JP2016509591A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016509591A5 JP2016509591A5 JP2015550788A JP2015550788A JP2016509591A5 JP 2016509591 A5 JP2016509591 A5 JP 2016509591A5 JP 2015550788 A JP2015550788 A JP 2015550788A JP 2015550788 A JP2015550788 A JP 2015550788A JP 2016509591 A5 JP2016509591 A5 JP 2016509591A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- diastereomer
- compound
- enantiomer
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 168
- 150000001875 compounds Chemical class 0.000 claims description 133
- 150000003839 salts Chemical class 0.000 claims description 116
- 229910052739 hydrogen Inorganic materials 0.000 claims description 88
- 239000001257 hydrogen Substances 0.000 claims description 76
- 150000002431 hydrogen Chemical class 0.000 claims description 72
- -1 OR 9 Chemical group 0.000 claims description 63
- 125000004429 atom Chemical group 0.000 claims description 48
- 239000012453 solvate Substances 0.000 claims description 47
- 229940002612 prodrug Drugs 0.000 claims description 42
- 239000000651 prodrug Substances 0.000 claims description 42
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 40
- 229910052736 halogen Inorganic materials 0.000 claims description 40
- 150000002367 halogens Chemical class 0.000 claims description 40
- 125000000623 heterocyclic group Chemical group 0.000 claims description 40
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 36
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 34
- 125000001072 heteroaryl group Chemical group 0.000 claims description 26
- 125000003107 substituted aryl group Chemical group 0.000 claims description 25
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 18
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 17
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 15
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 12
- 125000001153 fluoro group Chemical group F* 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 11
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims description 10
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
- 125000004122 cyclic group Chemical group 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 10
- 125000001246 bromo group Chemical group Br* 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 238000006467 substitution reaction Methods 0.000 claims description 8
- 125000002837 carbocyclic group Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 230000019552 anatomical structure morphogenesis Effects 0.000 claims description 4
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims description 4
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 208000002672 hepatitis B Diseases 0.000 claims description 4
- 125000002883 imidazolyl group Chemical group 0.000 claims description 4
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 4
- 125000006384 methylpyridyl group Chemical group 0.000 claims description 4
- BVOCPVIXARZNQN-UHFFFAOYSA-N nipecotamide Chemical compound NC(=O)C1CCCNC1 BVOCPVIXARZNQN-UHFFFAOYSA-N 0.000 claims description 4
- 125000002971 oxazolyl group Chemical group 0.000 claims description 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 4
- 125000000335 thiazolyl group Chemical group 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 230000010076 replication Effects 0.000 claims description 3
