|
US6548490B1
(en)
|
1997-10-28 |
2003-04-15 |
Vivus, Inc. |
Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
GB0008694D0
(en)
*
|
2000-04-07 |
2000-05-31 |
Novartis Ag |
Organic compounds
|
|
US20030032579A1
(en)
|
2001-04-20 |
2003-02-13 |
Pfizer Inc. |
Therapeutic use of selective PDE10 inhibitors
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
WO2003014116A1
(en)
|
2001-08-06 |
2003-02-20 |
Bayer Corporation |
Pyrrolo[2.1-a]isoquinoline derivatives
|
|
US20030114469A1
(en)
*
|
2001-09-27 |
2003-06-19 |
Cohen David Saul |
Combinations
|
|
WO2004002484A1
(ja)
|
2002-06-26 |
2004-01-08 |
Kyowa Hakko Kogyo Co., Ltd. |
ホスホジエステラーゼ阻害剤
|
|
DE10230605A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Substituierte Imidazotriazine
|
|
DE10230604A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Heterocyclisch substituierte Imidazotriazine
|
|
DE602004022415D1
(de)
|
2003-06-30 |
2009-09-17 |
Nycomed Gmbh |
Pyrrolo-dihydroisochinolin-derivate als pde10-inhibitoren
|
|
CN1809565A
(zh)
|
2003-06-30 |
2006-07-26 |
奥坦纳医药公司 |
用于治疗癌症的吡咯并二氢异喹啉
|
|
WO2005012485A2
(en)
|
2003-07-31 |
2005-02-10 |
Bayer Pharmaceuticals Corporation |
Methods for treating diabetes and related disorders using pde10a inhibitors
|
|
BRPI0507839A
(pt)
|
2004-02-18 |
2007-05-08 |
Pfizer Prod Inc |
derivados tetraidroisoquinolinil de quinazolina e isoquinolina
|
|
WO2005120514A1
(en)
|
2004-06-07 |
2005-12-22 |
Pfizer Products Inc. |
Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
|
|
US20060019975A1
(en)
|
2004-07-23 |
2006-01-26 |
Pfizer Inc |
Novel piperidyl derivatives of quinazoline and isoquinoline
|
|
WO2006028957A1
(en)
|
2004-09-03 |
2006-03-16 |
Memory Pharmaceuticals Corporation |
4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
|
|
WO2006034512A2
(en)
|
2004-09-23 |
2006-03-30 |
Bayer Pharmaceuticals Corporation |
Phenyl-substituted quinoline and quinazoline compounds for the treatment of diabetes
|
|
US7576080B2
(en)
|
2004-12-23 |
2009-08-18 |
Memory Pharmaceuticals Corporation |
Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
|
|
US20060183763A1
(en)
|
2004-12-31 |
2006-08-17 |
Pfizer Inc |
Novel pyrrolidyl derivatives of heteroaromatic compounds
|
|
ATE472543T1
(de)
|
2005-01-07 |
2010-07-15 |
Pfizer Prod Inc |
Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren
|
|
JP2008526817A
(ja)
|
2005-01-12 |
2008-07-24 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規のピロロジヒドロイソキノリン
|
|
US20080161338A1
(en)
|
2005-01-12 |
2008-07-03 |
Altana Pharma Ag |
Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors
|
|
CA2619462A1
(en)
|
2005-08-16 |
2007-02-22 |
Amgen, Inc. |
Phosphodiesterase 10 inhibitors
|
|
JP2009524637A
(ja)
|
2006-01-27 |
2009-07-02 |
ファイザー・プロダクツ・インク |
アミノフタラジン誘導体化合物
|
|
EP1991540A1
(en)
|
2006-02-21 |
2008-11-19 |
Amgen Inc. |
Cinnoline derivatives as phosphodiesterase 10 inhibitors
|
|
AU2007217750A1
(en)
|
2006-02-21 |
2007-08-30 |
Amgen Inc. |
