JP2010508296A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010508296A5 JP2010508296A5 JP2009534891A JP2009534891A JP2010508296A5 JP 2010508296 A5 JP2010508296 A5 JP 2010508296A5 JP 2009534891 A JP2009534891 A JP 2009534891A JP 2009534891 A JP2009534891 A JP 2009534891A JP 2010508296 A5 JP2010508296 A5 JP 2010508296A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- oxazepin
- benzamide
- hydroxy
- hydroxybenzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86334706P | 2006-10-28 | 2006-10-28 | |
| US60/863,347 | 2006-10-28 | ||
| US88428707P | 2007-01-10 | 2007-01-10 | |
| US60/884,287 | 2007-01-10 | ||
| PCT/US2007/082668 WO2008055068A2 (en) | 2006-10-28 | 2007-10-26 | Inhibitors of histone deacetylase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014111281A Division JP5727649B2 (ja) | 2006-10-28 | 2014-05-29 | ヒストンデアセチラーゼの阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508296A JP2010508296A (ja) | 2010-03-18 |
| JP2010508296A5 true JP2010508296A5 (enExample) | 2010-12-02 |
| JP5583406B2 JP5583406B2 (ja) | 2014-09-03 |
Family
ID=39309979
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534891A Expired - Fee Related JP5583406B2 (ja) | 2006-10-28 | 2007-10-26 | ヒストンデアセチラーゼの阻害剤 |
| JP2014111281A Expired - Fee Related JP5727649B2 (ja) | 2006-10-28 | 2014-05-29 | ヒストンデアセチラーゼの阻害剤 |
| JP2015075545A Pending JP2015145401A (ja) | 2006-10-28 | 2015-04-02 | ヒストンデアセチラーゼの阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014111281A Expired - Fee Related JP5727649B2 (ja) | 2006-10-28 | 2014-05-29 | ヒストンデアセチラーゼの阻害剤 |
| JP2015075545A Pending JP2015145401A (ja) | 2006-10-28 | 2015-04-02 | ヒストンデアセチラーゼの阻害剤 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US8399452B2 (enExample) |
| EP (4) | EP2966078A3 (enExample) |
| JP (3) | JP5583406B2 (enExample) |
| KR (1) | KR101312993B1 (enExample) |
| CN (3) | CN101573333B (enExample) |
| AR (1) | AR063720A1 (enExample) |
| AU (1) | AU2007313818B2 (enExample) |
| BR (1) | BRPI0718089A2 (enExample) |
| CA (2) | CA2667826C (enExample) |
| CL (1) | CL2007003108A1 (enExample) |
| DK (1) | DK2343286T3 (enExample) |
| ES (1) | ES2532899T3 (enExample) |
| HK (1) | HK1220179A1 (enExample) |
| PL (1) | PL2343286T3 (enExample) |
| PT (1) | PT2343286E (enExample) |
| RU (1) | RU2459811C2 (enExample) |
| SI (1) | SI2343286T1 (enExample) |
| TW (3) | TW201604187A (enExample) |
| WO (1) | WO2008055068A2 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| EP3354265A1 (en) | 2005-03-22 | 2018-08-01 | President and Fellows of Harvard College | Treatment of solid tumors |
| CA2662580C (en) | 2006-09-11 | 2013-05-21 | Curis, Inc. | Tyrosine kinase inhibitors containing a zinc binding moiety |
| US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| US8604044B2 (en) | 2006-09-11 | 2013-12-10 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| US7928136B2 (en) | 2006-09-11 | 2011-04-19 | Curis, Inc. | Substituted 2-indolinone as PTK inhibitors containing a zinc binding moiety |
| US8399452B2 (en) | 2006-10-28 | 2013-03-19 | Methylgene Inc. | Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors |
| JP5208963B2 (ja) | 2007-01-10 | 2013-06-12 | エフ.ホフマン−ラ ロシュ アーゲー | キマーゼ阻害剤としてのスルホンアミド誘導体 |
| CN101679347B (zh) | 2007-03-20 | 2014-10-22 | 柯瑞斯公司 | 作为hsp90抑制剂的稠和的氨基吡啶 |