- JNHULJPDNUCLHD-UHFFFAOYSA-N 5-[[3-[(4-methoxyphenyl)carbamoyl]phenyl]sulfonylamino]pentanoic acid Chemical compound C1=CC(OC)=CC=C1NC(=O)C1=CC=CC(S(=O)(=O)NCCCCC(O)=O)=C1 JNHULJPDNUCLHD-UHFFFAOYSA-N 0.000 claims description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims description 2
- 206010016654 Fibrosis Diseases 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 150000004703 alkoxides Chemical class 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 150000001409 amidines Chemical class 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 230000007882 cirrhosis Effects 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 125000004342 dicyclopropylmethyl group Chemical group [H]C1([H])C([H])([H])C1([H])C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 208000019423 liver disease Diseases 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- FVMAYATYZSYSFZ-UHFFFAOYSA-N n-(3-methoxy-5-phenoxypyridin-2-yl)-3-pyrrolidin-1-ylsulfonylbenzamide Chemical compound C=1N=C(NC(=O)C=2C=C(C=CC=2)S(=O)(=O)N2CCCC2)C(OC)=CC=1OC1=CC=CC=C1 FVMAYATYZSYSFZ-UHFFFAOYSA-N 0.000 claims description 2
- WFLQINZNNVGHIX-UHFFFAOYSA-N n-(3-methoxy-5-phenylsulfanylpyridin-2-yl)-3-pyrrolidin-1-ylsulfonylbenzamide Chemical compound C=1N=C(NC(=O)C=2C=C(C=CC=2)S(=O)(=O)N2CCCC2)C(OC)=CC=1SC1=CC=CC=C1 WFLQINZNNVGHIX-UHFFFAOYSA-N 0.000 claims description 2
- NPZTXJPMHHMWHQ-UHFFFAOYSA-N n-(5-bromo-3-methoxypyridin-2-yl)-3-piperidin-1-ylsulfonylbenzamide Chemical compound COC1=CC(Br)=CN=C1NC(=O)C1=CC=CC(S(=O)(=O)N2CCCCC2)=C1 NPZTXJPMHHMWHQ-UHFFFAOYSA-N 0.000 claims description 2
- SEFGEXQGNGLZAG-UHFFFAOYSA-N n-(5-ethenyl-3-methoxypyridin-2-yl)-3-piperidin-1-ylsulfonylbenzamide Chemical compound COC1=CC(C=C)=CN=C1NC(=O)C1=CC=CC(S(=O)(=O)N2CCCCC2)=C1 SEFGEXQGNGLZAG-UHFFFAOYSA-N 0.000 claims description 2
- MAQWAGCJOFDDNU-UHFFFAOYSA-N n-(5-ethyl-3-methoxypyridin-2-yl)-3-piperidin-1-ylsulfonylbenzamide Chemical compound COC1=CC(CC)=CN=C1NC(=O)C1=CC=CC(S(=O)(=O)N2CCCCC2)=C1 MAQWAGCJOFDDNU-UHFFFAOYSA-N 0.000 claims description 2
- 230000007170 pathology Effects 0.000 claims description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000004885 piperazines Chemical class 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 125000006318 tert-butyl amino group Chemical group [H]N(*)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 45
- 239000002904 solvent Substances 0.000 claims 24
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 150000001728 carbonyl compounds Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 0 CC1=CCCC(C2(*)CC2)=C1 Chemical compound CC1=CCCC(C2(*)CC2)=C1 0.000 description 32
- 125000000753 cycloalkyl group Chemical group 0.000 description 15
- 238000000034 method Methods 0.000 description 5
- DQOGDQIDOONUSK-REOHCLBHSA-N C[C@H](C(F)(F)F)C(O)=O Chemical compound C[C@H](C(F)(F)F)C(O)=O DQOGDQIDOONUSK-REOHCLBHSA-N 0.000 description 4
- DQOGDQIDOONUSK-UWTATZPHSA-N C[C@@H](C(F)(F)F)C(O)=O Chemical compound C[C@@H](C(F)(F)F)C(O)=O DQOGDQIDOONUSK-UWTATZPHSA-N 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- FILOYPQPSRQLRL-NRFANRHFSA-N 3-piperidin-1-ylsulfonyl-n-[(1s)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide Chemical compound N([C@@H]1C2=CC=CC=C2CCC1)C(=O)C(C=1)=CC=CC=1S(=O)(=O)N1CCCCC1 FILOYPQPSRQLRL-NRFANRHFSA-N 0.000 description 1
- BGNWXRJWDQHCRB-UHFFFAOYSA-N CC(C)c1ncccn1 Chemical compound CC(C)c1ncccn1 BGNWXRJWDQHCRB-UHFFFAOYSA-N 0.000 description 1
- WPPZHQBTLCZSEY-UHFFFAOYSA-N CC1(C)N=CC=C(C)N1 Chemical compound CC1(C)N=CC=C(C)N1 WPPZHQBTLCZSEY-UHFFFAOYSA-N 0.000 description 1
- ZHUGZTZOGHQIOD-UHFFFAOYSA-N CC1(C)OC(C)=NC=C1 Chemical compound CC1(C)OC(C)=NC=C1 ZHUGZTZOGHQIOD-UHFFFAOYSA-N 0.000 description 1
