JP2003528852A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003528852A5 JP2003528852A5 JP2001570615A JP2001570615A JP2003528852A5 JP 2003528852 A5 JP2003528852 A5 JP 2003528852A5 JP 2001570615 A JP2001570615 A JP 2001570615A JP 2001570615 A JP2001570615 A JP 2001570615A JP 2003528852 A5 JP2003528852 A5 JP 2003528852A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- alkoxy
- amino
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 13
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 description 7
- 125000003545 alkoxy group Chemical group 0.000 description 6
- -1 R 21 Chemical compound 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 5
- 125000001072 heteroaryl group Chemical group 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- NWBJAUFHPXRBKI-QMMMGPOBSA-N (2r)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]-2-methylpropanoic acid Chemical compound CC(=N)NCCSC[C@](C)(N)C(O)=O NWBJAUFHPXRBKI-QMMMGPOBSA-N 0.000 description 1
- ADDDJEDAMMOVRD-QMMMGPOBSA-N (2r)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfonyl]-2-methylpropanoic acid Chemical compound CC(=N)NCCS(=O)(=O)C[C@](C)(N)C(O)=O ADDDJEDAMMOVRD-QMMMGPOBSA-N 0.000 description 1
- 239000004201 L-cysteine Substances 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19192300P | 2000-03-24 | 2000-03-24 | |
| US60/191,923 | 2000-03-24 | ||
| PCT/US2001/009431 WO2001072702A2 (en) | 2000-03-24 | 2001-03-23 | Amidino compounds useful as nitric oxide synthase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003528852A JP2003528852A (ja) | 2003-09-30 |
| JP2003528852A5 true JP2003528852A5 (enExample) | 2008-05-08 |
| JP4216502B2 JP4216502B2 (ja) | 2009-01-28 |
Family
ID=22707469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570616A Expired - Fee Related JP4205340B2 (ja) | 2000-03-24 | 2001-03-23 | 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物およびその塩 |
| JP2001570615A Expired - Fee Related JP4216502B2 (ja) | 2000-03-24 | 2001-03-23 | 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570616A Expired - Fee Related JP4205340B2 (ja) | 2000-03-24 | 2001-03-23 | 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物およびその塩 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US6403830B2 (enExample) |
| EP (2) | EP1265859B1 (enExample) |
| JP (2) | JP4205340B2 (enExample) |
| KR (1) | KR100835265B1 (enExample) |
| CN (1) | CN1294117C (enExample) |
| AR (1) | AR033359A1 (enExample) |
| AT (2) | ATE313525T1 (enExample) |
| AU (4) | AU2001247745B2 (enExample) |
| BR (1) | BR0109386A (enExample) |
| CA (2) | CA2402199C (enExample) |
| DE (2) | DE60110902T2 (enExample) |
| DK (2) | DK1265860T3 (enExample) |
| ES (2) | ES2240445T3 (enExample) |
| GE (1) | GEP20094625B (enExample) |
| MX (1) | MXPA02009282A (enExample) |
| MY (1) | MY135721A (enExample) |
| NZ (4) | NZ532073A (enExample) |
| PT (1) | PT1265860E (enExample) |
| TW (1) | TWI294417B (enExample) |
| WO (2) | WO2001072702A2 (enExample) |
| ZA (2) | ZA200206459B (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1265860E (pt) * | 2000-03-24 | 2005-10-31 | Pharmacia Corp | Compostos amidino uteis como inibidores de sintase de oxido nitrico |
| US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7012098B2 (en) * | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
| AU2002307217A1 (en) * | 2001-03-28 | 2002-10-15 | University Of South Florida | Materials and methods for treatment of cancer and identification of anti-cancer compounds |
