JP2012524111A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012524111A5 JP2012524111A5 JP2012506232A JP2012506232A JP2012524111A5 JP 2012524111 A5 JP2012524111 A5 JP 2012524111A5 JP 2012506232 A JP2012506232 A JP 2012506232A JP 2012506232 A JP2012506232 A JP 2012506232A JP 2012524111 A5 JP2012524111 A5 JP 2012524111A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- och
- oneyl
- dihydro
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17030709P | 2009-04-17 | 2009-04-17 | |
| US61/170,307 | 2009-04-17 | ||
| PCT/US2010/031265 WO2010121046A1 (en) | 2009-04-17 | 2010-04-15 | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012524111A JP2012524111A (ja) | 2012-10-11 |
| JP2012524111A5 true JP2012524111A5 (enExample) | 2013-04-25 |
| JP5675773B2 JP5675773B2 (ja) | 2015-02-25 |
Family
ID=42167720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506232A Expired - Fee Related JP5675773B2 (ja) | 2009-04-17 | 2010-04-15 | Ｃｃｒ２の４−アゼチジニル−１−フェニル−シクロヘキサンアンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20100267689A1 (enExample) |
| EP (1) | EP2419419B1 (enExample) |
| JP (1) | JP5675773B2 (enExample) |
| KR (1) | KR20120006544A (enExample) |
| CN (1) | CN102459227B (enExample) |
| AR (1) | AR076328A1 (enExample) |
| AU (1) | AU2010236346B2 (enExample) |
| BR (1) | BRPI1016189A2 (enExample) |
| CA (1) | CA2758934A1 (enExample) |
| ES (1) | ES2528625T3 (enExample) |
| MX (1) | MX2011010964A (enExample) |
| NZ (1) | NZ595432A (enExample) |
| TW (1) | TW201102377A (enExample) |
| WO (1) | WO2010121046A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2745969C (en) | 2008-12-10 | 2017-04-25 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2 |
| MX2011010919A (es) * | 2009-04-16 | 2011-11-02 | Janssen Pharmaceutica Nv | Antagonistas del receptor 2 de citocina quimioatrayente de 4-azetidinil-1-heteroaril-ciclohexano. |
| KR20120006051A (ko) | 2009-04-17 | 2012-01-17 | 얀센 파마슈티카 엔.브이. | Ｃｃｒ2의 4-아제티디닐-1-헤테로원자 연결된 사이클로헥산 길항제 |
| NZ595432A (en) | 2009-04-17 | 2013-12-20 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
| TW201211027A (en) * | 2010-06-09 | 2012-03-16 | Janssen Pharmaceutica Nv | Cyclohexyl-azetidinyl antagonists of CCR2 |
| WO2011159854A1 (en) | 2010-06-17 | 2011-12-22 | Janssen Pharmaceutica Nv | Cyclohexyl-azetidinyl antagonists of ccr2 |
| EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| CN104039321B (zh) | 2011-11-18 | 2017-02-22 | 赫普泰雅治疗有限公司 | 药物化合物 |
| ES2648340T3 (es) * | 2011-12-01 | 2018-01-02 | Chemocentryx, Inc. | Benzoimidazoles y benzopirazoles substituidos como antagonistas de CCR(4) |
| US9546155B2 (en) | 2012-06-15 | 2017-01-17 | Mitsubishi Tanabe Pharma Corporation | Aromatic heterocyclic compound |
| GB201404922D0 (en) | 2014-03-19 | 2014-04-30 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| LT3209655T (lt) | 2014-10-24 | 2021-01-11 | Landos Biopharma, Inc. | Medicininiai preparatai į lantionino sintezę c panašaus baltymo 2 pagrindu |
| DK3050574T3 (da) | 2015-01-28 | 2020-01-20 | Univ Bordeaux | Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom |
| PT3297438T (pt) | 2015-05-21 | 2022-01-25 | Chemocentryx Inc | Moduladores de ccr2 |
| GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201617454D0 (en) * | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| US10259787B2 (en) | 2016-10-14 | 2019-04-16 | Heptares Therapeutics Limited | Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists |
| MA50665A (fr) | 2017-09-25 | 2020-08-05 | Chemocentryx Inc | Polythérapie utilisant un antagoniste du récepteur 2 de la chimiokine (ccr2) et un inhibiteur pd-1/pd-l1 |
| WO2019108418A1 (en) | 2017-11-30 | 2019-06-06 | Landos Biopharma, Inc. | Therapies with lanthionine c-like protein 2 ligands and cells prepared therewith |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| IL275898B2 (en) | 2018-01-08 | 2025-05-01 | Chemocentryx Inc | Methods for treating solid tumors with CCR2 antagonists |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819961D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| CN110028395A (zh) * | 2019-05-29 | 2019-07-19 | 宁夏中星显示材料有限公司 | 一种4-(4-羟基苯基)环己酮的制备方法 |