- LRNKDEJJYFZZOV-SCSAIBSYSA-N C[C@@H](C(F)(F)F)C(OC1(CC1)C(O)=O)=O Chemical compound C[C@@H](C(F)(F)F)C(OC1(CC1)C(O)=O)=O LRNKDEJJYFZZOV-SCSAIBSYSA-N 0.000 description 1
- FZMPLKVGINKUJZ-UHFFFAOYSA-N Cc(cc1F)ccc1F Chemical compound Cc(cc1F)ccc1F FZMPLKVGINKUJZ-UHFFFAOYSA-N 0.000 description 1
- BPWJEVHPHKDCLD-UHFFFAOYSA-N O=C(c(cc1)cc(F)c1F)NC(CC1S(NC2CC2)(=O)=O)=CC=C1F Chemical compound O=C(c(cc1)cc(F)c1F)NC(CC1S(NC2CC2)(=O)=O)=CC=C1F BPWJEVHPHKDCLD-UHFFFAOYSA-N 0.000 description 1
- FABZZCLPYQXJEY-UHFFFAOYSA-N O=C(c(cc1)cc(F)c1F)Nc(cc1NS(C2CC2)(=O)=O)ccc1F Chemical compound O=C(c(cc1)cc(F)c1F)Nc(cc1NS(C2CC2)(=O)=O)ccc1F FABZZCLPYQXJEY-UHFFFAOYSA-N 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746552P | 2012-12-27 | 2012-12-27 | |
| US61/746,552 | 2012-12-27 | ||
| PCT/US2013/077940 WO2014106019A2 (en) | 2012-12-27 | 2013-12-27 | Novel antiviral agents against hbv infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018177094A Division JP2019034943A (ja) | 2012-12-27 | 2018-09-21 | Ｈｂｖ感染に対する新規抗ウイルス剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016509591A JP2016509591A (ja) | 2016-03-31 |
| JP2016509591A5 true JP2016509591A5 (enExample) | 2016-07-21 |
| JP6409001B2 JP6409001B2 (ja) | 2018-10-17 |
Family
ID=51022201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550788A Expired - Fee Related JP6409001B2 (ja) | 2012-12-27 | 2013-12-27 | Ｈｂｖ感染に対する新規抗ウイルス剤 |
| JP2018177094A Pending JP2019034943A (ja) | 2012-12-27 | 2018-09-21 | Ｈｂｖ感染に対する新規抗ウイルス剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018177094A Pending JP2019034943A (ja) | 2012-12-27 | 2018-09-21 | Ｈｂｖ感染に対する新規抗ウイルス剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9938236B2 (enExample) |
| EP (1) | EP2938338A4 (enExample) |
| JP (2) | JP6409001B2 (enExample) |
| KR (1) | KR101942151B1 (enExample) |
| CN (1) | CN105209031A (enExample) |
| AU (2) | AU2013370300B2 (enExample) |
| BR (1) | BR112015015584A2 (enExample) |
| CA (1) | CA2896554C (enExample) |
| EA (1) | EA201591220A1 (enExample) |
| HK (1) | HK1217649A1 (enExample) |
| IL (2) | IL239397B (enExample) |
| MX (1) | MX2015008471A (enExample) |
| PH (1) | PH12015501473A1 (enExample) |
| SG (2) | SG10201803698UA (enExample) |
| WO (1) | WO2014106019A2 (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5977837B2 (ja) | 2011-12-21 | 2016-08-24 | ノヴィラ・セラピューティクス・インコーポレイテッド | Ｂ型肝炎抗ウイルス剤 |
| CN104902885A (zh) * | 2012-08-28 | 2015-09-09 | 爱尔兰詹森科学公司 | 氨磺酰基-芳基酰胺和其作为药物用于治疗乙型肝炎的用途 |
| WO2014106019A2 (en) * | 2012-12-27 | 2014-07-03 | Philadelphia Health & Education Corporation, D/B/A Drexel | Novel antiviral agents against hbv infection |
| BR112015020242A2 (pt) | 2013-02-28 | 2017-07-18 | Janssen Sciences Ireland Uc | sulfamoil-arilamidas e seu uso como medicamentos para o tratamento da hepatite b |
| JP6419155B2 (ja) | 2013-04-03 | 2018-11-07 | ヤンセン・サイエンシズ・アイルランド・ユーシー | Ｎ−フェニル−カルボキサミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用 |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| DK3024819T3 (en) | 2013-07-25 | 2018-06-06 | Janssen Sciences Ireland Uc | GLYOXAMIDE-SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B |
| EA034448B1 (ru) | 2013-10-23 | 2020-02-10 | Янссен Сайенсиз Айрлэнд Юси | Производные карбоксамида и их применение в качестве медикаментов для лечения гепатита b |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| CN106232136A (zh) * | 2014-02-05 | 2016-12-14 | 诺维拉治疗公司 | 用于治疗hbv感染的联合疗法 |