| MY137736A (en) * | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US20030109522A1 (en) * | 2001-09-24 | 2003-06-12 | Manning Pamela T. | Ophthalmologic treatment methods using selective iNOS inhibitors |
| US20030119826A1 (en) * | 2001-09-24 | 2003-06-26 | Pharmacia Corporation | Neuroprotective treatment methods using selective iNOS inhibitors |
| KR20050044459A (ko) * | 2001-11-13 | 2005-05-12 | 파마시아 코포레이션 | 파레콕시브 등의 설폰아미드 선구약물의 경구 투여 형태 |
| AU2003234606A1 (en) * | 2002-05-16 | 2003-12-02 | Pharmacia Corporation | Using a selective iNOS inhibitor for the treatment of respiratory diseases and conditions |
| US20040087653A1 (en) * | 2002-05-16 | 2004-05-06 | Manning Pamela T. | Methods for the treatment of respiratory diseases and conditions with a selective iNOS inhibitor and a PDE inhibitor and compositions therefor |
| EP1550725A4 (en) * | 2002-06-05 | 2010-08-25 | Kaneka Corp | PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE |
| WO2004012726A2 (en) * | 2002-08-02 | 2004-02-12 | Pharmacia Corporation | Methods for treatment and prevention of gastrointestinal conditions |
| AU2003269406A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Process for preparing s-(2-aminoethyl)-2-methyl-l-cysteine |
| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| EP1575563B1 (en) * | 2002-12-19 | 2007-02-14 | Pharmacia Corporation | Non-hygroscopic formulation comprising a hydroscopic drug |
| WO2004064767A2 (en) * | 2003-01-23 | 2004-08-05 | Kahn Nighat N | Nitric oxide inducing agents |
| DE10308580B3 (de) * | 2003-02-27 | 2004-09-09 | Consortium für elektrochemische Industrie GmbH | Verfahren zur elektrophilen Substitution von Thiazolidinen oder Oxazolidinen |
| AU2004220548A1 (en) | 2003-03-07 | 2004-09-23 | The Trustees Of Columbia University, In The City Of New York | Type 1 ryanodine receptor-based methods |
| ES2363001T3 (es) * | 2003-03-11 | 2011-07-18 | Pharmacia Corporation | Sal cristalina de clorhidrato de maleato de s-[2(1-iminoetil)etil]-2-metil-l-cisteina. |
| BRPI0408182A (pt) * | 2003-03-11 | 2006-03-21 | Pharmacia Corp | sal cristalino monoidrato de salicilato de s-[2-[(1-iminoetil)amino]etil]-2-metil-l-cisteìna |
| EP1603671A2 (en) * | 2003-03-11 | 2005-12-14 | Pharmacia Corporation | Methods for selectively removing counterions from compounds and compounds derived from such methods |
| JP2006519834A (ja) * | 2003-03-11 | 2006-08-31 | ファルマシア・コーポレーション | Ｓ−［２−［（１−イミノエチル）アミノ］エチル］−２−メチル−ｌ−システインマレエート結晶塩 |
| WO2004080954A1 (en) * | 2003-03-11 | 2004-09-23 | Pharmacia Corporation | S-[2-[(1-iminoethyl)amino]ethyl]-2-methyl-l-cysteine maleate form ii crystalline salt |
| US20040186046A1 (en) * | 2003-03-17 | 2004-09-23 | Pfizer Inc | Treatment of type 1 diabetes with PDE5 inhibitors |
| WO2004090152A1 (ja) * | 2003-04-08 | 2004-10-21 | Mitsubishi Gas Chemical Company, Inc. | ２－アルキルシステインアミド又はその塩、並びに、それらの製造方法及び用途 |
| DE602004023534D1 (de) * | 2003-11-18 | 2009-11-19 | Mitsubishi Gas Chemical Co | Verfahren zur herstellung von optisch aktivem 2-alkylcystein, derivate davon und herstellungsverfahren |
| US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US20060154981A1 (en) * | 2005-01-12 | 2006-07-13 | Alcon, Inc. | Method of reducing intraocular pressure and treating glaucoma |
| US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| WO2007092278A2 (en) * | 2006-02-02 | 2007-08-16 | University Of South Florida | Withacnistin compounds for treatment of cancer |
