-03-30 BR BRPI0612216-7A patent/BRPI0612216B1/pt active IP Right Grant
- 2006-03-30 PT PT67444661T patent/PT1863487E/pt unknown
- 2006-03-30 MX MX2007012162A patent/MX2007012162A/es active IP Right Grant
- 2006-03-30 SI SI200631636T patent/SI1863487T2/sl unknown
- 2006-03-30 US US11/909,778 patent/US8486947B2/en active Active
- 2006-03-30 DK DK06744466.1T patent/DK1863487T4/da active
- 2006-03-30 UA UAA200710712A patent/UA94902C2/ru unknown
- 2006-03-30 CN CN2006800157656A patent/CN101171009B/zh not_active Expired - Lifetime
- 2006-03-30 CA CA2603656A patent/CA2603656C/en not_active Expired - Lifetime
- 2006-03-30 RS RS20130359 patent/RS52911B2/sr unknown
- 2006-03-30 PL PL06744466T patent/PL1863487T5/pl unknown
- 2006-03-30 HR HRP20130748T patent/HRP20130748T4/hr unknown
- 2006-03-30 EP EP06744466.1A patent/EP1863487B2/en not_active Expired - Lifetime
- 2006-03-30 WO PCT/IB2006/000739 patent/WO2006103546A2/en not_active Ceased
- 2006-03-30 EA EA200702135A patent/EA016007B1/ru not_active IP Right Cessation
- 2006-03-30 NZ NZ561940A patent/NZ561940A/en unknown
-
2007
- 2007-09-20 ZA ZA200708086A patent/ZA200708086B/xx unknown
- 2007-09-26 TN TNP2007000365A patent/TNSN07365A1/fr unknown
- 2007-09-27 MA MA30254A patent/MA29353B1/fr unknown
- 2007-10-09 NO NO20075086A patent/NO343603B1/no unknown
-
2013
- 2013-08-14 CY CY20131100705T patent/CY1114636T1/el unknown
-
2014
- 2014-01-06 JP JP2014000383A patent/JP5955872B2/ja not_active Expired - Lifetime
-
2016
- 2016-03-09 JP JP2016045424A patent/JP2016106142A/ja active Pending
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