| CA2932551A1 (en) | 2014-02-06 | 2015-08-13 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| PL3116316T3 (pl) | 2014-03-13 | 2020-03-31 | Indiana University Research And Technology Corporation | Allosteryczne modulatory białka rdzeniowego wirusa zapalenia wątroby typu B |
| US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
| US20170266197A1 (en) * | 2014-05-09 | 2017-09-21 | Indiana University Research And Technology Corporation | Methods and compositions for treating hepatitis b virus infections |
| US9597332B2 (en) | 2014-12-02 | 2017-03-21 | Novira Therapeutics, Inc. | Sulfide alkyl compounds for HBV treatment |
| AU2015358561A1 (en) * | 2014-12-02 | 2017-06-08 | Novira Therapeutics, Inc. | Sulfide alkyl and pyridyl reverse sulfonamide compounds for HBV treatment |
| MA41140A (fr) * | 2014-12-12 | 2017-10-17 | Cancer Research Tech Ltd | Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg |
| MA41179A (fr) | 2014-12-19 | 2017-10-24 | Cancer Research Tech Ltd | Composés inhibiteurs de parg |
| WO2016107832A1 (en) | 2014-12-30 | 2016-07-07 | F. Hoffmann-La Roche Ag | Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection |
| US9765050B2 (en) | 2014-12-30 | 2017-09-19 | Novira Therapeutics, Inc. | Pyridyl reverse sulfonamides for HBV treatment |
| CA2980298A1 (en) | 2015-03-19 | 2016-09-22 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| EP3292120B1 (en) * | 2015-05-04 | 2019-06-19 | H. Hoffnabb-La Roche Ag | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections |
| WO2016183266A1 (en) | 2015-05-13 | 2016-11-17 | Enanta Pharmaceuticals, Inc. | Ehpatitis b antiviral agents |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| US10179131B2 (en) | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TWI721016B (zh) | 2015-09-15 | 2021-03-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| CN108430971A (zh) * | 2015-09-29 | 2018-08-21 | 诺维拉治疗公司 | 乙型肝炎抗病毒剂的晶体形式 |
| EP3426245B1 (en) * | 2016-03-07 | 2022-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| CN109640980A (zh) * | 2016-04-15 | 2019-04-16 | 诺维拉治疗公司 | 包含壳体装配抑制剂的组合和方法 |
| EP3464253A1 (en) * | 2016-06-03 | 2019-04-10 | University of Tennessee Research Foundation | Autotaxin inhibitors |
| WO2017214395A1 (en) | 2016-06-10 | 2017-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2018039131A1 (en) | 2016-08-22 | 2018-03-01 | Protiva Biotherapeutics, Inc. | Anti-pd-1 antibodies, or fragments thereof, for treating hepatitis b |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CA3036245C (en) * | 2016-09-13 | 2021-07-20 | Arbutus Biopharma Corporation | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same |
| CA3037151A1 (en) | 2016-09-15 | 2018-03-22 | Assembly Biosciences, Inc. | Hepatitis b core protein modulators |
| US10821103B2 (en) | 2016-11-07 | 2020-11-03 | Arbutus Biopharma Corporation | Substituted pyridinone-containing trycyclic compounds, and methods using same |
| EA037576B1 (ru) * | 2016-11-11 | 2021-04-15 | Новира Терапьютикс, Инк. | Комбинации и способы, включающие ингибитор сборки капсида |
| AU2018217664B2 (en) * | 2017-02-07 | 2022-03-03 | Janssen Pharmaceutica Nv | Sulphamoylaryl derivatives and use thereof as medicaments for the treatment of liver fibrosis |
| RU2650610C1 (ru) | 2017-02-28 | 2018-04-16 | Васильевич Иващенко Александр | Противовирусная композиция и способ ее применения |
| AU2018227811A1 (en) | 2017-03-02 | 2019-09-19 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
| CA3056886A1 (en) | 2017-03-21 | 2018-09-27 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same |