| CA2644613A1 (en) * | 2006-03-07 | 2007-09-13 | Endacea, Inc. | Compositions and methods for treating respiratory disorders |
| US20090186854A1 (en) * | 2006-03-23 | 2009-07-23 | Meditor Pharmaceuticals Ltd. | S-alkylisothiouronium derivatives for the treatment of inflammatory diseases |
| US7820689B2 (en) * | 2006-08-10 | 2010-10-26 | Hua-Lin Wu | Methods and compositions for preventing or treating cardiovascular disease |
| CN101758337B (zh) | 2009-12-03 | 2012-02-15 | 湖南阿斯达生化科技有限公司 | 一种助焊剂用非卤素活性剂 |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| CA3079122A1 (en) | 2010-03-26 | 2011-09-29 | Trustees Of Dartmouth College | Vista regulatory t cell mediator protein, vista binding agents and use thereof |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| US9293197B2 (en) | 2011-08-15 | 2016-03-22 | Lockheed Martin Corporation | Reconfigurable phase change material masks for electro-optical compressive sensing |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| BR112014032276A2 (pt) | 2012-06-22 | 2017-11-28 | King S College London | construtos de vista-ig e o uso de vista-ig para o tratamento de distúrbios autoimunes, alérgicos e inflamatórios |
| EP3552628A1 (en) | 2012-09-07 | 2019-10-16 | The Trustees Of Dartmouth College | Vista modulators for diagnosis and treatment of cancer |
| US9340446B1 (en) | 2013-02-04 | 2016-05-17 | Lockheed Martin Corporation | Optical apparatus and method of forming a gradient index device |
| US10071958B2 (en) | 2013-05-02 | 2018-09-11 | Api Corporation | Method for producing alpha-substituted cysteine or salt thereof or synthetic intermediate of alpha-substituted cysteine |
| EP3043788B1 (en) | 2013-09-13 | 2023-06-07 | Replicon Health OY | D-glyceric acid or dl-glyceric acid for use in the treatment of degeneration diseases related to aging |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| AU2014372309C1 (en) | 2013-12-24 | 2017-12-14 | Janssen Pharmaceutica Nv | Anti-VISTA antibodies and fragments |
| MX389695B (es) | 2014-06-11 | 2025-03-20 | Kathy A Green | Uso de agonistas y antagonistas vista para suprimir o aumentar la inmunidad humoral. |
| US10437083B1 (en) | 2014-10-20 | 2019-10-08 | Lockheed Martin Corporation | Individually addressable infrared mask array |
| CN107405398A (zh) | 2014-12-05 | 2017-11-28 | 伊穆奈克斯特股份有限公司 | 鉴定vsig8作为推定vista受体及其用以产生vista/vsig8激动剂和拮抗剂的用途 |
| CN107922497B (zh) | 2015-06-24 | 2022-04-12 | 詹森药业有限公司 | 抗vista抗体和片段 |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
| TWI756204B (zh) | 2016-02-12 | 2022-03-01 | 比利時商楊森製藥公司 | 抗ｖｉｓｔａ抗體及片段、其用途及鑑定其之方法 |
| BR112018071153A2 (pt) | 2016-04-15 | 2019-04-16 | Immunext, Inc. | anticorpos anti-vista humano e uso dos mesmos |
| US9969647B2 (en) | 2016-05-17 | 2018-05-15 | Lockheed Martin Energy, Llc | Glass composites having a gradient index of refraction and methods for production thereof |
| US9908808B1 (en) | 2016-08-18 | 2018-03-06 | Lockheed Martin Corporation | Ternary glass materials with low refractive index variability |
| EP3398941A1 (en) | 2017-05-03 | 2018-11-07 | AXXAM S.p.A. | Heterocyclic p2x7 antagonists |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2036770C (en) | 1990-02-26 | 2003-09-09 | Jeffrey P. Whitten | Inhibitors of nitric oxide biosynthesis |
| US5132453A (en) | 1991-03-22 | 1992-07-21 | Cornell Research Foundation, Inc. | N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body |
