|
US6548490B1
(en)
|
1997-10-28 |
2003-04-15 |
Vivus, Inc. |
Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
GB0008694D0
(en)
*
|
2000-04-07 |
2000-05-31 |
Novartis Ag |
Organic compounds
|
|
US20030032579A1
(en)
|
2001-04-20 |
2003-02-13 |
Pfizer Inc. |
Therapeutic use of selective PDE10 inhibitors
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
WO2003014116A1
(en)
|
2001-08-06 |
2003-02-20 |
Bayer Corporation |
Pyrrolo[2.1-a]isoquinoline derivatives
|
|
US20030114469A1
(en)
*
|
2001-09-27 |
2003-06-19 |
Cohen David Saul |
Combinations
|
|
US20060111368A1
(en)
|
2002-06-26 |
2006-05-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Phosphodiesterase inhibitor
|
|
DE10230604A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Heterocyclisch substituierte Imidazotriazine
|
|
DE10230605A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Substituierte Imidazotriazine
|
|
KR20060030483A
(ko)
|
2003-06-30 |
2006-04-10 |
알타나 파마 아게 |
Ｐｄｅ10 억제제로서 피롤로디히드로이소퀴놀린
|
|
CA2530114A1
(en)
|
2003-06-30 |
2005-01-13 |
Altana Pharma Ag |
Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
|
|
WO2005012485A2
(en)
|
2003-07-31 |
2005-02-10 |
Bayer Pharmaceuticals Corporation |
Methods for treating diabetes and related disorders using pde10a inhibitors
|
|
JP2007523152A
(ja)
|
2004-02-18 |
2007-08-16 |
ファイザー・プロダクツ・インク |
キナゾリンおよびイソキノリンのテトラヒドロイソキノリニル誘導体
|
|
EP1755611A1
(en)
|
2004-06-07 |
2007-02-28 |
Pfizer Products Inc. |
Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
|
|
US20060019975A1
(en)
|
2004-07-23 |
2006-01-26 |
Pfizer Inc |
Novel piperidyl derivatives of quinazoline and isoquinoline
|
|
AU2005282721A1
(en)
|
2004-09-03 |
2006-03-16 |
Memory Pharmaceuticals Corporation |
4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
|
|
WO2006034512A2
(en)
|
2004-09-23 |
2006-03-30 |
Bayer Pharmaceuticals Corporation |
Phenyl-substituted quinoline and quinazoline compounds for the treatment of diabetes
|
|
US7576080B2
(en)
|
2004-12-23 |
2009-08-18 |
Memory Pharmaceuticals Corporation |
Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
|
|
US20060183763A1
(en)
|
2004-12-31 |
2006-08-17 |
Pfizer Inc |
Novel pyrrolidyl derivatives of heteroaromatic compounds
|
|
EA012211B1
(ru)
|
2005-01-07 |
2009-08-28 |
Пфайзер Продактс Инк. |
Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10
|
|
ATE430148T1
(de)
|
2005-01-12 |
2009-05-15 |
Nycomed Gmbh |
Neue pyrrolodihydroisochinoline als pde10- inhibitoren
|
|
EP1838708A2
(en)
|
2005-01-12 |
2007-10-03 |
Nycomed GmbH |
Pyrrolodihydroisoquinolines as antiproliferative agents
|
|
JP2009504759A
(ja)
|
2005-08-16 |
2009-02-05 |
メモリ ファーマセチカル コーポレーション |
ホスホジエステラーゼ１０阻害剤
|
|
BRPI0707223A2
(pt)
|
2006-01-27 |
2011-04-26 |
Pfizer Prod Inc |
compostos de derivados de aminoftalazina
|
|
WO2007098169A1
(en)
|
2006-02-21 |
2007-08-30 |
Amgen Inc. |
Cinnoline derivatives as phosphodiesterase 10 inhibitors
|
|
JP2009527562A
(ja)
|
2006-02-21 |
2009-07-30 |
アムゲン インコーポレイティッド |
ホスホジエステラーゼ１０阻害剤としてのシンノリン誘導体
|
|
WO2007096743A1
(en)
|
2006-02-23 |
2007-08-30 |
Pfizer Products Inc. |
Substituted quinazolines as pde10 inhibitors