| CN113748109B (zh) | 2019-12-20 | 2023-07-21 | 朗多生物制药股份有限公司 | 羊毛硫氨酸c样蛋白2配体、用所述配体制备的细胞以及使用所述配体的疗法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037354A (en) * | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| WO1998057641A1 (en) | 1997-06-18 | 1998-12-23 | Merck & Co., Inc. | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS |
| WO2000069815A1 (en) * | 1999-05-13 | 2000-11-23 | Teijin Limited | Ureido-substituted cyclic amine derivatives and their use as drug |
| CN1192773C (zh) | 1999-08-04 | 2005-03-16 | 帝人株式会社 | 环胺ccr3拮抗剂 |
| US6245799B1 (en) * | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
| CA2390531A1 (en) | 1999-11-08 | 2001-05-17 | Wyeth | ¬(indol-3-yl)-cycloalkyl|-3-substituted azetidines for the treatment of central nervous system disorders |
| US6706712B2 (en) * | 2000-12-20 | 2004-03-16 | Bristol-Myers Squibb Pharma Company | Cyclic derivatives as modulators of chemokine receptor activity |
| CN1250605C (zh) * | 2001-03-26 | 2006-04-12 | 拜尔公司 | 具有显著剪切变稀行为的聚碳酸酯 |
| PL376925A1 (pl) * | 2002-11-27 | 2006-01-09 | Incyte Corporation | Pochodne 3-aminopirolidyny jako modulatory receptorów chemokiny |
| UA87449C2 (ru) * | 2002-11-27 | 2009-07-27 | Инсайт Корпорейшн | Производные 3-аминопиролидина как модуляторы рецепторов хемокина |
| BRPI0417605B8 (pt) | 2003-12-18 | 2021-05-25 | Incyte Corp | n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende. |
| EP1802602A1 (en) * | 2004-09-28 | 2007-07-04 | Janssen Pharmaceutica N.V. | Substituted dipiperdine ccr2 antagonists |
| PA8653301A1 (es) * | 2004-11-22 | 2006-11-09 | Incyte Corp Incyte Corp | Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin |
| GB0513747D0 (en) | 2005-07-06 | 2005-08-10 | Merck Sharp & Dohme | Therapeutic compounds |
| US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| US20070197590A1 (en) | 2006-01-31 | 2007-08-23 | Demong Duane E | Substituted dipiperidine ccr2 antagonists |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| KR20100102646A (ko) * | 2007-12-11 | 2010-09-24 | 가부시키가이샤 사이토파스파인더 | 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도 |
| CA2745969C (en) * | 2008-12-10 | 2017-04-25 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2 |
| MX2011010919A (es) * | 2009-04-16 | 2011-11-02 | Janssen Pharmaceutica Nv | Antagonistas del receptor 2 de citocina quimioatrayente de 4-azetidinil-1-heteroaril-ciclohexano. |
| NZ595432A (en) | 2009-04-17 | 2013-12-20 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
| KR20120006051A (ko) * | 2009-04-17 | 2012-01-17 | 얀센 파마슈티카 엔.브이. | Ｃｃｒ2의 4-아제티디닐-1-헤테로원자 연결된 사이클로헥산 길항제 |
-
2010
- 2010-04-15 NZ NZ595432A patent/NZ595432A/en not_active IP Right Cessation
- 2010-04-15 BR BRPI1016189A patent/BRPI1016189A2/pt not_active Application Discontinuation
- 2010-04-15 JP JP2012506232A patent/JP5675773B2/ja not_active Expired - Fee Related
- 2010-04-15 AU AU2010236346A patent/AU2010236346B2/en not_active Ceased
- 2010-04-15 MX MX2011010964A patent/MX2011010964A/es active IP Right Grant
- 2010-04-15 EP EP10714804.1A patent/EP2419419B1/en active Active
- 2010-04-15 ES ES10714804.1T patent/ES2528625T3/es active Active
- 2010-04-15 CA CA2758934A patent/CA2758934A1/en not_active Abandoned
- 2010-04-15 WO PCT/US2010/031265 patent/WO2010121046A1/en not_active Ceased
- 2010-04-15 CN CN201080027641.6A patent/CN102459227B/zh not_active Expired - Fee Related
- 2010-04-15 KR KR1020117026846A patent/KR20120006544A/ko not_active Withdrawn
- 2010-04-15 US US12/761,080 patent/US20100267689A1/en not_active Abandoned
- 2010-04-16 TW TW099111898A patent/TW201102377A/zh unknown
- 2010-04-19 AR ARP100101287A patent/AR076328A1/es unknown
-
2011
- 2011-10-25 US US13/280,690 patent/US8513229B2/en not_active Expired - Fee Related