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| GB9127376D0 (en) | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| DE4234867A1 (de) * | 1992-10-16 | 1994-04-21 | Degussa | Verfahren zur Herstellung von Aminoalkylhydantoin und Aminoalkyl-alpha-aminosäuren |
| JPH08503940A (ja) | 1992-11-27 | 1996-04-30 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬 |
| WO1994014780A1 (en) | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| DE4324088A1 (de) * | 1993-07-17 | 1995-01-19 | Hoechst Ag | Hochtemperatursupraleitende Massivkörper und Verfahren zu ihrer Herstellung |
| EP0724570B1 (en) | 1993-10-21 | 1999-03-03 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| PT724435E (pt) | 1993-10-21 | 2002-11-29 | Searle & Co | Derivados amidino uteis como inibidores de oxido nitrico sintase |
| GB9405211D0 (en) | 1994-03-17 | 1994-04-27 | Deas Alexander R | Noise cancellation apparatus |
| ES2141347T3 (es) | 1994-03-24 | 2000-03-16 | Searle & Co | Amidino-derivados utiles como inhibidores de oxido nitrico sintasa. |
| ATE229001T1 (de) * | 1994-06-15 | 2002-12-15 | Wellcome Found | Zwischenprodukte verwendbar in der herstellung von enzym-inhibitoren |
| US5994391A (en) | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5684008A (en) | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
| EP0821674B1 (en) | 1995-04-20 | 2003-08-06 | G.D. SEARLE & CO. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
| JPH11511741A (ja) | 1995-05-10 | 1999-10-12 | ジー．ディー．サール アンド カンパニー | 環状アミジン化合物から誘導される酸化窒素シンターゼインヒビター |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| US5830917A (en) | 1995-09-11 | 1998-11-03 | G. D. Searle & Co. | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors |
| US5945408A (en) | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
| US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| WO1999029865A2 (en) | 1997-12-12 | 1999-06-17 | The Rockefeller University | A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof |
| EA200000826A1 (ru) | 1998-03-11 | 2001-04-23 | Дж.Д.Сирл Энд Ко. | Галоидированные производные амидиноаминокислот, применимые в качестве ингибиторов no-синтазы |
| GB9811599D0 (en) | 1998-05-30 | 1998-07-29 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
| PT1265860E (pt) * | 2000-03-24 | 2005-10-31 | Pharmacia Corp | Compostos amidino uteis como inibidores de sintase de oxido nitrico |
-
2001
- 2001-03-23 PT PT01922636T patent/PT1265860E/pt unknown
- 2001-03-23 AU AU2001247745A patent/AU2001247745B2/en not_active Ceased
- 2001-03-23 ES ES01922636T patent/ES2240445T3/es not_active Expired - Lifetime
- 2001-03-23 WO PCT/US2001/009431 patent/WO2001072702A2/en not_active Ceased
- 2001-03-23 AT AT01920718T patent/ATE313525T1/de active
- 2001-03-23 NZ NZ532073A patent/NZ532073A/en not_active IP Right Cessation
- 2001-03-23 AU AU2001249415A patent/AU2001249415B2/en not_active Ceased
- 2001-03-23 JP JP2001570616A patent/JP4205340B2/ja not_active Expired - Fee Related
- 2001-03-23 GE GEAP200110668A patent/GEP20094625B/en unknown
- 2001-03-23 NZ NZ542734A patent/NZ542734A/en not_active IP Right Cessation
- 2001-03-23 EP EP01920718A patent/EP1265859B1/en not_active Expired - Lifetime
- 2001-03-23 NZ NZ520812A patent/NZ520812A/en not_active IP Right Cessation
- 2001-03-23 AR ARP010101388A patent/AR033359A1/es not_active Application Discontinuation
- 2001-03-23 EP EP01922636A patent/EP1265860B1/en not_active Expired - Lifetime