| EP2139850B1 (en) * | 2007-04-09 | 2018-09-12 | MethylGene Inc. | Inhibitors of histone deacetylase |
| JP5474792B2 (ja) | 2007-09-10 | 2014-04-16 | キュリス,インコーポレイテッド | 亜鉛結合部分を含むキナゾリンベースegfrインヒビターの酒石酸塩またはその複合体 |
| TW200922564A (en) | 2007-09-10 | 2009-06-01 | Curis Inc | CDK inhibitors containing a zinc binding moiety |
| US8119616B2 (en) | 2007-09-10 | 2012-02-21 | Curis, Inc. | Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CA2703718A1 (en) * | 2007-11-02 | 2009-05-07 | Tammy Mallais | Inhibitors of histone deacetylase |
| ITFI20070288A1 (it) * | 2007-12-21 | 2009-06-22 | A I L Firenze Sezione Autonoma | Inibitori delle deacetilasi istoniche |
| AU2009274549B2 (en) | 2008-07-23 | 2014-05-01 | Dana-Farber Cancer Institute, Inc. | Deacetylase inhibitors and uses thereof |
| WO2010018837A2 (ja) * | 2008-08-11 | 2010-02-18 | 独立行政法人科学技術振興機構 | 蛋白質架橋阻害剤 |
| WO2010062565A1 (en) * | 2008-10-27 | 2010-06-03 | Acadia Pharmaceuticals Inc. | Muscarinic agonists |
| RS54230B1 (sr) | 2009-01-08 | 2015-12-31 | Curis Inc. | Inhibitori fosfoinozitid 3-kinaze sa delom koji vezuje cink |
| EP2387316A4 (en) | 2009-01-16 | 2012-06-13 | Curis Inc | CONDENSED AMINOPYRIDINE FOR THE TREATMENT OF BRAIN TUMORS |
| ES2650810T3 (es) | 2009-01-28 | 2018-01-22 | Karus Therapeutics Limited | Isósteros de Scriptaid y su uso en terapia |
| AR077033A1 (es) | 2009-06-11 | 2011-07-27 | Hoffmann La Roche | Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas |
| JP5838157B2 (ja) * | 2009-07-22 | 2015-12-24 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイThe Board Of Trustees Of The University Of Illinois | Hdac阻害剤およびそれを用いる治療法 |
| SI2464645T1 (sl) | 2009-07-27 | 2017-10-30 | Gilead Sciences, Inc. | Zlite heterociklične spojine kot ionsko kanalni modulatorji |
| WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
| EP2638009A4 (en) * | 2010-01-08 | 2014-06-11 | Harvard College | FLUORINATED HDAC HEMMER AND USES THEREOF |
| WO2011113013A2 (en) | 2010-03-11 | 2011-09-15 | Hemaquest Pharmaceuticals, Inc. | Methods and compositions for treating viral or virally-induced conditions |
| MX2012015096A (es) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Compuestos heterociclicos fusionados como moduladores del canal ion. |
| ES2568260T3 (es) * | 2010-11-16 | 2016-04-28 | Acetylon Pharmaceuticals, Inc. | Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos |
| US8404738B2 (en) | 2011-01-21 | 2013-03-26 | Hoffmann-La Roche Inc. | 4-amino-N-hydroxy-benzamides for the treatment of cancer |
| CN103328446B (zh) * | 2011-01-21 | 2016-01-20 | 霍夫曼-拉罗奇有限公司 | 用于治疗癌症的新的4-氨基-n-羟基-苯甲酰胺 |
| WO2012106343A2 (en) * | 2011-02-01 | 2012-08-09 | The Board Of Trustees Of The University Of Illinois | Hdac inhibitors and therapeutic methods using the same |
| JP5995956B2 (ja) * | 2011-03-26 | 2016-09-21 | フォルム ファーマシューティカルズ、インコーポレイテッド | 前頭側頭葉変性症の標的治療の方法 |
| ME02451B (me) | 2011-04-01 | 2016-09-20 | Curis Inc | Inhibitor fosfoinozitid 3-kinaze sa delom koji vezuje cink |
| NZ716420A (en) | 2011-05-10 | 2017-05-26 | Gilead Sciences Inc | Fused heterocyclic compounds as sodium channel modulators |
| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (enExample) | 2011-07-01 | 2018-04-28 | ||
| EP2758403B1 (en) | 2011-09-21 | 2016-04-27 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