|
|
AU2007221049A1
(en)
|
2006-02-28 |
2007-09-07 |
Amgen Inc. |
Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors
|
|
US20090099175A1
(en)
|
2006-03-01 |
2009-04-16 |
Arrington Mark P |
Phosphodiesterase 10 inhibitors
|
|
US20070265258A1
(en)
|
2006-03-06 |
2007-11-15 |
Ruiping Liu |
Quinazoline derivatives as phosphodiesterase 10 inhibitors
|
|
WO2007103554A1
(en)
|
2006-03-08 |
2007-09-13 |
Amgen Inc. |
Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
|
|
TW200817400A
(en)
|
2006-05-30 |
2008-04-16 |
Elbion Ag |
Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
|
|
TW200815436A
(en)
|
2006-05-30 |
2008-04-01 |
Elbion Ag |
4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
|
|
US20080090834A1
(en)
|
2006-07-06 |
2008-04-17 |
Pfizer Inc |
Selective azole pde10a inhibitor compounds
|
|
US8492394B2
(en)
|
2006-07-10 |
2013-07-23 |
H. Lundbeck A/S |
(3-aryl-piperazin-1-yl), (2-aryl-morpholin-4-yl) and (2-aryl-thiomorpholin-4-yl) derivatives of 6,7-dialkoxy-quinazoline, 6,7-dialkoxyphtalazine and 6,7-dialkoxyisoquinoline as PDE10A enzyme inhibitors
|
|
WO2008020302A2
(en)
|
2006-08-17 |
2008-02-21 |
Pfizer Products Inc. |
Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
|
|
RU2009113585A
(ru)
|
2006-09-11 |
2010-10-20 |
Матрикс Лэборетериз Лтд. (In) |
Производные дибензофурана в качестве ингибиторов pde-4 и pde-10
|
|
CN101166128A
(zh)
|
2006-10-16 |
2008-04-23 |
琥珀技术有限公司 |
一种提供第三方服务的方法及相应的系统
|
|
US7786139B2
(en)
|
2006-11-21 |
2010-08-31 |
Omeros Corporation |
PDE10 inhibitors and related compositions and methods
|
|
EP2083819B1
(en)
|
2006-11-21 |
2017-02-22 |
Omeros Corporation |
Pde10 inhibitors and related compositions and methods
|
|
WO2009025823A1
(en)
|
2007-08-21 |
2009-02-26 |
Amgen Inc. |
Phosphodiesterase 10 inhibitors
|
|
US20090062291A1
(en)
|
2007-08-22 |
2009-03-05 |
Essa Hu |
Phosphodiesterase 10 inhibitors
|
|
WO2009029214A1
(en)
*
|
2007-08-23 |
2009-03-05 |
Amgen Inc. |
Isoquinolone derivatives as phosphodiesterase 10 inhibitors
|
|
TW200918519A
(en)
*
|
2007-09-19 |
2009-05-01 |
Lundbeck & Co As H |
Cyanoisoquinoline
|
|
WO2009068320A1
(en)
|
2007-11-30 |
2009-06-04 |
Elbion Gmbh |
Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
|
|
US20090143361A1
(en)
|
2007-11-30 |
2009-06-04 |
Elbion Gmbh |
Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
|
|
WO2009070584A1
(en)
|
2007-11-30 |
2009-06-04 |
Wyeth |
Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
|
|
WO2009143178A2
(en)
|
2008-05-20 |
2009-11-26 |
Omeros Corporation |
Pde10 inhibitors and related compositions and methods
|
|
US8133897B2
(en)
|
2008-06-20 |
2012-03-13 |
H. Lundbeck A/S |
Phenylimidazole derivatives as PDE10A enzyme inhibitors
|
|
TWI501965B
(zh)
|
2008-06-20 |
2015-10-01 |
Lundbeck & Co As H |
作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
|
|
WO2010145668A1
(en)
|
2009-06-19 |
2010-12-23 |
H. Lundbeck A/S |
Novel phenylimidazole derivative as pde10a enzyme inhibitor
|
|
MX2011000177A
(es)
|
2008-06-25 |
2011-06-20 |
Envivo Pharmaceuticals Inc |
Compuestos fenilo di-substituido como inhibidores de fosfodiesterasa 10.