| PL3621615T3 (pl) | 2017-05-12 | 2024-03-25 | Enanta Pharmaceuticals, Inc. | Inhibitory regulujące sygnał apoptozy kinazy 1 i sposoby ich stosowania |
| JP2020525490A (ja) | 2017-06-27 | 2020-08-27 | ヤンセン ファーマシューティカ エヌ．ベー． | ヘテロアリールジヒドロピリミジン誘導体及びｂ型肝炎感染を治療する方法 |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| US10597382B2 (en) | 2017-08-28 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| AU2018326474B2 (en) * | 2017-08-28 | 2024-07-25 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TW201912153A (zh) * | 2017-08-30 | 2019-04-01 | 加拿大商愛彼特生物製藥公司 | 用於治療ｂ型肝炎的化合物、醫藥組合物及方法 |
| TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| WO2019113175A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2019143902A2 (en) | 2018-01-22 | 2019-07-25 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US10836769B2 (en) | 2018-02-26 | 2020-11-17 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| EA202092171A1 (ru) | 2018-03-14 | 2020-12-01 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Схема дозирования модулятора сборки капсида |
| US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2019206072A1 (zh) * | 2018-04-24 | 2019-10-31 | 浙江海正药业股份有限公司 | 磺酰胺芳基甲酰胺衍生物及其制备方法和用途 |
| JP7328254B2 (ja) | 2018-05-02 | 2023-08-16 | エナンタ ファーマシューティカルズ インコーポレイテッド | アポトーシスシグナル調節キナーゼ１阻害剤を含むテトラゾール及びその使用方法 |
| US10683289B2 (en) | 2018-05-02 | 2020-06-16 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| EP3597653A1 (en) | 2018-07-19 | 2020-01-22 | Irbm S.P.A. | Cyclic inhibitors of hepatitis b virus |
| EP3597637A1 (en) | 2018-07-19 | 2020-01-22 | Irbm S.P.A. | Inhibitors of hepatitis b virus |
| TWI869058B (zh) | 2018-07-27 | 2025-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯，其類似物及使用其之方法 |
| CA3106239A1 (en) | 2018-07-27 | 2020-01-30 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
| US11053235B2 (en) | 2018-08-09 | 2021-07-06 | Janssen Sciences Ireland Unlimited Company | Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases |
| EP3608326A1 (en) | 2018-08-10 | 2020-02-12 | Irbm S.P.A. | Tricyclic inhibitors of hepatitis b virus |
| WO2020041417A1 (en) | 2018-08-22 | 2020-02-27 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| AR116474A1 (es) | 2018-09-21 | 2021-05-12 | Enanta Pharm Inc | DERIVADOS DEL ÁCIDO 6,7-DIHIDRO-2H-BENZOFURO[2,3-a]QUINOLIZIN-3-CARBOXÍLICO COMO AGENTES ANTIVIRALES PARA EL TRATAMIENTO O PREVENCIÓN DE UNA INFECCIÓN POR HBV |
| JP7648528B2 (ja) * | 2018-10-05 | 2025-03-18 | エモリー ユニバーシティ | モノマーおよびマルチマー抗ｈｂｖ薬 |
| BR112021007602A2 (pt) | 2018-10-22 | 2021-07-27 | Assembly Biosciences, Inc. | compostos de heteroaril carboxamida de 5 membros para tratamento de hbv |
| WO2020087107A1 (en) | 2018-10-31 | 2020-05-07 | The University Of Sydney | Compositions and methods for treating viral infections |
| WO2020106707A1 (en) | 2018-11-19 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| BR112021009854A2 (pt) | 2018-11-21 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | heterociclos funcionalizados como agentes antivirais |
| TWI827760B (zh) | 2018-12-12 | 2024-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
| WO2020163479A1 (en) * | 2019-02-05 | 2020-08-13 | Board Of Regents, The University Of Texas System | Antibiotic ammonium compounds and methods for the treatment of bacterial infections |
| MX2021010145A (es) | 2019-02-22 | 2021-09-14 | Janssen Sciences Ireland Unlimited Co | Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb. |
