AR033359A1 - AMIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO INHIBIT THE SYNTHESIS OF NITRIC OXIDE - Google Patents

AMIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO INHIBIT THE SYNTHESIS OF NITRIC OXIDE

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Publication number
AR033359A1
AR033359A1 ARP010101388A ARP010101388A AR033359A1 AR 033359 A1 AR033359 A1 AR 033359A1 AR P010101388 A ARP010101388 A AR P010101388A AR P010101388 A ARP010101388 A AR P010101388A AR 033359 A1 AR033359 A1 AR 033359A1
Authority
AR
Argentina
Prior art keywords
inhibit
synthesis
manufacture
nitric oxide
alkyl
Prior art date
Application number
ARP010101388A
Other languages
Spanish (es)
Inventor
Brian Hickory
Michelle A Promo
Kam Fok
Richard C Durley
Ronald Keith Webber
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR033359A1 publication Critical patent/AR033359A1/en

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    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Compuesto amidino de la formula (1) o una sal aceptable para uso farmacéutico del mismo, donde: R1 se selecciona entre el grupo que consiste en hidrogeno, metilo, C1-3 haloalquilo, C2-5 alquilo y C2-4 alquenilo, donde todos excepto el hidrogeno pueden ser sustituidos por uno o más hidroxi, alquilo, alquenilo, alquinilo, alcoxi y halo; y R2 se selecciona entre el grupo que consiste en metilo, C1-3 haloalquilo, C2-4 alquilo, C2-4 alquenilo, C1-3 alcoxi(C1-3 alquil), y C1-3 alquiltio (C1-3alquil), donde todos pueden ser opcionalmente sustituidos por uno o más hidroxi, alquilo, alquenilo, alquinilo, alcoxi y halo; las composiciones farmacéuticas que lo comprenden y su utilizacion en la fabricacion de un medicamento para inhibir la síntesis de oxido nítrico.Amidino compound of the formula (1) or a salt acceptable for pharmaceutical use thereof, wherein: R1 is selected from the group consisting of hydrogen, methyl, C1-3 haloalkyl, C2-5 alkyl and C2-4 alkenyl, where all except hydrogen can be substituted by one or more hydroxy, alkyl, alkenyl, alkynyl, alkoxy and halo; and R2 is selected from the group consisting of methyl, C1-3 haloalkyl, C2-4 alkyl, C2-4 alkenyl, C1-3 alkoxy (C1-3 alkyl), and C1-3 alkylthio (C1-3alkyl), where all may be optionally substituted by one or more hydroxy, alkyl, alkenyl, alkynyl, alkoxy and halo; the pharmaceutical compositions that comprise it and their use in the manufacture of a medicament to inhibit the synthesis of nitric oxide.

ARP010101388A 2000-03-24 2001-03-23 AMIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO INHIBIT THE SYNTHESIS OF NITRIC OXIDE AR033359A1 (en)

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