Cinnoline derivatives as phosphodiesterase 10 inhibitors
|
|
JP2009527542A
(ja)
|
2006-02-23 |
2009-07-30 |
ファイザー・プロダクツ・インク |
Pde10阻害薬としての置換キナゾリン
|
|
JP2009528365A
(ja)
|
2006-02-28 |
2009-08-06 |
アムゲン インコーポレイティッド |
ホスホジエステラーゼ10阻害剤としてのシンノリン及びキナゾリン誘導体
|
|
US20090099175A1
(en)
|
2006-03-01 |
2009-04-16 |
Arrington Mark P |
Phosphodiesterase 10 inhibitors
|
|
US20070265258A1
(en)
|
2006-03-06 |
2007-11-15 |
Ruiping Liu |
Quinazoline derivatives as phosphodiesterase 10 inhibitors
|
|
US20070299067A1
(en)
|
2006-03-08 |
2007-12-27 |
Ruiping Liu |
Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
|
|
TW200817400A
(en)
|
2006-05-30 |
2008-04-16 |
Elbion Ag |
Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
|
|
TW200815436A
(en)
|
2006-05-30 |
2008-04-01 |
Elbion Ag |
4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
|
|
US20080090834A1
(en)
|
2006-07-06 |
2008-04-17 |
Pfizer Inc |
Selective azole pde10a inhibitor compounds
|
|
JP2009542732A
(ja)
*
|
2006-07-10 |
2009-12-03 |
ハー・ルンドベック・アクチエゼルスカベット |
6,7−ジアルコキシキナゾリン、6,7−ジアルコキシフタラジンおよび6,7−ジアルコキシイソキノリンの(3−アリール−ピペラジン−1−イル)、(2−アリール−モルホリン−4−イル)および(2−アリール−チオモルホリン−4−イル)誘導体
|
|
WO2008020302A2
(en)
|
2006-08-17 |
2008-02-21 |
Pfizer Products Inc. |
Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
|
|
CA2663178C
(en)
|
2006-09-11 |
2016-01-12 |
Matrix Laboratories Ltd. |
Dibenzofuran derivatives as inhibitors of pde-4 and pde-10
|
|
CN101166128A
(zh)
|
2006-10-16 |
2008-04-23 |
琥珀技术有限公司 |
一种提供第三方服务的方法及相应的系统
|
|
EP2083819B1
(en)
|
2006-11-21 |
2017-02-22 |
Omeros Corporation |
Pde10 inhibitors and related compositions and methods
|
|
US7786139B2
(en)
|
2006-11-21 |
2010-08-31 |
Omeros Corporation |
PDE10 inhibitors and related compositions and methods
|
|
WO2009025823A1
(en)
|
2007-08-21 |
2009-02-26 |
Amgen Inc. |
Phosphodiesterase 10 inhibitors
|
|
WO2009025839A2
(en)
|
2007-08-22 |
2009-02-26 |
Amgen Inc. |
Phosphodiesterase 10 inhibitors
|
|
WO2009029214A1
(en)
|
2007-08-23 |
2009-03-05 |
Amgen Inc. |
Isoquinolone derivatives as phosphodiesterase 10 inhibitors
|
|
TW200918519A
(en)
|
2007-09-19 |
2009-05-01 |
Lundbeck & Co As H |
Cyanoisoquinoline
|
|
US7875618B2
(en)
|
2007-11-30 |
2011-01-25 |
Wyeth |
Substituted imidazo[1,5-a]quinoxalines useful as inhibitors of phosphodiesterase 10 for the treatment of neurological and other disorders
|
|
CA2706986A1
(en)
|
2007-11-30 |
2009-06-04 |
Elbion Gmbh |
Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
|
|
WO2009070583A1
(en)
|
2007-11-30 |
2009-06-04 |
Wyeth |
Pyrido[3,2-e]pyrazines, process for preparing the same, and their use as inhibitors of phosphodiesterase 10
|
|
WO2009143178A2
(en)
|
2008-05-20 |
2009-11-26 |
Omeros Corporation |
Pde10 inhibitors and related compositions and methods
|
|
UA102693C2
(ru)
|
2008-06-20 |
2013-08-12 |
Х. Луннбек А/С |
Производные фенилимидазола как ингибиторы фермента pde10a
|
|
US8133897B2
(en)
|
2008-06-20 |
2012-03-13 |