| WO2020198214A1 (en) | 2019-03-25 | 2020-10-01 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| BR112021021454A2 (pt) | 2019-05-06 | 2021-12-21 | Janssen Sciences Ireland Unlimited Co | Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv |
| EP3741762A1 (en) | 2019-05-23 | 2020-11-25 | Irbm S.P.A. | Oxalamido-substituted tricyclic inhibitors of hepatitis b virus |
| EP3825318A1 (en) | 2019-11-25 | 2021-05-26 | Promidis S.r.l. | Oxalamido-substituted tricyclic inhibitors of hepatitis b virus |
| UY38705A (es) | 2019-05-23 | 2020-12-31 | Irbm S P A | Inhibidores tricíclicos sustituidos con oxalamido del virus de hepatitis b |
| AU2020282318A1 (en) | 2019-05-24 | 2021-12-02 | Assembly Biosciences, Inc. | Pharmaceutical compositions for the treatment of HBV |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2020255013A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| CN114391040A (zh) | 2019-09-23 | 2022-04-22 | 欧米茄治疗公司 | 用于调节载脂蛋白b(apob)基因表达的组合物和方法 |
| US11987791B2 (en) | 2019-09-23 | 2024-05-21 | Omega Therapeutics, Inc. | Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4α) gene expression |
| CA3165101A1 (en) | 2019-12-20 | 2021-06-24 | Arbutus Biopharma Corporation | Synthetic processes and intermediates |
| AU2021234302A1 (en) | 2020-03-11 | 2022-11-10 | Omega Therapeutics, Inc. | Compositions and methods for modulating forkhead box p3 (foxp3) gene expression |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| KR20210126507A (ko) | 2020-04-10 | 2021-10-20 | 주식회사 스탠다임 | 벤즈아미드 화합물을 포함하는 암 예방 또는 치료용 조성물 |
| CN111393391B (zh) * | 2020-04-16 | 2022-07-26 | 南京安纳康生物科技有限公司 | 用于乙型肝炎病毒感染的抗病毒剂 |
| CN111349056B (zh) * | 2020-04-16 | 2022-08-02 | 南京安纳康生物科技有限公司 | 用于乙型肝炎病毒感染的抗病毒剂 |
| WO2021216656A1 (en) | 2020-04-22 | 2021-10-28 | Assembly Biosciences, Inc. | 5-membered heteroaryl carboxamide compounds for treatment of hbv |
| WO2021216661A1 (en) | 2020-04-22 | 2021-10-28 | Assembly Biosciences, Inc. | Pyrazole carboxamide compounds for treatment of hbv |
| WO2021216642A1 (en) | 2020-04-22 | 2021-10-28 | Assembly Biosciences, Inc. | Pyrazole carboxamide compounds for treatment of hbv |
| WO2021216660A1 (en) | 2020-04-22 | 2021-10-28 | Assembly Biosciences, Inc. | 5-membered heteroaryl carboxamide compounds for treatment of hbv |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| MX2023005436A (es) * | 2020-11-10 | 2023-07-25 | Foghorn Therapeutics Inc | Compuestos y usos de estos. |
| EP4367242A2 (en) | 2021-07-07 | 2024-05-15 | Omega Therapeutics, Inc. | Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression |
| WO2023069547A1 (en) | 2021-10-20 | 2023-04-27 | Assembly Biosciences, Inc. | 5-membered heteroaryl carboxamide compounds for treatment of hbv |
| WO2023069544A1 (en) | 2021-10-20 | 2023-04-27 | Assembly Biosciences, Inc. | 5-membered heteroaryl carboxamide compounds for treatment of hbv |
| WO2023069545A1 (en) | 2021-10-20 | 2023-04-27 | Assembly Biosciences, Inc. | 5-membered heteroaryl carboxamide compounds for treatment of hbv |
| KR102617049B1 (ko) | 2021-12-30 | 2023-12-21 | 장고옥 | 헤어고데기 |
| WO2023164186A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| US20250163009A1 (en) | 2022-02-25 | 2025-05-22 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164179A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164181A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023183850A1 (en) | 2022-03-23 | 2023-09-28 | Ideaya Biosciences, Inc. | Piperazine substituted indazole compounds as inhibitors of parg |
