DE602006001590D1 - 7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isochinolin-besylatsalz, dessen herstellung und dessen therapeutische verwendung - Google Patents

7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isochinolin-besylatsalz, dessen herstellung und dessen therapeutische verwendung

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Publication number
DE602006001590D1
DE602006001590D1 DE602006001590T DE602006001590T DE602006001590D1 DE 602006001590 D1 DE602006001590 D1 DE 602006001590D1 DE 602006001590 T DE602006001590 T DE 602006001590T DE 602006001590 T DE602006001590 T DE 602006001590T DE 602006001590 D1 DE602006001590 D1 DE 602006001590D1
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DE
Germany
Prior art keywords
tetrahydropyride
isochinoline
trifluoromethylphenyl
ethyl
production
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Application number
DE602006001590T
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English (en)
Inventor
Corinne Barre
Olivier Monnier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
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Sanofi Aventis France
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Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of DE602006001590D1 publication Critical patent/DE602006001590D1/de
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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DE602006001590T 2005-03-17 2006-03-15 7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isochinolin-besylatsalz, dessen herstellung und dessen therapeutische verwendung Active DE602006001590D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0502611A FR2883285B1 (fr) 2005-03-17 2005-03-17 Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
PCT/FR2006/000566 WO2006097624A1 (fr) 2005-03-17 2006-03-15 Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

Publications (1)

Publication Number Publication Date
DE602006001590D1 true DE602006001590D1 (de) 2008-08-07

Family

ID=35285429

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006001590T Active DE602006001590D1 (de) 2005-03-17 2006-03-15 7-(2-(4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl)ethyl)isochinolin-besylatsalz, dessen herstellung und dessen therapeutische verwendung

Country Status (34)

Country Link
US (1) US7795277B2 (de)
EP (1) EP1861389B1 (de)
JP (1) JP2008534450A (de)
KR (1) KR20070115258A (de)
CN (1) CN101137644A (de)
AR (1) AR053448A1 (de)
AT (1) ATE399161T1 (de)
AU (1) AU2006224465B2 (de)
BR (1) BRPI0607614A2 (de)
CA (1) CA2599637A1 (de)
CR (1) CR9352A (de)
CY (1) CY1108366T1 (de)
DE (1) DE602006001590D1 (de)
DK (1) DK1861389T3 (de)
EA (1) EA011560B1 (de)
ES (1) ES2309957T3 (de)
FR (1) FR2883285B1 (de)
HR (1) HRP20080447T3 (de)
IL (1) IL185537A (de)
MA (1) MA29348B1 (de)
MX (1) MX2007011021A (de)
MY (1) MY138296A (de)
NO (1) NO20075022L (de)
NZ (1) NZ561027A (de)
PL (1) PL1861389T3 (de)
PT (1) PT1861389E (de)
RS (1) RS50611B (de)
SI (1) SI1861389T1 (de)
TN (1) TNSN07317A1 (de)
TW (1) TW200700410A (de)
UA (1) UA90304C2 (de)
UY (1) UY29425A1 (de)
WO (1) WO2006097624A1 (de)
ZA (1) ZA200707488B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
EP2091948B1 (de) 2006-11-30 2012-04-18 Probiodrug AG Neue inhibitoren von glutaminylcyclase
MX2009009234A (es) 2007-03-01 2009-12-01 Probiodrug Ag Uso nuevo de inhibidores de ciclasa de glutaminilo.
EP2865670B1 (de) 2007-04-18 2017-01-11 Probiodrug AG Thioharnstoffderivative als Glutaminylcyclaseinhibitoren
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736053B1 (fr) * 1995-06-28 1997-09-19 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
ATE271554T1 (de) * 1999-10-22 2004-08-15 Sanofi Synthelabo Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung
FR2823749B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
JP4324382B2 (ja) * 2001-04-20 2009-09-02 サノフィ−アベンティス テトラヒドロピリジル−アルキル−複素環、その製造方法およびそれを含む医薬組成物

Also Published As

Publication number Publication date
IL185537A0 (en) 2008-01-06
PT1861389E (pt) 2008-09-11
JP2008534450A (ja) 2008-08-28
AR053448A1 (es) 2007-05-09
FR2883285A1 (fr) 2006-09-22
UA90304C2 (en) 2010-04-26
CN101137644A (zh) 2008-03-05
TW200700410A (en) 2007-01-01
DK1861389T3 (da) 2008-10-20
SI1861389T1 (sl) 2008-10-31
ZA200707488B (en) 2008-12-31
AU2006224465B2 (en) 2011-10-13
US7795277B2 (en) 2010-09-14
HRP20080447T3 (en) 2008-10-31
CY1108366T1 (el) 2014-02-12
NZ561027A (en) 2010-11-26
CR9352A (es) 2008-02-20
PL1861389T3 (pl) 2008-12-31
AU2006224465A1 (en) 2006-09-21
CA2599637A1 (fr) 2006-09-21
BRPI0607614A2 (pt) 2009-09-22
EA200702004A1 (ru) 2008-02-28
EP1861389B1 (de) 2008-06-25
NO20075022L (no) 2007-10-04
FR2883285B1 (fr) 2007-05-18
US20080085917A1 (en) 2008-04-10
UY29425A1 (es) 2006-10-31
WO2006097624A1 (fr) 2006-09-21
IL185537A (en) 2011-08-31
EA011560B1 (ru) 2009-04-28
ES2309957T3 (es) 2008-12-16
RS50611B (sr) 2010-06-30
KR20070115258A (ko) 2007-12-05
MA29348B1 (fr) 2008-03-03
TNSN07317A1 (en) 2008-12-31
ATE399161T1 (de) 2008-07-15
MX2007011021A (es) 2008-03-18
MY138296A (en) 2009-05-29
EP1861389A1 (de) 2007-12-05

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