AR033359A1 - Compuesto amidino, composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento para inhibir la sintesis de oxido nitrico - Google Patents

Compuesto amidino, composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento para inhibir la sintesis de oxido nitrico

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Publication number
AR033359A1
AR033359A1 ARP010101388A ARP010101388A AR033359A1 AR 033359 A1 AR033359 A1 AR 033359A1 AR P010101388 A ARP010101388 A AR P010101388A AR P010101388 A ARP010101388 A AR P010101388A AR 033359 A1 AR033359 A1 AR 033359A1
Authority
AR
Argentina
Prior art keywords
inhibit
synthesis
manufacture
nitric oxide
alkyl
Prior art date
Application number
ARP010101388A
Other languages
English (en)
Inventor
Brian Hickory
Michelle A Promo
Kam Fok
Richard C Durley
Ronald Keith Webber
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR033359A1 publication Critical patent/AR033359A1/es

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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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Abstract

Compuesto amidino de la formula (1) o una sal aceptable para uso farmacéutico del mismo, donde: R1 se selecciona entre el grupo que consiste en hidrogeno, metilo, C1-3 haloalquilo, C2-5 alquilo y C2-4 alquenilo, donde todos excepto el hidrogeno pueden ser sustituidos por uno o más hidroxi, alquilo, alquenilo, alquinilo, alcoxi y halo; y R2 se selecciona entre el grupo que consiste en metilo, C1-3 haloalquilo, C2-4 alquilo, C2-4 alquenilo, C1-3 alcoxi(C1-3 alquil), y C1-3 alquiltio (C1-3alquil), donde todos pueden ser opcionalmente sustituidos por uno o más hidroxi, alquilo, alquenilo, alquinilo, alcoxi y halo; las composiciones farmacéuticas que lo comprenden y su utilizacion en la fabricacion de un medicamento para inhibir la síntesis de oxido nítrico.
ARP010101388A 2000-03-24 2001-03-23 Compuesto amidino, composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento para inhibir la sintesis de oxido nitrico AR033359A1 (es)

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DE60110902T2 (de) 2006-04-27
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ATE295832T1 (de) 2005-06-15
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WO2001072702A2 (en) 2001-10-04
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