| WO2024029481A1 (ja) * | 2022-08-01 | 2024-02-08 | 国立研究開発法人理化学研究所 | 抗ｈｂｖ剤 |
| EP4580618A2 (en) * | 2022-08-30 | 2025-07-09 | Pannex Therapeutics Inc. | Pannexin-1 modulators and methods of treating disorders in which pannexin-1 is implicated |
| CN115677545B (zh) * | 2022-10-28 | 2024-03-15 | 潍坊医学院 | 一种抗hbv磺胺苯甲酰胺类衍生物及其制备方法和应用 |
| CN116410106B (zh) * | 2023-04-13 | 2024-12-06 | 山东第二医科大学 | 一种苯甲酰胺类hbv衣壳蛋白抑制剂及其制备方法与应用 |
| WO2024243438A2 (en) | 2023-05-23 | 2024-11-28 | Omega Therapeutics, Inc. | Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression |
| WO2025043094A1 (en) | 2023-08-23 | 2025-02-27 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2891938A (en) * | 1957-03-29 | 1959-06-23 | Geigy Ag J R | Chromium-containing monoazo dyestuffs |
| US3557111A (en) * | 1968-03-29 | 1971-01-19 | Bola Vithal Shetty | N and n,n-alkyl,acyl and arylsulfamyl-tetrahydroquinazolinones |
| US3567746A (en) * | 1968-07-10 | 1971-03-02 | Pennwalt Corp | N-aryl benzamides |
| JPH0625106B2 (ja) | 1985-07-24 | 1994-04-06 | 三共株式会社 | イソインドリン−１，３−ジオン誘導体およびその製造法 |
| EP2298311B1 (en) * | 1999-01-13 | 2012-05-09 | Bayer HealthCare LLC | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| CA2349832A1 (en) * | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzenesulfonamide derivatives and their use as mek inhibitors |
| JP2000212157A (ja) * | 1999-01-13 | 2000-08-02 | Warner Lambert Co | ジアリ―ルアミン |
| WO2007056016A2 (en) * | 2005-11-02 | 2007-05-18 | Kemia, Inc. | Bisamide cytokine inhibitors |
| CA2630233A1 (en) * | 2005-12-05 | 2007-06-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazole compounds useful as soluble epoxide hydrolase inhibitors |
| US7842713B2 (en) | 2006-04-20 | 2010-11-30 | Pfizer Inc | Fused phenyl amido heterocyclic compounds |
| JP2010511728A (ja) * | 2006-12-05 | 2010-04-15 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｉｌ−８受容体アンタゴニスト |
| JP2008184403A (ja) | 2007-01-29 | 2008-08-14 | Japan Health Science Foundation | 新規ｃ型肝炎ウイルス阻害剤 |
| CA2686382C (en) * | 2007-05-04 | 2013-09-17 | Irm Llc | Phenylaminopyrimidine derivatives and compositions thereof as c-kit and pdgfr kinase inhibitors |
| EP2148678A4 (en) * | 2007-05-23 | 2010-08-04 | Siga Technologies Inc | ANTIVIRAL DRUGS FOR THE TREATMENT AND PREVENTION OF DENGUE INFECTION |
| CA2695071A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of cns disorders |
| DE102007041116A1 (de) * | 2007-08-30 | 2009-03-05 | Merck Patent Gmbh | 1,3-Dihydro-isoindolderivate |
| EP2219646A4 (en) * | 2007-12-21 | 2010-12-22 | Univ Rochester | PROCESS FOR EXTENDING THE LIFE OF EUKARYOTIC ORGANISMS |
| US20090197787A1 (en) | 2008-02-04 | 2009-08-06 | Eurotab | Multilayer Detergent Tablet |
| UY31635A1 (es) * | 2008-02-06 | 2009-08-31 | Farmacóforos duales-antagonistas muscarínicos de pde4 | |
| US8263642B2 (en) | 2008-06-25 | 2012-09-11 | Vanderbilt University | Antimicrobial compounds and methods of use thereof |
| EP2236505A1 (de) * | 2009-04-03 | 2010-10-06 | Bayer CropScience AG | Acylierte Aminopyridine und - pyridazine als Insektizide |
| WO2010123139A1 (ja) * | 2009-04-24 | 2010-10-28 | 持田製薬株式会社 | スルファモイル基を有するアリールカルボキサミド誘導体 |
| KR101760956B1 (ko) * | 2009-05-12 | 2017-07-24 | 로마크 레버러토리즈, 엘.씨. | 할로알킬 헤테로아릴 벤즈아미드 화합물 |
| WO2011088561A1 (en) | 2010-01-20 | 2011-07-28 | University Of Manitoba | Anti-viral compounds and compositions |
| KR20130108543A (ko) | 2010-08-05 | 2013-10-04 | 암젠 인코포레이션 | 역형성 림프종 키나제를 억제하는 벤즈이미다졸 및 아자벤즈이미다졸 화합물 |
| US8987307B2 (en) * | 2011-03-03 | 2015-03-24 | Hoffmann-La Roche Inc. | 3-amino-pyridines as GPBAR1 agonists |