|
|
BRPI0914772A2
(pt)
|
2008-06-25 |
2015-10-20 |
Envivo Pharmaceuticals Inc |
compostos heterocíclicos 1,2-dissubstituídos
|
|
WO2010006130A2
(en)
|
2008-07-09 |
2010-01-14 |
Envivo Pharmaceuticals, Inc. |
Pde-10 inhibitors
|
|
CN102143752B
(zh)
|
2008-08-05 |
2014-12-10 |
奥默罗斯公司 |
Pde10抑制剂以及相关组合物和方法
|
|
WO2010027097A1
(en)
|
2008-09-04 |
2010-03-11 |
Mitsubishi Tanabe Pharma Corporation |
Tri-substituted pyrimidine compounds and their use as pde10 inhibitors
|
|
CA2741303A1
(en)
|
2008-10-28 |
2010-06-03 |
Schering Corporation |
Substituted pyrazoloquinolines and derivatives thereof
|
|
WO2010054253A1
(en)
|
2008-11-07 |
2010-05-14 |
Biotie Therapies Gmbh |
Triazine derivatives as inhibitors of phosphodiesterases
|
|
WO2010054260A1
(en)
|
2008-11-07 |
2010-05-14 |
Biotie Therapies Gmbh |
Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
|
|
TW201030001A
(en)
|
2008-11-14 |
2010-08-16 |
Amgen Inc |
Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
|
|
KR101371881B1
(ko)
|
2008-12-04 |
2014-03-07 |
에프. 호프만-라 로슈 아게 |
피리다진온 유도체
|
|
AU2009333214B2
(en)
|
2008-12-17 |
2013-09-26 |
Amgen Inc. |
Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors
|
|
MY170610A
(en)
|
2009-02-05 |
2019-08-20 |
Takeda Pharmaceuticals Co |
Pyridazinone compounds
|
|
US9187455B2
(en)
|
2009-02-23 |
2015-11-17 |
Hoffmann-La Roche Inc. |
Substituted pyridazines as PDE10A inhibitors
|
|
WO2010097367A1
(en)
|
2009-02-24 |
2010-09-02 |
Janssen Pharmaceutica Nv |
Radiolabelled pde10 ligands
|
|
US8685967B2
(en)
|
2009-04-07 |
2014-04-01 |
Merck Sharp & Dohme Corp. |
Substituted triazolopyridines and analogs thereof
|
|
CA2761032A1
(en)
|
2009-05-07 |
2010-11-11 |
Envivo Pharmaceuticals, Inc. |
Phenoxymethyl heterocyclic compounds
|
|
EP2434885B1
(en)
|
2009-05-27 |
2014-03-26 |
Merck Sharp & Dohme Corp. |
Alkoxy tetrahydro-pyridopyrimidine pde10 inhibitors
|
|
EP2435048B1
(en)
|
2009-05-29 |
2019-07-03 |
Merck Sharp & Dohme Corp. |
Radiolabeled pde10 inhibitors
|
|
WO2010138833A1
(en)
|
2009-05-29 |
2010-12-02 |
Wyeth |
SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10
|
|
WO2010138585A1
(en)
|
2009-05-29 |
2010-12-02 |
Merck Sharp & Dohme Corp. |
Pyrimidinones as pde10 inhibitors
|
|
WO2011022213A1
(en)
|
2009-08-17 |
2011-02-24 |
Merck Sharp & Dohme Corp. |
Amino tetrahydro-pyridopyrimidine pde10 inhibitors
|
|
PL2480546T3
(pl)
|
2009-09-24 |
2015-05-29 |
Hoffmann La Roche |
Pochodne imidazopirydyny i imidazopirymidyny jako inhibitory fosfodiesterazy 10A
|
|
CA2778949C
(en)
|
2009-10-30 |
2018-02-27 |
Janssen Pharmaceutica Nv |
Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors
|
|
US8349830B2
(en)
|
2009-10-30 |
2013-01-08 |
Merck Sharp & Dohme |
Aryl aminopyridine PDE10 inhibitors
|
|
WO2011051324A1
(en)
|
2009-10-30 |
2011-05-05 |
Janssen Pharmaceutica Nv |
Radiolabelled pde10 ligands
