NO20075086L - Behandling av Parkinsons sykdom, obstruktiv sovn apne, demens med Lewy legemer, vaskulaer demens med ikke-imidazol alkylamin histamin H3-reseptor ligander - Google Patents
Behandling av Parkinsons sykdom, obstruktiv sovn apne, demens med Lewy legemer, vaskulaer demens med ikke-imidazol alkylamin histamin H3-reseptor liganderInfo
- Publication number
- NO20075086L NO20075086L NO20075086A NO20075086A NO20075086L NO 20075086 L NO20075086 L NO 20075086L NO 20075086 A NO20075086 A NO 20075086A NO 20075086 A NO20075086 A NO 20075086A NO 20075086 L NO20075086 L NO 20075086L
- Authority
- NO
- Norway
- Prior art keywords
- dementia
- parkinson
- disease
- sleep apnea
- obstructive sleep
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 4
- 206010067889 Dementia with Lewy bodies Diseases 0.000 title abstract 2
- 102000004384 Histamine H3 receptors Human genes 0.000 title abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 title abstract 2
- 201000002832 Lewy body dementia Diseases 0.000 title abstract 2
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- 201000004810 Vascular dementia Diseases 0.000 title abstract 2
- -1 imidazole alkylamine Chemical class 0.000 title abstract 2
- 208000001797 obstructive sleep apnea Diseases 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer en ny behandlingsmetode av Parkinson's sykdom, obstruktiv søvnapné, narkolepsi, demens med Lewy bodies, vaskulær demens med ikke-imidazol alkylaminderivater som utgjør antagonister av H3-reseptorer av histamin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05290727A EP1707203A1 (en) | 2005-04-01 | 2005-04-01 | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
| US66861805P | 2005-04-06 | 2005-04-06 | |
| PCT/IB2006/000739 WO2006103546A2 (en) | 2005-04-01 | 2006-03-30 | Treatment of parkinson's disease, obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3-receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20075086L true NO20075086L (no) | 2007-12-27 |
| NO343603B1 NO343603B1 (no) | 2019-04-08 |
Family
ID=35169680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075086A NO343603B1 (no) | 2005-04-01 | 2007-10-09 | Forbindelse for anvendelse for behandling av søvnighet på dagtid assosiert med Parkinsons sykdom eller obstruktiv søvnapné, samt kombinasjon omfattende forbindelsen med et anti-parkinson medikament. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8486947B2 (no) |
| EP (2) | EP1707203A1 (no) |
| JP (3) | JP5546761B2 (no) |
| KR (1) | KR101308527B1 (no) |
| CN (1) | CN101171009B (no) |
| AU (1) | AU2006228413C1 (no) |
| BR (1) | BRPI0612216B1 (no) |
| CA (1) | CA2603656C (no) |
| CY (1) | CY1114636T1 (no) |
| DK (1) | DK1863487T4 (no) |
| EA (1) | EA016007B1 (no) |
| ES (1) | ES2426008T5 (no) |
| HR (1) | HRP20130748T4 (no) |
| MA (1) | MA29353B1 (no) |
| ME (1) | ME01713B (no) |
| MX (1) | MX2007012162A (no) |
| NO (1) | NO343603B1 (no) |
| NZ (1) | NZ561940A (no) |
| PL (1) | PL1863487T5 (no) |
| PT (1) | PT1863487E (no) |
| RS (1) | RS52911B2 (no) |
| SG (1) | SG147415A1 (no) |
| SI (1) | SI1863487T2 (no) |
| TN (1) | TNSN07365A1 (no) |
| UA (1) | UA94902C2 (no) |
| WO (1) | WO2006103546A2 (no) |
| ZA (1) | ZA200708086B (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008016343A (es) | 2006-06-23 | 2009-01-19 | Abbott Lab | Derivados ciclopropil amina como moduladores del receptro de histamina h3. |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| FR2903904A1 (fr) * | 2006-07-21 | 2008-01-25 | Bioprojet Soc Civ Ile | Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3 |
| RS52626B (sr) | 2006-07-25 | 2013-06-28 | Cephalon Inc. | Derivati piridizinona |
| US8153813B2 (en) | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| CA2712897A1 (en) | 2008-01-30 | 2009-08-06 | Pharmacopeia, Inc. | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands |
| FR2932479A1 (fr) * | 2008-06-13 | 2009-12-18 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US9181275B2 (en) | 2011-08-11 | 2015-11-10 | Abbvie Inc. | Mercaptoamidine derivatives and methods of use |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| MX377733B (es) * | 2012-10-05 | 2025-03-11 | Vtv Therapeutics Llc | Tratamiento de enfermedad de alzheimer leve y moderada. |
| EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
| US11266837B2 (en) | 2019-03-06 | 2022-03-08 | Medtronic Xomed, Inc. | Position sensitive lingual muscle simulation system for obstructive sleep apnea |
| EP4248969A1 (en) | 2022-03-23 | 2023-09-27 | Bioprojet | Use of pitolisant for treating severe fatigue |
| EP4688166A1 (en) | 2023-03-31 | 2026-02-11 | BIOPROJET Pharma | Polymorph form of pitolisant hydrochloride |
| TW202535385A (zh) | 2023-10-16 | 2025-09-16 | 法商拜爾普羅傑特醫藥有限公司 | 必托里賽(pitolisant)之新穎調配物及使用方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815945A (ja) * | 1981-07-21 | 1983-01-29 | Teikoku Hormone Mfg Co Ltd | 新規なフエノキシアルキルアミン誘導体 |
| FR2579596B1 (fr) | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
| FR2671083B1 (fr) | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
| EP0573542B1 (en) | 1991-02-27 | 1997-10-15 | Seed Capital Investments( Sci) B.V. | Imidazole-derivatives having antagonistic activity on the histamine h3-receptor |
| JPH07121938B2 (ja) | 1991-12-18 | 1995-12-25 | シェリング・コーポレーション | 窒素含有6員複素環で置換されたイミダゾイルアルキル化合物 |
| ES2090956T3 (es) | 1991-12-18 | 1996-10-16 | Schering Corp | Imidazolil o imidazolilalquil sustituido con un anillo heterociclico de cuatro o cinco miembros que contiene nitrogeno. |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5486526A (en) * | 1992-04-01 | 1996-01-23 | The University Of Toledo | Histamine H3 -receptor antagonists and therapeutic uses thereof |
| US5380858A (en) | 1992-04-01 | 1995-01-10 | The University Of Toledo | Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists |
| US5639775A (en) | 1992-04-01 | 1997-06-17 | The University Of Toledo | 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof |
| WO1994017058A1 (fr) | 1993-01-25 | 1994-08-04 | The Green Cross Corporation | Compose d'imidazole |
| JP3522790B2 (ja) | 1993-06-08 | 2004-04-26 | 花王株式会社 | H3−レセプター刺激薬 |
| AU7823894A (en) | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
| DE69432263T2 (de) | 1993-11-15 | 2003-12-04 | Schering Corp., Kenilworth | Phenylalkyl-imidazole als h3-rezeptor-antagonisten |
| GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| US5652258A (en) | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| WO1996038142A1 (en) | 1995-05-30 | 1996-12-05 | Gliatech, Inc. | 1h-4(5)-substituted imidazole derivatives |
| WO1996040126A1 (en) | 1995-06-07 | 1996-12-19 | Gliatech, Inc. | 1h-4(5)-substituted imidazole derivatives |
| CA2244745A1 (en) | 1996-02-09 | 1997-08-14 | James Black Foundation Limited | Histamine h3 receptor ligands |
| JP3925579B2 (ja) | 1998-02-03 | 2007-06-06 | 日本精工株式会社 | 潤滑剤供給体、並びに前記潤滑剤供給体を備える転がり軸受、リニアガイド装置及びボールねじ装置 |
| EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| US6797726B1 (en) * | 1999-06-11 | 2004-09-28 | Toyama Chemical Co., Ltd. | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same |
| GB9924941D0 (en) | 1999-10-22 | 1999-12-22 | Univ Manchester | Treatment of dyskinesia |
| US6620839B2 (en) * | 2000-07-13 | 2003-09-16 | Abbott Laboratories | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications |
| PT1313721E (pt) * | 2000-08-08 | 2006-06-30 | Ortho Mcneil Pharm Inc | Ariloxialquilaminas nao imidazoles como ligandos de receptor h3 |
| EP1313470A4 (en) | 2000-08-17 | 2005-02-16 | Gliatech Inc | NEW ALICYCLIC IMIDAZOLE AS H 3 ACTIVE SUBSTANCES |
| WO2002015905A1 (en) * | 2000-08-21 | 2002-02-28 | Gliatech, Inc. | The use of histamine h3 receptor inverse agonists for the control of appetite and treatment of obesity |
| DE60224509T2 (de) * | 2001-03-29 | 2009-03-05 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Imidazolderivate verwendbar als histamin h3 rezeptorliganden |
| EP1451225A1 (en) * | 2001-11-15 | 2004-09-01 | Ortho-McNeil Pharmaceutical, Inc. | Agonists of recombinant human histamine h3 receptor |
| PT1451167E (pt) * | 2001-12-10 | 2006-07-31 | Ortho Mcneil Pharm Inc | Fenilalcinos |
| WO2004037257A1 (en) * | 2002-10-23 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| WO2005007644A1 (ja) * | 2003-06-27 | 2005-01-27 | Banyu Pharmaceutical Co., Ltd | ヘテロアリールオキシ含窒素飽和へテロ環誘導体 |
| FR2856596B1 (fr) * | 2003-06-27 | 2007-04-27 | Bioprojet Soc Civ | Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes. |
| SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
| WO2005028438A1 (ja) * | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
-
2005
- 2005-04-01 EP EP05290727A patent/EP1707203A1/en not_active Withdrawn
-
2006
- 2006-03-29 AU AU2006228413A patent/AU2006228413C1/en active Active
- 2006-03-30 PL PL06744466T patent/PL1863487T5/pl unknown
- 2006-03-30 PT PT67444661T patent/PT1863487E/pt unknown
- 2006-03-30 SG SG200807447-8A patent/SG147415A1/en unknown
- 2006-03-30 DK DK06744466.1T patent/DK1863487T4/da active
- 2006-03-30 EP EP06744466.1A patent/EP1863487B2/en active Active
- 2006-03-30 UA UAA200710712A patent/UA94902C2/ru unknown
- 2006-03-30 CN CN2006800157656A patent/CN101171009B/zh active Active
- 2006-03-30 MX MX2007012162A patent/MX2007012162A/es active IP Right Grant
- 2006-03-30 EA EA200702135A patent/EA016007B1/ru not_active IP Right Cessation
- 2006-03-30 US US11/909,778 patent/US8486947B2/en active Active
- 2006-03-30 JP JP2008503613A patent/JP5546761B2/ja active Active
- 2006-03-30 RS RS20130359 patent/RS52911B2/sr unknown
- 2006-03-30 ME MEP-2013-98A patent/ME01713B/me unknown
- 2006-03-30 CA CA2603656A patent/CA2603656C/en active Active
- 2006-03-30 SI SI200631636T patent/SI1863487T2/sl unknown
- 2006-03-30 NZ NZ561940A patent/NZ561940A/en unknown
- 2006-03-30 KR KR1020077025126A patent/KR101308527B1/ko active Active
- 2006-03-30 ES ES06744466T patent/ES2426008T5/es active Active
- 2006-03-30 HR HRP20130748T patent/HRP20130748T4/hr unknown
- 2006-03-30 WO PCT/IB2006/000739 patent/WO2006103546A2/en not_active Ceased
- 2006-03-30 BR BRPI0612216-7A patent/BRPI0612216B1/pt active IP Right Grant
-
2007
- 2007-09-20 ZA ZA200708086A patent/ZA200708086B/xx unknown
- 2007-09-26 TN TNP2007000365A patent/TNSN07365A1/fr unknown
- 2007-09-27 MA MA30254A patent/MA29353B1/fr unknown
- 2007-10-09 NO NO20075086A patent/NO343603B1/no unknown
-
2013
- 2013-08-14 CY CY20131100705T patent/CY1114636T1/el unknown
-
2014
- 2014-01-06 JP JP2014000383A patent/JP5955872B2/ja active Active
-
2016
- 2016-03-09 JP JP2016045424A patent/JP2016106142A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20075086L (no) | Behandling av Parkinsons sykdom, obstruktiv sovn apne, demens med Lewy legemer, vaskulaer demens med ikke-imidazol alkylamin histamin H3-reseptor ligander | |
| HUS2100028I1 (hu) | ERBB I. típusú receptor tirozinkináz-gátló N4-fenil-kinazolin-4-amin származékok és rokon vegyületeik a hiperproliferatív betegségek kezelésére | |
| ATE435862T1 (de) | Azabicycloalkanverbindungen als muscarinrezeptor antagonisten | |
| NO20072971L (no) | Potentiatorer av glutamatreceptorer | |
| CY1109599T1 (el) | Κρυσταλλικες μορφες υδροχλωρικης (r)-8-χλωρο-1-μεθυλο-2,3,4,5-τετραϋδρο-1η-3-βενζαζεπινης | |
| NO20082136L (no) | 1,5-substituerte indol-2-yl-amidderivater | |
| ZA200700679B (en) | Novel piperidine derivatives as histamine H3 receptor ligands for treatment of depression | |
| MX2009004900A (es) | Arilamidas sustituidas por tiazol u oxazol. | |
| EA200970583A1 (ru) | Способ получения пиперазиниловых и диазепаниловых производных бензамида | |
| MX2011008336A (es) | Derivados de dihidroquinolinona. | |
| NO20074977L (no) | Fuserte tiazolderivater med affinitet for histamin H3 receptoren | |
| PT2221298E (pt) | Derivados de fenilpirazole | |
| MA28635B1 (fr) | Methode de production de derives de 1, 4-diphenylazetidinone | |
| DE602006001590D1 (de) | 7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isochinolin-besylatsalz, dessen herstellung und dessen therapeutische verwendung | |
| NO20050885L (no) | Ny fremgangsmate for syntesen av 1,3-dihydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre | |
| IL190783A0 (en) | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other cns disorders | |
| IS8388A (is) | Blandan af serótónín endurupptökuhindra og histamín 3 viðtaka mótlyfi, öflugum verka eða hlutaverka | |
| TW200519117A (en) | Crystal of sufoxide derivatives -HC1 | |
| ITTO20040024A1 (it) | Macchina per la produzione di fascicoli cuciti | |
| SE0303488D0 (sv) | New use 1X | |
| SE0303419D0 (sv) | New use 11 | |
| IN2015DN02599A (no) | ||
| FI20050586A0 (fi) | Menetelmä N-[4-(4-fluorofenyyli)-5-formyyli-6-isopropyylipyrimidiini-2-yyli]-N-metyylimetaanisulfonamidin valmistamiseksi |