| AU2012319188B2 (en) * | 2011-10-03 | 2016-11-24 | Sloan-Kettering Institute For Cancer Research | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
| EP2797875A4 (en) * | 2011-12-29 | 2015-09-02 | Pharmacyclics Inc | CINNAMIC ACID HYDROXYAMIDES AS HISTONE DEACETYLASE INHIBITORS 8 |
| CN103788014B (zh) * | 2012-10-29 | 2016-04-27 | 安徽安腾药业有限责任公司 | 制备10H-二苯并[b,f][1,4]硫氮杂卓-11-酮和喹硫平的方法 |
| MX364295B (es) | 2012-11-07 | 2019-04-22 | Karus Therapeutics Ltd | Inhibidores de histona desacetilasa novedosos y su uso en terapia. |
| LT2994465T (lt) * | 2013-05-10 | 2018-10-10 | Karus Therapeutics Limited | Nauji histono deacetilazės inhibitoriai |
| EP3054952B1 (en) | 2013-10-08 | 2022-10-26 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer |
| EP3055299B1 (en) | 2013-10-10 | 2021-01-06 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
| WO2015061684A1 (en) | 2013-10-24 | 2015-04-30 | Mayo Foundation For Medical Education And Research | Treatment of polycystic diseases with an hdac6 inhibitor |
| CN105939716A (zh) | 2013-12-03 | 2016-09-14 | 埃斯泰隆制药公司 | 组蛋白脱乙酰基酶抑制剂和免疫调节药物的组合 |
| CA2933907A1 (en) | 2013-12-23 | 2015-07-02 | The Trustees Of Columbia University In The City Of New York | Selective hdac6 inhibitors |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| CA2954522A1 (en) | 2014-07-07 | 2016-01-14 | Acetylon Pharmaceuticals, Inc. | Treatment of leukemia with histone deacetylase inhibitors |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| US9937174B2 (en) | 2014-12-05 | 2018-04-10 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| PL3292116T3 (pl) | 2015-02-02 | 2022-02-21 | Valo Health, Inc. | 3-arylo-4-amidobicykliczne kwasy [4,5,0]hydroksamowe jako inhibitory hdac |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| SG11201708191XA (en) | 2015-04-08 | 2017-11-29 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
| CN106279044B (zh) * | 2015-05-28 | 2021-02-19 | 厦门市博瑞来医药科技有限公司 | 嘧啶异羟肟酸衍生物及其制备方法和应用 |
| US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
| WO2017040564A1 (en) | 2015-09-03 | 2017-03-09 | The Board Of Trustees Of The University Of Illinois | Hdac inhibitors and therapeutic methods using the same |
| AR105911A1 (es) | 2015-09-03 | 2017-11-22 | Forma Therapeutics Inc | Inhibidores de hdac8 bicíclicos fusionados [6,6] |
| WO2017142883A1 (en) | 2016-02-16 | 2017-08-24 | The Board Of Trustees Of The University Of Illinois | Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors |
| WO2017184774A1 (en) | 2016-04-19 | 2017-10-26 | Acetylon Pharmaceuticals, Inc. | Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia |
| US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
| JP7373991B2 (ja) | 2016-07-15 | 2023-11-06 | ビラクタ セラピューティクス,インク. | 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤 |
| TW201821105A (zh) | 2016-10-20 | 2018-06-16 | 美商弗瑪治療公司 | 使用hdac11抑制劑之方法 |
| JP7068297B2 (ja) * | 2016-11-10 | 2022-05-16 | アセチロン ファーマシューティカルズ インコーポレイテッド | フェニル及びピリジニルヒドロキサム酸 |
| US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| CN107011238B (zh) * | 2017-03-14 | 2020-05-01 | 北京化工大学 | 一类组蛋白去乙酰化酶抑制剂及其制备方法和用途 |
| WO2018183701A1 (en) | 2017-03-29 | 2018-10-04 | The George Washington University | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors |
| US10934255B2 (en) | 2017-04-26 | 2021-03-02 | The Board Of Trustees Of The University Of Illinois | Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same |