|
|
TW201200516A
(en)
|
2009-12-17 |
2012-01-01 |
Lundbeck & Co As H |
Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
|
|
TWI481607B
(zh)
|
2009-12-17 |
2015-04-21 |
Lundbeck & Co As H |
作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
|
|
TWI485151B
(zh)
|
2009-12-17 |
2015-05-21 |
Lundbeck & Co As H |
作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
|
|
TWI487705B
(zh)
|
2009-12-17 |
2015-06-11 |
Lundbeck & Co As H |
作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
|
|
US8470820B2
(en)
|
2010-01-22 |
2013-06-25 |
Hoffman-La Roche Inc. |
Nitrogen-containing heteroaryl derivatives
|
|
TWI476200B
(zh)
|
2010-02-26 |
2015-03-11 |
Mitsubishi Tanabe Pharma Corp |
吡唑並嘧啶化合物及其充作ｐｄｅ１０抑制劑之用途
|
|
JP2011201873A
(ja)
|
2010-03-03 |
2011-10-13 |
Mitsubishi Tanabe Pharma Corp |
三置換ピリミジン化合物及びそのｐｄｅ１０阻害薬としての使用
|
|
AR080754A1
(es)
|
2010-03-09 |
2012-05-09 |
Janssen Pharmaceutica Nv |
Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
|
|
NZ601967A
(en)
|
2010-03-12 |
2015-03-27 |
Omeros Corp |
Pde10 inhibitors and related compositions and methods
|
|
US8410117B2
(en)
|
2010-03-26 |
2013-04-02 |
Hoffmann-La Roche Inc. |
Imidazopyrimidine derivatives
|
|
WO2011132051A2
(en)
|
2010-04-19 |
2011-10-27 |
Glenmark Pharmaceuticals S.A. |
Tricycle compounds as phosphodiesterase-10 inhibitors
|
|
WO2011132048A1
(en)
|
2010-04-19 |
2011-10-27 |
Glenmark Pharmaceutical S.A. |
Heteroaryl compounds as pde10a inhibitors
|
|
WO2011138657A1
(en)
|
2010-05-04 |
2011-11-10 |
Glenmark Pharmaceuticals S.A. |
Aryl substituted olefinic compounds as pde10a inhibitors
|
|
NZ603876A
(en)
|
2010-05-13 |
2015-02-27 |
Amgen Inc |
Nitrogen heterocyclic compounds useful as pde10 inhibitors
|
|
JP2013526537A
(ja)
|
2010-05-13 |
2013-06-24 |
アムジエン・インコーポレーテツド |
Ｐｄｅ１０阻害剤としてのヘテロアリールオキシカルボシクリル化合物
|
|
JP2013526546A
(ja)
|
2010-05-13 |
2013-06-24 |
アムジエン・インコーポレーテツド |
Ｐｄｅ１０阻害剤としてのヘテロアリ−ルオキシヘテロシクリル化合物
|
|
CA2800618C
(en)
|
2010-05-26 |
2018-08-28 |
Sunovion Pharmaceuticals Inc. |
Heteroaryl compounds and methods of use thereof
|
|
US8703768B2
(en)
|
2010-06-09 |
2014-04-22 |
Hoffmann-La Roche Inc. |
Nitrogen containing heteroaryl compounds
|
|
MA34385B1
(fr)
|
2010-06-24 |
2013-07-03 |
Takeda Pharmaceutical |
Composés hétérocycliques condensés comme inhibiteurs de phosphodiestérases (pdes)
|
|
TW201215607A
(en)
|
2010-07-02 |
2012-04-16 |
Lundbeck & Co As H |
Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor
|
|
TW201206935A
(en)
|
2010-07-16 |
2012-02-16 |
Lundbeck & Co As H |
Triazolo-and pyrazoloquinazoline derivatives as PDE10A enzyme inhibitor
|
|
MX2013009575A
(es)
*
|
2011-02-18 |
2014-10-14 |
Exonhit Therapeutics Sa |
Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a).
|
|
US9200016B2
(en)
*
|
2013-12-05 |
2015-12-01 |
Allergan, Inc. |
Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
|