NO20075022L - (7-(2-(4-(3-trifluormetylfenyl)-1,2,3,6-tetrahydropyrid-1-yl)etyl) isokinolinbesylatsalt, fremstilling og terapeutiske anvendelser derav - Google Patents

(7-(2-(4-(3-trifluormetylfenyl)-1,2,3,6-tetrahydropyrid-1-yl)etyl) isokinolinbesylatsalt, fremstilling og terapeutiske anvendelser derav

Info

Publication number
NO20075022L
NO20075022L NO20075022A NO20075022A NO20075022L NO 20075022 L NO20075022 L NO 20075022L NO 20075022 A NO20075022 A NO 20075022A NO 20075022 A NO20075022 A NO 20075022A NO 20075022 L NO20075022 L NO 20075022L
Authority
NO
Norway
Prior art keywords
ethyl
tetrahydropyrid
trifluoromethylphenyl
preparation
besylate salt
Prior art date
Application number
NO20075022A
Other languages
English (en)
Inventor
Olivier Monnier
Corinne Barre
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20075022L publication Critical patent/NO20075022L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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Abstract

Oppfinnelsen vedrører 7-(2-(4-(3-(trifiuormetyl)fienyl)-l,2,3,6-tetra-hydropyridyl)etyl)isokinolinbesylatsalt. Oppfinnelsen vedrører også en fiemgangsmåte fior å fiemstille 7-(2-(4-(3-(trifluormetyl)fienyl)-l,2,3,6-tetra- hydropyrid-l-yl)etyl)isokinolin besylatsalt samt den terapeutiske anvendelsen derav.
NO20075022A 2005-03-17 2007-10-04 (7-(2-(4-(3-trifluormetylfenyl)-1,2,3,6-tetrahydropyrid-1-yl)etyl) isokinolinbesylatsalt, fremstilling og terapeutiske anvendelser derav NO20075022L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0502611A FR2883285B1 (fr) 2005-03-17 2005-03-17 Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
PCT/FR2006/000566 WO2006097624A1 (fr) 2005-03-17 2006-03-15 Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

Publications (1)

Publication Number Publication Date
NO20075022L true NO20075022L (no) 2007-10-04

Family

ID=35285429

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075022A NO20075022L (no) 2005-03-17 2007-10-04 (7-(2-(4-(3-trifluormetylfenyl)-1,2,3,6-tetrahydropyrid-1-yl)etyl) isokinolinbesylatsalt, fremstilling og terapeutiske anvendelser derav

Country Status (34)

Country Link
US (1) US7795277B2 (no)
EP (1) EP1861389B1 (no)
JP (1) JP2008534450A (no)
KR (1) KR20070115258A (no)
CN (1) CN101137644A (no)
AR (1) AR053448A1 (no)
AT (1) ATE399161T1 (no)
AU (1) AU2006224465B2 (no)
BR (1) BRPI0607614A2 (no)
CA (1) CA2599637A1 (no)
CR (1) CR9352A (no)
CY (1) CY1108366T1 (no)
DE (1) DE602006001590D1 (no)
DK (1) DK1861389T3 (no)
EA (1) EA011560B1 (no)
ES (1) ES2309957T3 (no)
FR (1) FR2883285B1 (no)
HR (1) HRP20080447T3 (no)
IL (1) IL185537A (no)
MA (1) MA29348B1 (no)
MX (1) MX2007011021A (no)
MY (1) MY138296A (no)
NO (1) NO20075022L (no)
NZ (1) NZ561027A (no)
PL (1) PL1861389T3 (no)
PT (1) PT1861389E (no)
RS (1) RS50611B (no)
SI (1) SI1861389T1 (no)
TN (1) TNSN07317A1 (no)
TW (1) TW200700410A (no)
UA (1) UA90304C2 (no)
UY (1) UY29425A1 (no)
WO (1) WO2006097624A1 (no)
ZA (1) ZA200707488B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2008065141A1 (en) 2006-11-30 2008-06-05 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
EP2475428B1 (en) 2009-09-11 2015-07-01 Probiodrug AG Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
SG183229A1 (en) 2010-03-10 2012-09-27 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736053B1 (fr) * 1995-06-28 1997-09-19 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
ES2223594T3 (es) * 1999-10-22 2005-03-01 Sanofi-Aventis Fenil- y piridil-tetrahidro-piridinas con una actividad inhibidora de fnt.
FR2823749B1 (fr) 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
ATE365162T1 (de) * 2001-04-20 2007-07-15 Sanofi Aventis Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten

Also Published As

Publication number Publication date
IL185537A0 (en) 2008-01-06
CY1108366T1 (el) 2014-02-12
MA29348B1 (fr) 2008-03-03
US20080085917A1 (en) 2008-04-10
AU2006224465A1 (en) 2006-09-21
EA200702004A1 (ru) 2008-02-28
CR9352A (es) 2008-02-20
TW200700410A (en) 2007-01-01
UY29425A1 (es) 2006-10-31
US7795277B2 (en) 2010-09-14
FR2883285A1 (fr) 2006-09-22
EA011560B1 (ru) 2009-04-28
ZA200707488B (en) 2008-12-31
BRPI0607614A2 (pt) 2009-09-22
PL1861389T3 (pl) 2008-12-31
ES2309957T3 (es) 2008-12-16
SI1861389T1 (sl) 2008-10-31
ATE399161T1 (de) 2008-07-15
UA90304C2 (en) 2010-04-26
EP1861389B1 (fr) 2008-06-25
AR053448A1 (es) 2007-05-09
NZ561027A (en) 2010-11-26
DE602006001590D1 (de) 2008-08-07
DK1861389T3 (da) 2008-10-20
KR20070115258A (ko) 2007-12-05
PT1861389E (pt) 2008-09-11
IL185537A (en) 2011-08-31
RS50611B (sr) 2010-06-30
AU2006224465B2 (en) 2011-10-13
FR2883285B1 (fr) 2007-05-18
EP1861389A1 (fr) 2007-12-05
HRP20080447T3 (en) 2008-10-31
MX2007011021A (es) 2008-03-18
CA2599637A1 (fr) 2006-09-21
CN101137644A (zh) 2008-03-05
JP2008534450A (ja) 2008-08-28
MY138296A (en) 2009-05-29
WO2006097624A1 (fr) 2006-09-21
TNSN07317A1 (en) 2008-12-31

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