| US11649218B2 (en) | 2018-03-09 | 2023-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same |
| US11535607B2 (en) | 2018-04-20 | 2022-12-27 | Valo Health, Inc. | Isoindolines as HDAC inhibitors |
| WO2019208812A1 (ja) | 2018-04-27 | 2019-10-31 | 国立大学法人大阪大学 | ベンゾイソオキサゾール化合物 |
| CN109020921B (zh) * | 2018-07-10 | 2020-08-04 | 山东大学 | 一种组蛋白去乙酰化酶hdac6抑制剂及其制备方法与应用 |
| MX2021002742A (es) | 2018-09-11 | 2021-08-11 | Curis Inc | Terapia combinada con un inhibidor de la fosfoinositida 3-quinasa con un resto de unión a zinc. |
| AU2020283590A1 (en) | 2019-05-31 | 2022-01-20 | Viracta Subsidiary, Inc. | Methods of treating virally associated cancers with histone deacetylase inhibitors |
| JP2023503161A (ja) | 2019-11-26 | 2023-01-26 | ノバルティス アーゲー | Cd19及びcd22キメラ抗原受容体及びその使用 |
| CN114315736B (zh) * | 2020-03-30 | 2025-11-18 | 甫康(上海)健康科技有限责任公司 | 二氢化茚胺类衍生物、其制备方法和用途 |
| CN113527206B (zh) * | 2020-04-17 | 2022-12-30 | 上海中泽医药科技有限公司 | 一种苯并氮杂环类化合物、其制备方法及用途 |
| CN112358455B (zh) * | 2020-11-16 | 2022-07-19 | 吉林奥来德光电材料股份有限公司 | 一种二苯并七元杂环类化合物及其制备方法与应用 |
| CN112500395B (zh) * | 2020-12-02 | 2022-03-08 | 吉林奥来德光电材料股份有限公司 | 一种二苯并含氮七元杂环类有机化合物、其制备方法及有机电致发光器件 |
| CN115073424A (zh) * | 2021-03-10 | 2022-09-20 | 微境生物医药科技(上海)有限公司 | 组蛋白去乙酰化酶抑制剂及其应用 |
| CN117580577A (zh) * | 2021-06-29 | 2024-02-20 | 国立大学法人大阪大学 | 肾损伤的预防和/或治疗用医药组合物以及自噬活化剂 |
| WO2023020416A1 (zh) * | 2021-08-16 | 2023-02-23 | 勤浩医药(苏州)有限公司 | 三环化合物、包含其的药物组合物及其用途 |
| CN120917006A (zh) * | 2023-03-14 | 2025-11-07 | 米拉林制药有限公司 | 作为选择性hdac6抑制剂的杂环化合物 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US3510476A (en) * | 1967-02-08 | 1970-05-05 | American Home Prod | Dibenzazepine-5-hydroxamic acid and derivatives thereof |
| DE2337154C2 (de) * | 1973-07-18 | 1986-04-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue Carbazolderivate |
| CH620891A5 (en) | 1975-12-19 | 1980-12-31 | Teijin Ltd | Isomerisation process |
| GB1574822A (en) * | 1976-03-23 | 1980-09-10 | Lafon Labor | Acetohydroxamic acid derivatives and pharmaceutical compositions thereof |
| JPS5643283A (en) * | 1979-08-29 | 1981-04-21 | Schering Ag | Betaacarbolinee33carboxylic acid derivative* its manufacture and psychotic medicine containing it |
| NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| GB9021813D0 (en) * | 1990-10-08 | 1990-11-21 | Ici Plc | Tricyclic heterocycles |
| US5652355A (en) | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| US5512563A (en) * | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| DE19510957A1 (de) | 1995-03-25 | 1996-09-26 | Huels Chemische Werke Ag | Eingedickter Bodenverfestiger, sowie diesen enthaltende verpackte Fertigmischung für Bodenbehandlungen |
| WO1996033983A1 (en) * | 1995-04-25 | 1996-10-31 | Daiichi Radioisotope Laboratories, Ltd. | Dibenzoxazepine n-oxide derivatives and drug containing the same as the active ingredient |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| DK0938471T3 (da) | 1996-10-16 | 2002-01-28 | American Cyanamid Co | Fremstillingen og anvendelsen af ortho-sulfonamido-arylhydroxamsyrer som matrix-metalloproteinase- og TACE-inhibitorer |
| US6117869A (en) * | 1998-08-04 | 2000-09-12 | Warner-Lambert Company | Compounds for and methods of inhibiting matrix metalloproteinases |
| AR035311A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento |
| TR200202164T2 (tr) | 1999-08-18 | 2002-11-21 | Warner-Lambert Company | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri. |
| US6541661B1 (en) | 1999-11-23 | 2003-04-01 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| CA2404002A1 (en) | 2000-03-24 | 2001-09-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| AR035455A1 (es) * | 2001-04-23 | 2004-05-26 | Hoffmann La Roche | Derivados triciclicos de alquilhidroxamato , procesos para su elaboracion, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| BR0212510A (pt) | 2001-09-14 | 2004-08-24 | Methylgene Inc | Inibidor de histona desacetilase, composto e composição |
| EP1443928B1 (en) | 2001-10-16 | 2011-07-27 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| WO2003066579A2 (en) * | 2002-02-07 | 2003-08-14 | Axys Pharmaceuticals | Novel bicyclic hydroxamates as inhibitors of histone deacetylase |
| MY140390A (en) | 2002-03-13 | 2009-12-31 | Janssen Pharmaceutica Nv | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
| MXPA04007775A (es) * | 2002-03-13 | 2004-10-15 | Janssen Pharmaceutica Nv | Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa. |
| CA2501265A1 (en) | 2002-10-17 | 2004-04-29 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| EP1590349A1 (en) * | 2003-01-27 | 2005-11-02 | Pfizer Inc. | Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use |
| US7094791B2 (en) * | 2003-07-31 | 2006-08-22 | Avalon Pharmaceuticals, Inc. | Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof |
| US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
| JP4809228B2 (ja) | 2003-09-24 | 2011-11-09 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| US20050152323A1 (en) | 2004-01-12 | 2005-07-14 | Vincent Bonnassieux | Plug-in Wi-Fi access point device and system |
| US7417040B2 (en) * | 2004-03-01 | 2008-08-26 | Bristol-Myers Squibb Company | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| RS50980B (sr) * | 2004-07-26 | 2010-10-31 | Merck Serono Sa. | Derivati n-hidroksiamida i njihova upotreba |
| CA2580250C (en) * | 2004-09-21 | 2013-05-14 | Dale M. Edgar | Loxapine analogs and methods of use thereof |
| US7772245B2 (en) * | 2005-02-14 | 2010-08-10 | Miikana Therapeutics, Inc. | Inhibitors of histone deacetylase |
| IT1362675B (it) * | 2005-03-15 | 2009-06-25 | Menarini Internat Operations Luxembourg Sa | N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche |
| GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| EP1915626B1 (en) | 2005-08-16 | 2011-11-09 | Genentech, Inc. | Apoptosis sensitivity to apo2l/trail by testing for galnac-t14 expression in cells/tissues |
| WO2007118137A1 (en) * | 2006-04-07 | 2007-10-18 | Methylgene Inc. | Benzamide derivatives as inhibitors of histone deacetylase |
| US8399452B2 (en) * | 2006-10-28 | 2013-03-19 | Methylgene Inc. | Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors |
-
2007
- 2007-10-26 US US11/925,151 patent/US8399452B2/en not_active Expired - Fee Related
- 2007-10-26 JP JP2009534891A patent/JP5583406B2/ja not_active Expired - Fee Related
- 2007-10-26 PT PT111525762T patent/PT2343286E/pt unknown
- 2007-10-26 RU RU2009120204/04A patent/RU2459811C2/ru not_active IP Right Cessation
- 2007-10-26 KR KR1020097010969A patent/KR101312993B1/ko not_active Expired - Fee Related
- 2007-10-26 AU AU2007313818A patent/AU2007313818B2/en not_active Ceased