H. Lundbeck A/S |
Phenylimidazole derivatives as PDE10A enzyme inhibitors
|
|
TWI501965B
(zh)
|
2008-06-20 |
2015-10-01 |
Lundbeck & Co As H |
作為pde10a酵素抑制劑之新穎苯基咪唑衍生物
|
|
CN102131798A
(zh)
|
2008-06-25 |
2011-07-20 |
英维沃医药有限公司 |
用作磷酸二酯酶10抑制剂的二取代的苯基化合物
|
|
JP5658664B2
(ja)
|
2008-06-25 |
2015-01-28 |
フォルム ファーマシューティカルズ、インコーポレイテッド |
1,2−二置換複素環式化合物
|
|
WO2010006130A2
(en)
|
2008-07-09 |
2010-01-14 |
Envivo Pharmaceuticals, Inc. |
Pde-10 inhibitors
|
|
CN102143752B
(zh)
|
2008-08-05 |
2014-12-10 |
奥默罗斯公司 |
Pde10抑制剂以及相关组合物和方法
|
|
KR101324329B1
(ko)
|
2008-09-04 |
2013-10-31 |
미쓰비시 타나베 파마 코퍼레이션 |
삼치환된 피리미딘 화합물 및 pde10 억제제로서의 그의 용도
|
|
AU2009320125A1
(en)
|
2008-10-28 |
2010-06-03 |
Schering Corporation |
Substituted pyrazoloquinolines and derivatives thereof
|
|
US20100120762A1
(en)
|
2008-11-07 |
2010-05-13 |
Wyeth |
Triazine derivatives as inhibitors of phosphodiesterases
|
|
US20100120763A1
(en)
|
2008-11-07 |
2010-05-13 |
Wyeth |
Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
|
|
TW201030001A
(en)
|
2008-11-14 |
2010-08-16 |
Amgen Inc |
Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
|
|
WO2010063610A1
(en)
|
2008-12-04 |
2010-06-10 |
F. Hoffmann-La Roche Ag |
Pyridazinone derivatives
|
|
WO2010077992A1
(en)
|
2008-12-17 |
2010-07-08 |
Amgen Inc. |
Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors
|
|
US8916566B2
(en)
|
2009-02-05 |
2014-12-23 |
Takeda Pharmaceutical Company Limited |
Pyridazinone compounds as phosphodiesterase inhibitors and methods of treating disorders
|
|
US9187455B2
(en)
|
2009-02-23 |
2015-11-17 |
Hoffmann-La Roche Inc. |
Substituted pyridazines as PDE10A inhibitors
|
|
US20110305637A1
(en)
|
2009-02-24 |
2011-12-15 |
Janssen Pharmaceutica N.V. |
Radiolabelled pde10 ligands
|
|
EP2417135A1
(en)
|
2009-04-07 |
2012-02-15 |
Schering Corporation |
Substituted triazolopyridines and analogs thereof
|
|
CA2761032A1
(en)
|
2009-05-07 |
2010-11-11 |
Envivo Pharmaceuticals, Inc. |
Phenoxymethyl heterocyclic compounds
|
|
US8492392B2
(en)
|
2009-05-27 |
2013-07-23 |
Merck Sharp & Dohme Corp. |
Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors
|
|
CA2763130C
(en)
|
2009-05-29 |
2017-01-17 |
Merck Sharp & Dohme Corp. |
Radiolabeled pde10 inhibitors
|
|
TW201111383A
(en)
|
2009-05-29 |
2011-04-01 |
Wyeth Llc |
Substituted imidazo[1,5-a]quinoxalines as inhibitors of phosphodiesterase 10
|
|
WO2010138585A1
(en)
|
2009-05-29 |
2010-12-02 |
Merck Sharp & Dohme Corp. |
Pyrimidinones as pde10 inhibitors
|
|
US8691827B2
(en)
|
2009-08-17 |
2014-04-08 |
Merck Sharp & Dohme Corp. |
Amino tetrahydro-pyridopyrimidine PDE10 inhibitors
|
|
PE20121438A1
(es)
|
2009-09-24 |
2012-10-26 |
Hoffmann La Roche |
Derivados de imidazopiridina o imidazopirimidina como inhibidores de fosfodiesterasa 10a
|
|
CA2776240C
(en)
|
2009-10-30 |
2017-06-13 |
Janssen Pharmaceutica Nv |
Radiolabelled pde10 ligands
|
|
ES2651296T3
(es)
|
2009-10-30 |
2018-01-25 |
Janssen Pharmaceutica, N.V. |