| CN105001225B (zh) | 2011-03-08 | 2018-04-06 | 3-V 生物科学公司 | 脂质合成的杂环调节剂 |
| EP2726459B1 (en) * | 2011-07-01 | 2019-09-11 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
| JP5977837B2 (ja) | 2011-12-21 | 2016-08-24 | ノヴィラ・セラピューティクス・インコーポレイテッド | Ｂ型肝炎抗ウイルス剤 |
| BR112014021498A2 (pt) | 2012-02-29 | 2017-07-18 | Institute For Hepatitis And Virus Res | composto, composição e método para tratar uma doença associada com formação de dna circular covalentemente fechado |
| CN104902885A (zh) | 2012-08-28 | 2015-09-09 | 爱尔兰詹森科学公司 | 氨磺酰基-芳基酰胺和其作为药物用于治疗乙型肝炎的用途 |
| SG10201900695PA (en) | 2012-12-06 | 2019-02-27 | Baruch S Blumberg Inst | Functionalized benzamide derivatives as antiviral agents against hbv infection |
| WO2014106019A2 (en) * | 2012-12-27 | 2014-07-03 | Philadelphia Health & Education Corporation, D/B/A Drexel | Novel antiviral agents against hbv infection |
-
2013
- 2013-12-27 WO PCT/US2013/077940 patent/WO2014106019A2/en not_active Ceased
- 2013-12-27 SG SG10201803698UA patent/SG10201803698UA/en unknown
- 2013-12-27 HK HK16105705.7A patent/HK1217649A1/zh unknown
- 2013-12-27 EP EP13868405.5A patent/EP2938338A4/en not_active Withdrawn
- 2013-12-27 SG SG11201504740UA patent/SG11201504740UA/en unknown
- 2013-12-27 AU AU2013370300A patent/AU2013370300B2/en not_active Ceased
- 2013-12-27 MX MX2015008471A patent/MX2015008471A/es unknown
- 2013-12-27 CN CN201380072796.5A patent/CN105209031A/zh active Pending
- 2013-12-27 KR KR1020157020432A patent/KR101942151B1/ko not_active Expired - Fee Related
- 2013-12-27 CA CA2896554A patent/CA2896554C/en not_active Expired - Fee Related
- 2013-12-27 US US14/759,385 patent/US9938236B2/en not_active Expired - Fee Related
- 2013-12-27 EA EA201591220A patent/EA201591220A1/ru unknown
- 2013-12-27 JP JP2015550788A patent/JP6409001B2/ja not_active Expired - Fee Related
- 2013-12-27 BR BR112015015584A patent/BR112015015584A2/pt not_active Application Discontinuation
-
2015
- 2015-06-14 IL IL239397A patent/IL239397B/en not_active IP Right Cessation
- 2015-06-26 PH PH12015501473A patent/PH12015501473A1/en unknown
-
2018
- 2018-03-11 IL IL258007A patent/IL258007A/en unknown
- 2018-03-22 US US15/933,098 patent/US20180230092A1/en not_active Abandoned
- 2018-09-21 JP JP2018177094A patent/JP2019034943A/ja active Pending
-
2019
- 2019-01-31 AU AU2019200663A patent/AU2019200663A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016509591A5 (enExample) | ||
| JP2019034943A5 (enExample) | ||
| JP2013545798A5 (enExample) | ||
| JP2015509110A5 (enExample) | ||
| JP2020522520A5 (enExample) | ||
| JP2018504393A5 (enExample) | ||
| JP2012524111A5 (enExample) | ||
| JP2015517981A5 (enExample) | ||
| RU2012116877A (ru) | Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы | |
| RU2218337C2 (ru) | Производные тиазола, способ их получения и фармацевтическая композиция на их основе | |
| JP2017537940A5 (enExample) | ||
| JP2010520893A5 (enExample) | ||
| JP2008510828A5 (enExample) | ||
| JP2007517846A5 (enExample) | ||
| JP2015535252A5 (enExample) | ||
| JPWO2019013311A5 (enExample) | ||
| JP2004502670A5 (enExample) | ||
| JP2013542267A5 (enExample) | ||
| RU99100277A (ru) | Производные тиазола | |
| JP2016508135A5 (enExample) | ||
| JP2016529235A5 (enExample) | ||
| JP2010527985A5 (enExample) | ||
| JP2018503661A5 (enExample) | ||
| JP2013506674A5 (enExample) | ||
| RU2009102270A (ru) | Производные тиазолилмочевины в качестве ингибиторов фосфатидилинозитол-3-киназы |