- 2007-10-26 EP EP14194168.2A patent/EP2966078A3/en not_active Withdrawn
- 2007-10-26 CN CN2007800486643A patent/CN101573333B/zh not_active Expired - Fee Related
- 2007-10-26 EP EP11152576.2A patent/EP2343286B1/en not_active Not-in-force
- 2007-10-26 DK DK11152576.2T patent/DK2343286T3/en active
- 2007-10-26 CN CN201510481994.8A patent/CN105481788A/zh active Pending
- 2007-10-26 EP EP11187842A patent/EP2489657A3/en not_active Withdrawn
- 2007-10-26 CA CA2667826A patent/CA2667826C/en not_active Expired - Fee Related
- 2007-10-26 PL PL11152576T patent/PL2343286T3/pl unknown
- 2007-10-26 EP EP07863550A patent/EP2049483A2/en not_active Withdrawn
- 2007-10-26 CA CA2822776A patent/CA2822776A1/en not_active Abandoned
- 2007-10-26 WO PCT/US2007/082668 patent/WO2008055068A2/en not_active Ceased
- 2007-10-26 CN CN201310169400.0A patent/CN103275067B/zh not_active Expired - Fee Related
- 2007-10-26 CL CL200703108A patent/CL2007003108A1/es unknown
- 2007-10-26 BR BRPI0718089-6A patent/BRPI0718089A2/pt not_active IP Right Cessation
- 2007-10-26 SI SI200731637T patent/SI2343286T1/sl unknown
- 2007-10-26 ES ES11152576.2T patent/ES2532899T3/es active Active
- 2007-10-29 AR ARP070104794A patent/AR063720A1/es unknown
- 2007-10-29 TW TW104134125A patent/TW201604187A/zh unknown
- 2007-10-29 TW TW096140659A patent/TWI427070B/zh not_active IP Right Cessation
- 2007-10-29 TW TW102141992A patent/TWI511961B/zh not_active IP Right Cessation
-
2011
- 2011-04-04 US US13/079,458 patent/US20110196147A1/en not_active Abandoned
-
2013
- 2013-02-14 US US13/767,478 patent/US9193749B2/en not_active Expired - Fee Related
-
2014
- 2014-05-29 JP JP2014111281A patent/JP5727649B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-02 JP JP2015075545A patent/JP2015145401A/ja active Pending
- 2015-09-14 US US14/853,222 patent/US20160222026A1/en not_active Abandoned
-
2016
- 2016-07-12 HK HK16108132.4A patent/HK1220179A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010508296A5 (enExample) | ||
| RU2459811C2 (ru) | Ингибиторы гистоновой деацетилазы | |
| RU2006107653A (ru) | Связующее вспомогательное вещество и приготовленная на его основе таблетка в форме капли | |
| JP2006517572A5 (enExample) | ||
| JP2006077019A5 (enExample) | ||
| RU2011103741A (ru) | Композиции и способы лечения заболевания сетчатки | |
| JP2007502806A5 (enExample) | ||
| JP2019509276A5 (enExample) | ||
| JP2008531537A5 (enExample) | ||
| JP2014530900A5 (enExample) | ||
| JP2013512277A5 (enExample) | ||
| JP2003528852A5 (enExample) | ||
| RU2004117887A (ru) | Ариланилиновые агонисты бета2 адренергических рецепторов | |
| JP2012526728A5 (enExample) | ||
| JP2006512339A5 (enExample) | ||
| JP2005516967A5 (enExample) | ||
| JP2017214387A5 (enExample) | ||
| JP2011518811A5 (enExample) | ||
| JP2010526819A5 (enExample) | ||
| CN113825754A (zh) | 包括甲基和三氟甲基的双取代磺酰胺类选择性bcl-2抑制剂 | |
| JP2007522142A5 (enExample) | ||
| JP2004532894A5 (enExample) | ||
| RU2009108275A (ru) | Соединение сульфонамида или его соль | |
| RU2489433C2 (ru) | Производное циклобутилпурина, агент, активирующий ангиогенез, агент, активирующий образование просвета, агент, активирующий рост нейронов, и лекарственное средство | |
| RU2006124856A (ru) | Гидронопольные производные в качестве агонистов по отношению к orl1 рецепторам человека |