- 2001-03-23 DE DE60110902T patent/DE60110902T2/de not_active Expired - Lifetime
- 2001-03-23 CA CA2402199A patent/CA2402199C/en not_active Expired - Fee Related
- 2001-03-23 DK DK01922636T patent/DK1265860T3/da active
- 2001-03-23 ZA ZA200206459A patent/ZA200206459B/en unknown
- 2001-03-23 CA CA2402436A patent/CA2402436C/en not_active Expired - Fee Related
- 2001-03-23 AU AU4941501A patent/AU4941501A/xx active Pending
- 2001-03-23 AU AU4774501A patent/AU4774501A/xx active Pending
- 2001-03-23 ES ES01920718T patent/ES2256223T3/es not_active Expired - Lifetime
- 2001-03-23 US US09/816,577 patent/US6403830B2/en not_active Expired - Lifetime
- 2001-03-23 JP JP2001570615A patent/JP4216502B2/ja not_active Expired - Fee Related
- 2001-03-23 AT AT01922636T patent/ATE295832T1/de active
- 2001-03-23 WO PCT/US2001/009433 patent/WO2001072703A1/en not_active Ceased
- 2001-03-23 NZ NZ520813A patent/NZ520813A/en not_active IP Right Cessation
- 2001-03-23 CN CNB018070655A patent/CN1294117C/zh not_active Expired - Fee Related
- 2001-03-23 DE DE60116067T patent/DE60116067T2/de not_active Expired - Lifetime
- 2001-03-23 MX MXPA02009282A patent/MXPA02009282A/es active IP Right Grant
- 2001-03-23 BR BR0109386-0A patent/BR0109386A/pt active Search and Examination
- 2001-03-23 MY MYPI20011391A patent/MY135721A/en unknown
- 2001-03-23 DK DK01920718T patent/DK1265859T3/da active
- 2001-03-23 KR KR1020027012229A patent/KR100835265B1/ko not_active Expired - Fee Related
- 2001-03-23 US US09/816,575 patent/US6586474B2/en not_active Expired - Lifetime
- 2001-05-29 TW TW090106982A patent/TWI294417B/zh not_active IP Right Cessation
-
2002
- 2002-08-13 ZA ZA200206455A patent/ZA200206455B/en unknown
- 2002-12-17 US US10/321,969 patent/US7102013B2/en not_active Expired - Fee Related
-
2004
- 2004-04-01 US US10/815,375 patent/US6914158B2/en not_active Expired - Lifetime
-
2005
- 2005-01-10 US US11/032,650 patent/US7196118B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003528852A5 (enExample) | ||
| JP2002508352A5 (ja) | ４(３)置換−４(３)−アミノメチル−（チオ）ピラン又はピペリジン誘導体（＝ガバペンチン類似体） | |
| RU2397168C2 (ru) | Производные тиофена в качестве ингибиторов снк 1 | |
| JP2005523922A5 (enExample) | ||
| RU2459811C2 (ru) | Ингибиторы гистоновой деацетилазы | |
| JP2005506348A5 (enExample) | ||
| JP2006501295A5 (enExample) | ||
| JP2010508296A5 (enExample) | ||
| RU2005100836A (ru) | Производные пептидов, содержащие тиазепиновую группу, для лечения гиперлипемических состояний | |
| RU2008106058A (ru) | Производные пиридазинона в качестве агонистов рецептора тиреоидного гормона | |
| EP1797878A3 (en) | Benzothiazole derivatives | |
| RU2006107653A (ru) | Связующее вспомогательное вещество и приготовленная на его основе таблетка в форме капли | |
| RU2004104625A (ru) | Аналоги простагландинов в качестве агонистов рецептора ep4 | |
| JP2016509591A5 (enExample) | ||
| JP2010077141A5 (enExample) | ||
| JP2008509166A5 (enExample) | ||
| RU95120598A (ru) | Производные 10,11-метандибензосуберана, используемые в качестве хемосенсибилизующих агентов | |
| JP2007502806A5 (enExample) | ||
| JP2003506354A5 (enExample) | ||
| JPWO2019155399A5 (enExample) | ||
| RU2005107314A (ru) | Пиримидопроизводные, характеризующиеся антипролиферативной активностью | |
| JPH10279578A5 (enExample) | ||
| KR970014765A (ko) | 신경보호제를 이용한 이명의 치료 | |
| KR890005031A (ko) | L-도파유도체 또는 그의 산부가염, 그의 제조방법 및 그의 용도 | |
| JPWO2020123827A5 (enExample) |