Derivados de imidazo[1,2-b]piridacina y su uso como inhibidores de PDE10
|
|
EP2493308A4
(en)
|
2009-10-30 |
2013-05-15 |
Merck Sharp & Dohme |
ARYLAMINOPYRIDIN PDE10 INHIBITORS
|
|
TWI481607B
(zh)
|
2009-12-17 |
2015-04-21 |
Lundbeck & Co As H |
作為pde10a酵素抑制劑的2-芳基咪唑衍生物
|
|
TWI487705B
(zh)
|
2009-12-17 |
2015-06-11 |
Lundbeck & Co As H |
作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物
|
|
TW201200516A
(en)
|
2009-12-17 |
2012-01-01 |
Lundbeck & Co As H |
Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
|
|
TWI485151B
(zh)
|
2009-12-17 |
2015-05-21 |
Lundbeck & Co As H |
作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物
|
|
US8470820B2
(en)
|
2010-01-22 |
2013-06-25 |
Hoffman-La Roche Inc. |
Nitrogen-containing heteroaryl derivatives
|
|
PH12012501643A1
(en)
|
2010-02-26 |
2017-07-19 |
Mitsubishi Tanabe Pharma Corp |
Pyrazolopyrimidine compounds and their use as pde 10 inhibitors
|
|
JP2011201873A
(ja)
|
2010-03-03 |
2011-10-13 |
Mitsubishi Tanabe Pharma Corp |
三置換ピリミジン化合物及びそのpde10阻害薬としての使用
|
|
AR080754A1
(es)
|
2010-03-09 |
2012-05-09 |
Janssen Pharmaceutica Nv |
Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
|
|
NZ724645A
(en)
|
2010-03-12 |
2018-04-27 |
Omeros Corp |
Pde10 inhibitors and related compositions and methods
|
|
US8410117B2
(en)
|
2010-03-26 |
2013-04-02 |
Hoffmann-La Roche Inc. |
Imidazopyrimidine derivatives
|
|
WO2011132051A2
(en)
|
2010-04-19 |
2011-10-27 |
Glenmark Pharmaceuticals S.A. |
Tricycle compounds as phosphodiesterase-10 inhibitors
|
|
WO2011132048A1
(en)
|
2010-04-19 |
2011-10-27 |
Glenmark Pharmaceutical S.A. |
Heteroaryl compounds as pde10a inhibitors
|
|
WO2011138657A1
(en)
|
2010-05-04 |
2011-11-10 |
Glenmark Pharmaceuticals S.A. |
Aryl substituted olefinic compounds as pde10a inhibitors
|
|
MX2012013124A
(es)
|
2010-05-13 |
2013-01-18 |
Amgen Inc |
Compuestos heteroariloxicarbociclico como inhibidores pde10.
|
|
WO2011143495A1
(en)
|
2010-05-13 |
2011-11-17 |
Amgen Inc. |
Heteroaryloxyheterocyclyl compounds as pde10 inhibitors
|
|
CN103221404B
(zh)
|
2010-05-13 |
2015-12-16 |
安姆根有限公司 |
可用作pde10抑制剂的不饱和氮杂环化合物
|
|
EP3318561B1
(en)
|
2010-05-26 |
2021-12-22 |
Sunovion Pharmaceuticals Inc. |
Heteroaryl compounds and methods of use thereof
|
|
US8703768B2
(en)
|
2010-06-09 |
2014-04-22 |
Hoffmann-La Roche Inc. |
Nitrogen containing heteroaryl compounds
|
|
TWI546302B
(zh)
|
2010-06-24 |
2016-08-21 |
武田藥品工業股份有限公司 |
稠合雜環化合物
|
|
TW201215607A
(en)
|
2010-07-02 |
2012-04-16 |
Lundbeck & Co As H |
Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor
|
|
TW201206935A
(en)
|
2010-07-16 |
2012-02-16 |
Lundbeck & Co As H |
Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor
|
|
SG192839A1
(en)
|
2011-02-18 |
2013-09-30 |
Allergan Inc |
Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
|
|
US9200016B2
(en)
*
|
2013-12-05 |
2015-12-01 |
Allergan, Inc. |
Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
|