PL1861389T3 - Sól, besylan 7-(2-(4-(3-trifluorometylofenylo)-1,2,3,6-tetrahydropiryd-1-ylo)etylo)izochinoliny, jej wytwarzanie i jej zastosowanie w lecznictwie - Google Patents
Sól, besylan 7-(2-(4-(3-trifluorometylofenylo)-1,2,3,6-tetrahydropiryd-1-ylo)etylo)izochinoliny, jej wytwarzanie i jej zastosowanie w lecznictwieInfo
- Publication number
- PL1861389T3 PL1861389T3 PL06726092T PL06726092T PL1861389T3 PL 1861389 T3 PL1861389 T3 PL 1861389T3 PL 06726092 T PL06726092 T PL 06726092T PL 06726092 T PL06726092 T PL 06726092T PL 1861389 T3 PL1861389 T3 PL 1861389T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrid
- tetrahydro
- trifluoromethyl
- phenyl
- ethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0502611A FR2883285B1 (fr) | 2005-03-17 | 2005-03-17 | Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique |
| EP06726092A EP1861389B1 (fr) | 2005-03-17 | 2006-03-15 | Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique |
| PCT/FR2006/000566 WO2006097624A1 (fr) | 2005-03-17 | 2006-03-15 | Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1861389T3 true PL1861389T3 (pl) | 2008-12-31 |
Family
ID=35285429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06726092T PL1861389T3 (pl) | 2005-03-17 | 2006-03-15 | Sól, besylan 7-(2-(4-(3-trifluorometylofenylo)-1,2,3,6-tetrahydropiryd-1-ylo)etylo)izochinoliny, jej wytwarzanie i jej zastosowanie w lecznictwie |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US7795277B2 (pl) |
| EP (1) | EP1861389B1 (pl) |
| JP (1) | JP2008534450A (pl) |
| KR (1) | KR20070115258A (pl) |
| CN (1) | CN101137644A (pl) |
| AR (1) | AR053448A1 (pl) |
| AT (1) | ATE399161T1 (pl) |
| AU (1) | AU2006224465B2 (pl) |
| BR (1) | BRPI0607614A2 (pl) |
| CA (1) | CA2599637A1 (pl) |
| CR (1) | CR9352A (pl) |
| CY (1) | CY1108366T1 (pl) |
| DE (1) | DE602006001590D1 (pl) |
| DK (1) | DK1861389T3 (pl) |
| EA (1) | EA011560B1 (pl) |
| ES (1) | ES2309957T3 (pl) |
| FR (1) | FR2883285B1 (pl) |
| HR (1) | HRP20080447T3 (pl) |
| IL (1) | IL185537A (pl) |
| MA (1) | MA29348B1 (pl) |
| MX (1) | MX2007011021A (pl) |
| MY (1) | MY138296A (pl) |
| NO (1) | NO20075022L (pl) |
| NZ (1) | NZ561027A (pl) |
| PL (1) | PL1861389T3 (pl) |
| PT (1) | PT1861389E (pl) |
| RS (1) | RS50611B (pl) |
| SI (1) | SI1861389T1 (pl) |
| TN (1) | TNSN07317A1 (pl) |
| TW (1) | TW200700410A (pl) |
| UA (1) | UA90304C2 (pl) |
| UY (1) | UY29425A1 (pl) |
| WO (1) | WO2006097624A1 (pl) |
| ZA (1) | ZA200707488B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| NZ579310A (en) | 2007-03-01 | 2012-03-30 | Probiodrug Ag | Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof |
| DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| EP2542549B1 (en) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2736053B1 (fr) * | 1995-06-28 | 1997-09-19 | Sanofi Sa | Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines |
| UA72934C2 (uk) * | 1999-10-22 | 2005-05-16 | Санофі-Авантіс | Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція |
| FR2823749B1 (fr) | 2001-04-20 | 2004-02-20 | Sanofi Synthelabo | Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| JP4324382B2 (ja) * | 2001-04-20 | 2009-09-02 | サノフィ−アベンティス | テトラヒドロピリジル−アルキル−複素環、その製造方法およびそれを含む医薬組成物 |
-
2005
- 2005-03-17 FR FR0502611A patent/FR2883285B1/fr not_active Expired - Fee Related
-
2006
- 2006-03-14 MY MYPI20061092A patent/MY138296A/en unknown
- 2006-03-15 BR BRPI0607614-9A patent/BRPI0607614A2/pt not_active IP Right Cessation
- 2006-03-15 CN CNA2006800080866A patent/CN101137644A/zh active Pending
- 2006-03-15 SI SI200630065T patent/SI1861389T1/sl unknown
- 2006-03-15 JP JP2008501367A patent/JP2008534450A/ja not_active Ceased
- 2006-03-15 MX MX2007011021A patent/MX2007011021A/es active IP Right Grant
- 2006-03-15 PL PL06726092T patent/PL1861389T3/pl unknown
- 2006-03-15 AU AU2006224465A patent/AU2006224465B2/en not_active Ceased
- 2006-03-15 DK DK06726092T patent/DK1861389T3/da active
- 2006-03-15 EP EP06726092A patent/EP1861389B1/fr active Active
- 2006-03-15 UA UAA200711489A patent/UA90304C2/ru unknown
- 2006-03-15 DE DE602006001590T patent/DE602006001590D1/de active Active
- 2006-03-15 ZA ZA200707488A patent/ZA200707488B/xx unknown
- 2006-03-15 AT AT06726092T patent/ATE399161T1/de active
- 2006-03-15 NZ NZ561027A patent/NZ561027A/en not_active IP Right Cessation
- 2006-03-15 PT PT06726092T patent/PT1861389E/pt unknown
- 2006-03-15 ES ES06726092T patent/ES2309957T3/es active Active
- 2006-03-15 WO PCT/FR2006/000566 patent/WO2006097624A1/fr active Application Filing
- 2006-03-15 EA EA200702004A patent/EA011560B1/ru not_active IP Right Cessation
- 2006-03-15 CA CA002599637A patent/CA2599637A1/fr not_active Abandoned
- 2006-03-15 RS RSP-2008/0423A patent/RS50611B/sr unknown
- 2006-03-15 KR KR1020077021155A patent/KR20070115258A/ko not_active Application Discontinuation
- 2006-03-16 TW TW095108870A patent/TW200700410A/zh unknown
- 2006-03-16 AR ARP060101027A patent/AR053448A1/es unknown
- 2006-03-17 UY UY29425A patent/UY29425A1/es unknown
-
2007
- 2007-08-17 TN TNP2007000317A patent/TNSN07317A1/en unknown
- 2007-08-27 IL IL185537A patent/IL185537A/en not_active IP Right Cessation
- 2007-08-28 CR CR9352A patent/CR9352A/es not_active Application Discontinuation
- 2007-09-12 US US11/853,920 patent/US7795277B2/en not_active Expired - Fee Related
- 2007-09-26 MA MA30248A patent/MA29348B1/fr unknown
- 2007-10-04 NO NO20075022A patent/NO20075022L/no not_active Application Discontinuation
-
2008
- 2008-09-15 HR HR20080447T patent/HRP20080447T3/xx unknown
- 2008-09-24 CY CY20081101039T patent/CY1108366T1/el unknown
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